Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0056 | 0.06 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.025 | 0.0679 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.025 | 0.0298 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0116 | 0.0113 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0264 | 0.3184 | 0.3223 |
Echinococcus multilocularis | snurportin 1 | 0.0301 | 0.3642 | 0.364 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0339 | 0.0337 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0184 | 0.0218 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0977 | 0.2676 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0264 | 0.3184 | 0.3182 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0316 | 0.032 |
Leishmania major | dihydroorotate dehydrogenase | 0.0677 | 0.8312 | 1 |
Schistosoma mansoni | atpase class VI type 11c | 0.0008 | 0.0003 | 0.0003 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.025 | 0.0298 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0092 | 0.0091 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0897 | 0.1076 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0056 | 0.06 | 0.164 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0509 | 0.1391 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Schistosoma mansoni | eyes absent homolog | 0.0087 | 0.0977 | 0.0989 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0677 | 0.8312 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0509 | 0.0609 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0977 | 0.1172 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0339 | 0.1058 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0677 | 0.8312 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0677 | 0.8312 | 1 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0008 | 0.0003 | 0.0003 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.025 | 0.0247 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0003 | 0.0003 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0677 | 0.8312 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0017 | 0.0116 | 0.0311 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0339 | 0.0344 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 0.3829 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0677 | 0.8312 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0116 | 0.0115 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0802 | 0.9873 | 0.9873 |
Schistosoma mansoni | ATPase | 0.0008 | 0.0003 | 0.0003 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0339 | 0.0405 |
Echinococcus granulosus | snurportin 1 | 0.0301 | 0.3642 | 0.3687 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0977 | 0.2676 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0301 | 0.3642 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0264 | 0.3184 | 0.3223 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0.0003 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.025 | 0.0298 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0184 | 0.0569 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.3642 | 0.3689 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Schistosoma mansoni | cation-transporting ATPase | 0.0008 | 0.0003 | 0.0003 |
Schistosoma mansoni | cation-transporting atpase 13a1 (G-box binding protein) | 0.0008 | 0.0003 | 0.0003 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0092 | 0.0091 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.025 | 0.0251 |
Trichomonas vaginalis | helicase, putative | 0.0013 | 0.0058 | 0.0174 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0677 | 0.8312 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0677 | 0.8312 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0677 | 0.8312 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0677 | 0.8312 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0184 | 0.0569 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0092 | 0.009 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0677 | 0.8312 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0339 | 0.1058 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0074 | 0.0071 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.025 | 0.0253 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0184 | 0.0218 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0264 | 0.3184 | 0.3182 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0092 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0339 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0509 | 0.1391 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0092 | 0.009 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0003 | 0.0003 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0008 | 0.0003 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0339 | 0.1058 |
Giardia lamblia | Phospholipid-transporting ATPase IA, putative | 0.0008 | 0.0003 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0677 | 0.8312 | 1 |
Chlamydia trachomatis | metal transport ATPase | 0.0008 | 0.0003 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0003 | 0.0003 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0264 | 0.3184 | 0.3829 |
Brugia malayi | CXXC zinc finger family protein | 0.0056 | 0.06 | 0.0718 |
Schistosoma mansoni | cation-transporting atpase worm | 0.0008 | 0.0003 | 0.0003 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Schistosoma mansoni | ATPase | 0.0008 | 0.0003 | 0.0003 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0316 | 0.0861 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0017 | 0.0113 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 0.9873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0092 | 0.0094 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0014 | 0.0074 | 0.0074 |
Schistosoma mansoni | cation-transporting atpase worm | 0.0008 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0339 | 0.1058 |
Echinococcus granulosus | cpg binding protein | 0.006 | 0.064 | 0.0645 |
Giardia lamblia | Copper-transporting P-type ATPase | 0.0008 | 0.0003 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.025 | 0.0298 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0184 | 0.0569 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.064 | 0.0648 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.064 | 0.0648 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0014 | 0.0074 | 0.0071 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0092 | 0.0108 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.025 | 0.0298 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0677 | 0.8312 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0316 | 0.0377 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0677 | 0.8312 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.006 | 0.064 | 0.0637 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0003 | 0.0003 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0003 | 0.0003 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0119 | 0.1385 | 0.1403 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.025 | 0.0298 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0184 | 0.0569 |
Echinococcus granulosus | dnaJ subfamily B | 0.0802 | 0.9873 | 1 |
Schistosoma mansoni | phosphoserine phosphatase | 0.0008 | 0.0003 | 0.0003 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0014 | 0.0074 | 0.0072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0092 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0092 | 0.0246 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0092 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0092 | 0.0094 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0074 | 0.0072 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0107 | 0.1226 | 0.1472 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0339 | 0.0341 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0677 | 0.8312 | 0.8419 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Schistosoma mansoni | copper ABC transporter ATPase | 0.0008 | 0.0003 | 0.0003 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0058 | 0.0174 |
Trichomonas vaginalis | ferritin, putative | 0.0008 | 0.0003 | 0.0001 |
Schistosoma mansoni | type V p-type atpase isoform | 0.0008 | 0.0003 | 0.0003 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0092 | 0.009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0058 | 0.0174 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0264 | 0.3184 | 1 |
Onchocerca volvulus | 0.0056 | 0.06 | 1 | |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0003 | 0.0003 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0509 | 0.0609 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0092 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0092 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.