Detailed information for compound 580382

Basic information

Technical information
  • TDR Targets ID: 580382
  • Name: 2,2-difluoro-1,3-benzodioxole
  • MW: 158.102 | Formula: C7H4F2O2
  • H donors: 0 H acceptors: 0 LogP: 2.5 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC1(F)Oc2c(O1)cccc2
  • InChi: 1S/C7H4F2O2/c8-7(9)10-5-3-1-2-4-6(5)11-7/h1-4H
  • InChiKey: DGCOGZQDAXUUBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1583-59-1
  • EINECS 216-431-4
  • ZINC00157363

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1231 0.2647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Brugia malayi TAR-binding protein 0.0192 0.3801 0.3801
Mycobacterium ulcerans lipase LipD 0.0072 0.1231 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0369 0.0779
Echinococcus granulosus Smad4 0.0033 0.0398 0.0841
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0398 0.0898
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0369 0.0369
Brugia malayi Fli-1 protein 0.0217 0.4333 0.4333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.3801 0.3801
Brugia malayi RNA binding protein 0.0192 0.3801 0.3801
Schistosoma mansoni tar DNA-binding protein 0.0192 0.3801 0.8768
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.9505 1
Schistosoma mansoni hypothetical protein 0.0032 0.0369 0.0832
Brugia malayi beta-lactamase family protein 0.0072 0.1231 0.1231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0369 0.0369
Onchocerca volvulus 0.0072 0.1231 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1231 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1231 0.2825
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.4624 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0009 0.0009
Loa Loa (eye worm) RNA binding protein 0.0192 0.3801 0.3801
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0701 0.0701
Echinococcus multilocularis tar DNA binding protein 0.0192 0.3801 0.8216
Echinococcus granulosus intermediate filament protein 0.0027 0.0264 0.0552
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0649 0.1386
Onchocerca volvulus 0.0027 0.0264 0.2084
Schistosoma mansoni tar DNA-binding protein 0.0192 0.3801 0.8768
Schistosoma mansoni hypothetical protein 0.0047 0.0701 0.1599
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0398 0.0841
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1223 0.263
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Echinococcus multilocularis musashi 0.0027 0.0264 0.0552
Loa Loa (eye worm) hypothetical protein 0.0061 0.1002 0.1002
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1231 0.5
Loa Loa (eye worm) hypothetical protein 0.0423 0.8727 0.8727
Loa Loa (eye worm) beta-lactamase 0.0072 0.1231 0.1231
Brugia malayi MH2 domain containing protein 0.0033 0.0398 0.0398
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0264 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0369 0.0779
Schistosoma mansoni tar DNA-binding protein 0.0192 0.3801 0.8768
Brugia malayi intermediate filament protein 0.0027 0.0264 0.0264
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1231 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Brugia malayi MH1 domain containing protein 0.0033 0.0398 0.0398
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1231 0.1231
Schistosoma mansoni lamin 0.0027 0.0264 0.0589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1824 0.1824
Echinococcus granulosus smad 0.0033 0.0398 0.0841
Schistosoma mansoni ets-related 0.0217 0.4333 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0398 0.0841
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0649 0.1386
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1231 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0369 0.0779
Loa Loa (eye worm) nuclear factor I 0.0018 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0253
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1824 0.1824
Brugia malayi beta-lactamase family protein 0.0072 0.1231 0.1231
Brugia malayi hypothetical protein 0.0423 0.8727 0.8727
Echinococcus granulosus tar DNA binding protein 0.0192 0.3801 0.8216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1231 0.2825
Brugia malayi sulfakinin receptor protein 0.0423 0.8727 0.8727
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1231 0.5
Onchocerca volvulus 0.0072 0.1231 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.3801 0.8768
Schistosoma mansoni Smad4 0.0033 0.0398 0.0898
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.3801 0.3801
Loa Loa (eye worm) hypothetical protein 0.0231 0.4624 0.4624
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0398 0.0398
Trichomonas vaginalis esterase, putative 0.0072 0.1231 0.5
Schistosoma mansoni smad1 5 8 and 0.0033 0.0398 0.0898
Loa Loa (eye worm) hypothetical protein 0.0068 0.115 0.115
Schistosoma mansoni hypothetical protein 0.0032 0.0369 0.0832
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0009 0.0009
Echinococcus multilocularis geminin 0.0165 0.3227 0.6973
Echinococcus multilocularis lamin dm0 0.0027 0.0264 0.0552
Mycobacterium leprae conserved hypothetical protein 0.0072 0.1231 0.5
Schistosoma mansoni smad1 5 8 and 0.0033 0.0398 0.0898
Mycobacterium leprae Probable lipase LipE 0.0072 0.1231 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1231 0.5
Onchocerca volvulus 0.0072 0.1231 1
Brugia malayi hypothetical protein 0.0231 0.4624 0.4624
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0032 0.0369 0.0779
Echinococcus granulosus lamin dm0 0.0027 0.0264 0.0552
Brugia malayi MH1 domain containing protein 0.0018 0.0084 0.0084
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1223 0.263
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1231 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0649 0.1479
Mycobacterium ulcerans hypothetical protein 0.0072 0.1231 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1231 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0369 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0649 0.1386
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1231 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0264
Schistosoma mansoni smad 0.0033 0.0398 0.0898
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1824 0.1824
Onchocerca volvulus 0.0027 0.0264 0.2084
Loa Loa (eye worm) TAR-binding protein 0.0192 0.3801 0.3801
Schistosoma mansoni intermediate filament proteins 0.0027 0.0264 0.0589
Brugia malayi MH2 domain containing protein 0.0033 0.0398 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0192 0.3801 0.8768
Toxoplasma gondii ABC1 family protein 0.0072 0.1231 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.115 0.115
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1231 0.5
Brugia malayi MH1 domain containing protein 0.0033 0.0398 0.0398
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0398 0.0841
Brugia malayi Ets-domain containing protein 0.0071 0.1223 0.1223
Echinococcus multilocularis GPCR, family 2 0.0032 0.0369 0.0779
Brugia malayi beta-lactamase 0.0072 0.1231 0.1231
Schistosoma mansoni hypothetical protein 0.0032 0.0369 0.0832
Schistosoma mansoni gabp alpha 0.0071 0.1223 0.2807
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0398 0.0841
Onchocerca volvulus 0.0047 0.0701 0.566
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1231 0.1231
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0084
Mycobacterium ulcerans beta-lactamase 0.0072 0.1231 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0398 0.0398
Echinococcus granulosus geminin 0.0165 0.3227 0.6973
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1231 0.2647
Echinococcus multilocularis lamin 0.0027 0.0264 0.0552
Leishmania major hypothetical protein, conserved 0.0072 0.1231 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0649 0.0649
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1231 0.5
Echinococcus granulosus lamin 0.0027 0.0264 0.0552
Brugia malayi Smad1 0.0033 0.0398 0.0398
Echinococcus multilocularis smad 0.0033 0.0398 0.0841
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0649 0.1386
Brugia malayi MH2 domain containing protein 0.0015 0.0009 0.0009
Echinococcus multilocularis Smad4 0.0033 0.0398 0.0841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0649 0.1479
Loa Loa (eye worm) fli-1 protein 0.0217 0.4333 0.4333
Loa Loa (eye worm) transcription factor SMAD2 0.0482 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.3227 0.7442
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1223 0.1223
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Schistosoma mansoni smad1 5 8 and 0.0033 0.0398 0.0898
Loa Loa (eye worm) Smad1 0.0033 0.0398 0.0398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0369 0.0779
Loa Loa (eye worm) hypothetical protein 0.0072 0.1231 0.1231
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0068 0.115 0.2639
Schistosoma mansoni hypothetical protein 0.0032 0.0369 0.0832
Schistosoma mansoni lamin 0.0027 0.0264 0.0589
Loa Loa (eye worm) hypothetical protein 0.01 0.1824 0.1824
Schistosoma mansoni survival motor neuron protein 0.0047 0.0701 0.1599
Brugia malayi MH1 domain containing protein 0.0018 0.0084 0.0084
Brugia malayi Ets-domain containing protein 0.0071 0.1223 0.1223
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.4624 1
Schistosoma mansoni hypothetical protein 0.0165 0.3227 0.7442
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0649 0.1479

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.