Detailed information for compound 580425

Basic information

Technical information
  • TDR Targets ID: 580425
  • Name: (E)-7-(4-butyl-2,5-dioxo-3,3a,4,6,7,7a-hexahy dro-1H-inden-1-yl)hept-5-enoic acid
  • MW: 334.45 | Formula: C20H30O4
  • H donors: 1 H acceptors: 4 LogP: 3.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1C(=O)CCC2C1CC(=O)C2CC=CCCCC(=O)O
  • InChi: 1S/C20H30O4/c1-2-3-8-16-17-13-19(22)15(14(17)11-12-18(16)21)9-6-4-5-7-10-20(23)24/h4,6,14-17H,2-3,5,7-13H2,1H3,(H,23,24)/b6-4+
  • InChiKey: CGCZPIJMGKLVTQ-GQCTYLIASA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-7-(4-butyl-2,5-dioxo-3,3a,4,6,7,7a-hexahydro-1H-inden-1-yl)-5-heptenoic acid
  • (E)-7-(4-butyl-2,5-diketo-3,3a,4,6,7,7a-hexahydro-1H-inden-1-yl)hept-5-enoic acid
  • 11-deoxy-15-keto-13,14-dihydro-11 beta,16-cycloprostaglandin E2
  • 74158-09-1
  • 11-Deoxy-13,14-dihydro-15-keto-11beta,16xi-cyclo-PGE2
  • 11-Deoxy-15-keto-13,14-dihydro-11beta,16-cyclo-PGE2
  • 11-Deoxy-15-keto-13,14-dihydro-11beta,16-cycloprostaglandin E2
  • 5-Heptenoic acid, 7-(4-butyloctahydro-2,5-dioxo-1H-inden-1-yl)-
  • Bicyclo-PGEM
  • DKDBCYPGE2
  • PGE2-M
  • Pgem-II

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0136 0.0172
Brugia malayi CHE-14 protein 0.0045 0.0189 0.0241
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0031
Schistosoma mansoni sodium/solute symporter 0.0046 0.0197 0.025
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0197 0.025
Schistosoma mansoni hypothetical protein 0.0043 0.0179 0.0227
Schistosoma mansoni nuclear hormone receptor 0.003 0.01 0.0126
Echinococcus granulosus microtubule associated protein 2 0.0676 0.405 0.5168
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0189 0.0746
Loa Loa (eye worm) steroid hormone receptor 0.003 0.01 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.01 0.099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0127
Brugia malayi conserved hypotetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0015
Schistosoma mansoni inositol transporter 0.0046 0.0197 0.025
Brugia malayi Steroid receptor seven-up type 2 0.003 0.01 0.0127
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0189 0.024
Brugia malayi nuclear receptor NHR-67 0.0014 0.0001 0.0002
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0126
Echinococcus granulosus expressed conserved protein 0.0099 0.0517 0.0658
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0188
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0088 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.01 0.0126
Brugia malayi hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.042 0.2483 0.3169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0154 0.0196
Trichomonas vaginalis glutaminase, putative 0.0268 0.1552 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0018
Brugia malayi tailless protein 0.0014 0.0001 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0032
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.2483 0.2482
Echinococcus multilocularis chromobox protein 1 0.0068 0.0331 0.033
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0197 0.0196
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0189 0.0188
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.01 0.0126
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0014
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0481 0.286 0.3625
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.01 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0556 0.0709
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.01 0.0098
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.0831 0.1059
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0088 0.0111
Brugia malayi nuclear receptor RXR 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0015
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0001 0.0002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0486 0.0485
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0088 1
Brugia malayi nuclear receptor NHR-88 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Brugia malayi ecdysteroid receptor 0.003 0.01 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.01 0.0127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0274 0.035
Schistosoma mansoni glutaminase 0.0268 0.1552 0.1979
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0029
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0088 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0012 0.0015
Plasmodium falciparum phd finger protein, putative 0.0029 0.0088 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0165 0.0585
Schistosoma mansoni hypothetical protein 0.0043 0.0179 0.0227
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0041 0.0167 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0127
Schistosoma mansoni high-affinity choline transporter 0.042 0.2483 0.3168
Schistosoma mansoni zinc finger protein 0.0019 0.0031 0.0038
Brugia malayi hypothetical protein 0.0148 0.0819 0.1045
Brugia malayi jmjC domain containing protein 0.0093 0.0486 0.062
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1294 0.7837 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0265 0.0338
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0148 0.1471
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0037
Echinococcus multilocularis chromobox protein 1 0.0068 0.0331 0.033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0113
Leishmania major 0.1294 0.7837 1
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.01 0.0126
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.003 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0701 0.07
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0481 0.286 0.3645
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0025 0.0023
Brugia malayi nuclear hormone receptor 0.003 0.01 0.0127
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0098
Brugia malayi Heterochromatin protein 1 0.0068 0.0331 0.0422
Loa Loa (eye worm) glutaminase 2 0.0268 0.1552 0.1981
Echinococcus multilocularis solute carrier family 5 0.0046 0.0197 0.0196
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.003 0.0032
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0556 0.0554
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0701 0.0893
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Brugia malayi GH02984p 0.042 0.2483 0.3169
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0197 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0088 0.0111
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0011
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1294 0.7837 1
Mycobacterium ulcerans glutaminase 0.0268 0.1552 0.5
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1294 0.7837 0.7837
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0126
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0088 0.0087
Schistosoma mansoni hypothetical protein 0.002 0.0037 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0183
Echinococcus granulosus FTZ F1 alpha 0.003 0.01 0.0126
Brugia malayi RNA binding protein 0.0129 0.0701 0.0895
Schistosoma mansoni hypothetical protein 0.0043 0.0179 0.0227
Echinococcus granulosus chromobox protein 1 0.0068 0.0331 0.0421
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.003 0.0097 0.0962
Brugia malayi TAR-binding protein 0.0129 0.0701 0.0895
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0556 0.0708
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.003 0.5
Echinococcus multilocularis musashi 0.0026 0.0075 0.0074
Loa Loa (eye worm) DR-78 0.0014 0.0001 0.0002
Loa Loa (eye worm) glutaminase 0.0268 0.1552 0.1981
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0189 0.024
Brugia malayi ecdysone receptor 0.0014 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0205 0.1166 0.1487
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0701 0.0893
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0025 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.01 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0265 0.0338
Brugia malayi intermediate filament protein 0.0026 0.0075 0.0096
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0029
Echinococcus multilocularis protein patched 0.0045 0.0189 0.0188
Brugia malayi steroid hormone receptor 0.003 0.01 0.0127
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0125 0.0124
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0025 0.0031
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0001 0.0002
Brugia malayi fructose-1,6-bisphosphatase 0.1294 0.7837 1
Brugia malayi nuclear hormone receptor 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0213 0.0272
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0265 0.0338
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0331 0.171
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0331 0.171
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1294 0.7837 1
Echinococcus granulosus lamin 0.0026 0.0075 0.0094
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0486 0.0618
Brugia malayi nuclear receptor RXR 0.0016 0.0012 0.0015
Brugia malayi Bromodomain containing protein 0.0037 0.0143 0.0182
Loa Loa (eye worm) hypothetical protein 0.0055 0.0251 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.01 0.0127
Brugia malayi hypothetical protein 0.0016 0.0012 0.0015
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0481 0.286 0.3645
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0165 0.165
Loa Loa (eye worm) hypothetical protein 0.0045 0.0189 0.0241
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.01 0.0127
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0197 0.025
Schistosoma mansoni intermediate filament proteins 0.0026 0.0075 0.0094
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0148 0.0819 0.1045
Echinococcus granulosus GPCR family 2 0.0018 0.0025 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0018
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0001 0.0002
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0026 0.0075 0.0742
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0265 0.0338
Onchocerca volvulus Alhambra homolog 0.0029 0.0088 0.0874
Echinococcus granulosus high affinity choline transporter 1 0.042 0.2483 0.3168
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.405 0.5168
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0701 0.0893
Schistosoma mansoni hypothetical protein 0.0205 0.1166 0.1487
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0015
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0331 0.0422
Brugia malayi Isocitrate dehydrogenase 0.0019 0.003 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.01 0.0126
Echinococcus granulosus lamin dm0 0.0026 0.0075 0.0094
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1294 0.7837 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus geminin 0.0205 0.1166 0.1487
Schistosoma mansoni lamin 0.0026 0.0075 0.0094
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.003 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0025 0.0023
Echinococcus multilocularis lamin 0.0026 0.0075 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0016 0.0014
Onchocerca volvulus 0.0026 0.0075 0.0742
Loa Loa (eye worm) hypothetical protein 0.0046 0.0197 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0148 0.0464
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0136 0.0174
Echinococcus multilocularis geminin 0.0205 0.1166 0.1165
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0271 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0098
Brugia malayi hypothetical protein 0.0014 0.0001 0.0002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0556 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0088 0.0074
Echinococcus multilocularis GPCR, family 2 0.0018 0.0025 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0148 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.01 0.0127
Echinococcus granulosus solute carrier family 5 0.0046 0.0197 0.025
Schistosoma mansoni coup transcription factor 0.003 0.01 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0701 0.0895
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0167 0.0166
Brugia malayi PHD-finger family protein 0.0029 0.0088 0.0113
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.01 0.0126
Schistosoma mansoni chromobox protein 0.0068 0.0331 0.0421
Onchocerca volvulus Huntingtin homolog 0.0148 0.0819 0.8226
Loa Loa (eye worm) hypothetical protein 0.0177 0.0996 0.127
Schistosoma mansoni lamin 0.0026 0.0075 0.0094
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0037 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0012 0.0013
Toxoplasma gondii fructose-bisphospatase I 0.0481 0.286 0.3625
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0001 0.0002
Echinococcus granulosus zinc finger protein 0.0019 0.0031 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.0201
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0032
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0015
Loa Loa (eye worm) RNA binding protein 0.0129 0.0701 0.0895
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0701 0.0893
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0019 0.0025
Schistosoma mansoni inositol transporter 0.0046 0.0197 0.025
Brugia malayi jmjC domain containing protein 0.0036 0.0136 0.0174
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0167 0.0211
Echinococcus multilocularis protein dispatched 1 0.0051 0.0228 0.0227
Schistosoma mansoni zinc finger protein 0.0015 0.0005 0.0005
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0197 0.025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0271 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0016 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0098
Onchocerca volvulus 0.003 0.01 0.099
Brugia malayi glutaminase DH11.1 0.0268 0.1552 0.1981
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0025 0.003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0216
Brugia malayi hypothetical protein 0.0041 0.0167 0.0213
Echinococcus multilocularis expressed conserved protein 0.0099 0.0517 0.0516
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0481 0.286 0.3645
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0566 0.072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0189 0.0241
Brugia malayi Bromodomain containing protein 0.0031 0.0102 0.0131
Echinococcus multilocularis lamin dm0 0.0026 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0105 0.0556 0.0709
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.01 0.0126
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.01 0.099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.01 0.0127
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0701 0.0895
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0167 0.0211
Brugia malayi nuclear receptor NHR-88 0.003 0.01 0.0127
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0157 0.0155
Echinococcus multilocularis peregrin 0.0031 0.0102 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.0029
Onchocerca volvulus Huntingtin homolog 0.0148 0.0819 0.8226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.01 0.0127
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0032
Schistosoma mansoni hypothetical protein 0.0029 0.0088 0.0111
Echinococcus granulosus chromobox protein 1 0.0068 0.0331 0.0421
Onchocerca volvulus Bile acid receptor homolog 0.003 0.01 0.099
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.01 0.0127
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0197 0.0196
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0092
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.003 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0154 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0136 0.0172
Brugia malayi hypothetical protein 0.0016 0.0012 0.0015
Schistosoma mansoni hypothetical protein 0.0043 0.0179 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0165 0.0585
Echinococcus granulosus peregrin 0.0031 0.0102 0.0129
Echinococcus granulosus jumonji domain containing protein 0.004 0.0157 0.0198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0098
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.003 0.0037
Brugia malayi isocitrate dehydrogenase 0.0019 0.003 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.405 0.405
Schistosoma mansoni patched 1 0.0045 0.0189 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0018
Echinococcus granulosus intermediate filament protein 0.0026 0.0075 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.01 0.0127
Echinococcus multilocularis FTZ F1 alpha 0.003 0.01 0.0098
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0075 0.0096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0025 0.0031
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.01 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0701 0.0895
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0197 0.025
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Schistosoma mansoni bromodomain containing protein 0.0062 0.0293 0.0372
Echinococcus multilocularis zinc finger protein 0.0019 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.0337 0.043
Toxoplasma gondii fructose-bisphospatase II 0.1294 0.7837 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0012 0.0013
Brugia malayi N-terminal motif family protein 0.0177 0.0996 0.127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0075 0.0096
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0097 0.0124
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.003 0.0029
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0018
Schistosoma mansoni chromobox protein 0.0068 0.0331 0.0421
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0126
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0163
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0127
Onchocerca volvulus 0.0046 0.0197 0.1967
Brugia malayi Bromodomain containing protein 0.0073 0.0363 0.0463
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.0148 0.0819 0.1045
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.0831 0.083
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0127
Schistosoma mansoni hypothetical protein 0.0039 0.0154 0.0194
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0049 0.006
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0001 0.0002
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1294 0.7837 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.01 0.0127
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1294 0.7837 1
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0197 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0701 0.0893
Giardia lamblia PHD finger protein 15 0.0029 0.0088 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0136 0.0172
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0368 0.0468
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0098
Echinococcus granulosus tar DNA binding protein 0.0129 0.0701 0.0893
Brugia malayi PHD-finger family protein 0.0024 0.0063 0.008
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0197 0.0213
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0049 0.0047
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0049 0.006
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.0996 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.01 0.0127
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.01 0.0126
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.01 0.0126
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.01 0.0127
Brugia malayi chromobox protein homolog 3 0.0038 0.0148 0.0188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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