Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.013 | 0.0206 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.008 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0164 | 0.026 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.008 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.0164 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0375 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0375 | 0.0375 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0375 | 0.0593 |
Echinococcus multilocularis | muscleblind protein 1 | 0.029 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0375 | 0.0375 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0188 | 0.6329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0375 | 0.0375 |
Trypanosoma brucei | pteridine reductase 1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0375 | 1 |
Onchocerca volvulus | 0.0023 | 0.0375 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.013 | 0.0206 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0375 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.013 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.0164 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0188 | 0.6329 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0375 | 0.0593 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0375 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0164 | 0.026 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0164 | 0.026 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.013 | 0.0206 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0375 | 0.0593 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0375 | 0.0593 |
Trichomonas vaginalis | hypothetical protein | 0.0188 | 0.6329 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0375 | 0.0593 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0375 | 0.0593 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2422 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0375 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2422 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.008 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.0164 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0375 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.0164 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.029 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0188 | 0.6329 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.008 | 0.2422 | 0.2422 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0375 | 0.0593 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0188 | 0.6329 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.008 | 0.2422 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.0164 |
Echinococcus multilocularis | muscleblind protein | 0.029 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0188 | 0.6329 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0375 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0188 | 0.6329 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0164 | 0.026 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2422 | 0.2422 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0164 | 0.026 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.008 | 0.2422 | 0.2422 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0188 | 0.6329 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.008 | 0.2422 | 0.2422 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0188 | 0.6329 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0375 | 0.0593 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2422 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0375 | 0.0593 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0375 | 0.0593 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.008 | 0.2422 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.