Detailed information for compound 580749

Basic information

Technical information
  • TDR Targets ID: 580749
  • Name: (E)-5-(hydroxyamino)-1,5-bis(4-methoxyphenyl) pent-1-en-3-one oxime
  • MW: 342.389 | Formula: C19H22N2O4
  • H donors: 3 H acceptors: 2 LogP: 2.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=C/C(=N/O)/CC(c1ccc(cc1)OC)NO
  • InChi: 1S/C19H22N2O4/c1-24-17-9-4-14(5-10-17)3-8-16(20-22)13-19(21-23)15-6-11-18(25-2)12-7-15/h3-12,19,21-23H,13H2,1-2H3/b8-3+,20-16+
  • InChiKey: NJAQMAVGELKCCS-FROOSJIMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-5-(hydroxyamino)-1,5-bis(4-methoxyphenyl)-1-penten-3-one oxime
  • (NZ)-N-[(E)-5-(hydroxyamino)-1,5-bis(4-methoxyphenyl)pent-1-en-3-ylidene]hydroxylamine
  • 1-Penten-3-one, 5-(hydroxyamino)-1,5-bis(4-methoxyphenyl)-, oxime (9CI)
  • 4-15-00-00042 (Beilstein Handbook Reference)
  • 5-(hydroxyamino)-1,5-bis(4-methoxyphenyl)pent-1-en-3-one oxime
  • 5-(Hydroxyamino)-1,5-bis(4-methoxyphenyl)-1-penten-3-one oxime
  • 5397-97-7
  • AIDS-125503
  • AIDS125503
  • BRN 3167423
  • N-[(E,3Z)-3-hydroxyimino-1,5-bis(4-methoxyphenyl)pent-4-enyl]hydroxylamine
  • N-[3-hydroxyimino-1,5-bis(4-methoxyphenyl)pent-4-enyl]hydroxylamine
  • NSC 231374
  • NSC 74596
  • NSC74596

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1911 0.6769
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0098 0.0392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1143 0.3108
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0003 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0334 0.0902
Schistosoma mansoni tar DNA-binding protein 0.0066 0.073 0.1763
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.067
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0101 0.0167
Loa Loa (eye worm) cytochrome P450 0.0017 0.0101 0.0266
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0112 0.0112
Echinococcus granulosus FTZ F1 alpha 0.001 0.0003 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0003 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.025 0.025
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0101 0.0167
Onchocerca volvulus 0.0018 0.0104 0.0357
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0003 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0101 0.0167
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0112 0.0154
Loa Loa (eye worm) retinol dehydrogenase 12 0.0014 0.0055 0.0141
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0098 0.0158
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0018 0.0104 0.0202
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0334 0.1018
Mycobacterium tuberculosis Conserved protein 0.0036 0.0334 0.1018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0071
Onchocerca volvulus 0.0014 0.0055 0.0183
Loa Loa (eye worm) hypothetical protein 0.0295 0.3671 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1602 0.1602
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0743 0.2016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1602 0.3866
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2475 0.674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0409 0.1444
Onchocerca volvulus 0.0011 0.0013 0.0036
Brugia malayi RNA binding protein 0.0066 0.073 0.1982
Brugia malayi hypothetical protein 0.0017 0.0096 0.0254
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0101 0.0125
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0101 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0395
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0101 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0217 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0066 0.073 0.1763
Onchocerca volvulus 0.023 0.2834 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.025 0.0603
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0014 0.0055 0.022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0003
Onchocerca volvulus 0.0036 0.0334 0.1168
Loa Loa (eye worm) TAR-binding protein 0.0066 0.073 0.1982
Echinococcus granulosus tar DNA binding protein 0.0066 0.073 0.1763
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0141
Mycobacterium tuberculosis Conserved protein 0.0036 0.0334 0.1018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0494 0.1339
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0101 0.0188
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1143 0.3108
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0217 0.0439
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0154
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.067
Onchocerca volvulus 0.0029 0.025 0.0871
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0101 0.0125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0334 0.0902
Loa Loa (eye worm) hypothetical protein 0.0229 0.2829 0.7705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0278 0.067
Mycobacterium ulcerans hypothetical protein 0.0023 0.0173 0.0482
Brugia malayi hypothetical protein 0.0122 0.1443 0.3926
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0112 0.0296
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0014 0.0055 0.022
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0101 0.0167
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0101 0.0188
Trichomonas vaginalis hypothetical protein 0.0204 0.2504 0.8834
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0173 0.0482
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Schistosoma mansoni cytochrome P450 0.0017 0.0101 0.0244
Loa Loa (eye worm) acetyltransferase 0.0141 0.1686 0.459
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0334 0.1179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0236 0.057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0278 0.0748
Schistosoma mansoni survival motor neuron protein 0.0047 0.0479 0.1157
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0008
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0112 0.0208
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0217 0.0865
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0101 0.0167
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0101 0.0188
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1704 0.4478
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0101 0.0167
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2829 0.6828
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0014 0.0055 0.1507
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0334 0.0758
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0112 0.0232
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0101 0.0167
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0101 0.0266
Loa Loa (eye worm) hypothetical protein 0.0026 0.0217 0.0582
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Onchocerca volvulus 0.0023 0.0173 0.06
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0101 0.0188
Echinococcus multilocularis geminin 0.0331 0.4143 0.4143
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0334 0.114
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0395
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0101 0.0188
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0259
Onchocerca volvulus Huntingtin homolog 0.0122 0.1443 0.5087
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0014 0.0055 0.022
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0101 0.0188
Mycobacterium leprae Probable lipase LipE 0.0036 0.0334 0.114
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0101 0.0167
Mycobacterium ulcerans short chain dehydrogenase 0.0018 0.0104 0.0202
Leishmania major cytochrome p450-like protein 0.0017 0.0101 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.0482
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0101 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.1602 0.4358
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0334 0.1018
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0003 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0295 0.3671 0.3671
Leishmania major cytochrome p450-like protein 0.0017 0.0101 0.0125
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.042 0.0991
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0204 0.2504 1
Schistosoma mansoni hypothetical protein 0.0067 0.0743 0.1792
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0539 0.1313
Brugia malayi hypothetical protein 0.0035 0.0326 0.0881
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0101 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0003 0.0008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0018 0.0104 0.0202
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0003 0.0003
Onchocerca volvulus 0.0036 0.0334 0.1168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.025 0.0603
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0409 0.1634
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0826 0.2243
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0365 1
Echinococcus multilocularis 0.0017 0.0101 0.0101
Brugia malayi Pre-SET motif family protein 0.0029 0.025 0.0672
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0101 0.0167
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.0447
Loa Loa (eye worm) hypothetical protein 0.0122 0.1443 0.3926
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0365 0.1457
Echinococcus granulosus GPCR family 2 0.0031 0.0278 0.067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0101 0.0403
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0003 0.0008
Brugia malayi Cytochrome P450 family protein 0.0017 0.0101 0.0266
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0101 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1602 0.3866
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0112 0.0154
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0217 0.0865
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3738 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0101 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0326 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0066 0.073 0.1763
Echinococcus multilocularis tar DNA binding protein 0.0066 0.073 0.073
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0204 0.2504 1
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2797 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0055 0.0141
Leishmania major cytochrome p450-like protein 0.0017 0.0101 0.0125
Schistosoma mansoni dihydropteridine reductase 0.0014 0.0055 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0066 0.073 0.1763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.025 0.0603
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0479 0.1298
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.3738 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0112 0.0447
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0204 0.2504 1
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0244
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0173 0.0482
Brugia malayi Cytochrome P450 family protein 0.0074 0.0826 0.2243
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0334 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0101 0.0167
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0003 0.0008
Toxoplasma gondii hypothetical protein 0.0048 0.05 0.1996
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0101 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0278 0.0748
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.025 0.025
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0101 0.0188
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0029 0.0071
Loa Loa (eye worm) hypothetical protein 0.0122 0.1443 0.3926
Brugia malayi cytochrome P450 0.0017 0.0101 0.0266
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0112 0.3066
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.027
Loa Loa (eye worm) hypothetical protein 0.0295 0.3671 1
Brugia malayi Pre-SET motif family protein 0.0202 0.2475 0.674
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.042 0.0991
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0334 0.1179
Brugia malayi Cytochrome P450 family protein 0.0017 0.0101 0.0266
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1686 0.1686
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0173 0.4743
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0125
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1704 0.4478
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0334 0.0758
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0463
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0014 0.0055 0.0055
Brugia malayi beta-lactamase family protein 0.0036 0.0334 0.0902
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0101 0.0188
Echinococcus multilocularis tumor protein p63 0.0328 0.4095 0.4095
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.8941
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0014 0.0055 0.022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0112 0.3066
Mycobacterium leprae putative cytochrome p450 0.0017 0.0101 0.0188
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0098 0.0177
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.0447
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0018 0.0104 0.0417
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0008
Loa Loa (eye worm) oxidoreductase 0.0014 0.0055 0.0141
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0101 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0326 0.0787
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0101 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.025 0.0603
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0463
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0003 0.0008
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0098 0.0392
Leishmania major pteridine reductase 1 0.0018 0.0104 0.0134
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0204 0.2504 1
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.8941
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0409 0.0988
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0334 0.0334
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0278 0.0278
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0173 0.0482
Echinococcus granulosus tumor protein p63 0.0328 0.4095 0.9885
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.0672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1602 0.3866
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0259
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0112 0.0232
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0259
Trypanosoma brucei oxidoreductase-like protein 0.0018 0.0104 0.0134
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0494 0.1194
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0334 0.114
Brugia malayi hypothetical protein 0.0026 0.0217 0.0582
Schistosoma mansoni hypothetical protein 0.0035 0.0326 0.0787
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0334 0.1334
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0321
Leishmania major hypothetical protein, conserved 0.0026 0.0217 0.0439
Brugia malayi TAR-binding protein 0.0066 0.073 0.1982
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0014 0.0055 0.0141
Trichomonas vaginalis set domain proteins, putative 0.023 0.2834 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0125
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3738 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0003 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0112 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0463
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.0482
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0101 0.0188
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0008
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0018 0.0104 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1143 0.3108
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.067
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0101 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.8941
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0101 0.0266
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0029 0.0029
Mycobacterium ulcerans hypothetical protein 0.0036 0.0334 0.114
Brugia malayi beta-lactamase 0.0036 0.0334 0.0902
Brugia malayi hypothetical protein 0.0229 0.2829 0.7705
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0101 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.025 0.0603
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0014 0.0055 0.0133
Schistosoma mansoni hypothetical protein 0.0331 0.4143 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.042 0.0991
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0334 0.0806
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0409 0.1634
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0018 0.0104 0.0202
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0334 0.1179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0173 0.0482
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0463
Trichomonas vaginalis esterase, putative 0.0036 0.0334 0.1179
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0173 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0173 0.0482
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0173 0.4743
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0003 0.0008
Loa Loa (eye worm) beta-lactamase 0.0036 0.0334 0.0902
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0204 0.2504 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0173 0.0431
Echinococcus multilocularis muscleblind protein 0.0295 0.3671 0.3671
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0003 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0086 0.0114
Loa Loa (eye worm) hypothetical protein 0.0098 0.1143 0.3108
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0334 0.1018
Leishmania major mitochondrial DNA polymerase beta 0.03 0.3738 1
Echinococcus granulosus muscleblind protein 0.0295 0.3671 0.886
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0101 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0086 0.0114
Schistosoma mansoni hypothetical protein 0.0047 0.0479 0.1157
Mycobacterium tuberculosis Conserved protein 0.0036 0.0334 0.1018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0086 0.0114
Onchocerca volvulus Huntingtin homolog 0.0122 0.1443 0.5087
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0101 0.0167
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0278 0.067
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0409 0.1634
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0409 0.1444
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0173 0.0482
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0334 0.0758
Schistosoma mansoni hypothetical protein 0.0331 0.4143 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0008
Mycobacterium ulcerans beta-lactamase 0.0036 0.0334 0.114
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0101 0.0167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0463
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0334 0.114
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0101 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0003
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0014 0.0055 0.0133
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0101 0.0125
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.027
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0101 0.0188
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Mycobacterium ulcerans lipase LipD 0.0036 0.0334 0.114
Onchocerca volvulus 0.0048 0.0494 0.1735
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0334 0.1018
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1686 0.4071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1602 0.1602
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0125
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0098 0.0177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.1602 0.4358
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0204 0.2504 0.8932
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0101 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0334 0.1179
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0101 0.0266
Loa Loa (eye worm) hypothetical protein 0.0067 0.0743 0.2016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0055 0.0141
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0334 0.1018
Mycobacterium ulcerans hypothetical protein 0.0158 0.1911 0.7578
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0217 0.0865
Brugia malayi Muscleblind-like protein 0.0295 0.3671 1
Onchocerca volvulus 0.0036 0.0334 0.1168
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0173 0.4743
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0101 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0278 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0066 0.073 0.1763
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1602 0.3866
Plasmodium vivax SET domain protein, putative 0.0029 0.025 0.0998
Mycobacterium tuberculosis Probable oxidoreductase 0.0018 0.0104 0.018
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0217 0.0865
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0326 0.0787
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0003
Echinococcus granulosus geminin 0.0331 0.4143 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.073 0.1982
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.8941
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0101 0.0167
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0334 0.1018
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0101 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1704 0.4478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1602 0.3866
Toxoplasma gondii ABC1 family protein 0.0036 0.0334 0.1334
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1686 0.459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0334 0.0806
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0278 0.0278
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.073 0.1982
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0204 0.2504 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0112 0.0296
Plasmodium falciparum enoyl-acyl carrier reductase 0.0204 0.2504 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0112 0.5
Leishmania major hypothetical protein, conserved 0.0036 0.0334 0.0758
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.073 0.1982
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2829 0.2829
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0365 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0334 0.0806
Echinococcus multilocularis GPCR, family 2 0.0031 0.0278 0.0278
Brugia malayi Cytochrome P450 family protein 0.0017 0.0101 0.0266
Brugia malayi beta-lactamase family protein 0.0036 0.0334 0.0902
Schistosoma mansoni coup transcription factor 0.001 0.0003 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0217 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0334 0.1179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0259
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0902
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.042 0.0991
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0173 0.0321
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.025 0.0998
Leishmania major oxidoreductase-like protein 0.0018 0.0104 0.0134
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0278 0.0748
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1636 0.3948
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0173 0.0463
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0173 0.0482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0086 0.0114
Onchocerca volvulus 0.0047 0.0479 0.1681

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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