Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.1056 | 0.1023 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.1056 | 0.1056 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0089 | 0.516 | 0.5091 |
Echinococcus multilocularis | musashi | 0.0029 | 0.1056 | 0.1023 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0459 | 0.0425 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0459 | 0.0425 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.8442 | 0.8436 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0459 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.516 | 0.516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.8442 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.177 | 0.1653 |
Onchocerca volvulus | 0.0089 | 0.516 | 1 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0459 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0025 | 0.0794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.8442 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.8442 | 0.8442 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.8442 | 0.8442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.8442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1056 | 0.1056 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0089 | 0.516 | 0.5143 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0036 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.1056 | 0.1023 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.8442 | 0.842 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0025 | 0.0794 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0025 | 0.0794 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0141 | 0.0141 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.177 | 0.1643 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.177 | 0.1741 |
Schistosoma mansoni | lamin | 0.0029 | 0.1056 | 0.0747 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0025 | 0.0794 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0459 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.8442 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0459 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.102 | 0.102 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.177 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0459 | 0.0459 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0025 | 0.0794 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.177 | 0.1741 |
Echinococcus multilocularis | lamin | 0.0029 | 0.1056 | 0.1023 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0794 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0089 | 0.516 | 0.5889 |
Mycobacterium leprae | conserved hypothetical protein | 0.0025 | 0.0794 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0089 | 0.516 | 0.5143 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0025 | 0.0794 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.177 | 0.1643 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.1056 | 0.1023 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.8442 | 0.842 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.1056 | 0.0928 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0794 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.1056 | 0.0928 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0794 | 0.2551 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0794 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.1056 | 0.1056 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0025 | 0.0794 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0025 | 0.0794 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.1056 | 0.0747 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0459 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.016 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.1056 | 0.0747 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.177 | 1 |
Echinococcus granulosus | lamin | 0.0029 | 0.1056 | 0.1023 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0025 | 0.0794 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.8442 | 0.8442 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.177 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.8442 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.177 | 1 |
Brugia malayi | RNA binding protein | 0.0137 | 0.8442 | 0.842 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0459 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.8442 | 0.8436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.