Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0658 | 0.1062 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.037 | 0.037 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0199 | 0.0321 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.1194 | 0.5108 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0235 | 0.6193 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0293 | 0.0293 |
Brugia malayi | jmjC domain containing protein | 0.0102 | 0.2148 | 0.9193 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0159 | 0.0258 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0675 | 0.1089 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.1194 | 0.1194 |
Onchocerca volvulus | 0.0053 | 0.0658 | 1 | |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0199 | 0.085 |
Echinococcus multilocularis | tumor protein p63 | 0.0361 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0199 | 0.0199 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0227 | 0.5946 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0235 | 0.6193 | 0.6193 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.1194 | 0.1928 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0159 | 0.0258 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.067 | 0.1082 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0159 | 0.0682 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.1194 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0199 | 0.0321 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0102 | 0.2148 | 0.2148 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.1513 | 0.2443 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0235 | 0.6193 | 0.6193 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0199 | 0.0321 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0227 | 0.5946 | 1 |
Brugia malayi | hypothetical protein | 0.0108 | 0.2337 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0235 | 0.6193 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0658 | 0.1062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.067 | 0.1082 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.067 | 0.2868 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.067 | 0.2868 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0102 | 0.2148 | 0.2148 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.1005 | 0.1624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0227 | 0.5946 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.1194 | 0.1928 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0293 | 0.0293 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.037 | 0.037 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0227 | 0.5946 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.1194 | 0.1194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.