Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 119 mg dl-1 | Total cholesterol present in New Zealand white rabbits fed with control diet (100 g/day) for seven days | ChEMBL. | No reference |
Control (functional) | = 17 % | Tested for antioxidant activity against serum thiobarbituric acid relative substances(TBARS), | ChEMBL. | No reference |
Control (functional) | = 42 % | Low density lipoprotein(LDL) percent control of cholesterol after administration of the compound in rabbits. | ChEMBL. | No reference |
Control (functional) | = 52 % | Total percent control of cholesterol after administration of the compound in rabbits. | ChEMBL. | No reference |
Control (functional) | = 75 % | High density lipoprotein(HDL) percent control of cholesterol after administration of the compound in rabbits. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.