Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0265 | 0.0421 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.0421 |
Brugia malayi | Animal haem peroxidase family protein | 0.0238 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.091 | 0.1983 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0074 | 0.2587 | 0.4105 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.0052 | 0.1548 | 0.2124 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0265 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0265 | 0.0421 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0238 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 1 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0095 | 0.3517 | 1 |
Onchocerca volvulus | 0.0157 | 0.6302 | 0.6201 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0265 | 0.0421 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0074 | 0.2587 | 0.311 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0238 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0238 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0238 | 1 | 1 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0095 | 0.3517 | 0.2868 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0095 | 0.3517 | 0.4835 |
Onchocerca volvulus | Peroxidasin homolog | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0265 | 0.0421 |
Brugia malayi | Inositol-1 | 0.0037 | 0.091 | 0.0662 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.0421 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0265 | 0.0421 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0265 | 0.0421 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0095 | 0.3517 | 0.3517 |
Brugia malayi | Animal haem peroxidase family protein | 0.0238 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0238 | 1 | 1 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0095 | 0.3517 | 0.334 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0238 | 1 | 1 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0095 | 0.3517 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.2587 | 0.6432 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.091 | 0.5 |
Onchocerca volvulus | 0.0238 | 1 | 1 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0157 | 0.6302 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0238 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0238 | 1 | 1 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0095 | 0.3517 | 0.5581 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.091 | 0.1444 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0238 | 1 | 1 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.0052 | 0.1548 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0733 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.0733 | 0.0774 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 1 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0095 | 0.3517 | 0.4835 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.091 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0095 | 0.3517 | 0.2868 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 0.5931 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0157 | 0.6302 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0238 | 1 | 1 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0095 | 0.3517 | 0.4835 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0265 |
Echinococcus granulosus | thymidylate synthase | 0.0157 | 0.6302 | 0.5931 |
Brugia malayi | thymidylate synthase | 0.0157 | 0.6302 | 0.6201 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0095 | 0.3517 | 0.3517 |
Brugia malayi | hypothetical protein | 0.0074 | 0.2587 | 0.2385 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0265 | 0.0421 |
Echinococcus multilocularis | thymidylate synthase | 0.0157 | 0.6302 | 0.5931 |
Onchocerca volvulus | Peroxidasin homolog | 0.0238 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0238 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0157 | 0.6302 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0238 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0238 | 1 | 1 |
Trypanosoma brucei | phosphomannose isomerase | 0.0095 | 0.3517 | 0.4835 |
Loa Loa (eye worm) | thymidylate synthase | 0.0157 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0238 | 1 | 1 | |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0095 | 0.3517 | 0.5581 |
Schistosoma mansoni | peroxidasin | 0.0238 | 1 | 1 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.0044 | 0.1185 | 0.2829 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0157 | 0.6302 | 1 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0095 | 0.3517 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0265 | 0.0265 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0095 | 0.3517 | 0.5581 |
Onchocerca volvulus | 0.0238 | 1 | 1 | |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.091 | 0.091 |
Echinococcus granulosus | peroxidasin | 0.0238 | 1 | 1 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0095 | 0.3517 | 0.2868 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0265 | 0.0421 |
Leishmania major | phosphomannose isomerase | 0.0095 | 0.3517 | 0.5387 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0157 | 0.6302 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.