Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0048 | 0.1133 | 0.5 | |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0055 | 0.1659 | 0.0593 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.2375 | 0.2253 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7583 | 0.683 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.1133 | 0.2017 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1731 | 0.1599 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7583 | 0.683 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0159 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.7583 | 0.7544 |
Brugia malayi | RNA binding protein | 0.0129 | 0.7583 | 0.7274 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.1133 | 0.2017 |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.7583 | 0.7544 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.2375 | 0.4228 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7583 | 0.683 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.7583 | 0.7544 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0048 | 0.1133 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0104 | 0.5616 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.1133 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.7583 | 0.7274 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.7583 | 0.7274 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.2375 | 0.2253 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0104 | 0.5616 | 0.4251 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0104 | 0.5616 | 0.5056 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.1133 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0055 | 0.1659 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.1133 | 0.0991 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0159 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.1133 | 0.0991 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.2375 | 0.1401 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0055 | 0.1659 | 0.1526 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.7583 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1133 | 0.0991 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.2375 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0159 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0157 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1133 | 0.0991 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0104 | 0.5616 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.1133 | 0.0991 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.1133 | 0.0991 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7583 | 0.683 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0159 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7583 | 0.683 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0159 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0104 | 0.5616 | 0.4251 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.7583 | 0.683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.