Detailed information for compound 581971

Basic information

Technical information
  • TDR Targets ID: 581971
  • Name: cobaltic; 2-[3-[(4-amino-2-methyl-pyrimidin-5 -yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethan ol; 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3 -ol; [5-(5,6-dimethylbenzimidazol-1-yl)-4-hyd roxy-2-(hydroxymethyl)tetrahydrofuran-3-yl] [ 1-methyl-2-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-ami no-2-oxo-ethyl)-7,12,17-tris(3-amino-3-oxo-pr opyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,1 7-tetrahydro-1H-corrin-21-id-3-yl]propanoylam ino]ethyl] phosphate; chloride; cyanide
  • MW: 1825.35 | Formula: C83H116ClCoN19O18PS
  • H donors: 15 H acceptors: 19 LogP: -1.86 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCc1c(CO)cnc(c1O)C.OCC1OC(C(C1OP(=O)(OC(CNC(=O)CCC1(C)C2=C(C)C3=N/C(=C/C4=N/C(=C(/C5=NC(C(C1CC(=O)N)[N-]2)(C)C(C)(CC(=O)N)C5CCC(=O)N)\C)/C(C4CCC(=O)N)(C)CC(=O)N)/C(C3CCC(=O)N)(C)C)C)[O-])O)n1cnc2c1cc(C)c(c2)C.OCCc1sc[n+](c1C)Cc1cnc(nc1N)C.[C-]#N.[Cl-].[Co+3]
  • InChi: 1S/C62H90N13O14P.C12H17N4OS.C8H11NO3.CN.ClH.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;1-5-8(12)7(4-11)6(3-10)2-9-5;1-2;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2,10-12H,3-4H2,1H3;;1H;/q;+1;;-1;;+3/p-3
  • InChiKey: SSACIBATDRWBKH-UHFFFAOYSA-K  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • cobaltic; 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-thiazol-3-iumyl]ethanol; 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol; [5-(5,6-dimethyl-1-benzimidazolyl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl] [1-methyl-2-[[1-oxo-3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propyl]amino]ethyl] phosphate; chloride; cyanide
  • 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol; 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol; cobalt(3+); [5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-azanyl-2-oxo-ethyl)-7,12,17-tris(3-azanyl-3-oxo-propyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate; chloride; cyanide
  • cobaltic; [5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] [1-methyl-2-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-keto-ethyl)-7,12,17-tris(3-amino-3-keto-propyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]ethyl] phosphate; 2-methyl-4,5-dimethylol-pyridin-3-ol; thiamin; chloride; cyanide
  • 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol; cobalt(3+); [5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl phosphate; chloride; cyanide
  • triredisol
  • 76773-81-4
  • Triredisol-H
  • Vitamin B12, mixt. with 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 5-hydroxy-6-methyl-3,4-pyridinedimethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0152 0.3678 0.3678
Echinococcus granulosus geminin 0.0337 0.8828 0.8828
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0268 0.0268
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0602 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0877 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0196 0.3257
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0196 0.3257
Echinococcus multilocularis adam 0.0166 0.4062 0.4062
Trypanosoma cruzi ISWI complex protein 0.0031 0.0295 0.3361
Brugia malayi Reprolysin 0.0168 0.411 0.411
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1564 0.1564
Loa Loa (eye worm) angiogenesis inhibito 0.0026 0.0163 0.0163
Brugia malayi angiogenesis inhibito 0.0073 0.1475 0.1475
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0877 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.053 0.053
Mycobacterium ulcerans hypothetical protein 0.0028 0.0196 0.3257
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0196 0.2238
Brugia malayi Bromodomain containing protein 0.0034 0.0383 0.0383
Trichomonas vaginalis set domain proteins, putative 0.0239 0.6099 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0249 0.2822
Onchocerca volvulus 0.0042 0.0602 0.0688
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0602 0.0869
Mycobacterium ulcerans hypothetical protein 0.0042 0.0602 1
Echinococcus granulosus disintegrin and metalloproteinase 0.0127 0.2961 0.2961
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0196 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0268 0.0268
Echinococcus multilocularis peregrin 0.0034 0.0383 0.0383
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0196 0.0196
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0705 0.0705
Mycobacterium ulcerans beta-lactamase 0.0042 0.0602 1
Brugia malayi metalloprotease 0.0026 0.0163 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0379 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.2811 0.2811
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0231 0.5875 0.5875
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.2148 0.2148
Brugia malayi beta-lactamase 0.0042 0.0602 0.0602
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0196 0.3257
Onchocerca volvulus 0.003 0.0268 0.0122
Echinococcus multilocularis geminin 0.0337 0.8828 0.8828
Brugia malayi Disintegrin family protein 0.0127 0.2961 0.2961
Mycobacterium leprae Probable lipase LipE 0.0042 0.0602 1
Brugia malayi beta-lactamase family protein 0.0042 0.0602 0.0602
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0602 0.0602
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0144 0.3436 0.3436
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0705 0.0705
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.1235 0.1235
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0705 0.0705
Toxoplasma gondii ABC1 family protein 0.0042 0.0602 0.5632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.1235 0.1235
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0231 0.5875 0.5875
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0249 0.2822
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0237 0.0237
Brugia malayi Pre-SET motif family protein 0.003 0.0268 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0196 0.0283
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.2148 0.2148
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0196 0.2238
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0877 1
Brugia malayi PHD-finger family protein 0.0029 0.0249 0.0249
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0602 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0031 0.0295 0.0295
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0877 1
Giardia lamblia PHD finger protein 15 0.0029 0.0249 1
Mycobacterium ulcerans lipase LipD 0.0042 0.0602 1
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0602 0.0869
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1464 0.1464
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0196 1
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0166 0.4062 0.4062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0602 0.0869
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0196 1
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0877 1
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0602 0.0869
Echinococcus multilocularis disintegrin and metalloproteinase 0.0127 0.2961 0.2961
Schistosoma mansoni hypothetical protein 0.0029 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0249 0.0249
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0394 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0196 0.3257
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0065 0.1235 0.1235
Leishmania major hypothetical protein, conserved 0.0052 0.0877 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0002 0.0031
Loa Loa (eye worm) disintegrin family protein 0.0063 0.1196 0.1196
Echinococcus granulosus jumonji domain containing protein 0.0041 0.057 0.057
Echinococcus granulosus zinc finger protein 0.004 0.0537 0.0537
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.057 0.057
Loa Loa (eye worm) reprolysin 0.0231 0.5875 0.5875
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0196 0.2238
Schistosoma mansoni dihydroceramide desaturase 0.0127 0.2961 0.2961
Leishmania major hypothetical protein, conserved 0.0031 0.0295 0.3361
Brugia malayi beta-lactamase family protein 0.0042 0.0602 0.0602
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0196 0.3257
Brugia malayi MH2 domain containing protein 0.0119 0.275 0.275
Leishmania major hypothetical protein, conserved 0.0042 0.0602 0.6871
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0042 0.0602 0.0869
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.053 0.053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0602 0.0602
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0083 0.1736 0.1736
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0119 0.2749 0.2749
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0231 0.5875 0.5875
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0042 0.0597 0.0597
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0597 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0379 1 1
Brugia malayi Pre-SET motif family protein 0.021 0.529 0.529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0379 1 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0073 0.1475 0.1475
Plasmodium vivax SET domain protein, putative 0.003 0.0268 0.3046
Loa Loa (eye worm) hypothetical protein 0.0078 0.1602 0.1602
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0602 0.0602
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0077 0.0077
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0394 0.0394
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0077 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1464 0.1464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0379 1 1
Echinococcus multilocularis zinc finger protein 0.004 0.0537 0.0537
Onchocerca volvulus 0.0239 0.6099 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0602 0.0869
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0196 0.0196
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.053 0.053
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0026 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0087 0.1845 0.1845
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1123 0.1123
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0047 0.074 0.074
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0602 0.0869
Onchocerca volvulus Alhambra homolog 0.0029 0.0249 0.0089
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0231 0.5875 0.5875
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Brugia malayi hypothetical protein 0.0166 0.4062 0.4062
Echinococcus granulosus adam 0.0166 0.4062 0.4062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0268 0.0313
Schistosoma mansoni hypothetical protein 0.0023 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0096 0.2117 0.2117
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0602 0.0602
Trypanosoma cruzi ISWI complex protein 0.0031 0.0295 0.3361
Loa Loa (eye worm) hypothetical protein 0.0073 0.1475 0.1475
Schistosoma mansoni zinc finger protein 0.0031 0.0295 0.0295
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.6933 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0196 0.3257
Schistosoma mansoni zinc finger protein 0.004 0.0537 0.0537
Mycobacterium tuberculosis Conserved protein 0.0042 0.0602 0.0869
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.529 0.529
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0602 0.6871
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0602 0.0988
Brugia malayi hypothetical protein 0.0052 0.0877 0.0877
Schistosoma mansoni hypothetical protein 0.0337 0.8828 0.8828
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0196
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0877 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0002 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.275 0.275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0097 0.2148 0.2148
Echinococcus granulosus adam 17 protease 0.0063 0.1192 0.1192
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0602 0.6871
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.2117 0.2117
Loa Loa (eye worm) hypothetical protein 0.0052 0.0877 0.0877
Onchocerca volvulus 0.0042 0.0602 0.0688
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0602 0.0988
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0877 1
Loa Loa (eye worm) beta-lactamase 0.0042 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0337 0.8828 0.8828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0379 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.2117 0.2117
Brugia malayi Bromodomain containing protein 0.0078 0.1598 0.1598
Loa Loa (eye worm) metalloprotease 0.0026 0.0163 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0602 0.6871
Brugia malayi hypothetical protein 0.0034 0.0363 0.0363
Trypanosoma brucei ISWI complex protein 0.0031 0.0295 0.3361
Schistosoma mansoni bromodomain containing protein 0.0128 0.3014 0.3014
Trichomonas vaginalis esterase, putative 0.0042 0.0602 0.0988
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0379 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0421 0.0421
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0196 0.0196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0196 0.0283
Brugia malayi PHD-finger family protein 0.0051 0.0839 0.0839
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0602 0.0602
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0429 0.0429
Brugia malayi jmjC domain containing protein 0.0039 0.053 0.053
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0602 0.0602
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0602 0.0869
Loa Loa (eye worm) hypothetical protein 0.0029 0.0249 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0602 0.0988
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0249 0.0249
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.1235 0.1235
Mycobacterium tuberculosis Conserved protein 0.0042 0.0602 0.0869
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0268 0.0268
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.2811 0.2811
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0602 0.0988
Loa Loa (eye worm) hypothetical protein 0.005 0.0835 0.0835
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.053 0.053
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.275 0.275
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0602 0.6864
Loa Loa (eye worm) hypothetical protein 0.0073 0.1475 0.1475
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0249 0.0249
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0196 0.3257
Brugia malayi ADAMTS-like protease 0.0073 0.1475 0.1475
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0602 0.0988
Onchocerca volvulus 0.0042 0.0602 0.0688
Echinococcus granulosus peregrin 0.0034 0.0383 0.0383

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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