Detailed information for compound 582356

Basic information

Technical information
  • TDR Targets ID: 582356
  • Name: (3aR,8bR)-7-hydroxy-8-(p-tolylsulfonyl)-3a,8b -dihydro-3H-furo[3,2-b]benzofuran-2-one
  • MW: 346.354 | Formula: C17H14O6S
  • H donors: 1 H acceptors: 4 LogP: 2.52 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C[C@@H]2[C@H](O1)c1c(O2)ccc(c1S(=O)(=O)c1ccc(cc1)C)O
  • InChi: 1S/C17H14O6S/c1-9-2-4-10(5-3-9)24(20,21)17-11(18)6-7-12-15(17)16-13(22-12)8-14(19)23-16/h2-7,13,16,18H,8H2,1H3/t13-,16+/m1/s1
  • InChiKey: MSGRILAFVNUCAG-CJNGLKHVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3aR,8bR)-7-hydroxy-8-(4-methylphenyl)sulfonyl-3a,8b-dihydro-3H-furo[3,2-b][1]benzofuran-2-one
  • (3aR,8bR)-7-hydroxy-8-tosyl-3a,8b-dihydro-3H-furo[3,2-b]benzofuran-2-one
  • (3aR,8bR)-7-hydroxy-8-(4-methylphenyl)sulfonyl-3a,8b-dihydro-3H-furo[4,5-b][1]benzoxol-2-one
  • (3aR,8bR)-7-hydroxy-8-(4-methylphenyl)sulfonyl-3a,8b-dihydro-3H-furo[4,5-b]benzofuran-2-one
  • InChI=1/C17H14O6S/c1-9-2-4-10(5-3-9)24(20,21)17-11(18)6-7-12-15(17)16-13(22-12)8-14(19)23-16/h2-7,13,16,18H,8H2,1H

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0509 0.1394
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0041 0.0041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0007 0.0002
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1974 0.1969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.152 0.5874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0509 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Brugia malayi CXXC zinc finger family protein 0.0062 0.0717 0.1961
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.009 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Onchocerca volvulus Cathepsin L homolog 0.0019 0.009 0.0538
Loa Loa (eye worm) hypothetical protein 0.0149 0.1974 0.4103
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0286 0.0333
Leishmania major trypanothione reductase 0.0038 0.0364 0.0426
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0385 0.0452
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0096 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0007 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0385 0.1491
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0162 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1202 0.2757
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0007 0.0007
Schistosoma mansoni lamin 0.0028 0.0226 0.0226
Loa Loa (eye worm) glutathione reductase 0.0038 0.0364 0.0757
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0601 0.1644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0006 0.0062
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0007 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Leishmania major cathepsin L-like protease 0.0072 0.0853 0.1008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0031
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0084 0.1027 0.1215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0853 0.1008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.009 0.0327
Treponema pallidum NADH oxidase 0.0013 0.0007 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.1292 0.1529
Echinococcus multilocularis cpg binding protein 0.0066 0.0768 0.0763
Onchocerca volvulus 0.0019 0.009 0.0538
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Plasmodium falciparum thioredoxin reductase 0.0038 0.0364 0.1391
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1063 0.2437
Brugia malayi Muscleblind-like protein 0.0149 0.1974 0.5402
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.009 0.1006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.029 0.0285
Entamoeba histolytica cysteine protease, putative 0.0019 0.009 0.1006
Echinococcus granulosus snurportin 1 0.0346 0.4811 0.4811
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1202 0.2757
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0385 0.1473
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0364 0.0426
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0226 0.0469
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1724 0.1724
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.029 0.0604
Schistosoma mansoni hypothetical protein 0.0347 0.4824 0.4824
Mycobacterium ulcerans hypothetical protein 0.0314 0.4347 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.8416 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0197 0.0764
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0007 0.0002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0041 0.0036
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0162 0.0162
Onchocerca volvulus 0.0028 0.0226 0.1352
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0004
Schistosoma mansoni intermediate filament proteins 0.0028 0.0226 0.0226
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0192 0.2584 0.594
Onchocerca volvulus 0.0019 0.009 0.0538
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0007 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.029 0.0285
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0093 0.0253
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Toxoplasma gondii thioredoxin reductase 0.0038 0.0364 0.1391
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0041 0.0036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.009 0.0187
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0007 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Loa Loa (eye worm) hypothetical protein 0.0103 0.1311 0.2724
Schistosoma mansoni ran 0.0024 0.0162 0.0162
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.3654 0.365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.009 0.0084
Schistosoma mansoni cpg binding protein 0.0066 0.0768 0.0768
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0007 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1311 0.3587
Plasmodium vivax importin-beta 2, putative 0.0032 0.0286 0.1087
Toxoplasma gondii hypothetical protein 0.0096 0.1205 0.4651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0509 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Schistosoma mansoni hypothetical protein 0.0074 0.0893 0.0893
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0632 0.0744
Onchocerca volvulus 0.0019 0.009 0.0538
Plasmodium vivax vivapain-2 0.0019 0.009 0.0327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0509 0.0509
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0838 0.2294
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0006 0.0015
Schistosoma mansoni ran 0.0024 0.0162 0.0162
Entamoeba histolytica hypothetical protein 0.0039 0.0385 0.4316
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0162 0.0445
Schistosoma mansoni hypothetical protein 0.0071 0.0838 0.0838
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Brugia malayi Importin beta-1 subunit 0.0032 0.0286 0.0782
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Onchocerca volvulus 0.0028 0.0226 0.1352
Leishmania major cysteine peptidase A (CPA) 0.0019 0.009 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0385 0.1491
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.6453 0.6451
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0007 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0853 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0364 0.0757
Plasmodium vivax glutathione reductase, putative 0.0038 0.0364 0.1391
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0197 0.0228
Trichomonas vaginalis helicase, putative 0.0014 0.0022 0.0084
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0128 0.167 0.347
Echinococcus granulosus geminin 0.0347 0.4824 0.4824
Entamoeba histolytica hypothetical protein 0.0074 0.0893 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0007
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0006 0.0006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1063 0.4103
Onchocerca volvulus Huntingtin homolog 0.0128 0.167 1
Echinococcus multilocularis cysteine protease 0.0019 0.009 0.0084
Echinococcus multilocularis cysteine protease 0.0019 0.009 0.0084
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0007 0.0007
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.009 0.0187
Loa Loa (eye worm) hypothetical protein 0.0149 0.1974 0.4103
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0084 0.1027 0.1215
Leishmania major cathepsin L-like protease 0.0019 0.009 0.01
Leishmania major cathepsin L-like protease 0.0019 0.009 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0509 0.1059
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.009 0.0327
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.3887 0.4615
Echinococcus granulosus cpg binding protein 0.0066 0.0768 0.0768
Echinococcus granulosus transcription factor btf3 0.0039 0.0385 0.0385
Echinococcus multilocularis musashi 0.0028 0.0226 0.022
Schistosoma mansoni hypothetical protein 0.0347 0.4824 0.4824
Loa Loa (eye worm) fibroinase 0.0019 0.009 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0096 0.0096
Trypanosoma brucei trypanothione reductase 0.0038 0.0364 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0162 0.0187
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0037 0.0076
Plasmodium falciparum thioredoxin reductase 0.0013 0.0007 0.0007
Onchocerca volvulus 0.0013 0.0006 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.3654 0.3654
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.009 0.0084
Loa Loa (eye worm) oxidoreductase 0.0013 0.0006 0.0011
Echinococcus multilocularis snurportin 1 0.0346 0.4811 0.4808
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0074 0.0893 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0007 0.002
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1063 0.2437
Onchocerca volvulus Huntingtin homolog 0.0128 0.167 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0197 0.0764
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0385 0.4316
Echinococcus multilocularis lamin dm0 0.0028 0.0226 0.022
Echinococcus multilocularis microtubule associated protein 2 0.0705 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0162 0.0609
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1202 0.4642
Leishmania major cathepsin L-like protease 0.0072 0.0853 0.1008
Leishmania major importin beta-1 subunit, putative 0.0026 0.0197 0.0228
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0007 0.0004
Onchocerca volvulus 0.0019 0.009 0.0538
Schistosoma mansoni microtubule-associated protein tau 0.0705 1 1
Schistosoma mansoni hypothetical protein 0.0054 0.0601 0.0601
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0197 0.0764
Onchocerca volvulus 0.0019 0.009 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0007 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0314 0.4347 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Loa Loa (eye worm) ctsf protein 0.0019 0.009 0.0187
Echinococcus granulosus intermediate filament protein 0.0028 0.0226 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Schistosoma mansoni cpg binding protein 0.0066 0.0768 0.0768
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0385 0.0452
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.009 0.0347
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0385 0.1473
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.009 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0162 0.0157
Onchocerca volvulus 0.0019 0.009 0.0538
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.009 0.01
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0763 0.0901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0509 0.0509
Leishmania major basic transcription factor 3a, putative 0.0039 0.0385 0.0452
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0192 0.2584 1
Leishmania major cathepsin L-like protease 0.0019 0.009 0.01
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0282 0.3887 0.4615
Schistosoma mansoni lamin 0.0028 0.0226 0.0226
Schistosoma mansoni transcription factor btf3 0.0039 0.0385 0.0385
Plasmodium falciparum glutathione reductase 0.0013 0.0007 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1063 0.2437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.1027 0.1215
Schistosoma mansoni cpg binding protein 0.0062 0.0717 0.0717
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.009 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Schistosoma mansoni hypothetical protein 0.0033 0.029 0.029
Schistosoma mansoni survival motor neuron protein 0.0054 0.0601 0.0601
Echinococcus granulosus importin subunit beta 1 0.0032 0.0286 0.0286
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0192 0.2584 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0015 0.0009
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.009 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0286 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Loa Loa (eye worm) hypothetical protein 0.0028 0.0226 0.0469
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0192 0.2584 1
Leishmania major cathepsin L-like protease 0.0072 0.0853 0.1008
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0007 0.0007
Echinococcus multilocularis GPCR, family 2 0.0033 0.029 0.0285
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0286 0.1087
Mycobacterium tuberculosis Probable reductase 0.0086 0.1063 0.2437
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0595 0.8416 1
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0385 0.1473
Loa Loa (eye worm) hypothetical protein 0.0033 0.029 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Echinococcus multilocularis lamin 0.0028 0.0226 0.022
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.009 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.029 0.029
Schistosoma mansoni importin beta-1 0.0032 0.0286 0.0286
Plasmodium falciparum importin beta, putative 0.0032 0.0286 0.1087
Plasmodium vivax vivapain-2 0.0019 0.009 0.0327
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0385 0.0801
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0893 0.0893
Brugia malayi hypothetical protein 0.0074 0.0893 0.2443
Brugia malayi RNA, U transporter 1 0.0092 0.1148 0.3143
Toxoplasma gondii cathepsin CPL 0.0019 0.009 0.0327
Trichomonas vaginalis hypothetical protein 0.0192 0.2584 1
Leishmania major cathepsin L-like protease 0.0019 0.009 0.01
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0509 0.0509
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0385 0.0452
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0192 0.2584 0.594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0509 0.0509
Echinococcus granulosus muscleblind protein 0.0149 0.1974 0.1974
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0162 0.0187
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0717 0.1489
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0007 0.0002
Entamoeba histolytica hypothetical protein 0.0074 0.0893 1
Onchocerca volvulus 0.0013 0.0006 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.009 0.1006
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Plasmodium falciparum glutathione reductase 0.0038 0.0364 0.1391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.029 0.029
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0853 0.1008
Onchocerca volvulus 0.0062 0.0717 0.4292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.4811 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0084
Echinococcus granulosus lamin 0.0028 0.0226 0.0226
Brugia malayi intermediate filament protein 0.0028 0.0226 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0385 0.1491
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.1027 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.8416 1
Entamoeba histolytica hypothetical protein 0.0026 0.0197 0.2212
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1508 0.3134
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0096 0.02
Loa Loa (eye worm) hypothetical protein 0.0266 0.3654 0.7594
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0371 0.0371
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0226 0.0469
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0893 0.0888
Brugia malayi Latrophilin receptor protein 2 0.0033 0.029 0.0795
Echinococcus multilocularis geminin 0.0347 0.4824 0.4821
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0192 0.2584 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0364 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0838 0.1742
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0187
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0226 0.0618
Brugia malayi beta-NAC-like protein 0.0039 0.0385 0.1055
Echinococcus multilocularis muscleblind protein 0.0149 0.1974 0.1969
Onchocerca volvulus 0.0019 0.009 0.0538
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Leishmania major cathepsin L-like protease 0.0019 0.009 0.01
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0162 0.0338
Plasmodium falciparum enoyl-acyl carrier reductase 0.0192 0.2584 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.029 0.029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.009 0.0347
Onchocerca volvulus Cathepsin F homolog 0.0019 0.009 0.0538
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1063 0.2437
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.029 0.0795
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0286 0.0333
Brugia malayi Thioredoxin reductase 0.0038 0.0364 0.0996
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0074 0.0893 1
Echinococcus granulosus cathepsin l1 0.0019 0.009 0.009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0192 0.2584 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0084
Brugia malayi MH2 domain containing protein 0.0117 0.1508 0.4127
Leishmania major mitochondrial DNA polymerase beta 0.0595 0.8416 1
Leishmania major GTP-binding protein, putative 0.0024 0.0162 0.0187
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0037 0.01
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0007 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0853 0.1008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1063 0.2437
Loa Loa (eye worm) hypothetical protein 0.0128 0.167 0.347
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0006 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1202 0.2757
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0162 0.0609
Echinococcus granulosus lamin dm0 0.0028 0.0226 0.0226
Schistosoma mansoni hypothetical protein 0.0459 0.6453 0.6453
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0893 0.0893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Loa Loa (eye worm) cysteine protease 0.0019 0.009 0.0187
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0007 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0364 0.1391
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0162 0.0187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1311 0.2724
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0015
Brugia malayi hypothetical protein 0.0128 0.167 0.4569
Onchocerca volvulus 0.0054 0.0601 0.3597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0002
Trichomonas vaginalis ran, putative 0.0024 0.0162 0.0629
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0007 0.0004
Schistosoma mansoni hypothetical protein 0.0033 0.029 0.029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Brugia malayi hypothetical protein 0.0266 0.3654 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0033 0.029 0.029
Entamoeba histolytica Ran family GTPase 0.0024 0.0162 0.1819
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.009 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0371 0.0366
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0007 0.0007
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0007 0.0007
Onchocerca volvulus Cathepsin L homolog 0.0019 0.009 0.0538
Loa Loa (eye worm) hypothetical protein 0.0032 0.0286 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0853 0.1008
Schistosoma mansoni hypothetical protein 0.0346 0.4811 0.4811
Echinococcus multilocularis transcription factor btf3 0.0039 0.0385 0.038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0007 0.0002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0162 0.0609
Brugia malayi glutathione reductase 0.0038 0.0364 0.0996
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1508 0.3134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0347
Echinococcus granulosus GPCR family 2 0.0033 0.029 0.029
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.0246
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1311 0.3587
Echinococcus granulosus dnaJ subfamily B 0.0459 0.6453 0.6453
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.3887 0.4615

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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