Detailed information for compound 582493

Basic information

Technical information
  • TDR Targets ID: 582493
  • Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydrox y-2-(hydroxymethyl)tetrahydrofuran-3-yl] 5-(d imethylamino)naphthalene-1-sulfonate
  • MW: 500.528 | Formula: C22H24N6O6S
  • H donors: 3 H acceptors: 7 LogP: 0.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1OS(=O)(=O)c1cccc2c1cccc2N(C)C)O)n1cnc2c1ncnc2N
  • InChi: 1S/C22H24N6O6S/c1-27(2)14-7-3-6-13-12(14)5-4-8-16(13)35(31,32)34-19-15(9-29)33-22(18(19)30)28-11-26-17-20(23)24-10-25-21(17)28/h3-8,10-11,15,18-19,22,29-30H,9H2,1-2H3,(H2,23,24,25)/t15-,18-,19-,22-/m1/s1
  • InChiKey: PFVOMAIBZGSHNC-CIVUBGFFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(dimethylamino)-1-naphthalenesulfonic acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl] ester
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 5-(dimethylamino)naphthalene-1-sulfonate
  • 5-(dimethylamino)naphthalene-1-sulfonic acid [(2R,3S,4R,5R)-5-adenin-9-yl-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] ester
  • 3'-O-dansyladenosine
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 5-dimethylaminonaphthalene-1-sulfonate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl] 5-dimethylaminonaphthalene-1-sulfonate
  • 5-dimethylamino-1-naphthalenesulfonic acid [(2R,3S,4R,5R)-5-(6-amino-9-purinyl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl] ester
  • 5-dimethylaminonaphthalene-1-sulfonic acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] ester
  • 77446-71-0
  • Adenosine, 3'-(5-(dimethylamino)-1-naphthalenesulfonate)
  • 3'-O-(5-(Dimethylamino)naphthalene-1-sulfonyl)adenosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0366 0.0796
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0344 0.0601
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0146
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0019 0.0027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0344 0.0749
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0265 0.0575
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0147 0.0143
Echinococcus multilocularis cpg binding protein 0.0063 0.0354 0.0351
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0317 0.2212 0.6189
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0147 0.041
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2162 0.6049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0381 0.0377
Loa Loa (eye worm) cysteine protease 0.0017 0.0019 0.0054
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0079 0.0132
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0054 0.0287 0.0499
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.015 0.0258
Onchocerca volvulus 0.0017 0.0019 0.0068
Entamoeba histolytica hypothetical protein 0.0107 0.0675 1
Echinococcus granulosus lamin 0.0027 0.009 0.0086
Leishmania major cathepsin L-like protease 0.0017 0.0019 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0019 0.0054
Schistosoma mansoni Smad4 0.0034 0.0147 0.0143
Schistosoma mansoni hypothetical protein 0.0866 0.6214 0.6213
Loa Loa (eye worm) histone methyltransferase 0.002 0.0038 0.0108
Schistosoma mansoni ets-related 0.0212 0.1446 0.1443
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0181 0.0505
Onchocerca volvulus 0.0032 0.0128 0.0721
Mycobacterium ulcerans hypothetical protein 0.0336 0.2345 0.4136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0181 0.0177
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.015 0.0146
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Echinococcus granulosus cpg binding protein 0.0063 0.0354 0.0351
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.015 0.0258
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0004 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.015 0.0258
Loa Loa (eye worm) fli-1 protein 0.0212 0.1446 0.4046
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0019 0.0068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.011 0.0106
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Plasmodium vivax enoyl-acyl carrier protein reductase 0.079 0.5663 1
Echinococcus granulosus intermediate filament protein 0.0027 0.009 0.0086
Schistosoma mansoni hypothetical protein 0.0144 0.0944 0.094
Brugia malayi Pre-SET motif family protein 0.0032 0.0128 0.0358
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0019 0.0015
Loa Loa (eye worm) MH2 domain-containing protein 0.0504 0.3574 1
Echinococcus multilocularis cysteine protease 0.0017 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Leishmania major cytochrome p450-like protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1429 0.3998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0019 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.015 0.0321
Brugia malayi CXXC zinc finger family protein 0.0059 0.033 0.0923
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0054 0.0287 0.0499
Echinococcus granulosus Smad4 0.0034 0.0147 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Loa Loa (eye worm) fibroinase 0.0017 0.0019 0.0054
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0128 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0344 0.0601
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0004 0.0001
Brugia malayi MH2 domain containing protein 0.0504 0.3574 1
Leishmania major pteridine reductase 1 0.0054 0.0287 0.0622
Plasmodium vivax SET domain protein, putative 0.0032 0.0128 0.0219
Echinococcus multilocularis lamin 0.0027 0.009 0.0086
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0019 0.0027
Brugia malayi Cytochrome P450 family protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0381 0.1066
Brugia malayi hypothetical protein 0.0016 0.0014 0.004
Plasmodium vivax vivapain-2 0.0017 0.0019 0.0027
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0181 0.0177
Trypanosoma brucei pteridine reductase 1 0.0054 0.0287 0.0622
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0381 0.1066
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0052 0.0085
Schistosoma mansoni lipoxygenase 0.0102 0.0643 0.064
Leishmania major mitochondrial DNA polymerase beta 0.0637 0.4545 1
Schistosoma mansoni smad1 5 8 and 0.0034 0.0147 0.0143
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Schistosoma mansoni Smad4 0.0015 0.0008 0.0004
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0054 0.0287 0.0283
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0052 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0152 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0344 0.034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.015 0.0258
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 1
Schistosoma mansoni ran 0.0021 0.0052 0.0048
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0287 0.0802
Brugia malayi hypothetical protein 0.0039 0.0181 0.0505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.09 0.0897
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Echinococcus multilocularis RUN 0.0039 0.0181 0.0177
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.015 0.0258
Leishmania major hypothetical protein, conserved 0.0035 0.015 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0852 0.0848
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0607 0.1065
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Echinococcus multilocularis muscleblind protein 0.0317 0.2212 0.2209
Echinococcus multilocularis muscleblind protein 1 0.0317 0.2212 0.2209
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0407 0.0403
Brugia malayi Ets-domain containing protein 0.007 0.0407 0.1138
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0004 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.055 0.1202
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.015 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0153 0.0264
Schistosoma mansoni hypothetical protein 0.0413 0.2907 0.2904
Loa Loa (eye worm) hypothetical protein 0.0039 0.0181 0.0505
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.033 0.0923
Schistosoma mansoni cpg binding protein 0.0063 0.0354 0.0351
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Echinococcus granulosus GPCR family 2 0.0066 0.0381 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.09 0.0897
Loa Loa (eye worm) hypothetical protein 0.006 0.0333 0.0931
Brugia malayi MH1 domain containing protein 0.0034 0.0147 0.041
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0068 0.0113
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0052 0.0085
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.2907 0.2904
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0287 0.0499
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0128 0.0124
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0054 0.0287 0.0499
Schistosoma mansoni lamin 0.0027 0.009 0.0086
Onchocerca volvulus 0.0054 0.0287 0.1676
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0054 0.0287 0.0499
Loa Loa (eye worm) hypothetical protein 0.0066 0.0381 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0153 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0128 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0079 0.0165
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0181 0.0312
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0052 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0607 0.1066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0109 0.0693 0.1517
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0366 0.0796
Plasmodium falciparum thioredoxin reductase 0.0043 0.0208 0.036
Brugia malayi beta-lactamase family protein 0.0035 0.015 0.0419
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0675 0.0671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0381 0.0377
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0147 0.0143
Brugia malayi beta-lactamase family protein 0.0035 0.015 0.0419
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0054 0.0287 0.0499
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0079 0.0132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.009 0.0252
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.1156 0.1152
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0242
Plasmodium vivax vivapain-2 0.0017 0.0019 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Loa Loa (eye worm) oxidoreductase 0.0054 0.0287 0.0802
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2096 0.4607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Echinococcus multilocularis transcription factor btf3 0.0035 0.0153 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0675 0.0671
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0852 0.2384
Trichomonas vaginalis set domain proteins, putative 0.0243 0.167 0.2944
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0181 0.0177
Brugia malayi glutathione reductase 0.0043 0.0208 0.0581
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0019 0.0054
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0687 0.1206
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.079 0.5663 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0019 0.0015
Mycobacterium tuberculosis Conserved protein 0.0035 0.015 0.0258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0381 0.0377
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.015 0.0258
Schistosoma mansoni dihydropteridine reductase 0.0054 0.0287 0.0283
Echinococcus multilocularis musashi 0.0027 0.009 0.0086
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.3382 0.338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.015 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0147 0.041
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0054 0.0287 0.0283
Leishmania major cathepsin L-like protease 0.0064 0.0366 0.0796
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0208 0.036
Schistosoma mansoni rab6-interacting 0.0039 0.0181 0.0177
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0153 0.0264
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.079 0.5663 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0252
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0381 0.1066
Toxoplasma gondii hypothetical protein 0.0103 0.0646 0.1134
Leishmania major GTP-binding protein, putative 0.0021 0.0052 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Schistosoma mansoni hypothetical protein 0.0039 0.0181 0.0177
Brugia malayi cytochrome P450 0.0015 0.0004 0.0012
Schistosoma mansoni transcription factor btf3 0.0035 0.0153 0.0149
Mycobacterium leprae Probable lipase LipE 0.0035 0.015 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0097
Echinococcus multilocularis snurportin 1 0.031 0.2162 0.2159
Loa Loa (eye worm) Smad1 0.0034 0.0147 0.041
Loa Loa (eye worm) nuclear factor I 0.0019 0.0035 0.0097
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0008 0.0023
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.1156 0.1152
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0008 0.0023
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0054 0.0287 0.0283
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0019 0.0068
Schistosoma mansoni hypothetical protein 0.0066 0.0381 0.0377
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0054 0.0287 0.0622
Plasmodium vivax importin-beta 2, putative 0.0029 0.0108 0.0184
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0153 0.2046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0153 0.0329
Toxoplasma gondii thioredoxin reductase 0.0043 0.0208 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0607 0.1066
Loa Loa (eye worm) intermediate filament protein 0.0027 0.009 0.0252
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1456 0.4073
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0287 0.0499
Brugia malayi RNA, U transporter 1 0.0083 0.05 0.1398
Onchocerca volvulus 0.0039 0.0181 0.1038
Entamoeba histolytica hypothetical protein 0.0107 0.0675 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0054 0.0287 0.0622
Mycobacterium tuberculosis Conserved protein 0.0035 0.015 0.0258
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.015 0.0146
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0153 0.0329
Echinococcus granulosus smad 0.0034 0.0147 0.0143
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0054 0.0287 0.0622
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Leishmania major cytochrome p450-like protein 0.0015 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0066 0.0381 0.0377
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0381 0.0377
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.0113
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0128 0.0219
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0153 0.0429
Loa Loa (eye worm) cytochrome P450 0.0015 0.0004 0.0012
Onchocerca volvulus 0.0017 0.0019 0.0068
Schistosoma mansoni hypothetical protein 0.0866 0.6214 0.6213
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2096 0.4607
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0054 0.0287 0.0499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0407 0.1138
Onchocerca volvulus 0.0017 0.0019 0.0068
Schistosoma mansoni lipoxygenase 0.0173 0.1156 0.1152
Loa Loa (eye worm) glutathione reductase 0.0043 0.0208 0.0581
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0181 0.0505
Leishmania major cytochrome p450-like protein 0.0015 0.0004 0.0001
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0181 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Treponema pallidum NADH oxidase 0.0015 0.0004 0.5
Mycobacterium ulcerans lipase LipD 0.0035 0.015 0.0258
Mycobacterium ulcerans hypothetical protein 0.0035 0.015 0.0258
Loa Loa (eye worm) hypothetical protein 0.021 0.1429 0.3998
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.015 0.0258
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0107 0.0675 0.0671
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.3382 0.338
Loa Loa (eye worm) hypothetical protein 0.0054 0.0287 0.0802
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0221
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1429 0.3998
Brugia malayi beta-lactamase 0.0035 0.015 0.0419
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0366 0.0796
Brugia malayi Thioredoxin reductase 0.0043 0.0208 0.0581
Brugia malayi MH1 domain containing protein 0.0019 0.0035 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0344 0.0601
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.015 0.0258
Echinococcus granulosus muscleblind protein 0.0317 0.2212 0.2209
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0852 0.2384
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0012 0.0008
Echinococcus multilocularis Smad4 0.0034 0.0147 0.0143
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0019 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.015 0.0257
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.09 0.2519
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0181 0.0177
Onchocerca volvulus 0.0017 0.0019 0.0068
Mycobacterium tuberculosis Possible oxidoreductase 0.0054 0.0287 0.0499
Schistosoma mansoni intermediate filament proteins 0.0027 0.009 0.0086
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0019 0.0068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0687 0.1206
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.015 0.0419
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0824 0.082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0301 0.2096 0.4607
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0147 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.09 0.0897
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0687 0.1206
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0208 0.0581
Trypanosoma brucei trypanothione reductase 0.0043 0.0208 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0852 0.0848
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.015 0.0258
Loa Loa (eye worm) hypothetical protein 0.0121 0.0777 0.2174
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0054 0.0287 0.0499
Brugia malayi intermediate filament protein 0.0027 0.009 0.0252
Onchocerca volvulus 0.0027 0.009 0.0493
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.015 0.0258
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0108 0.023
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0407 0.0403
Loa Loa (eye worm) hypothetical protein 0.0035 0.015 0.0419
Brugia malayi MH1 domain containing protein 0.0034 0.0147 0.041
Leishmania major importin beta-1 subunit, putative 0.0024 0.0068 0.0141
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0008 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0212 0.0208
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0478 0.3382 0.9462
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.015 0.0321
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0054 0.0287 0.0499
Brugia malayi MH1 domain containing protein 0.0019 0.0035 0.0097
Plasmodium vivax glutathione reductase, putative 0.0043 0.0208 0.036
Onchocerca volvulus 0.0097 0.0607 0.3604
Onchocerca volvulus 0.0243 0.167 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0004 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0004 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0153 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0852 0.0848
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0852 0.0848
Mycobacterium ulcerans oxidoreductase 0.0054 0.0287 0.0499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0012 0.0008
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0054 0.0287 0.0499
Loa Loa (eye worm) hypothetical protein 0.0032 0.0128 0.0358
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.079 0.5663 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0079 0.0132
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0208 0.0449
Schistosoma mansoni cpg binding protein 0.0063 0.0354 0.0351
Onchocerca volvulus 0.0039 0.0181 0.1038
Brugia malayi Pre-SET motif family protein 0.0214 0.1456 0.4073
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0366 0.0796
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.0287 0.4079
Schistosoma mansoni hypothetical protein 0.0066 0.0381 0.0377
Entamoeba histolytica hypothetical protein 0.0107 0.0675 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.079 0.5663 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0054
Brugia malayi Smad1 0.0034 0.0147 0.041
Echinococcus granulosus lamin dm0 0.0027 0.009 0.0086
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0726 0.1275
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0068 0.0141
Echinococcus granulosus RUN 0.0039 0.0181 0.0177
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0054 0.0287 0.0622
Brugia malayi Cytochrome P450 family protein 0.0035 0.0152 0.0425
Mycobacterium tuberculosis Conserved hypothetical protein 0.0336 0.2345 0.4136
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0079 0.0165
Leishmania major cathepsin L-like protease 0.0017 0.0019 0.0034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.055 0.1202
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0607 0.1699
Echinococcus granulosus transcription factor btf3 0.0035 0.0153 0.0149
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Schistosoma mansoni rab6-interacting 0.0039 0.0181 0.0177
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0054 0.0287 0.0499
Echinococcus multilocularis GPCR, family 2 0.0066 0.0381 0.0377
Schistosoma mansoni polycystin 1-related 0.0039 0.0181 0.0177
Toxoplasma gondii ABC1 family protein 0.0035 0.015 0.0258
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0153 0.0264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Brugia malayi MH2 domain containing protein 0.0015 0.0008 0.0023
Brugia malayi Importin beta-1 subunit 0.0029 0.0108 0.0303
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.015 0.0258
Mycobacterium tuberculosis Possible oxidoreductase 0.0054 0.0287 0.0499
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.1384 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0054 0.0287 0.0622
Schistosoma mansoni hypothetical protein 0.0097 0.0607 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0019 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Plasmodium falciparum glutathione reductase 0.0043 0.0208 0.036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0128 0.0124
Echinococcus granulosus dnaJ subfamily B 0.0413 0.2907 0.2904
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0325 0.0707
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0054 0.0287 0.0499
Leishmania major trypanothione reductase 0.0043 0.0208 0.0449
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0019 0.0015
Brugia malayi Muscleblind-like protein 0.0317 0.2212 0.6189
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0344 0.034
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0012 0.0008
Schistosoma mansoni survival motor neuron protein 0.0097 0.0607 0.0603
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0106
Mycobacterium tuberculosis Probable reductase 0.0097 0.0607 0.1066
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0128 0.0124
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0852 0.2384
Schistosoma mansoni smad1 5 8 and 0.0034 0.0147 0.0143
Schistosoma mansoni hypothetical protein 0.0066 0.0381 0.0377
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0287 0.0499
Schistosoma mansoni lamin 0.0027 0.009 0.0086
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0008 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0852 0.0848
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0208 0.036
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0944 0.2641
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0852 0.0848
Brugia malayi Ets-domain containing protein 0.007 0.0407 0.1138
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0128 0.0124
Schistosoma mansoni cpg binding protein 0.0059 0.033 0.0326
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0181 0.0312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0019 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0153 0.0264
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0344 0.034
Echinococcus granulosus geminin 0.0866 0.6214 0.6213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0019 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0344 0.034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0687 0.1206
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0108 0.0184
Entamoeba histolytica Ran family GTPase 0.0021 0.0052 0.0503
Trichomonas vaginalis hypothetical protein 0.079 0.5663 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Brugia malayi TAR-binding protein 0.0131 0.0852 0.2384
Echinococcus granulosus cathepsin l1 0.0017 0.0019 0.0015
Onchocerca volvulus 0.0017 0.0019 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Brugia malayi hypothetical protein 0.0478 0.3382 0.9462
Brugia malayi Fli-1 protein 0.0212 0.1446 0.4046
Echinococcus multilocularis geminin 0.0866 0.6214 0.6213
Brugia malayi RNA binding protein 0.0131 0.0852 0.2384
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0287 0.0499
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0054 0.0287 0.0802
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.079 0.5663 1
Brugia malayi hypothetical protein 0.0025 0.0079 0.0221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0675 0.0671
Leishmania major cathepsin L-like protease 0.0064 0.0366 0.0796
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0052 0.0048
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0054 0.0287 0.0499
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0054 0.0287 0.0499
Entamoeba histolytica hypothetical protein 0.0107 0.0675 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0004 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.055 0.1202
Onchocerca volvulus Huntingtin homolog 0.0121 0.0777 0.4628
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0079 0.0132
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0181 0.0177
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0607 0.1066
Brugia malayi Doublecortin family protein 0.0039 0.0181 0.0505
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Loa Loa (eye worm) RNA binding protein 0.0131 0.0852 0.2384
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.0113
Schistosoma mansoni gabp alpha 0.007 0.0407 0.0403
Leishmania major cathepsin L-like protease 0.0017 0.0019 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0344 0.0601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1429 0.3998
Brugia malayi MH2 domain containing protein 0.0034 0.0147 0.041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.09 0.0897
Brugia malayi MH2 domain containing protein 0.0034 0.0147 0.041
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0004 0.0001
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.079 0.5663 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0012 0.0008
Schistosoma mansoni importin beta-1 0.0029 0.0108 0.0104
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0052 0.0106
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0054 0.0287 0.0622
Mycobacterium ulcerans short chain dehydrogenase 0.0054 0.0287 0.0499
Brugia malayi hypothetical protein 0.0039 0.0181 0.0505
Schistosoma mansoni loxhd1 0.0039 0.0181 0.0177
Entamoeba histolytica hypothetical protein 0.0024 0.0068 0.0746
Brugia malayi Cytochrome P450 family protein 0.0015 0.0004 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0128 0.0124
Leishmania major cathepsin L-like protease 0.0017 0.0019 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.015 0.0146
Schistosoma mansoni smad 0.0015 0.0008 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0035 0.015 0.0258
Loa Loa (eye worm) ctsf protein 0.0017 0.0019 0.0054
Plasmodium falciparum importin beta, putative 0.0029 0.0108 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0108 0.023
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0054 0.0287 0.0499
Leishmania major oxidoreductase-like protein 0.0054 0.0287 0.0622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.0504 0.3574 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.055 0.1202
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.015 0.0419
Echinococcus multilocularis lamin dm0 0.0027 0.009 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.09 0.2519
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.009 0.0252
Leishmania major hypothetical protein, conserved 0.0025 0.0079 0.0165
Echinococcus granulosus importin subunit beta 1 0.0029 0.0108 0.0104
Echinococcus multilocularis cysteine protease 0.0017 0.0019 0.0015
Trichomonas vaginalis ran, putative 0.0021 0.0052 0.0085
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0147 0.0143
Leishmania major cathepsin L-like protease 0.0017 0.0019 0.0034
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0054 0.0287 0.0622
Brugia malayi hypothetical protein 0.0121 0.0777 0.2174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0019 0.0027
Echinococcus multilocularis microtubule associated protein 2 0.1384 1 1
Schistosoma mansoni Smad4 0.0015 0.0008 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1518 0.2675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.09 0.0897
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0147 0.0143
Onchocerca volvulus 0.0035 0.015 0.0853
Echinococcus granulosus tar DNA binding protein 0.0131 0.0852 0.0848
Schistosoma mansoni smad 0.0034 0.0147 0.0143
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 0.4545 1
Onchocerca volvulus 0.0059 0.033 0.1935
Schistosoma mansoni hypothetical protein 0.031 0.2162 0.2159
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0054 0.0287 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0019 0.0027
Trichomonas vaginalis esterase, putative 0.0035 0.015 0.0258
Echinococcus multilocularis smad 0.0034 0.0147 0.0143
Loa Loa (eye worm) beta-lactamase 0.0035 0.015 0.0419
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0607 0.1066
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0317 0.2212 0.6189
Onchocerca volvulus 0.0017 0.0019 0.0068
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0153 0.0329
Brugia malayi beta-NAC-like protein 0.0035 0.0153 0.0429
Entamoeba histolytica hypothetical protein 0.0035 0.0153 0.2046
Onchocerca volvulus 0.0017 0.0019 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.09 0.0897
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0121 0.0777 0.2174
Leishmania major basic transcription factor 3a, putative 0.0035 0.0153 0.0329
Mycobacterium ulcerans beta-lactamase 0.0035 0.015 0.0258
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0037 0.0103
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.015 0.0258
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0607 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0054 0.0287 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0144 0.0944 0.2641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0012 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0004 0.0012
Trypanosoma brucei oxidoreductase-like protein 0.0054 0.0287 0.0622
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0038 0.0034
Schistosoma mansoni smad1 5 8 and 0.0034 0.0147 0.0143
Mycobacterium tuberculosis Probable oxidoreductase 0.0054 0.0287 0.0499
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0079 0.0165
Onchocerca volvulus 0.0035 0.015 0.0853
Onchocerca volvulus 0.0054 0.0287 0.1676
Brugia malayi Cathepsin L-like precursor 0.0017 0.0019 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0637 0.4545 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.079 0.5663 1
Leishmania major cathepsin L-like protease 0.0064 0.0366 0.0796
Schistosoma mansoni ran 0.0021 0.0052 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 0.4545 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0344 0.0601
Echinococcus granulosus snurportin 1 0.031 0.2162 0.2159
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0108 0.0104
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0008 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.09 0.0897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0366 0.0796
Chlamydia trachomatis oxoacy-ACP reductase 0.0054 0.0287 0.0499
Brugia malayi hypothetical protein 0.0107 0.0675 0.1888
Onchocerca volvulus 0.0027 0.009 0.0493
Toxoplasma gondii cathepsin CPL 0.0017 0.0019 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0054 0.0287 0.0802
Mycobacterium tuberculosis Conserved protein 0.0035 0.015 0.0258
Onchocerca volvulus Huntingtin homolog 0.0121 0.0777 0.4628
Loa Loa (eye worm) retinol dehydrogenase 12 0.0054 0.0287 0.0802
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0303
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.015 0.0258
Onchocerca volvulus 0.0035 0.015 0.0853
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0212 0.0208
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0004 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0287 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0019 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0004 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.015 0.0258

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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