Detailed information for compound 58268

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.393 | Formula: C21H20F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(C(=O)N[C@@H]([C@H](c1ccccc1)Oc1cc(F)ccc1F)C)C1CC1
  • InChi: 1S/C21H20F2N2O2/c1-13(25-21(26)17(12-24)14-7-8-14)20(15-5-3-2-4-6-15)27-19-11-16(22)9-10-18(19)23/h2-6,9-11,13-14,17,20H,7-8H2,1H3,(H,25,26)/t13-,17?,20-/m1/s1
  • InChiKey: SWLAKWKAZNBZBM-SJRGXIAMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) Scytalone dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0126 0.0124
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0016 0.0071
Brugia malayi A-kinase anchor protein 10, precursor 0.0082 0.0122 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0055 0.0261
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.063 0.1237 0.9699
Chlamydia trachomatis neutral amino acid transporter 0.06 0.1176 0.4333
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0133 0.0482
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0126 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0058
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0007 0.0037
Schistosoma mansoni pyruvate kinase 0.0035 0.0026 0.0021
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.06 0.1176 0.1345
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.008 0.0078
Schistosoma mansoni polycystin 1-related 0.0042 0.0039 0.0037
Mycobacterium ulcerans glutaminase 0.0563 0.1101 0.8626
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0034 0.0252
Schistosoma mansoni lipoxygenase 0.0117 0.0192 0.0212
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0192 0.019
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Echinococcus granulosus tyrosine kinase 0.0642 0.1262 0.126
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0642 0.1262 0.1535
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.063 0.1237 0.9699
Mycobacterium leprae PROBABLE GLUTAMATE RACEMASE MURI 0.0649 0.1276 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0062 0.008 0.0607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0249 0.0909
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0016 0.0072
Brugia malayi Pre-SET motif family protein 0.0893 0.1772 0.2155
Plasmodium falciparum thioredoxin reductase 0.0088 0.0133 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0024 0.0108
Brugia malayi 6-phosphofructokinase 0.0119 0.0197 0.024
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0055 0.0415
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0016 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Trichomonas vaginalis rotamase, putative 0.0035 0.0026 0.0116
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0026 0.0031
Echinococcus granulosus lamin 0.0087 0.0132 0.013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0016 0.0739
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0024 0.0169
Echinococcus granulosus expressed protein 0.0035 0.0026 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0111 0.0119
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0055 0.0415
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0026 0.0041
Schistosoma mansoni lamin 0.0087 0.0132 0.0144
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0016 0.0051
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0613 0.1202 0.1461
Echinococcus multilocularis excitatory amino acid transporter 3 0.1353 0.271 0.2708
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0055 0.0378
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0055 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0197 0.0356 0.1306
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.1255 0.2509 0.2508
Echinococcus granulosus glutamate receptor 2 0.219 0.4414 0.4412
Brugia malayi Cytochrome P450 family protein 0.0026 0.0007 0.0009
Giardia lamblia GTOR 0.0049 0.0055 0.0743
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0197 0.1546
Echinococcus multilocularis nmda type glutamate receptor 0.1273 0.2547 0.2545
Plasmodium falciparum pyruvate kinase 0.0035 0.0026 0.1751
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0007 0.0037
Echinococcus multilocularis receptor type guanylyl cyclase 0.0642 0.1262 0.126
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0007 0.0005
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0007 0.0037
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.004 0.0038
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0162 0.0178
Loa Loa (eye worm) glutathione reductase 0.0088 0.0133 0.0131
Echinococcus multilocularis GPCR, family 3, C terminal 0.0613 0.1202 0.12
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0007 0.0018
Brugia malayi Cytochrome P450 family protein 0.0026 0.0007 0.0009
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.002 0.0138
Toxoplasma gondii thioredoxin reductase 0.0088 0.0133 0.3693
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0027 0.0025
Echinococcus granulosus glutamate receptor 4 0.04 0.0769 0.0767
Schistosoma mansoni rab6-interacting 0.0042 0.0039 0.0037
Echinococcus granulosus neutral amino acid transporter A 0.1353 0.271 0.2708
Trypanosoma brucei trypanothione reductase 0.0088 0.0133 0.6716
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.008 0.0578
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0055 0.0067
Brugia malayi PXA domain containing protein 0.0082 0.0122 0.0148
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0197 0.153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0557 0.4402
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.063 0.1237 0.9699
Loa Loa (eye worm) hypothetical protein 0.04 0.0769 0.0767
Echinococcus granulosus receptor type guanylyl cyclase 0.0642 0.1262 0.126
Echinococcus multilocularis geminin 0.0358 0.0683 0.0681
Echinococcus granulosus lamin dm0 0.0087 0.0132 0.013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2444 0.493 0.4929
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.02 0.0362 0.1328
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0026 0.0041
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0007 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.008 0.0614
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0039 0.0037
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0132
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.002 0.1334
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.008 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Onchocerca volvulus 0.1016 0.2023 0.7452
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Chlamydia trachomatis glutamate symporter 0.1353 0.271 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0007 0.0018
Brugia malayi Cytochrome P450 family protein 0.0104 0.0167 0.0203
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0007 0.028
Onchocerca volvulus 0.0042 0.0039 0.0091
Loa Loa (eye worm) hypothetical protein 0.0086 0.0129 0.0127
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0961 0.1911 0.1909
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.1214 0.2427 0.2425
Brugia malayi regulator of G-protein signaling rgs-7 0.0082 0.0122 0.0148
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0557 0.4402
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.4292 0.8692 1
Onchocerca volvulus 0.0642 0.1262 0.4629
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0197 0.0966
Echinococcus multilocularis excitatory amino acid transporter 2 0.1353 0.271 0.2708
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0102 0.0754
Mycobacterium leprae putative cytochrome p450 0.0026 0.0007 0.0037
Loa Loa (eye worm) glutamate receptor 0.4062 0.8224 0.8224
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0037
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0561 0.1096 0.1094
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0016 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0132
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0102 0.0109
Echinococcus granulosus glutamate receptor 1 0.04 0.0769 0.0767
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.008 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.271 0.2708
Treponema pallidum glutamate transporter 0.06 0.1176 0.9216
Echinococcus granulosus pyruvate kinase 0.0035 0.0026 0.0023
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.1214 0.2427 0.2425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.008 0.0078
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0007 0.0037
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0016 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0249 0.1934
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0007 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Loa Loa (eye worm) glutaminase 0.0563 0.1101 0.1099
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0016 0.0109
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0122 0.0132
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.0134 0.0132
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0151 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0151 0.0149
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1353 0.271 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0642 0.1262 0.4629
Echinococcus granulosus RUN 0.0042 0.0039 0.0037
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0016 0.0014
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0007 0.0037
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0026 0.0023
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0296 0.0556 0.0554
Brugia malayi intermediate filament protein 0.0087 0.0132 0.0161
Mycobacterium tuberculosis Putative ferredoxin reductase 0.02 0.0362 0.1328
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.008 0.3639
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.0215 0.0213
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0197 0.1546
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0016 0.001
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0055 0.0415
Schistosoma mansoni glutaminase 0.0563 0.1101 0.1259
Echinococcus multilocularis tyrosine kinase 0.0642 0.1262 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.004 0.0188
Schistosoma mansoni tyrosine kinase 0.0642 0.1262 0.1445
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.02 0.0362 0.1328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0015 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.008 0.0385
Echinococcus granulosus atrial natriuretic peptide receptor 0.0642 0.1262 0.126
Brugia malayi Cache domain containing protein 0.006 0.0076 0.0092
Schistosoma mansoni ap endonuclease 0.0062 0.008 0.0084
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Onchocerca volvulus 0.0084 0.0126 0.0413
Leishmania major cytochrome p450-like protein 0.0026 0.0007 0.0038
Echinococcus granulosus glutamate receptor NMDA 0.0083 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0039 0.0037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0102 0.0754
Echinococcus granulosus transcription factor Dp 1 0.0042 0.004 0.0038
Schistosoma mansoni ap endonuclease 0.0062 0.008 0.0084
Echinococcus granulosus Regulator of G protein signaling 20 0.0082 0.0122 0.012
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0007 0.0018
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.219 0.4414 0.4412
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0122 0.0132
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0016 0.0072
Echinococcus multilocularis sodium:dicarboxylate symporter 0.06 0.1176 0.1174
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0215 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0007 0.0018
Schistosoma mansoni glutamate receptor kainate 0.1802 0.3623 0.4162
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0007 0.0037
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0082 0.0122 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.002 0.0087
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0055 0.0415
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0197 0.0966
Echinococcus granulosus beta-adrenergic receptor kinase 0.0082 0.0122 0.012
Loa Loa (eye worm) excitatory amino acid transporter 0.1353 0.271 0.2708
Brugia malayi Bromodomain containing protein 0.003 0.0015 0.0018
Echinococcus granulosus geminin 0.0358 0.0683 0.0681
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0356 0.2777
Plasmodium vivax hypothetical protein, conserved 0.003 0.0015 0.056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0082 0.0122 0.012
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0197 1
Echinococcus multilocularis NMDA receptor 0.1214 0.2427 0.2425
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0122 0.012
Mycobacterium ulcerans hydantoin racemase 0.0255 0.0473 0.3699
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0197 0.0719
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0109
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0197 0.1514
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0007 0.0037
Treponema pallidum glutamate racemase 0.0649 0.1276 1
Onchocerca volvulus 0.0087 0.0132 0.0436
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.06 0.1176 0.1174
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0026 0.0031
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2444 0.493 0.4929
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0026 0.1076
Schistosoma mansoni metabotropic glutamate receptor 0.3449 0.6977 0.8025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0206 0.0203
Onchocerca volvulus 0.0087 0.0132 0.0436
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0102 0.01
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0132
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.063 0.1237 0.456
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.008 0.0286
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.063 0.1237 0.456
Schistosoma mansoni lipoxygenase 0.0042 0.0039 0.0037
Brugia malayi hypothetical protein 0.0138 0.0235 0.0286
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0197 0.153
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0039 0.2797
Echinococcus multilocularis expressed protein 0.1602 0.3215 0.3214
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0007 0.0037
Schistosoma mansoni protein kinase 0.0642 0.1262 0.1445
Schistosoma mansoni intermediate filament proteins 0.0087 0.0132 0.0144
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0197 0.0195
Mycobacterium tuberculosis Probable dehydrogenase 0.02 0.0362 0.1328
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.008 0.0286
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0016 0.0739
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0026 0.0647
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.002 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0159
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.005 0.006
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0642 0.1262 0.126
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0007 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0133 0.0131
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0162 0.0178
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0132
Leishmania major cytochrome p450-like protein 0.0026 0.0007 0.0038
Echinococcus multilocularis glutamate receptor 2 0.163 0.3272 0.3271
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0037
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0007 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0027 0.0025
Echinococcus multilocularis lamin dm0 0.0087 0.0132 0.013
Schistosoma mansoni rotamase 0.0035 0.0026 0.0021
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0197 0.0356 0.2806
Echinococcus multilocularis expressed protein 0.0035 0.0026 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0197 0.0966
Treponema pallidum glutamate/aspartate transporter 0.06 0.1176 0.9216
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1353 0.271 1
Echinococcus granulosus nmda type glutamate receptor 0.1273 0.2547 0.2545
Echinococcus granulosus sodium:dicarboxylate symporter 0.1353 0.271 0.2708
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0082 0.0122 0.012
Echinococcus granulosus glutamate NMDA receptor subunit 0.1206 0.2409 0.2407
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0007 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0055 0.0261
Loa Loa (eye worm) hypothetical protein 0.1255 0.2509 0.2508
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0016 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0104 0.0167 0.0165
Mycobacterium ulcerans glutamate racemase 0.0649 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0642 0.1262 0.126
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0561 0.1096 0.1094
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0102 0.01
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.0134 0.0132
Loa Loa (eye worm) glutamate receptor 2 0.1148 0.2291 0.229
Loa Loa (eye worm) hypothetical protein 0.4934 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0039 0.0037
Trypanosoma cruzi extracellular receptor, putative 0.0642 0.1262 1
Mycobacterium tuberculosis Probable glutamate racemase MurI 0.0649 0.1276 0.4702
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0015 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0197 0.0195
Loa Loa (eye worm) glutamate receptor 1 0.1548 0.3106 0.3104
Brugia malayi hypothetical protein 0.0082 0.0122 0.0148
Schistosoma mansoni glutamate receptor AMPA 0.1148 0.2291 0.263
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1353 0.271 0.3112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Echinococcus granulosus voltage dependent calcium channel subunit 0.0296 0.0556 0.0554
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0039 0.1718
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0129 0.0217 0.0241
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.002 0.1334
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0102 0.5119
Onchocerca volvulus 0.0115 0.0188 0.0643
Loa Loa (eye worm) hypothetical protein 0.0128 0.0215 0.0213
Loa Loa (eye worm) PXA domain-containing protein 0.0082 0.0122 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0016 0.0739
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0126 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0039 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0007 0.0018
Echinococcus multilocularis regulator of G protein signaling 0.0082 0.0122 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0055 0.2709
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0024 0.0602
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0197 0.0195
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0027 0.0023
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0122 0.0148
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1353 0.271 0.2708
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0197 0.1546
Brugia malayi Glutamate receptor 1 precursor 0.1548 0.3106 0.3777
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0893 0.1772 0.177
Loa Loa (eye worm) hypothetical protein 0.04 0.0769 0.0767
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0026 0.0041
Brugia malayi Guanylyl cyclase protein 23 0.0642 0.1262 0.1535
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0356 0.2777
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0197 0.0356 0.0354
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0039 0.0037
Echinococcus granulosus neutral amino acid transporter 0.1353 0.271 0.2708
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0115 0.0188 0.0186
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0055 0.2709
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.002 0.0137
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0039 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Schistosoma mansoni loxhd1 0.0042 0.0039 0.0037
Brugia malayi glutaminase DH11.1 0.0563 0.1101 0.1338
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0007 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0084 0.0126 0.0124
Brugia malayi M-phase phosphoprotein, mpp8 0.0115 0.0188 0.0229
Loa Loa (eye worm) glutamate receptor 0.1485 0.2978 0.2976
Brugia malayi hypothetical protein 0.0082 0.0122 0.0148
Echinococcus multilocularis glutamate receptor 2 0.219 0.4414 0.4412
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0122 0.012
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0197 0.0219
Echinococcus granulosus excitatory amino acid transporter 2 0.1353 0.271 0.2708
Schistosoma mansoni glutamate receptor kainate 0.1148 0.2291 0.263
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Echinococcus granulosus Excitatory amino acid transporter 0.1353 0.271 0.2708
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.008 0.0385
Echinococcus multilocularis glutamate receptor NMDA 0.0083 0.0123 0.012
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1353 0.271 0.2708
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0026 0.0116
Echinococcus granulosus GPCR family 3 C terminal 0.0613 0.1202 0.12
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0026 0.0023
Leishmania major trypanothione reductase 0.0088 0.0133 0.1036
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0007 0.028
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0122 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0215 0.0239
Echinococcus multilocularis Regulator of G protein signaling 20 0.0082 0.0122 0.012
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0026 0.018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.008 0.0614
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0016 0.0034
Schistosoma mansoni hypothetical protein 0.0358 0.0683 0.0777
Schistosoma mansoni hypothetical protein 0.0613 0.1202 0.1375
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0122 0.012
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.0557 1
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0132
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0016 0.0051
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0613 0.1202 0.4405
Chlamydia trachomatis glutamine binding protein 0.063 0.1237 0.456
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0122 0.0132
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0015 0.0337
Echinococcus granulosus glutamate receptor 2 0.163 0.3272 0.3271
Loa Loa (eye worm) hypothetical protein 0.0087 0.0132 0.013
Loa Loa (eye worm) hypothetical protein 0.0115 0.0188 0.0186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.008 0.0578
Echinococcus multilocularis glutamate receptor 4 0.04 0.0769 0.0767
Brugia malayi cytochrome P450 0.0026 0.0007 0.0009
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0102 0.0789
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0102 0.0789
Brugia malayi Excitatory amino acid transporter 0.1353 0.271 0.3295
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.1262 0.126
Echinococcus multilocularis pyruvate kinase 0.0035 0.0026 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0015 0.0061
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.02 0.0362 0.2825
Schistosoma mansoni hypothetical protein 0.0069 0.0096 0.0102
Plasmodium vivax SET domain protein, putative 0.0128 0.0215 1
Plasmodium falciparum glutathione reductase 0.003 0.0016 0.1051
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.02 0.0362 0.1328
Trichomonas vaginalis glutaminase, putative 0.0563 0.1101 0.5436
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.008 0.5923
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.0947
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0079 0.0076
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0274 0.0512 0.4001
Schistosoma mansoni ATP-binding cassette transporter 0.1148 0.2291 0.263
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0007 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0197 0.0356 0.0401
Plasmodium falciparum phd finger protein, putative 0.003 0.0015 0.0911
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0197 0.0966
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0007 0.0018
Echinococcus multilocularis peregrin 0.003 0.0015 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0015 0.0337
Brugia malayi hypothetical protein 0.0115 0.0188 0.0229
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0126 0.0124
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0026 0.0116
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0027 0.0025
Brugia malayi phosphofructokinase 0.0119 0.0197 0.024
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0007 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0007 0.0018
Echinococcus granulosus pyruvate kinase 0.0035 0.0026 0.0023
Onchocerca volvulus Poor gastrulation protein homolog 0.0613 0.1202 0.4405
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0132
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Echinococcus granulosus intermediate filament protein 0.0087 0.0132 0.013
Loa Loa (eye worm) hypothetical protein 0.0642 0.1262 0.126
Brugia malayi PHD-finger family protein 0.003 0.0015 0.0018
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.002 0.0064
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.002 0.0089
Brugia malayi Thioredoxin reductase 0.0088 0.0133 0.0162
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0055 0.0378
Onchocerca volvulus 0.0042 0.0039 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0022 0.0097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0192 0.019
Plasmodium falciparum thioredoxin reductase 0.003 0.0016 0.1051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0016 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0132
Loa Loa (eye worm) hypothetical protein 0.04 0.0769 0.0767
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0132 0.0161
Loa Loa (eye worm) hypothetical protein 0.006 0.0076 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0215 0.0213
Echinococcus multilocularis Excitatory amino acid transporter 0.1353 0.271 0.2708
Brugia malayi hypothetical protein 0.0042 0.0039 0.0048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.005 0.0048
Mycobacterium tuberculosis Probable reductase 0.02 0.0362 0.1328
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0133 0.1003
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0055 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0159
Echinococcus multilocularis metabotropic glutamate receptor 5 0.4934 1 1
Treponema pallidum NADH oxidase 0.003 0.0016 0.0108
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0102 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0024 0.1125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0035
Brugia malayi jmjC domain containing protein 0.0097 0.0151 0.0184
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0122 0.012
Brugia malayi regulator of G-protein signaling egl-10 0.0082 0.0122 0.0148
Echinococcus multilocularis pyruvate kinase 0.0028 0.0011 0.0008
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0016 0.0388
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0055 0.0055
Echinococcus multilocularis RUN 0.0042 0.0039 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Echinococcus granulosus glutamate receptor ionotropic kainate 0.1214 0.2427 0.2425
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0007 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0223 0.0408 0.3182
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0007 0.0018
Leishmania major pyruvate kinase 0.0035 0.0026 0.0182
Brugia malayi hypothetical protein 0.0642 0.1262 0.1535
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0356 0.2777
Echinococcus granulosus neutral amino acid transporter A 0.1353 0.271 0.2708
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.004 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0223 0.0408 0.1496
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0197 0.1546
Echinococcus multilocularis beta adrenergic receptor kinase 0.0082 0.0122 0.012
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0007 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.0215 0.6012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0029 0.0749
Brugia malayi hypothetical protein 0.0042 0.0039 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.002 0.0089
Schistosoma mansoni lamin 0.0087 0.0132 0.0144
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.004 0.0038
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0026 0.1206
Echinococcus granulosus excitatory amino acid transporter 3 0.1353 0.271 0.2708
Schistosoma mansoni pyruvate kinase 0.0035 0.0026 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0007 0.0005
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0122 0.012
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0026 0.0023
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0122 0.012
Brugia malayi Receptor family ligand binding region containing protein 0.0642 0.1262 0.1535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0122 0.012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0055 0.0053
Brugia malayi PXA domain containing protein 0.0082 0.0122 0.0148
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0007 0.0038
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0016 0.0388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0034 0.1661
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.002 0.0102
Schistosoma mansoni tyrosine kinase 0.0642 0.1262 0.1445
Onchocerca volvulus 0.0642 0.1262 0.4629
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0015 0.0012
Brugia malayi Doublecortin family protein 0.0042 0.0039 0.0048
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0132 0.013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.008 0.3993
Brugia malayi Pre-SET motif family protein 0.0128 0.0215 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0007 0.0018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0122 0.0132
Onchocerca volvulus 0.0141 0.0241 0.0842
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.002 0.0493
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2444 0.493 0.4929
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1844 0.371 0.3708
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0007 0.0037
Schistosoma mansoni glutamate receptor NMDA 0.1206 0.2409 0.2765
Echinococcus granulosus expressed protein 0.1602 0.3215 0.3214
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0122 0.0148
Plasmodium falciparum glutathione reductase 0.0088 0.0133 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0055 0.0261
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0134 0.0228 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0215 0.0239
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.219 0.4414 0.4412
Leishmania major cytochrome p450-like protein 0.0026 0.0007 0.0038
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0026 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0038 0.0036
Brugia malayi Receptor family ligand binding region containing protein 0.1255 0.2509 0.3051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0215 0.0213
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0102 0.0162 0.0159
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.06 0.1176 0.1345
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0197 0.0219
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0007 0.0037
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0082 0.0122 0.0593
Echinococcus granulosus glutamate receptor subunit protein glur 0.0961 0.1911 0.1909
Echinococcus multilocularis 0.0026 0.0007 0.0005
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0007 0.0037
Echinococcus multilocularis musashi 0.0087 0.0132 0.013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0141 0.0241 0.0269
Brugia malayi jmjC domain containing protein 0.0036 0.0027 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0026 0.0031
Schistosoma mansoni serine-rich repeat protein 0.0069 0.0096 0.0102
Brugia malayi 6-phosphofructokinase 0.0119 0.0197 0.024
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0007 0.0037
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0197 0.153
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0034 0.0215
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0197 0.0195
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0082 0.0122 0.012
Echinococcus granulosus Excitatory amino acid transporter 0.1353 0.271 0.2708
Mycobacterium tuberculosis Probable oxidoreductase 0.0223 0.0408 0.1496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0015 0.0061
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.0947
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0026 0.018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2444 0.493 0.4929
Loa Loa (eye worm) cytochrome P450 0.0026 0.0007 0.0005
Schistosoma mansoni glutamate receptor AMPA 0.1148 0.2291 0.263
Echinococcus multilocularis Excitatory amino acid transporter 0.1353 0.271 0.2708
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0016 0.0646
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0007 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0016 0.0072
Echinococcus granulosus peregrin 0.003 0.0015 0.0012
Leishmania major extracellular receptor, putative 0.0642 0.1262 1
Echinococcus granulosus excitatory amino acid transporter 2 0.1353 0.271 0.2708
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.1255 0.2509 0.2508
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0016 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.008 0.1206
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0007 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0223 0.0408 0.1496
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0007 0.0018
Schistosoma mansoni metabotropic glutamate receptor 0.2127 0.4285 0.4926
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0133 0.6144
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.1262 0.126
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0027 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0002 0.0003
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0015 0.0012
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0007 0.0134
Brugia malayi metabotropic glutamate receptor type 2 0.2127 0.4285 0.521
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0016 0.0646
Toxoplasma gondii exonuclease III APE 0.0062 0.008 0.2188
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0016 0.0072
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0026 0.1206
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.3419 0.6917 0.841
Schistosoma mansoni glutamate receptor kainate 0.1802 0.3623 0.4162
Plasmodium vivax glutathione reductase, putative 0.0088 0.0133 0.6144
Chlamydia trachomatis pyruvate kinase 0.0035 0.0026 0.0084
Schistosoma mansoni hypothetical protein 0.0358 0.0683 0.0777
Trichomonas vaginalis set domain proteins, putative 0.1016 0.2023 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0003 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0007 0.0018
Schistosoma mansoni z-protein (S1r protein) 0.0082 0.0122 0.0132
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.271 0.2708
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0082 0.0122 0.012
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1353 0.271 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0026 0.0144
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0122 0.012
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Giardia lamblia Pyruvate kinase 0.0035 0.0026 0.0202
Echinococcus granulosus nmda type glutamate receptor 0.0725 0.143 0.1428
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0102 0.01
Leishmania major pyruvate kinase 0.0035 0.0026 0.0182
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0065 0.0087 0.0091
Onchocerca volvulus 0.0115 0.0188 0.0643
Brugia malayi Glutamate receptor 2 precursor 0.1548 0.3106 0.3777
Echinococcus multilocularis neutral amino acid transporter A 0.1353 0.271 0.2708
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0016 0.0108
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0249 0.1934
Brugia malayi glutathione reductase 0.0088 0.0133 0.0162
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0197 0.0356 0.0354
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0016 0.0108
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.003 0.0015 0.0008
Echinococcus multilocularis metabotropic glutamate receptor 2 0.3449 0.6977 0.6976
Echinococcus granulosus voltage dependent calcium channel subunit 0.0134 0.0228 0.0226
Loa Loa (eye worm) hypothetical protein 0.0359 0.0686 0.0684
Toxoplasma gondii aldehyde dehydrogenase 0.0197 0.0356 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.002 0.082
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.1262 0.126
Loa Loa (eye worm) RGS-3 protein 0.0082 0.0122 0.012
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.002 0.0493
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0024 0.0169
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0082 0.0122 0.012
Loa Loa (eye worm) glutaminase 2 0.0563 0.1101 0.1099
Schistosoma mansoni rab6-interacting 0.0042 0.0039 0.0037
Echinococcus granulosus metabotropic glutamate receptor 2 0.3449 0.6977 0.6976
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0039 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0159
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0102 0.0162 0.0159
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0007 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0557 0.2746
Entamoeba histolytica hypothetical protein 0.0642 0.1262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0134
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2444 0.493 0.4929
Schistosoma mansoni aldehyde dehydrogenase 0.0197 0.0356 0.0401
Loa Loa (eye worm) hypothetical protein 0.0051 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0613 0.1202 0.12
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0016 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0058
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.0557 0.4356
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.002 0.0493
Echinococcus multilocularis lamin 0.0087 0.0132 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.0593
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0026 0.0023
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0004 0.0002
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.1206 0.2409 0.2407
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0016 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0016 0.1051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Brugia malayi Cytochrome P450 family protein 0.0026 0.0007 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.008 0.0607
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0122 0.012
Schistosoma mansoni glutamate receptor NMDA 0.1873 0.3767 0.4329
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0016 0.0109
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2444 0.493 0.4929
Echinococcus multilocularis nmda type glutamate receptor 0.0725 0.143 0.1428
Brugia malayi Metabotropic glutamate receptor precursor. 0.4062 0.8224 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0159
Schistosoma mansoni hypothetical protein 0.0561 0.1096 0.1253
Echinococcus multilocularis glutamate receptor 2 0.1548 0.3106 0.3104
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0122 0.012
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0132 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0009 0.0032
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0035
Echinococcus multilocularis excitatory amino acid transporter 2 0.1353 0.271 0.2708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0159
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0026 0.0084
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0132
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.012
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0122 0.012
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0007 0.0037
Echinococcus multilocularis pyruvate kinase 0.0035 0.0026 0.0023
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0082 0.0122 0.0148
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0038 0.0036

Activities

Activity type Activity value Assay description Source Reference
ED90 (functional) = 2 mg l-1 Concentration that affords 90% control of blast disease on rice plants in greenhouse assay ChEMBL. 10386946
Ki (binding) = 14 pM Inhibition of scytalone dehydratase purified from Magnaporthe grisea ChEMBL. 10386946
Ki (binding) = 14 pM Inhibition of scytalone dehydratase purified from Magnaporthe grisea ChEMBL. 10386946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.