Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0588 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0588 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0894 | 0.0667 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3864 | 0.3972 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0717 | 0.0891 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4261 | 0.4413 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3456 | 0.4427 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.8037 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.1214 | 0.1287 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.161 | 0.1086 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0588 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0397 | 0.0114 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0588 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3853 | 0.3469 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0588 | 0.0327 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0294 | 0.0366 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0717 | 0.0592 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0588 | 0.0411 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3456 | 0.4427 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7437 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0588 | 0.0731 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.9283 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0588 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0588 | 0.0731 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0894 | 0.1112 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.1214 | 0.1287 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0294 | 0.0366 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0294 | 0.0366 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0588 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0588 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0588 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0717 | 0.0592 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0588 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0588 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0588 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.1214 | 0.151 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0588 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0294 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4581 | 0.4769 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0588 | 0.0411 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0588 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.