Detailed information for compound 582992

Basic information

Technical information
  • TDR Targets ID: 582992
  • Name: 2-chloro-N-(ethoxymethyl)-N-[2-methyl-6-(trif luoromethyl)phenyl]acetamide
  • MW: 309.712 | Formula: C13H15ClF3NO2
  • H donors: 0 H acceptors: 1 LogP: 3.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCN(c1c(C)cccc1C(F)(F)F)C(=O)CCl
  • InChi: 1S/C13H15ClF3NO2/c1-3-20-8-18(11(19)7-14)12-9(2)5-4-6-10(12)13(15,16)17/h4-6H,3,7-8H2,1-2H3
  • InChiKey: KTFNPLHWDYECSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(ethoxymethyl)-N-[2-methyl-6-(trifluoromethyl)phenyl]ethanamide
  • 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide
  • 78194-29-3
  • Acetamide, 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)-
  • MON 4601

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0061 0.0293 0.0535
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0399
Onchocerca volvulus 0.0074 0.0371 0.0595
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0298 0.0518
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0086
Plasmodium falciparum glutathione reductase 0.0038 0.0152 0.5214
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0154 0.0645
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0373 0.068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.2479 0.451
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0194 0.5228
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0686 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0194 0.52
Echinococcus granulosus snurportin 1 0.0649 0.3903 0.7123
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0194 0.2826
Mycobacterium ulcerans hypothetical protein 0.0074 0.0371 0.4694
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.002 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0047 0.0086
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0194 0.0354
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0047
Echinococcus granulosus Excitatory amino acid transporter 0.0905 0.548 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0905 0.548 0.548
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0086
Leishmania major hypothetical protein, conserved 0.0074 0.0371 0.5406
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0293 0.0535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0552 0.1008
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0371 0.1309
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1361 0.2484
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0293 0.0535
Loa Loa (eye worm) beta-lactamase 0.0074 0.0371 0.0651
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0152 0.4112
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0373 0.0373
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0047 0.0086
Mycobacterium tuberculosis Conserved protein 0.0074 0.0371 0.0677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0047 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0371 0.0677
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Plasmodium vivax importin-beta 2, putative 0.0061 0.0292 0.7886
Schistosoma mansoni hypothetical protein 0.0174 0.0988 0.1803
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0371 0.0677
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0371 0.1309
Trichomonas vaginalis set domain proteins, putative 0.0474 0.2832 1
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.2739 0.2739
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.002 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0194 0.0354
Toxoplasma gondii thioredoxin reductase 0.0038 0.0152 0.2223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Brugia malayi hypothetical protein 0.0016 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0165 0.0931 0.1677
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0154 0.0154
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0047 0.0086
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0401 0.2384 0.435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0293 0.0535
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0222 0.0783
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0373 0.068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0686 0.8683
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.2493
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0187 0.0341
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0035 0.0064
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.081 0.081
Echinococcus granulosus excitatory amino acid transporter 2 0.0905 0.548 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.0152 0.5214
Echinococcus granulosus geminin 0.0174 0.0988 0.1803
Trichomonas vaginalis ran, putative 0.0045 0.0194 0.0684
Schistosoma mansoni hypothetical protein 0.0649 0.3903 0.7123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0154 0.4126
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0373 0.068
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0027
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.0216
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0156 0.0284
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0222 0.0783
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0027
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0047 0.0086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0293 0.4272
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0373 0.5434
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0154 0.0281
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0222 0.595
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0154 0.0904
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0047 0.0086
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0371 0.0371
Echinococcus multilocularis expressed conserved protein 0.0095 0.0505 0.0505
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0371 0.0651
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0451 0.1922
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Mycobacterium ulcerans beta-lactamase 0.0074 0.0371 0.4694
Echinococcus multilocularis neutral amino acid transporter A 0.0905 0.548 0.548
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0323
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0323
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0543 0.0543
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0047 0.0086
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0292 0.4263
Onchocerca volvulus 0.0074 0.0371 0.0595
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0686 0.1252
Brugia malayi beta-lactamase family protein 0.0074 0.0371 0.0677
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0315
Schistosoma mansoni ran 0.0045 0.0194 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0118 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0373 0.1316
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0373 0.2191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0373 0.1316
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0047 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0371 0.9947
Brugia malayi CHE-14 protein 0.0044 0.0187 0.0341
Echinococcus granulosus neuropeptide s receptor 0.0459 0.2739 0.4999
Leishmania major GTP-binding protein, putative 0.0045 0.0194 0.2826
Loa Loa (eye worm) hypothetical protein 0.0053 0.0247 0.0425
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0373 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0027
Echinococcus granulosus muscleblind protein 0.0165 0.0931 0.17
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0216
Echinococcus granulosus cpg binding protein 0.0061 0.0291 0.0532
Brugia malayi steroid hormone receptor 0.0021 0.0047 0.0086
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0154 0.0281
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0451 0.0824
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0371 0.4694
Brugia malayi Pre-SET motif family protein 0.0417 0.2479 0.4525
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0042 0.0042
Toxoplasma gondii ABC1 family protein 0.0074 0.0371 0.5406
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0152 0.409
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0371 0.1309
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0047 0.0047
Loa Loa (eye worm) glutathione reductase 0.0038 0.0152 0.0252
Echinococcus granulosus neutral amino acid transporter 0.0905 0.548 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0371 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0047 0.0086
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0035 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0086
Echinococcus granulosus expressed conserved protein 0.0095 0.0505 0.0921
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0371 0.1309
Echinococcus granulosus sodium:dicarboxylate symporter 0.0905 0.548 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0543 0.099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0047 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0047 0.0086
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0047 0.0086
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0213 0.0389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0293 0.0293
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1702 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0686 0.1252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0778 0.142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0451 0.0824
Schistosoma mansoni hypothetical protein 0.0032 0.0118 0.0216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0778 0.0778
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0027
Brugia malayi Thioredoxin reductase 0.0038 0.0152 0.0278
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.079 1
Brugia malayi beta-lactamase family protein 0.0074 0.0371 0.0677
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0298 0.0544
Schistosoma mansoni importin beta-1 0.0061 0.0292 0.0534
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0272 0.0496
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Brugia malayi Muscleblind-like protein 0.0165 0.0931 0.17
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.2739 0.2739
Loa Loa (eye worm) excitatory amino acid transporter 0.0905 0.548 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0154 0.2242
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0649 0.3903 0.7115
Schistosoma mansoni survival motor neuron protein 0.0048 0.0213 0.0389
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0194 0.52
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0118 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0371 0.1309
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0323
Schistosoma mansoni ran 0.0045 0.0194 0.0354
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0154 0.0281
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0401 0.2384 0.2384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0086
Echinococcus multilocularis snurportin 1 0.0649 0.3903 0.3903
Schistosoma mansoni hypothetical protein 0.0032 0.0118 0.0216
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0373 0.0373
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.079 0.1441
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0278 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0154 0.4126
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0298 0.0544
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0015
Mycobacterium ulcerans lipase LipD 0.0074 0.0371 0.4694
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0373 0.068
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0686 0.1252
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0401 0.2384 0.2384
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0451 0.0824
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.004 0.0073
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0027
Onchocerca volvulus 0.0048 0.0213 0.0305
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Schistosoma mansoni patched 1 0.0044 0.0187 0.0341
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0154 0.0543
Leishmania major importin beta-1 subunit, putative 0.0049 0.0222 0.3234
Leishmania major trypanothione reductase 0.0038 0.0152 0.2223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0222 0.0783
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0686 0.8683
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0047 0.0086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0371 0.0677
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0371 0.0677
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0371 0.0677
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0165 0.0931 0.1677
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0118 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.4273 0.7797
Echinococcus multilocularis neutral amino acid transporter A 0.0905 0.548 0.548
Brugia malayi CXXC zinc finger family protein 0.0057 0.0271 0.0495
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0905 0.548 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0154 0.0254
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0194 0.663
Schistosoma mansoni cpg binding protein 0.0061 0.0291 0.0532
Brugia malayi nuclear hormone receptor 0.0021 0.0047 0.0086
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0905 0.548 0.548
Brugia malayi ecdysteroid receptor 0.0021 0.0047 0.0086
Echinococcus granulosus microtubule associated protein 2 0.0709 0.4273 0.7797
Loa Loa (eye worm) hypothetical protein 0.0061 0.0293 0.0509
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0373 0.1415
Brugia malayi hypothetical protein 0.0025 0.0073 0.0133
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.2804 0.5118
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.1955
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0154 0.0281
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0027
Plasmodium vivax glutathione reductase, putative 0.0038 0.0152 0.4112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0042 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0086
Entamoeba histolytica hypothetical protein 0.0049 0.0222 0.0439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0118 0.0118
Echinococcus granulosus neutral amino acid transporter A 0.0905 0.548 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0194 0.52
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0027
Brugia malayi hypothetical protein 0.0235 0.1361 0.2484
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0086
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0118 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0778 0.142
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0543 0.2513
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0451 0.0824
Schistosoma mansoni hypothetical protein 0.0032 0.0118 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.006
Echinococcus multilocularis Excitatory amino acid transporter 0.0905 0.548 0.548
Mycobacterium tuberculosis Conserved protein 0.0074 0.0371 0.0677
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.06 0.8748
Mycobacterium tuberculosis Conserved protein 0.0074 0.0371 0.0677
Entamoeba histolytica Ran family GTPase 0.0045 0.0194 0.0259
Trypanosoma brucei trypanothione reductase 0.0038 0.0152 0.409
Schistosoma mansoni coup transcription factor 0.0021 0.0047 0.0086
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0187 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0548 0.0976
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0154 0.0543
Loa Loa (eye worm) hypothetical protein 0.0074 0.0371 0.0651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0371 0.0677
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0027
Echinococcus multilocularis excitatory amino acid transporter 2 0.0905 0.548 0.548
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0047 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0778 0.142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0778 0.142
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0086
Brugia malayi RNA, U transporter 1 0.0173 0.098 0.1789
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0931 0.0931
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0073 0.1966
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0194 0.1139
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0187 0.0187
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0817 0.4936 0.4936
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.002 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0073 0.2493
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0511 0.0932
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0401 0.2384 0.435
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.4273 0.4273
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0349 0.0637
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0154 0.2242
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0047 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0778 0.142
Schistosoma mansoni hypothetical protein 0.0048 0.0213 0.0389
Echinococcus granulosus excitatory amino acid transporter 2 0.0905 0.548 1
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0058 0.0278 0.0507
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0194 0.0328
Brugia malayi jmjC domain containing protein 0.0062 0.0298 0.0544
Trichomonas vaginalis esterase, putative 0.0074 0.0371 0.1309
Loa Loa (eye worm) hypothetical protein 0.007 0.0349 0.0612
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0511 0.0932
Treponema pallidum glutamate/aspartate transporter 0.0401 0.2384 1
Schistosoma mansoni hypothetical protein 0.007 0.0349 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0086
Schistosoma mansoni hypothetical protein 0.0174 0.0988 0.1803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Echinococcus granulosus importin subunit beta 1 0.0061 0.0292 0.0534
Chlamydia trachomatis neutral amino acid transporter 0.0401 0.2384 0.435
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0073 0.1955
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0371 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0905 0.548 1
Plasmodium falciparum importin beta, putative 0.0061 0.0292 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.068 0.1241
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.0216
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0373 0.0373
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0271 0.047
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0154 0.526
Echinococcus granulosus dnaJ subfamily B 0.0817 0.4936 0.9008
Brugia malayi Excitatory amino acid transporter 0.0905 0.548 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0371 0.9947
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.081 0.1479
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0371 0.0677
Plasmodium vivax SET domain protein, putative 0.0061 0.0293 0.7903
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0156 0.0156
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0686 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0905 0.548 0.548
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0187 0.0315
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1702 1
Leishmania major hypothetical protein, conserved 0.0025 0.0073 0.1063
Treponema pallidum glutamate transporter 0.0401 0.2384 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0086
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0047 0.0047
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0905 0.548 1
Echinococcus multilocularis muscleblind protein 0.0165 0.0931 0.0931
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0373 0.1316
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0154 0.1947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0778 0.1397
Schistosoma mansoni cpg binding protein 0.0057 0.0271 0.0495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0293 0.0535
Echinococcus multilocularis excitatory amino acid transporter 2 0.0905 0.548 0.548
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0323
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0086
Echinococcus granulosus neutral amino acid transporter A 0.0905 0.548 1
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.1702 0.7138
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0451 0.0824
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0511 0.3339
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0073 0.1063
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0371 0.0677
Mycobacterium tuberculosis Probable reductase 0.0087 0.0451 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0187 0.0659
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0905 0.548 0.548
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.2739 0.4999
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1361 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0293 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0086
Echinococcus multilocularis neutral amino acid transporter A 0.0905 0.548 0.548
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.079 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0152 0.0252
Brugia malayi nuclear receptor NHR-88 0.0021 0.0047 0.0086
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0278 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0293 0.0535
Loa Loa (eye worm) histone methyltransferase 0.002 0.0042 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.0118 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.006
Onchocerca volvulus 0.0057 0.0271 0.0412
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0371 0.0677
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.1702 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0371 0.0677
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0371 0.9947
Onchocerca volvulus 0.0474 0.2832 0.5126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0278 0.0507
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0235 0.1361 0.2464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0118 0.0216
Schistosoma mansoni cpg binding protein 0.0061 0.0291 0.0532
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0373 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0047 0.0086
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0373 1
Echinococcus granulosus GPCR family 2 0.0032 0.0118 0.0216
Schistosoma mansoni hypothetical protein 0.0817 0.4936 0.9008
Brugia malayi glutathione reductase 0.0038 0.0152 0.0278
Echinococcus multilocularis protein patched 0.0044 0.0187 0.0187
Chlamydia trachomatis glutamate symporter 0.0905 0.548 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0686 0.8683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.006
Echinococcus multilocularis geminin 0.0174 0.0988 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.006
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0543 0.099
Brugia malayi Importin beta-1 subunit 0.0061 0.0292 0.0534
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0027
Schistosoma mansoni ap endonuclease 0.0038 0.0154 0.0281
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0905 0.548 1
Onchocerca volvulus 0.0061 0.0293 0.0452
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0047 0.006
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0292 0.7844
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0073 0.1955
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0047 0.006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1702 0.6008
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0506
Echinococcus multilocularis protein dispatched 1 0.005 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0074 0.0373 0.0655
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0118 0.0216
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0292 0.7844
Echinococcus granulosus Excitatory amino acid transporter 0.0905 0.548 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0154 0.4126
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0194 0.0194
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0373 0.068
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.002 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0086
Echinococcus multilocularis GPCR, family 2 0.0032 0.0118 0.0118
Echinococcus multilocularis cpg binding protein 0.0061 0.0291 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.006
Schistosoma mansoni ap endonuclease 0.0038 0.0154 0.0281
Onchocerca volvulus 0.0074 0.0371 0.0595
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0686 0.1252
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0152 0.0278
Loa Loa (eye worm) hypothetical protein 0.0061 0.0292 0.0508
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0548 0.1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0543 0.0966
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0047 0.0086
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0373 0.068
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0154 0.4148
Loa Loa (eye worm) hypothetical protein 0.0102 0.0548 0.0976
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0778 0.142
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0511 0.0932
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0298 0.0544
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0548 0.1
Echinococcus granulosus excitatory amino acid transporter 3 0.0905 0.548 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0086
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0371 0.4694
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0086
Brugia malayi beta-lactamase 0.0074 0.0371 0.0677
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0292 0.0292

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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