Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.1115 | 0.094 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.1115 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.4784 | 0.4681 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.2193 | 0.2713 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.2193 | 0.3641 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1115 | 0.6729 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.1115 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.425 | 0.4137 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1563 | 0.1677 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.5685 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0249 | 0.041 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0249 | 0.0102 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1115 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1115 | 0.094 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.1115 | 0.094 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1115 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1115 | 0.1547 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.1115 | 0.6729 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.1115 | 0.1379 |
Brugia malayi | beta-lactamase | 0.0038 | 0.1115 | 0.1379 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1563 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.4913 | 0.5953 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1563 | 0.1934 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.4913 | 0.5953 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2193 | 0.2481 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0249 | 0.041 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.425 | 0.4137 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0249 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.1115 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0201 | 0.8083 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0249 | 0.0308 |
Onchocerca volvulus | 0.0038 | 0.1115 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4913 | 0.7918 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.2193 | 0.2481 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.2193 | 0.3641 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1115 | 0.1379 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1115 | 0.6729 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.1115 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.1115 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.1563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.8083 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.1115 | 0.094 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0249 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1115 | 0.094 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.1563 | 0.2495 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2193 | 0.3355 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.4784 | 0.4681 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.425 | 0.4137 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.2193 | 0.3641 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.4913 | 0.6078 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0249 | 0.061 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0249 | 0.041 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.1115 | 0.6729 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4913 | 0.7918 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.1563 | 0.2495 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.425 | 0.4137 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2193 | 0.3355 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.1115 | 0.094 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0249 | 0.061 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0249 | 0.061 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0249 | 0.0057 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.1563 | 0.1397 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0193 | 0.0239 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.4933 | 0.6103 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1115 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.5357 | 0.8662 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.1563 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.1115 | 0.6729 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.1115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1115 | 0.1379 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.4913 | 0.5953 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0249 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0249 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.1115 | 0.6729 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1115 | 0.1105 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5685 | 0.6939 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5685 | 0.6939 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0201 | 0.8083 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.5685 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.4784 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0193 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4913 | 0.7918 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1563 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1115 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.1115 | 0.094 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.1115 | 0.094 |
Brugia malayi | glutathione reductase | 0.0049 | 0.1563 | 0.1934 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.4913 | 0.8594 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.4913 | 0.6078 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0249 | 0.041 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.425 | 0.4137 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0249 | 0.041 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0137 | 0.5357 | 0.6627 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0249 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0249 | 0.0102 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.4933 | 0.5979 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1563 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0249 | 0.0094 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.4933 | 0.5979 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1115 | 0.094 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1563 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.4784 | 0.4681 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.5685 | 0.7033 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.1115 | 0.1105 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.4913 | 0.8594 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0201 | 0.8083 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.2193 | 0.3641 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0249 | 0.041 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2193 | 0.3355 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.5685 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.2193 | 0.3641 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0112 | 0.425 | 0.8545 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1563 | 0.1677 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.5357 | 0.652 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0249 | 0.041 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.1115 | 0.1105 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1115 | 0.1547 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2193 | 0.3355 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.2193 | 0.3641 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.2193 | 0.2713 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.1115 | 0.1679 |
Onchocerca volvulus | 0.0038 | 0.1115 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.1115 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4913 | 0.7918 |
Brugia malayi | RNA binding protein | 0.0127 | 0.4913 | 0.6078 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1563 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.1115 | 0.1679 |
Onchocerca volvulus | 0.0038 | 0.1115 | 0.5 | |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.425 | 0.4137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.4913 | 0.7918 |
Leishmania major | trypanothione reductase | 0.0049 | 0.1563 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.