Detailed information for compound 583100

Basic information

Technical information
  • TDR Targets ID: 583100
  • Name: 9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphe nyl)imino-6,7-dihydropyrimido[6,1-a]isoquinol in-4-one hydrochloride
  • MW: 441.95 | Formula: C24H28ClN3O3
  • H donors: 0 H acceptors: 1 LogP: 4.74 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OC)CCn1c2c/c(=N\c2c(C)cc(cc2C)C)/n(c1=O)C.Cl
  • InChi: 1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;
  • InChiKey: DTCZZBVPTHVXFA-OSMRDGEFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-mesitylimino-9,10-dimethoxy-3-methyl-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one hydrochloride
  • trequinsin

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens heat shock 27kDa protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi small heat shock protein Get druggable targets OG5_141248 All targets in OG5_141248
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141248 All targets in OG5_141248
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi Hsp20/alpha crystallin family protein heat shock 27kDa protein 1 205 aa 168 aa 25.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0145 0.0145
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0906 0.6454 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0031
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0022 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0354 0.0585
Leishmania major DNA polymerase kappa, putative 0.0115 0.072 0.1084
Trypanosoma brucei protein kinase, putative 0.0062 0.0332 0.0482
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0292 0.1999 0.5968
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0781 0.8223
Loa Loa (eye worm) hypothetical protein 0.01 0.0608 0.1006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00171918 0.5 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0024
Echinococcus granulosus tar DNA binding protein 0.0125 0.0795 0.0795
Echinococcus multilocularis neuropeptide s receptor 0.056 0.3947 0.3947
Echinococcus granulosus lamin 0.0033 0.0122 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0158 0.1029 0.1029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0145 0.0191
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1051 0.172
Onchocerca volvulus 0.0035 0.0137 0.0116
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0332 0.0482
Onchocerca volvulus 0.0094 0.0571 0.075
Brugia malayi nuclear hormone receptor 0.00171918 0.5 0.5
Onchocerca volvulus 0.00171918 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0494 0.3466 0.3458
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0207 0.0287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0608 0.0987
Onchocerca volvulus 0.0033 0.0122 0.0094
Schistosoma mansoni chromobox protein 0.0071 0.0403 0.039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0292 0.1999 0.5968
Trypanosoma brucei trypanothione reductase 0.0128 0.0813 0.1229
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0114
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0094 0.0571 0.0559
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0083 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0751 0.1242
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0207 0.0598
Echinococcus multilocularis dna polymerase eta 0.0191 0.127 0.127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0192 0.1274 0.1846
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0083 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0083 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0115 0.072 0.072
Echinococcus granulosus polycomb protein SCMH1 0.0094 0.0571 0.0571
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0055 0.0359
Brugia malayi chromobox protein homolog 3 0.004 0.0176 0.027
Onchocerca volvulus 0.03 0.2063 0.2932
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0198 0.0285
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.1934 0.3198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.1029 0.1018
Schistosoma mansoni hypothetical protein 0.0068 0.038 0.0368
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00171918 0.5 0.5
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0403 0.0666
Trypanosoma brucei DNA polymerase eta, putative 0.0191 0.127 0.194
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0464 0.0464
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0044
Trypanosoma cruzi DNA polymerase eta, putative 0.0191 0.127 0.194
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0059 0.0314 0.0454
Brugia malayi mbt repeat family protein 0.0094 0.0571 0.0925
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0145 0.0239
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0145 0.1327
Mycobacterium tuberculosis Conserved protein 0.005 0.0251 0.0729
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0145 0.0208
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0028 0.0038
Plasmodium falciparum thioredoxin reductase 0.0128 0.0813 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0207 0.2414
Echinococcus multilocularis citrate lyase subunit beta protein 0.005 0.0251 0.0251
Schistosoma mansoni cpg binding protein 0.0035 0.0137 0.0125
Echinococcus multilocularis chromobox protein 1 0.0071 0.0403 0.0403
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0083 0.0117
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0192 0.1274 0.2107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0083 0.007
Schistosoma mansoni zinc finger protein 0.0041 0.0185 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00171918 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Mycobacterium ulcerans hypothetical protein 0.005 0.0251 0.0623
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0292 0.1999 0.8918
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0332 0.0332
Brugia malayi steroid hormone receptor 0.0027 0.0083 0.0117
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0145 0.0191
Onchocerca volvulus 0.0093 0.056 0.0734
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0324 0.0814
Brugia malayi ecdysteroid receptor 0.0027 0.0083 0.0117
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1051 0.1051
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0108 0.0665 0.0654
Brugia malayi ImpB/MucB/SamB family protein 0.0191 0.127 0.2083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0769 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00171918 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0698 0.4941 0.817
Schistosoma mansoni lamin 0.0033 0.0122 0.011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0115 0.072 0.0708
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0192 0.1274 0.1846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0115 0.0115
Trichomonas vaginalis glutaminase, putative 0.0541 0.381 0.5522
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.072 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0083 0.0137
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2002 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0192 0.1274 0.1846
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0906 0.6454 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Trypanosoma brucei unspecified product 0.0115 0.072 0.1084
Echinococcus granulosus neuropeptide s receptor 0.056 0.3947 0.3947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00171918 0.5 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0145 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0158 0.1029 0.1029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00171918 0.5 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0134 0.0121
Giardia lamblia DINP protein human, muc B family 0.0115 0.072 0.3522
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0055 0.0167
Brugia malayi mbt repeat family protein 0.0094 0.0571 0.0925
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0145 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0083 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0192 0.1274 0.3319
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0332 0.0482
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0192 0.1274 0.6322
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0128 0.0813 0.1229
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0145 0.0208
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0332 0.3356
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0083 0.0083
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0228 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.013
Onchocerca volvulus 0.0967 0.6897 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.072 0.1084
Trypanosoma cruzi ISWI complex protein 0.0031 0.0109 0.0134
Onchocerca volvulus 0.0031 0.0113 0.0081
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0115 0.072 0.0708
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1051 0.1051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0145 0.0208
Leishmania major hypothetical protein, conserved 0.0031 0.0109 0.0134
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0115 0.0169
Mycobacterium ulcerans hypothetical protein 0.0477 0.3345 0.8777
Echinococcus granulosus chromobox protein 1 0.0071 0.0403 0.0403
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0176 0.0172
Echinococcus granulosus dna polymerase kappa 0.0115 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0088 0.0521 0.0861
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0354 0.0342
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0429 0.2994 0.4621
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0115 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00171918 0.5 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0129 0.082 0.082
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0083 0.007
Brugia malayi CXXC zinc finger family protein 0.0035 0.0137 0.0207
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0135 0.0866 0.0854
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.029
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0192 0.1274 0.1846
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0207 0.0287
Schistosoma mansoni RAR-like nuclear receptor 0.00171918 0.5 0.5
Brugia malayi RNA binding protein 0.0125 0.0795 0.1297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00171918 0.5 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0324 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0437 0.3053 0.4713
Giardia lamblia DNA damage repair protein 0.0036 0.0145 0.0619
Echinococcus multilocularis GPCR, family 2 0.0032 0.0115 0.0115
Loa Loa (eye worm) glutathione reductase 0.0128 0.0813 0.1343
Schistosoma mansoni alpha-glucosidase 0.0138 0.0889 0.0877
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0024
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0207 0.0287
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0464 0.0687
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0324 0.0324
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0079 0.046 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0795 0.0784
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0332 0.048
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0004 0.0007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0312 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0251 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0461 0.0682
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0075
Trypanosoma brucei glucosidase, putative 0.0036 0.0145 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0083 0.0083
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0251 0.0355
Trypanosoma brucei unspecified product 0.0079 0.0461 0.0682
Echinococcus multilocularis histone acetyltransferase MYST2 0.0108 0.0665 0.0665
Schistosoma mansoni microtubule-associated protein tau 0.1395 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0128 0.0813 0.2412
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0145 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0145 0.0191
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0083 0.0083
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0055 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0145 0.0191
Echinococcus granulosus intermediate filament protein 0.0033 0.0122 0.0122
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0207 0.0299
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0083 0.0083
Leishmania major DNA polymerase eta, putative 0.0191 0.127 0.194
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0608 0.1006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0115 0.019
Echinococcus multilocularis microtubule associated protein 2 0.1395 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0058 0.018
Schistosoma mansoni retinoic acid receptor RXR 0.00171918 0.5 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0292 0.1999 0.5968
Schistosoma mansoni hypothetical protein 0.0205 0.1369 0.1358
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0198 0.0285
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00171918 0.5 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0207
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0192 0.1274 0.6322
Echinococcus granulosus neuropeptide receptor A26 0.056 0.3947 0.3947
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0145 0.0208
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0059 0.0314 0.0454
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0055 0.0513
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0083 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00171918 0.5 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00171918 0.5 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0145 0.0208
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0145 0.0191
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0488 0.0788
Echinococcus granulosus histone acetyltransferase MYST2 0.0108 0.0665 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0083 0.0117
Brugia malayi glutaminase DH11.1 0.0541 0.381 0.6291
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00171918 0.5 0.5
Brugia malayi nuclear receptor NHR-88 0.00171918 0.5 0.5
Toxoplasma gondii thioredoxin reductase 0.0128 0.0813 0.8561
Leishmania major DNA polymerase kappa, putative 0.0036 0.0145 0.0191
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0324 0.3263
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0192 0.1274 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0253
Schistosoma mansoni hypothetical protein 0.0205 0.1369 0.1358
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0207 0.0508
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.085 0.6048 1
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0083 0.007
Schistosoma mansoni alpha glucosidase 0.0036 0.0145 0.0132
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0122 0.0202
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0108 0.0665 0.1082
Echinococcus granulosus FTZ F1 alpha 0.00171918 0.5 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0332 0.1564
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0332 0.0549
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00171918 0.5 0.5
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0013 0.0021
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0145 0.1633
Loa Loa (eye worm) hypothetical protein 0.0094 0.0571 0.0944
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.0571 0.0559
Toxoplasma gondii hypothetical protein 0.0146 0.0945 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0058 0.0114
Plasmodium vivax thioredoxin reductase, putative 0.0128 0.0813 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Schistosoma mansoni DNA polymerase eta 0.0191 0.127 0.1259
Brugia malayi MAP kinase sur-1 0.0062 0.0332 0.0529
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0145 0.1327
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Schistosoma mansoni bromodomain containing protein 0.0129 0.0821 0.0809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00171918 0.5 0.5
Onchocerca volvulus 0.0192 0.1274 0.1778
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0332 0.032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0083 0.0117
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0143 0.0236
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0083 0.0037
Plasmodium vivax glutathione reductase, putative 0.0128 0.0813 1
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.072 0.1084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00171918 0.5 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.2002 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00171918 0.5 0.5
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0464 0.0687
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0251 0.0355
Onchocerca volvulus Bile acid receptor homolog 0.00171918 0.5 0.5
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0145 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0076 0.0437 0.4493
Echinococcus granulosus dna polymerase eta 0.0191 0.127 0.127
Brugia malayi SET domain containing protein 0.0018 0.0016 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0508
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.038 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0083 0.0137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00171918 0.5 0.5
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0403 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0083 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0083 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0145 0.0617
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0207
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0608 0.0987
Schistosoma mansoni glutaminase 0.0541 0.381 0.3802
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0083 0.0083
Brugia malayi small heat shock protein 0.0698 0.4941 0.8167
Echinococcus granulosus ecdysone induced protein 78C 0.00171918 0.5 0.5
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0795 0.1315
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0134 0.0134
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.3947 0.3947
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.072 0.1084
Onchocerca volvulus Protein ultraspiracle homolog 0.00171918 0.5 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0324 0.2235 0.6674
Mycobacterium ulcerans hypothetical protein 0.0024 0.0058 0.0114
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0145 0.0191
Echinococcus multilocularis geminin 0.0205 0.1369 0.1369
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0736 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0461 0.0682
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0028 0.0038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.092 0.2386
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0145 0.0191
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0055 0.0108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0083 0.0083
Schistosoma mansoni coup transcription factor 0.00171918 0.5 0.5
Brugia malayi nuclear receptor NHR-88 0.0027 0.0083 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0083 0.0117
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0192 0.1274 0.1846
Loa Loa (eye worm) hypothetical protein 0.0191 0.127 0.2099
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0207 0.0934
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0207 0.0287
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0122 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00171918 0.5 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0324 0.0311
Echinococcus granulosus thioredoxin glutathione reductase 0.0129 0.082 0.082
Brugia malayi Pre-SET motif family protein 0.0124 0.0781 0.1274
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0112 0.0695 0.7286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0083 0.0117
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0083 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0292 0.1999 0.5968
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0058 0.0114
Echinococcus multilocularis polycomb protein SCMH1 0.0094 0.0571 0.0571
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00171918 0.5 0.5
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0122 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0461 0.0682
Echinococcus multilocularis zinc finger protein 0.0041 0.0185 0.0185
Entamoeba histolytica deoxycytidyl transferase, putative 0.0115 0.072 0.3522
Mycobacterium tuberculosis Probable oxidoreductase 0.0324 0.2235 0.6674
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0488 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0102
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0083 0.0117
Echinococcus granulosus citrate lyase subunit beta protein 0.005 0.0251 0.0251
Echinococcus multilocularis cpg binding protein 0.004 0.018 0.018
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0221 0.0221
Loa Loa (eye worm) thioredoxin reductase 0.0128 0.0813 0.1343
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00171918 0.5 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0083 0.007
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0376 0.2611 0.2611
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0207 0.2003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Leishmania major hypothetical protein, conserved 0.0059 0.0314 0.0454
Onchocerca volvulus 0.0027 0.0083 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0176 0.0253
Mycobacterium ulcerans glutaminase 0.0541 0.381 1
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0083 0.0137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0113 0.0187
Echinococcus granulosus GPCR family 2 0.0032 0.0115 0.0115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0083 0.0117
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0207 0.2414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00171918 0.5 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00171918 0.5 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Schistosoma mansoni SET domain protein 0.0022 0.0042 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0207 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0464 0.0687
Plasmodium vivax SET domain protein, putative 0.0124 0.0781 0.9609
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0083 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0083 0.0117
Schistosoma mansoni SET domain protein 0.0038 0.0158 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.072 0.1084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0058 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00171918 0.5 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0332 0.048
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.0207 1
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0083 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0083 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0115 0.072 0.1042
Loa Loa (eye worm) steroid hormone receptor 0.00171918 0.5 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0096
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0055 0.0144
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0207 0.0287
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2002 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0083 0.0137
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0145 0.0191
Loa Loa (eye worm) hypothetical protein 0.0077 0.0444 0.0734
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00171918 0.5 0.5
Brugia malayi Pre-SET motif family protein 0.085 0.6048 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00171918 0.5 0.5
Brugia malayi polk-prov protein 0.0036 0.0145 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0055 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0083 0.0117
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0083 0.0037
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0198 0.0204
Trichomonas vaginalis set domain proteins, putative 0.0967 0.6897 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Echinococcus multilocularis ecdysone induced protein 78C 0.00171918 0.5 0.5
Echinococcus granulosus lamin dm0 0.0033 0.0122 0.0122
Brugia malayi Steroid receptor seven-up type 2 0.00171918 0.5 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0013 0.0013
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0332 0.0332
Echinococcus granulosus cpg binding protein 0.004 0.018 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0437 0.3053 0.4713
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0083 0.0083
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00171918 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0083 0.0117
Echinococcus multilocularis thyroid hormone receptor alpha 0.00171918 0.5 0.5
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0795 0.0795
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.072 0.1858
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0115 0.0115
Schistosoma mansoni lamin 0.0033 0.0122 0.011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0115 0.072 0.072
Schistosoma mansoni chromobox protein 0.0071 0.0403 0.039
Schistosoma mansoni cpg binding protein 0.004 0.018 0.0167
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.072 0.1172
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.00171918 0.5 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00171918 0.5 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.2994 0.4621
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0207 0.2414
Loa Loa (eye worm) RNA binding protein 0.0125 0.0795 0.1315
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0324 0.2235 0.6674
Brugia malayi Bromodomain containing protein 0.0077 0.0443 0.0713
Trypanosoma brucei ISWI complex protein 0.0031 0.0109 0.0134
Mycobacterium ulcerans hypothetical protein 0.0036 0.0145 0.0343
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0403 0.0582
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0228 0.0216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00171918 0.5 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0083 0.0083
Brugia malayi Bromodomain containing protein 0.0152 0.0991 0.1621
Loa Loa (eye worm) hypothetical protein 0.0036 0.0145 0.0239
Mycobacterium tuberculosis Conserved hypothetical protein 0.0477 0.3345 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0031
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0055 0.0359
Trypanosoma cruzi DNA polymerase eta, putative 0.0112 0.0695 0.1046
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0145 0.0208
Loa Loa (eye worm) hypothetical protein 0.0083 0.0488 0.0807
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0145 0.019
Loa Loa (eye worm) MBCTL1 0.0108 0.0665 0.11
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0488 0.0488
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0795 0.1315
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0312 0.0312
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0038 0.0158 0.0158
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0011
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.005 0.0251 0.0729
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0332 0.0332
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0145 0.0617
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0031 0.003
Brugia malayi intermediate filament protein 0.0033 0.0122 0.0182
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0251 0.0623
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1051 0.1051
Onchocerca volvulus 0.0135 0.0866 0.1181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0781 0.077
Brugia malayi Heterochromatin protein 1 0.0071 0.0403 0.0646
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0332 0.0332
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0207 0.2414
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0207 0.0508
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0192 0.1274 0.6322
Schistosoma mansoni alpha-glucosidase 0.0138 0.0889 0.0877
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0464 0.0748
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0376 0.2611 0.2611
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.2994 0.4621
Brugia malayi glutathione reductase 0.0128 0.0813 0.1325
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0127 0.081 0.1224
Brugia malayi Thioredoxin reductase 0.0128 0.0813 0.1325
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00171918 0.5 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0058 0.0114
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0207 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0324 0.0814
Trypanosoma brucei hypothetical protein, conserved 0.0437 0.3053 0.4713
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0332 0.048
Echinococcus multilocularis dna polymerase kappa 0.0115 0.072 0.072
Trichomonas vaginalis DNA polymerase eta, putative 0.0115 0.072 0.1042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.072 0.1084
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0127 0.081 0.1224
Echinococcus granulosus geminin 0.0205 0.1369 0.1369
Mycobacterium ulcerans DNA polymerase IV 0.0115 0.072 0.1858
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0287
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0137 0.0227
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Onchocerca volvulus 0.0033 0.0122 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Schistosoma mansoni intermediate filament proteins 0.0033 0.0122 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0314 0.0454
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0083 0.0117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.072 0.2134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0083 0.0117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0324 0.0324
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0134 0.0134
Echinococcus multilocularis chromobox protein 1 0.0071 0.0403 0.0403
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0134 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.00171918 0.5 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0324 0.0947
Brugia malayi follicle stimulating hormone receptor 0.0283 0.1934 0.3184
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0083 0.007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0098
Brugia malayi steroid hormone receptor 0.00171918 0.5 0.5
Leishmania major DNA polymerase eta, putative 0.0112 0.0695 0.1046
Loa Loa (eye worm) glutaminase 0.0541 0.381 0.6299
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0145 0.0191
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0055 0.1793
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0038 0.0158 0.0158
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0122 0.0202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0115 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.081 0.1224
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0083 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00171918 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0083 0.0117
Schistosoma mansoni hypothetical protein 0.0062 0.0339 0.0326
Echinococcus granulosus SAM and MBT domain containing protein 0.0094 0.0571 0.0571
Echinococcus multilocularis musashi 0.0033 0.0122 0.0122
Schistosoma mansoni zinc finger protein 0.0031 0.0109 0.0096
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.081 0.1224
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0122 0.0181
Loa Loa (eye worm) hypothetical protein 0.0142 0.0915 0.1512
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.001
Loa Loa (eye worm) glutaminase 2 0.0541 0.381 0.6299
Brugia malayi photoreceptor-specific nuclear receptor 0.00171918 0.5 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0409 0.0409
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0083 0.007
Treponema pallidum NADH oxidase 0.0044 0.0207 0.0934
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Loa Loa (eye worm) mbt repeat family protein 0.0094 0.0571 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0083 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00171918 0.5 0.5
Trypanosoma cruzi ISWI complex protein 0.0031 0.0109 0.0134
Brugia malayi TAR-binding protein 0.0125 0.0795 0.1297
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0108 0.0665 0.0665
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0145 0.0208
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0059 0.0314 0.0454
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0464 0.0767
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3466 0.3466
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0083 0.0083
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0464 0.0687
Plasmodium falciparum glutathione reductase 0.0044 0.0207 0.2414
Schistosoma mansoni hypothetical protein 0.0041 0.0186 0.0174
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0094 0.0571 0.075
Echinococcus granulosus chromobox protein 1 0.0071 0.0403 0.0403
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0751 0.1242
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0332 0.048
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0221 0.0221
Schistosoma mansoni thyroid hormone receptor 0.00171918 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0578 0.4075 0.4068
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0145 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0795 0.0784
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.092 0.3966
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0195
Echinococcus multilocularis lamin 0.0033 0.0122 0.0122
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0332 0.0482
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0042 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0058 0.0075
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0058 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0324 0.0814
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00171918 0.5 0.5
Trichomonas vaginalis Citrate lyase beta chain, putative 0.005 0.0251 0.0362
Echinococcus multilocularis lamin dm0 0.0033 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00171918 0.5 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0324 0.2235 1
Onchocerca volvulus 0.0083 0.0488 0.0629
Trypanosoma brucei unspecified product 0.0079 0.0461 0.0682
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.03 0.2063 0.3411
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Loa Loa (eye worm) hypothetical protein 0.0158 0.1029 0.1702
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0192 0.1274 0.209
Schistosoma mansoni thyroid hormone receptor 0.00171918 0.5 0.5
Mycobacterium tuberculosis Probable reductase 0.0292 0.1999 0.5968
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0332 0.0482
Brugia malayi jmjC domain containing protein 0.0065 0.0354 0.0566
Brugia malayi PHD-finger family protein 0.0052 0.0263 0.0414
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0102
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0083 0.0083
Brugia malayi MH2 domain containing protein 0.0119 0.0751 0.1224
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0769 0.0769
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0228 0.0228
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00171918 0.5 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1051 0.1737
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0137
Leishmania major mitochondrial DNA polymerase beta 0.0906 0.6454 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0795 0.1297
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0314 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0145 0.1325
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.005 0.0251 0.0623
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1012 0.1538
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0795 0.0784
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0058 0.0114
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0186 0.0308
Entamoeba histolytica hypothetical protein 0.0023 0.0055 0.0167
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0207 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0409 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0145 0.019
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Leishmania major DNA damage repair protein, putative 0.0036 0.0145 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0145 0.1633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0083 0.0137
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0083 0.0083
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0207 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0083 0.0137
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.092 0.2734
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3466 0.3466
Loa Loa (eye worm) hypothetical protein 0.0108 0.0665 0.11
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0145 0.0191
Echinococcus multilocularis SAM and MBT domain containing protein 0.0094 0.0571 0.0571
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0083 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0083 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00171918 0.5 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0207 0.0299
Schistosoma mansoni steroid hormone receptor ad4bp 0.00171918 0.5 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0781 0.0781
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0354 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.0115 0.072 0.1084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0122 0.0202
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0207 0.0287
Leishmania major hypothetical protein, conserved 0.0437 0.3053 0.4713
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0055 0.2126
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.072 0.1084
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0014 0.0021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0115 0.072 0.119
Schistosoma mansoni cpg binding protein 0.004 0.018 0.0167
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.0571 0.0559
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0312 0.0312
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0083 0.0137
Brugia malayi nuclear hormone receptor 0.0027 0.0083 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0906 0.6454 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0115 0.072 0.2134
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0108 0.0665 0.0665
Brugia malayi hypothetical protein 0.03 0.2063 0.3398
Leishmania major trypanothione reductase 0.0128 0.0813 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0096
Brugia malayi ecdysteroid receptor 0.00171918 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.038 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2002 0.2902
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0083 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0332 0.0482
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0042 0.0042
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0058 0.0011
Schistosoma mansoni coup transcription factor 0.0027 0.0083 0.007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0332 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00171918 0.5 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0058 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00171918 0.5 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0324 0.0311
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.2002 1
Plasmodium falciparum thioredoxin reductase 0.0044 0.0207 0.2414
Loa Loa (eye worm) hypothetical protein 0.00171918 0.5 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0332 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00171918 0.5 0.5
Echinococcus multilocularis FTZ F1 alpha 0.00171918 0.5 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.1029 0.1018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0464 0.0464
Brugia malayi jmjC domain containing protein 0.0059 0.0312 0.0496
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0207 0.2003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00171918 0.5 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0207 0.0287
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0464 0.0452
Echinococcus granulosus zinc finger protein 0.0041 0.0185 0.0185
Mycobacterium ulcerans hypothetical protein 0.005 0.0251 0.0623
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0058 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0795 0.0784
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0145 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0795 0.0784
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0058 0.018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.072 0.1084
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0055 0.0052
Schistosoma mansoni nuclear hormone receptor 0.00171918 0.5 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0021
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0251 0.0623
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0354 0.0354
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0083 0.007
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0132 0.0846 0.2513
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0145 0.0219
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0055 0.0052
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0292 0.1999 0.5968
Loa Loa (eye worm) hypothetical protein 0.0082 0.0478 0.0791
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0464 0.223
Plasmodium falciparum glutathione reductase 0.0128 0.0813 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -5.7 Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.6 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.6 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.4 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.4 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.4 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.1 Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
Inhibition (binding) Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay ChEMBL. No reference
LD50 (ADMET) = 150 mg kg-1 Compound was tested for toxicity in mice after intraperitoneal administration ChEMBL. 6492077
Potency (functional) 0.6746 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7569 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.4241 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.9589 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.9959 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3703 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element beta-lactamase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.847 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.8493 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.8554 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.4889 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 33.8078 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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