Detailed information for compound 583382

Basic information

Technical information
  • TDR Targets ID: 583382
  • Name: (2,5-dioxopyrrolidin-1-yl) (2S)-2-(tert-butox ycarbonylamino)-3-(4-hydroxy-3-iodo-phenyl)pr opanoate
  • MW: 504.273 | Formula: C18H21IN2O7
  • H donors: 2 H acceptors: 5 LogP: 2.25 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)N[C@H](C(=O)ON1C(=O)CCC1=O)Cc1ccc(c(c1)I)O
  • InChi: 1S/C18H21IN2O7/c1-18(2,3)27-17(26)20-12(9-10-4-5-13(22)11(19)8-10)16(25)28-21-14(23)6-7-15(21)24/h4-5,8,12,22H,6-7,9H2,1-3H3,(H,20,26)/t12-/m0/s1
  • InChiKey: ZSHWOTBCGGDEQO-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[tert-butoxy(oxo)methyl]amino]-3-(4-hydroxy-3-iodophenyl)propanoic acid (2,5-dioxo-1-pyrrolidinyl) ester
  • (2,5-dioxopyrrolidin-1-yl) (2S)-3-(4-hydroxy-3-iodo-phenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  • (2S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxy-3-iodo-phenyl)propionic acid succinimido ester
  • (2,5-dioxopyrrolidin-1-yl) (2S)-3-(4-hydroxy-3-iodophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  • tertiary-butyloxycarbonyl-L-iodotyrosine-N-hydroxysuccininimide ester
  • (2S)-2-[(tert-butoxy-oxomethyl)amino]-3-(4-hydroxy-3-iodophenyl)propanoic acid (2,5-dioxo-1-pyrrolidinyl) ester
  • 79028-57-2
  • Boc-itry-nhse
  • Carbamic acid, (2-((2,5-dioxo-1-pyrrolidinyl)oxy)-1-((4-hydroxy-3-iodophenyl)methyl)-2-oxoethyl)-, 1,1-dimethylethyl ester, (S)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0292 0.0113
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0037 0.0221 0.3309
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1298 0.1718
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0532 0.0468
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0433 0.2877
Schistosoma mansoni hypothetical protein 0.0175 0.1904 0.4512
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0175 0.0109
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0037 0.0221 0.5934
Loa Loa (eye worm) hypothetical protein 0.0055 0.0433 0.09
Loa Loa (eye worm) retinol dehydrogenase 12 0.0037 0.0221 0.0378
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0855 0.1937
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.055 0.6489 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0037 0.0221 0.4154
Echinococcus granulosus snurportin 1 0.0358 0.4139 1
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Schistosoma mansoni heat shock protein 0.0046 0.0326 0.0637
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1469 0.1991
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0326 0.0637
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0532 0.0724
Schistosoma mansoni biogenic amine (5HT) receptor 0.0127 0.1321 0.3079
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1469 0.1991
Plasmodium falciparum importin beta, putative 0.0034 0.0175 0.0168
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0037 0.0221 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0097 0.0048
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0221 0.1208
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0037 0.0221 0.024
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0326 0.0404
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0326 0.0404
Echinococcus granulosus lamin dm0 0.0055 0.0433 0.09
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.055 0.6489 1
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0292 0.0113
Giardia lamblia Grp94/Hsp90 0.0043 0.0292 0.8671
Plasmodium vivax importin-beta 2, putative 0.0034 0.0175 0.0168
Plasmodium vivax heat shock protein 90, putative 0.003 0.0138 0.0111
Leishmania major oxidoreductase-like protein 0.0037 0.0221 0.3309
Mycobacterium tuberculosis Probable reductase 0.0125 0.1298 0.1718
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0532 0.1142
Plasmodium falciparum glutathione reductase 0.0055 0.0437 0.0577
Schistosoma mansoni lamin 0.0055 0.0433 0.09
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0358 0.4139 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1298 0.1718
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0021
Plasmodium vivax glutathione reductase, putative 0.0055 0.0437 0.0577
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0326 0.7459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0855 0.0794
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0045 0.0318 0.0618
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0855 0.1937
Plasmodium falciparum thioredoxin reductase 0.0055 0.0437 0.0577
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0037 0.0221 0.3309
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0326 0.7459
Trypanosoma brucei oxidoreductase-like protein 0.0037 0.0221 0.4154
Echinococcus multilocularis heat shock protein 90 0.0046 0.0326 0.0261
Schistosoma mansoni endoplasmin 0.0046 0.0326 0.0637
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0433 0.09
Leishmania major heat shock protein, putative 0.003 0.0138 0.1528
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0097 0.0048
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0067 0.1527
Leishmania major serine/threonine protein phosphatase, putative 0.0045 0.0318 0.5413
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0123 0.0138
Loa Loa (eye worm) RNA binding protein 0.0129 0.134 0.3127
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0292 0.4836
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0292 0.035
Echinococcus multilocularis heat shock protein 0.0046 0.0326 0.0261
Brugia malayi Importin beta-1 subunit 0.0034 0.0175 0.085
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0245 0.5605
Brugia malayi RNA binding protein 0.0129 0.134 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0037 0.0221 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0855 0.1937
Loa Loa (eye worm) heat shock protein 75 0.003 0.0138 0.0174
Leishmania major trypanothione reductase 0.0055 0.0437 0.7965
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Schistosoma mansoni hypothetical protein 0.0175 0.1904 0.4512
Loa Loa (eye worm) hypothetical protein 0.0045 0.0318 0.0618
Echinococcus multilocularis serotonin receptor 0.0127 0.1321 0.1262
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0532 1
Plasmodium falciparum heat shock protein 90 0.0046 0.0326 0.0404
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0138 0.274
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0855 0.6194
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0037 0.0221 0.024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0221 0.1208
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.055 0.6489 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0174 0.189 0.284
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0045 0.0318 0.9707
Echinococcus granulosus biogenic amine 5HT receptor 0.0127 0.1321 0.3079
Echinococcus multilocularis heat shock protein 90 0.0039 0.0245 0.0179
Schistosoma mansoni hypothetical protein 0.0358 0.4139 1
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0326 0.7001
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0855 0.0794
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0245 0.6875
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0175 0.2921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0532 0.0496
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0037 0.0221 0.0378
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Brugia malayi heat shock protein 90 0.0046 0.0326 0.2036
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0138 0.0174
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0437 0.0345
Schistosoma mansoni importin beta-1 0.0034 0.0175 0.0266
Brugia malayi Thioredoxin reductase 0.0055 0.0437 0.2908
Loa Loa (eye worm) glutathione reductase 0.0055 0.0437 0.0909
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0326 0.7001
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0326 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1298 0.1718
Echinococcus granulosus importin subunit beta 1 0.0034 0.0175 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0129 0.134 0.3127
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0175 0.2921
Schistosoma mansoni endoplasmin 0.0046 0.0326 0.0637
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0045 0.0318 0.9707
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0045 0.0318 0.0618
Echinococcus multilocularis serotonin receptor 0.0127 0.1321 0.1262
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0037 0.0221 0.5047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0067 0.1527
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Echinococcus multilocularis geminin 0.0175 0.1904 0.185
Echinococcus multilocularis musashi 0.0055 0.0433 0.0369
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0292 0.035
Plasmodium falciparum endoplasmin, putative 0.0033 0.0172 0.0164
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0326 0.7001
Schistosoma mansoni lamin 0.0055 0.0433 0.09
Onchocerca volvulus 0.0037 0.0221 0.2804
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0045 0.0318 0.0253
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1469 0.1991
Plasmodium falciparum enoyl-acyl carrier reductase 0.055 0.6489 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0855 0.1937
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0021
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0045 0.0318 0.9707
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1298 0.1718
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0326 0.0404
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0037 0.0221 0.3309
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Schistosoma mansoni heat shock protein 0.003 0.0138 0.0174
Echinococcus multilocularis lamin dm0 0.0055 0.0433 0.0369
Schistosoma mansoni intermediate filament proteins 0.0055 0.0433 0.09
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.055 0.6489 1
Echinococcus multilocularis endoplasmin 0.0043 0.0292 0.0226
Trypanosoma brucei pteridine reductase 1 0.0037 0.0221 0.4154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0855 0.1937
Schistosoma mansoni tar DNA-binding protein 0.0129 0.134 0.3127
Loa Loa (eye worm) hypothetical protein 0.0045 0.0311 0.0599
Schistosoma mansoni dihydropteridine reductase 0.0037 0.0221 0.0378
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0091 0.0038
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0326 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1298 0.1718
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0037 0.0221 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0855 0.1937
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1298 0.1718
Schistosoma mansoni heat shock protein 0.0046 0.0326 0.0637
Echinococcus granulosus tar DNA binding protein 0.0129 0.134 0.3127
Leishmania major importin beta-1 subunit, putative 0.0027 0.0097 0.066
Loa Loa (eye worm) hypothetical protein 0.0127 0.1321 0.3079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0532 0.0496
Onchocerca volvulus 0.0055 0.0433 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0088 0.0021
Entamoeba histolytica hypothetical protein 0.0027 0.0097 0.1184
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0433 0.09
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0175 0.0168
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0437 0.0909
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0037 0.0221 0.024
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.055 0.6489 1
Echinococcus multilocularis tar DNA binding protein 0.0129 0.134 0.1282
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0037 0.0221 0.0378
Onchocerca volvulus 0.0055 0.0433 1
Brugia malayi Hsp90 protein 0.003 0.0138 0.0558
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0326 0.7459
Loa Loa (eye worm) hypothetical protein 0.0127 0.1321 0.3079
Echinococcus granulosus heat shock protein 90 0.0039 0.0245 0.0438
Trypanosoma cruzi heat shock protein, putative 0.003 0.0138 0.3152
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0437 0.0373
Loa Loa (eye worm) hypothetical protein 0.0054 0.0421 0.087
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Brugia malayi intermediate filament protein 0.0055 0.0433 0.2877
Plasmodium vivax endoplasmin, putative 0.0046 0.0326 0.0404
Schistosoma mansoni protein phosphatase-2b 0.0045 0.0318 0.0618
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0045 0.0318 0.7285
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0532 0.0496
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0091 0.0038
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0045 0.0318 0.9707
Echinococcus granulosus lamin 0.0055 0.0433 0.09
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Echinococcus granulosus intermediate filament protein 0.0055 0.0433 0.09
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0045 0.0318 0.0392
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0097 0.2229
Loa Loa (eye worm) TAR-binding protein 0.0129 0.134 0.3127
Echinococcus multilocularis snurportin 1 0.0358 0.4139 0.4099
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0045 0.0318 0.9707
Toxoplasma gondii thioredoxin reductase 0.0055 0.0437 0.0577
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0245 0.0438
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0045 0.0318 0.9707
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1469 0.1991
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0037 0.0221 0.0378
Brugia malayi RNA, U transporter 1 0.0095 0.093 0.6782
Loa Loa (eye worm) oxidoreductase 0.0037 0.0221 0.0378
Brugia malayi glutathione reductase 0.0055 0.0437 0.2908
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0037 0.0221 0.5047
Plasmodium vivax enoyl-acyl carrier protein reductase 0.055 0.6489 1
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0245 0.0278
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0326 0.7459
Treponema pallidum heat shock protein 90 0.0043 0.0292 0.5
Echinococcus granulosus geminin 0.0175 0.1904 0.4512
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0045 0.0318 0.1976
Schistosoma mansoni protein phosphatase-2b 0.0045 0.0318 0.0618
Trypanosoma brucei protein phosphatase 2B, putative 0.0045 0.0318 0.6796
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0292 0.0113
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0045 0.0318 0.7285
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.055 0.6489 1
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0045 0.0318 0.0392
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0532 0.0496
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0045 0.0318 0.0253
Trypanosoma brucei trypanothione reductase 0.0055 0.0437 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0437 0.0909
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0326 0.0404
Onchocerca volvulus 0.0037 0.0221 0.2804
Loa Loa (eye worm) hypothetical protein 0.0034 0.0175 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0129 0.134 0.3127
Schistosoma mansoni tar DNA-binding protein 0.0129 0.134 0.3127
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Loa Loa (eye worm) endoplasmin 0.0046 0.0326 0.0637
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.134 0.3127
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0437 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0532 0.1142
Echinococcus multilocularis lamin 0.0055 0.0433 0.0369
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0045 0.0318 0.5413
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0123 0.0442
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0437 0.0577
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0532 0.1142
Brugia malayi Endoplasmin precursor 0.0046 0.0326 0.2036
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.134 1
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0097 0.0048
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0292 0.0113
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0045 0.0318 0.7285
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0037 0.0221 0.5047
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0088 0.0051
Brugia malayi TAR-binding protein 0.0129 0.134 1
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0045 0.0318 0.0392
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0138 0.0071
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0326 0.7459
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Echinococcus granulosus heat shock protein 0.0046 0.0326 0.0637
Echinococcus granulosus endoplasmin 0.0043 0.0292 0.0552
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0138 0.1918
Plasmodium vivax heat shock protein, putative 0.0174 0.189 0.284
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0172 0.0164
Trypanosoma brucei heat shock protein, putative 0.0046 0.0326 0.7001
Trichomonas vaginalis hypothetical protein 0.055 0.6489 1
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0138 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0221 0.0378
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0245 0.5605
Plasmodium falciparum heat shock protein 90, putative 0.0174 0.189 0.284
Leishmania major heat shock protein 83-1 0.0046 0.0326 0.5577
Schistosoma mansoni tar DNA-binding protein 0.0129 0.134 0.3127
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0326 1
Echinococcus granulosus heat shock protein 90 0.0046 0.0326 0.0637
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0172 0.0164
Leishmania major pteridine reductase 1 0.0037 0.0221 0.3309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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