Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9419 | 1 |
Onchocerca volvulus | 0.0154 | 0.8285 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1167 | 0.1239 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.3581 | 0.3969 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9419 | 1 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Echinococcus granulosus | geminin | 0.0173 | 0.9419 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0339 | 0.036 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2636 | 0.2798 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0173 | 0.9419 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0221 | 0.0267 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0221 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.8285 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1313 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1317 | 0.159 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1167 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3317 | 0.4003 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0339 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1464 | 0.1767 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2636 | 0.2798 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0038 | 0.0046 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2857 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1582 | 0.1909 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0339 | 0.036 |
Brugia malayi | hypothetical protein | 0.0154 | 0.8285 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of intracellular momilactone B at 10 ug/ml after 48 hr by GC/GC-MS analysis | ChEMBL. | No reference | |
Activity (functional) | = 16 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of intracellular momilactone A at 0.7 x 10'-9 to 0.7 x 10'-6 M after 24 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Activity (functional) | = 24 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of momilactone A in culture medium at 0.7 x 10'-9 to 0.7 x 10'-6 M after 24 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Activity (functional) | = 41 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of intracellular momilactone A at 0.7 x 10'-9 to 0.7 x 10'-6 M after 48 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Activity (functional) | = 56 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of intracellular momilactone A at 0.7 x 10'-9 to 0.7 x 10'-6 M after 72 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Activity (functional) | = 149 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of momilactone A in culture medium at 0.7 x 10'-9 to 0.7 x 10'-6 M after 72 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Activity (functional) | = 161 ug/g | Induction of phytoalexin formation in suspension-cultured Oryza sativa (rice) cells assessed as accumulation of momilactone A in culture medium at 0.7 x 10'-9 to 0.7 x 10'-6 M after 48 hr by GC/GC-MS analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.