Detailed information for compound 583471

Basic information

Technical information
  • TDR Targets ID: 583471
  • Name: 8-azido-7H-purin-6-amine
  • MW: 177.147 | Formula: C5H5N8
  • H donors: 2 H acceptors: 3 LogP: 1.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH-]=[N+]=Nc1nc2c([nH]1)c(N)ncn2
  • InChi: 1S/C5H4N8/c6-3-2-4(9-1-8-3)11-5(10-2)12-13-7/h1H,(H3,6,8,9,10,11)
  • InChiKey: ZTWYAIASAJSBMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (8-azido-7H-purin-6-yl)amine
  • 8-azidoadenine
  • 79270-98-7
  • 1H-Purin-6-amine, 8-azido-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0412 0.0542
Loa Loa (eye worm) hypothetical protein 0.0124 0.2601 0.2601
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0546 0.0546
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0239 0.0794
Schistosoma mansoni smad1 5 8 and 0.0008 0.0044 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 1
Brugia malayi MH2 domain containing protein 0.0008 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0546 0.072
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0239 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.292 0.292
Mycobacterium tuberculosis Probable reductase 0.011 0.2308 0.8837
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0044 0.0057
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0159 0.3859
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2433 0.2433
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0044 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0905 0.0905
Onchocerca volvulus Huntingtin homolog 0.0119 0.25 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0239 0.1733
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.201 0.201
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0432 0.4017
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.4947 0.6516
Brugia malayi hypothetical protein 0.0119 0.25 0.25
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0938 0.1235
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0297 0.0392
Loa Loa (eye worm) hypothetical protein 0.023 0.4947 0.4947
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.0794
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0093 0.0122
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0546 0.072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.0794
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0432 0.3511
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0239 0.0315
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1333 0.1333
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0239 0.1033
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0239 0.5815
Loa Loa (eye worm) Smad1 0.0008 0.0044 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.201 0.201
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0239 0.005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0044 0.0057
Schistosoma mansoni hypothetical protein 0.0066 0.1333 0.1755
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0432 0.3511
Loa Loa (eye worm) hypothetical protein 0.0031 0.0546 0.0546
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1173 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.201 0.201
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0239 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0239 0.1033
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0432 0.4017
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0346 0.2991
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0239 0.1033
Onchocerca volvulus Huntingtin homolog 0.0119 0.25 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0938 0.2985
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0093 0.0122
Schistosoma mansoni hypothetical protein 0.0031 0.0546 0.072
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.25 0.25
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1173 0.3989
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0044 0.0044
Echinococcus granulosus bloom syndrome protein 0.0025 0.0412 0.0542
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0938 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0239 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1173 0.1545
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0141 0.0141
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0239 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.292 0.3847
Echinococcus multilocularis geminin 0.035 0.7592 1
Schistosoma mansoni hypothetical protein 0.0031 0.0546 0.072
Echinococcus multilocularis GPCR, family 2 0.0031 0.0546 0.072
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0093 0.0093
Schistosoma mansoni smad1 5 8 and 0.0008 0.0044 0.0057
Echinococcus granulosus survival motor neuron protein 1 0.023 0.4947 0.6516
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0093 0.00000000094487
Schistosoma mansoni DNA helicase recq1 0.001 0.0093 0.0122
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.2308 0.8837
Onchocerca volvulus 0.0047 0.0905 0.3619
Schistosoma mansoni survival motor neuron protein 0.0047 0.0905 0.1192
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.2308 0.8837
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0044 0.0057
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.258 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0239 0.1356
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0239 0.1733
Loa Loa (eye worm) RecQ helicase 0.0025 0.0412 0.0412
Brugia malayi Smad1 0.0008 0.0044 0.0044
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.2308 0.8837
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0122 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.292 0.3847
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0141 0.0141
Brugia malayi Thioredoxin reductase 0.0048 0.0938 0.0938
Leishmania major trypanothione reductase 0.0048 0.0938 0.7684
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1173 1
Echinococcus multilocularis Smad4 0.0008 0.0044 0.0057
Plasmodium falciparum glutathione reductase 0.0048 0.0938 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1173 0.1545
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0938 0.1235
Echinococcus granulosus smad 0.0008 0.0044 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0122 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.292 0.3847
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0239 0.0315
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0122 0.016
Loa Loa (eye worm) hypothetical protein 0.0066 0.1333 0.1333
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2433 0.2433
Loa Loa (eye worm) hypothetical protein 0.0119 0.25 0.25
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0938 0.0938
Schistosoma mansoni hypothetical protein 0.035 0.7592 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0432 0.3143
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0239 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.258 1
Brugia malayi MH2 domain containing protein 0.0008 0.0044 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0546 0.072
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0159 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0232 0.1283
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0412 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.258 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0239 0.1033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0044 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0412 0.0412
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0044 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0432 0.2799
Brugia malayi MH1 domain containing protein 0.0008 0.0044 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0459 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0239 0.0239
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0239 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0432 0.3511
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0239 0.1033
Schistosoma mansoni hypothetical protein 0.035 0.7592 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0938 0.7825
Brugia malayi hypothetical protein 0.023 0.4947 0.4947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.292 0.292
Brugia malayi hypothetical protein 0.0026 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0097 0.201 0.201
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0093 0.0093
Trypanosoma brucei trypanothione reductase 0.0048 0.0938 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0546 0.0546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0938 1
Brugia malayi hypothetical protein 0.0016 0.0233 0.0233
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0239 0.1356
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.258 1
Treponema pallidum NADH oxidase 0.0017 0.0239 0.5
Echinococcus granulosus geminin 0.035 0.7592 1
Brugia malayi MH1 domain containing protein 0.0008 0.0044 0.0044
Plasmodium falciparum glutathione reductase 0.0017 0.0239 0.1733
Schistosoma mansoni smad 0.0008 0.0044 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.292 0.3847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1173 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0546 0.0546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1173 0.1545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Schistosoma mansoni DNA helicase recq5 0.001 0.0093 0.0122
Echinococcus multilocularis smad 0.0008 0.0044 0.0057
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.2308 0.8837
Loa Loa (eye worm) glutathione reductase 0.0048 0.0938 0.0938
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0239 0.0794
Echinococcus granulosus Smad4 0.0008 0.0044 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0546 0.072
Leishmania major hypothetical protein, conserved 0.0026 0.0432 0.2698
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0093 0.0122
Brugia malayi MH2 domain containing protein 0.0116 0.2433 0.2433
Schistosoma mansoni Smad4 0.0008 0.0044 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0546 0.072
Plasmodium vivax glutathione reductase, putative 0.0048 0.0938 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.0093
Schistosoma mansoni smad1 5 8 and 0.0008 0.0044 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.292 0.3847
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0093 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0239 0.1033
Schistosoma mansoni hypothetical protein 0.0031 0.0546 0.072
Plasmodium falciparum thioredoxin reductase 0.0017 0.0239 0.1733
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0239 0.1033
Echinococcus granulosus GPCR family 2 0.0031 0.0546 0.072
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.2308 0.8837
Loa Loa (eye worm) hypothetical protein 0.0026 0.0432 0.0432
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0239 0.5815
Brugia malayi glutathione reductase 0.0048 0.0938 0.0938
Plasmodium falciparum thioredoxin reductase 0.0048 0.0938 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1173 0.1545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0239 0.1033
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0093 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.292 0.3847
Schistosoma mansoni hypothetical protein 0.0047 0.0905 0.1192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.292 0.3847

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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