Detailed information for compound 58378

Basic information

Technical information
  • TDR Targets ID: 58378
  • Name: 7-chloro-6-ethylsulfanyl-5-nitro-1,4-dihydroq uinoxaline-2,3-dione
  • MW: 301.706 | Formula: C10H8ClN3O4S
  • H donors: 2 H acceptors: 6 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1c(Cl)cc2c(c1[N+](=O)[O-])nc(c(n2)O)O
  • InChi: 1S/C10H8ClN3O4S/c1-2-19-8-4(11)3-5-6(7(8)14(17)18)13-10(16)9(15)12-5/h3H,2H2,1H3,(H,12,15)(H,13,16)
  • InChiKey: AEOIZSSKEQUNLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-6-(ethylthio)-5-nitro-1,4-dihydroquinoxaline-2,3-dione
  • 7-chloro-6-(ethylthio)-5-nitro-1,4-dihydroquinoxaline-2,3-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A References
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3B References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0317 0.1485 0.1485
Leishmania major subtilisin-like serine peptidase 0.0091 0.0173 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0951 0.5154 1
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Echinococcus granulosus furin 0.1787 1 1
Toxoplasma gondii subtilisin SUB1 0.0091 0.0173 0.5
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0071 0.0056 0.0056
Echinococcus granulosus enteropeptidase 0.0077 0.0091 0.0091
Schistosoma mansoni glutamate receptor NMDA 0.0387 0.1886 0.1886
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus granulosus glutamate receptor subunit protein glur 0.0075 0.0078 0.0078
Loa Loa (eye worm) glutamate receptor 1 0.0187 0.0727 0.0727
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.086 0.086
Echinococcus multilocularis NMDA receptor 0.0075 0.0078 0.0099
Brugia malayi neuroendocrine convertase 1 precursor 0.1699 0.9492 0.9492
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0134 0.0423 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Plasmodium vivax subtilisin-like serine protease, putative 0.0091 0.0173 0.5
Giardia lamblia Furin precursor putative serine protease 0.0487 0.2465 1
Brugia malayi Glutamate receptor 1 precursor 0.0187 0.0727 0.0727
Toxoplasma gondii subtilisin SUB12 0.0091 0.0173 0.5
Toxoplasma gondii subtilisin SUB11 0.0091 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.03 0.1383 0.1383
Echinococcus multilocularis membrane bound transcription factor site 1 0.0091 0.0173 0.0221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Toxoplasma gondii subtilisin SUB6 0.0091 0.0173 0.5
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0487 0.2465 0.4725
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus multilocularis glutamate receptor 2 0.0187 0.0727 0.0927
Schistosoma mansoni glutamate receptor kainate 0.0187 0.0727 0.0727
Onchocerca volvulus Deterin homolog 0.0134 0.0423 0.264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Brugia malayi Protein kinase domain containing protein 0.1049 0.5723 0.5723
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0091 0.0173 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0317 0.1485 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0075 0.0078 0.0099
Echinococcus granulosus nmda type glutamate receptor 0.0288 0.1315 0.1315
Echinococcus multilocularis snurportin 1 0.03 0.1383 0.1764
Schistosoma mansoni glutamate receptor AMPA 0.0187 0.0727 0.0727
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0134 0.0423 0.0423
Echinococcus granulosus glutamate receptor NMDA 0.019 0.0749 0.0749
Plasmodium falciparum subtilisin-like protease 1 0.0091 0.0173 0.5
Schistosoma mansoni glutamate receptor AMPA 0.0187 0.0727 0.0727
Brugia malayi Will die slowly protein 0.0135 0.0429 0.0429
Plasmodium falciparum subtilisin-like protease 2 0.0091 0.0173 0.5
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0075 0.0078 0.0078
Plasmodium vivax subtilisin-like protease 1 0.0091 0.0173 0.5
Echinococcus multilocularis glutamate receptor 2 0.021 0.086 0.1097
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0091 0.0173 0.5
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0951 0.5154 0.5154
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0091 0.0173 0.0173
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0134 0.0423 0.0423
Echinococcus granulosus rho-associated protein kinase 1 0.0338 0.1601 0.1601
Schistosoma mansoni ATP-binding cassette transporter 0.0187 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0071 0.0056 0.0056
Echinococcus multilocularis inhibitor of apoptosis protein 0.0134 0.0423 0.0539
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.086 0.1097
Brugia malayi proprotein convertase 2 0.1414 0.7839 0.7839
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.021 0.086 0.1097
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Loa Loa (eye worm) hypothetical protein 0.036 0.1728 0.1728
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1787 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.086 0.086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Schistosoma mansoni inhibitor of apoptosis protein 0.0134 0.0423 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Loa Loa (eye worm) hypothetical protein 0.0235 0.1006 0.1006
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0165 0.0603 0.0603
Brugia malayi Tachykinin-like peptides receptor 99D 0.0235 0.1006 0.1006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus multilocularis wd40 repeat 0.0071 0.0056 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Loa Loa (eye worm) hypothetical protein 0.0134 0.0423 0.0423
Echinococcus granulosus gamma secretase subunit aph 1 0.0242 0.1047 0.1047
Echinococcus granulosus nmda type glutamate receptor 0.0213 0.0882 0.0882
Echinococcus granulosus neuropeptide FF receptor 2 0.0235 0.1006 0.1006
Onchocerca volvulus 0.0338 0.1601 1
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1049 0.5723 0.5723
Schistosoma mansoni hypothetical protein 0.0412 0.2035 0.2035
Loa Loa (eye worm) hypothetical protein 0.0134 0.0423 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0165 0.0603 0.1073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0173 0.0229
Toxoplasma gondii subtilisin SUB10 0.0091 0.0173 0.5
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.086 0.086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus granulosus snurportin 1 0.03 0.1383 0.1383
Echinococcus granulosus protein will die slowly 0.0135 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.0134 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0165 0.0599 0.0599
Trypanosoma brucei Aph-1 protein, putative 0.0094 0.0191 1
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0134 0.0423 0.0539
Echinococcus granulosus geminin 0.0165 0.0599 0.0599
Schistosoma mansoni glutamate receptor NMDA 0.04 0.1964 0.1964
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0951 0.5154 0.6575
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0091 0.0173 0.5
Brugia malayi Subtilase family protein 0.0091 0.0173 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.1601 0.1601
Loa Loa (eye worm) TK/EGFR protein kinase 0.0317 0.1485 0.1485
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0173 0.0229
Schistosoma mansoni site-1 peptidase (S08 family) 0.0091 0.0173 0.0173
Echinococcus multilocularis glutamate receptor 2 0.0135 0.0427 0.0544
Echinococcus multilocularis protein will die slowly 0.0135 0.0429 0.0547
Loa Loa (eye worm) hypothetical protein 0.0911 0.4921 0.4921
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0173 0.0229
Echinococcus granulosus Mastin 0.0077 0.0091 0.0091
Echinococcus multilocularis nmda type glutamate receptor 0.0288 0.1315 0.1677
Brugia malayi Glutamate receptor 2 precursor 0.0187 0.0727 0.0727
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0091 0.0173 0.0173
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1383 0.1383
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0091 0.0173 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0091 0.0173 0.5
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0091 0.0173 0.5
Echinococcus granulosus glycoprotein Antigen 5 0.0077 0.0091 0.0091
Echinococcus multilocularis gamma secretase subunit aph 1 0.0242 0.1047 0.1336
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Brugia malayi gamma-secretase subunit aph-1 0.0242 0.1047 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Loa Loa (eye worm) proprotein convertase 2 0.0578 0.2993 0.2993
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0578 0.2993 0.2993
Echinococcus multilocularis neuropeptide FF receptor 2 0.0235 0.1006 0.1283
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0077 0.0091 0.0091
Echinococcus granulosus glutamate receptor 2 0.0135 0.0427 0.0427
Plasmodium vivax subtilisin-like protease 2, putative 0.0091 0.0173 0.5
Mycobacterium leprae Possible secreted protease 0.0091 0.0173 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0951 0.5154 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.086 0.1097
Schistosoma mansoni site-1 peptidase (S08 family) 0.0091 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0135 0.0429 0.0429
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Loa Loa (eye worm) subtilase 0.0091 0.0173 0.0173
Trichomonas vaginalis hypothetical protein 0.0412 0.2035 0.3881
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.0191 1
Echinococcus multilocularis glutamate receptor NMDA 0.019 0.0749 0.0955
Echinococcus multilocularis Mastin 0.0077 0.0091 0.0116
Toxoplasma gondii subtilisin SUB2 0.0091 0.0173 0.5
Toxoplasma gondii subtilisin SUB4 0.0091 0.0173 0.5
Toxoplasma gondii subtilisin SUB5 0.0091 0.0173 0.5
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0075 0.0078 0.0078
Echinococcus granulosus inhibitor of apoptosis protein 0.0134 0.0423 0.0423
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0242 0.1047 0.1047
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0091 0.0173 0.5
Echinococcus granulosus wd40 repeat 0.0071 0.0056 0.0056
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0091 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Echinococcus multilocularis enteropeptidase 0.0077 0.0091 0.0116
Toxoplasma gondii subtilisin SUB9 0.0091 0.0173 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.086 0.1097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0412 0.2035 0.3881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Loa Loa (eye worm) glutamate receptor 2 0.0187 0.0727 0.0727
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Plasmodium falciparum subtilisin-like protease 3 0.0091 0.0173 0.5
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0487 0.2465 0.4725
Schistosoma mansoni glutamate receptor kainate 0.0187 0.0727 0.0727
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0091 0.0173 0.5
Echinococcus multilocularis rho associated protein kinase 0.0338 0.1601 0.2043
Echinococcus multilocularis 0.1375 0.761 0.9708
Schistosoma mansoni furin-1 (S08 family) 0.0927 0.5019 0.5019
Onchocerca volvulus 0.0337 0.1597 0.9974
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.021 0.086 0.086
Echinococcus granulosus membrane bound transcription factor site 1 0.0091 0.0173 0.0173
Echinococcus granulosus epidermal growth factor receptor 0.0317 0.1485 0.1485
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0134 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0091 0.0173 0.0173
Schistosoma mansoni retinoblastoma binding protein 0.0071 0.0056 0.0056
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0091 0.0173 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Onchocerca volvulus 0.0135 0.0429 0.268
Schistosoma mansoni hypothetical protein 0.0165 0.0599 0.0599
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0098 0.0211 0.0269
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Echinococcus granulosus glutamate NMDA receptor subunit 0.0387 0.1886 0.1886
Echinococcus granulosus neuroendocrine convertase 2 0.1414 0.7839 0.7839
Onchocerca volvulus 0.0074 0.0076 0.0473
Loa Loa (eye worm) hypothetical protein 0.1787 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0075 0.0037
Schistosoma mansoni hypothetical protein 0.0075 0.0078 0.0078
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0387 0.1886 0.2405
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0173 0.0229
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0075 0.0078 0.0099
Loa Loa (eye worm) endoprotease bli-4 0.1787 1 1
Echinococcus multilocularis nmda type glutamate receptor 0.0213 0.0882 0.1125
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0317 0.0317
Brugia malayi celfurPC protein 0.1375 0.761 0.761
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Onchocerca volvulus 0.0134 0.0423 0.264
Toxoplasma gondii subtilisin SUB8 0.0091 0.0173 0.5
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.0191 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0317 0.0317
Echinococcus multilocularis Furin 1 0.0578 0.2993 0.3818
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Onchocerca volvulus 0.0091 0.0173 0.108
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0091 0.0173 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.2035 0.3881
Echinococcus multilocularis neuroendocrine convertase 2 0.1414 0.7839 1
Toxoplasma gondii subtilisin SUB7 0.0091 0.0173 0.5
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0075 0.0078 0.0099
Echinococcus granulosus glutamate receptor 2 0.021 0.086 0.086
Schistosoma mansoni gamma-secretase subunit aph-1 0.0242 0.1047 0.1047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Loa Loa (eye worm) WD40 repeat protein 0.0135 0.0429 0.0429
Trichomonas vaginalis WD repeat domain, putative 0.0135 0.0429 0.0732
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Brugia malayi RNA, U transporter 1 0.008 0.0108 0.0108
Echinococcus multilocularis glycoprotein Antigen 5 0.0077 0.0091 0.0116
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0091 0.0173 0.0229
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0091 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0173 0.0229
Echinococcus multilocularis geminin 0.0165 0.0599 0.0764
Echinococcus granulosus Furin 1 0.0578 0.2993 0.2993
Brugia malayi MH2 domain containing protein 0.0116 0.0317 0.0317
Brugia malayi Furin-like cysteine rich region family protein 0.0317 0.1485 0.1485
Schistosoma mansoni glutamate receptor kainate 0.0187 0.0727 0.0727
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0578 0.2993 0.5761
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0075 0.0078 0.0078

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.19 Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor ChEMBL. 12699379
IC50 (binding) = 0.64 uM Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor ChEMBL. 12699379
IC50 (binding) = 0.64 uM Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain cortical membranes. ChEMBL. 9057859
IC50 (binding) = 0.64 uM Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor ChEMBL. 12699379
IC50 (binding) = 0.64 uM Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain cortical membranes. ChEMBL. 9057859
Log (binding) = 0.19 1/IC50 Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor ChEMBL. 12699379

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.