Detailed information for compound 583832

Basic information

Technical information
  • TDR Targets ID: 583832
  • Name: 6-acetyl-2-amino-1,7,8,9-tetrahydropyrimido[4 ,5-b][1,4]diazepin-4-one
  • MW: 221.216 | Formula: C9H11N5O2
  • H donors: 3 H acceptors: 2 LogP: -1.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)C1=Nc2c(NCC1)[nH]c(nc2=O)N
  • InChi: 1S/C9H11N5O2/c1-4(15)5-2-3-11-7-6(12-5)8(16)14-9(10)13-7/h2-3H2,1H3,(H4,10,11,13,14,16)
  • InChiKey: XEAAIJWYCBLWNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-azanyl-6-ethanoyl-1,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-4-one
  • 2-amino-4-oxo-6-acetyl-7,8-dihydro-3H,9H-pyrimidodiazepine
  • 6-acetyl-2-amino-1,7,8,9-tetrahydropyrimido[6,5-b][1,4]diazepin-4-one
  • 2-amino-6-ethanoyl-1,7,8,9-tetrahydropyrimido[6,5-b][1,4]diazepin-4-one
  • 80003-63-0
  • C02587
  • 4H-Pyrimido(4,5-b)(1,4)diazepin-4-one, 6-acetyl-2-amino-1,7,8,9-tetrahydro-
  • 6-Acetyldihydrohomopterin
  • Pyrimidodiazepine
  • Aoadpd
  • Quench spot
  • 6-Acetylhomopterin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0367 0.0355
Onchocerca volvulus Alhambra homolog 0.0032 0.0205 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0622 0.0481
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0205 0.0193
Echinococcus granulosus importin subunit beta 1 0.0031 0.02 0.0188
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0428 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0176 0.0412
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0349 1
Entamoeba histolytica hypothetical protein 0.0025 0.0123 0.2222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0492 0.0552
Loa Loa (eye worm) hypothetical protein 0.0056 0.0527 0.0592
Loa Loa (eye worm) TAR-binding protein 0.0682 0.8699 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0092 0.1167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0767 0.0767
Brugia malayi Pre-SET motif family protein 0.0217 0.2622 0.3004
Schistosoma mansoni tar DNA-binding protein 0.0682 0.8699 0.8699
Echinococcus multilocularis cpg binding protein 0.0035 0.0248 0.0236
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0292 0.028
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0058 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0294 0.0324
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0058 0.0136
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0058 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2622 0.3004
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1487 0.1697
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0349 0.0388
Loa Loa (eye worm) hypothetical protein 0.0088 0.094 0.1067
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0767 0.24
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0437 0.0437
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1905 0.4473
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.206 0.2358
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0205 0.2069
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0868 0.0868
Mycobacterium tuberculosis Conserved protein 0.0075 0.0767 0.0736
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0058 0.0137
Brugia malayi beta-lactamase family protein 0.0075 0.0767 0.0869
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0204 0.2062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0294 0.0799
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0767 0.0736
Toxoplasma gondii ABC1 family protein 0.0075 0.0767 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0349 0.082
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0158 0.0371
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0622 0.0611
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0767 0.0736
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0058 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Mycobacterium ulcerans hypothetical protein 0.0075 0.0767 0.2329
Mycobacterium leprae Probable lipase LipE 0.0075 0.0767 0.5
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0092 0.0479
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.02 0.047
Echinococcus granulosus tar DNA binding protein 0.0682 0.8699 0.8698
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0058 0.0136
Brugia malayi jmjC domain containing protein 0.0042 0.0341 0.0379
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0622 0.0611
Echinococcus multilocularis dna polymerase eta 0.0043 0.0349 0.0337
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0419 0.0983
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1487 0.1697
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0058 0.0046
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.234 0.233
Trichomonas vaginalis esterase, putative 0.0075 0.0767 0.24
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0349 0.0337
Schistosoma mansoni microtubule-associated protein tau 0.0782 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1882 0.1872
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0058 0.0053
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0058 0.0053
Brugia malayi Importin beta-1 subunit 0.0031 0.02 0.0216
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0216
Entamoeba histolytica hypothetical protein 0.0028 0.0158 0.3434
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1147 0.1136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.3048 0.3048
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0622 0.0622
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0349 0.0337
Echinococcus multilocularis tar DNA binding protein 0.0682 0.8699 0.8698
Brugia malayi beta-lactamase 0.0075 0.0767 0.0869
Onchocerca volvulus 0.0032 0.0204 0.002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Schistosoma mansoni hypothetical protein 0.0445 0.5602 0.5602
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.02 0.2005
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0123 0.0219
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0349 0.082
Schistosoma mansoni hypothetical protein 0.0037 0.027 0.027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0294 0.8114
Toxoplasma gondii hypothetical protein 0.0055 0.0511 0.639
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0342 0.4259 1
Schistosoma mansoni DNA polymerase eta 0.0043 0.0349 0.0349
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0092 0.0216
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0058 0.0136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0106 0.025
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1882 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0349 0.082
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0294 0.0691
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0058 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0646 0.0729
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0622 0.1522
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0527 0.0592
Onchocerca volvulus 0.0075 0.0767 0.2021
Echinococcus granulosus dna polymerase eta 0.0043 0.0349 0.0337
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0058 0.0046
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0349 0.082
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0083 0.0081
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0158 0.0371
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0092 0.0216
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0123 0.0219
Echinococcus multilocularis importin subunit beta 1 0.0031 0.02 0.0188
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0205 0.0205
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0346 0.9882
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0767 0.0736
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0767 0.24
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.018 0.0168
Onchocerca volvulus 0.0101 0.1103 0.3216
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0123 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.3048 0.3048
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0092 0.008
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0058 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.02 0.047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0767 0.0869
Mycobacterium ulcerans lipase LipD 0.0075 0.0767 0.2329
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0058 0.0136
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0123 0.0288
Onchocerca volvulus 0.0075 0.0767 0.2021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0349 0.082
Mycobacterium ulcerans hypothetical protein 0.018 0.2144 1
Trypanosoma brucei unspecified product 0.0029 0.0176 0.0412
Brugia malayi Bromodomain containing protein 0.0038 0.0288 0.0317
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0428 0.1254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.3048 0.304
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0492 0.0552
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0158 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Schistosoma mansoni hypothetical protein 0.0301 0.3723 0.3723
Brugia malayi Bromodomain containing protein 0.0044 0.0366 0.0407
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0367 0.0355
Schistosoma mansoni hypothetical protein 0.0022 0.0073 0.0073
Trypanosoma brucei glucosidase, putative 0.0039 0.0294 0.0691
Echinococcus granulosus peregrin 0.0038 0.0288 0.0276
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0437 0.0437
Trichomonas vaginalis ran, putative 0.0023 0.0092 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0294 0.0799
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.206 0.2051
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0092 0.0092
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0294 0.3331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0767 0.0869
Schistosoma mansoni importin beta-1 0.0031 0.02 0.02
Schistosoma mansoni ran 0.0023 0.0092 0.0092
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0527 0.0515
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0092 0.008
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0158 0.0158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0349 0.0985
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.4259 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1147 0.1136
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0294 0.0691
Giardia lamblia PHD finger protein 15 0.0032 0.0205 0.504
Loa Loa (eye worm) hypothetical protein 0.0054 0.0501 0.0562
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1905 0.4473
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0058 0.0137
Mycobacterium tuberculosis Conserved protein 0.0075 0.0767 0.0736
Loa Loa (eye worm) hypothetical protein 0.005 0.0437 0.0489
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0205 0.2069
Schistosoma mansoni tar DNA-binding protein 0.0682 0.8699 0.8699
Loa Loa (eye worm) hypothetical protein 0.0032 0.0205 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.3048 0.304
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0527 0.0515
Schistosoma mansoni bromodomain containing protein 0.0072 0.0731 0.0731
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0283 0.0271
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1882 0.1882
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0058 0.0136
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0092 0.0216
Schistosoma mansoni cpg binding protein 0.0031 0.0198 0.0198
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0346 1
Trypanosoma brucei unspecified product 0.0043 0.0349 0.082
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3012 1
Schistosoma mansoni tar DNA-binding protein 0.0682 0.8699 0.8699
Loa Loa (eye worm) hypothetical protein 0.005 0.0448 0.0502
Brugia malayi RNA binding protein 0.0682 0.8699 1
Echinococcus granulosus geminin 0.0714 0.9117 0.9116
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0294 0.0799
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0158 0.0146
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.206 0.2051
Brugia malayi Pre-SET motif family protein 0.0032 0.0204 0.0221
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.4164 0.4779
Mycobacterium tuberculosis Conserved protein 0.0075 0.0767 0.0736
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0024 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0058 0.0136
Echinococcus multilocularis zinc finger protein 0.0026 0.0132 0.012
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0058 0.0136
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0198 0.0214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Leishmania major DNA polymerase kappa, putative 0.0043 0.0349 0.082
Echinococcus multilocularis geminin 0.0714 0.9117 0.9116
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0349 0.0349
Brugia malayi MH2 domain containing protein 0.013 0.1487 0.1697
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0058 0.0136
Onchocerca volvulus 0.0247 0.3012 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0283 0.0271
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0767 0.0736
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0767 0.0767
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0294 0.0799
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0294 0.0324
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0349 0.0985
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Loa Loa (eye worm) beta-lactamase 0.0075 0.0767 0.0869
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0123 0.0219
Loa Loa (eye worm) MBCTL1 0.0056 0.0527 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0249 0.3048 0.3495
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0767 0.0756
Plasmodium vivax SET domain protein, putative 0.0032 0.0204 0.1663
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0058 0.0053
Schistosoma mansoni alpha glucosidase 0.0039 0.0294 0.0294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0622 0.1461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0249 0.3048 0.304
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0437 0.0489
Schistosoma mansoni alpha-glucosidase 0.015 0.1744 0.1744
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0158 0.0168
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0294 0.8114
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0437 0.0437
Brugia malayi PHD-finger family protein 0.0032 0.0205 0.0221
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0058 0.0058
Brugia malayi Bromodomain containing protein 0.0084 0.0892 0.1012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0058 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0556 0.1306
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0437 0.0426
Schistosoma mansoni cpg binding protein 0.0035 0.0248 0.0248
Leishmania major hypothetical protein, conserved 0.0075 0.0767 0.1801
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0349 0.082
Onchocerca volvulus 0.005 0.0437 0.0849
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0622 0.0622
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0767 0.24
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0428 0.4985
Brugia malayi RNA recognition motif domain containing protein 0.0682 0.8699 1
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0341 0.0329
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0058 0.0136
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0527 0.0527
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0058 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0205 0.0221
Brugia malayi mbt repeat family protein 0.005 0.0437 0.0489
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0527 0.0515
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.2144 0.316
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0349 0.0337
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0123 0.0123
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0024 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0682 0.8699 1
Echinococcus multilocularis dnaJ subfamily B 0.0445 0.5602 0.5597
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.1905 0.4473
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0682 0.8699 0.8699
Brugia malayi hypothetical protein 0.0088 0.094 0.1067
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0428 0.1254
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0349 0.082
Loa Loa (eye worm) acetyltransferase 0.016 0.1882 0.2153
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0054 0.0492 0.0552
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0294 0.0282
Leishmania major importin beta-1 subunit, putative 0.0025 0.0123 0.0288
Onchocerca volvulus 0.0075 0.0767 0.2021
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0346 0.9882
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.234 0.233
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0767 0.0756
Leishmania major GTP-binding protein, putative 0.0023 0.0092 0.0216
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0294 0.0799
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0073 0.007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.206 0.2051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0349 0.082
Entamoeba histolytica Ran family GTPase 0.0023 0.0092 0.1167
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.4259 1
Echinococcus granulosus cpg binding protein 0.0035 0.0248 0.0236
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0437 0.0426
Schistosoma mansoni ran 0.0023 0.0092 0.0092
Brugia malayi RNA, U transporter 1 0.0089 0.0956 0.1086
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0024 0.0024
Schistosoma mansoni alpha-glucosidase 0.015 0.1744 0.1744
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0058 0.0136
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0205 0.0193
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0622 0.7958
Plasmodium vivax importin-beta 2, putative 0.0031 0.02 0.1602
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0438 0.0426
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0294 0.0691
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0767 0.2329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0438 0.0438
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0249 0.3048 0.3495
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0767 0.2329
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0294 0.0282
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0042 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.0342 0.4259 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0419 0.0983
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0428 0.5225
Echinococcus multilocularis peregrin 0.0038 0.0288 0.0276
Leishmania major DNA polymerase eta, putative 0.0043 0.0349 0.082
Brugia malayi CXXC zinc finger family protein 0.0031 0.0198 0.0214
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0294 0.0799
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0158 0.0146
Loa Loa (eye worm) RNA binding protein 0.0682 0.8699 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0058 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.0782 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0767 0.1801
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0294 0.0799
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0349 0.0388
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.035
Echinococcus granulosus zinc finger protein 0.0026 0.0132 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0294 0.0799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0204 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0622 0.1522
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0204 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0671 0.0671
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0419 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0176 0.0412
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0767 0.0736
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0108
Brugia malayi PHD-finger family protein 0.0032 0.0205 0.0222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0349 0.0349
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0341 0.0379
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0478 0.603 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0349 0.082
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0205 0.167
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0335 0.4164 0.4164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0661 0.8509
Mycobacterium ulcerans beta-lactamase 0.0075 0.0767 0.2329
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0767 0.1801
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0294 0.0799
Brugia malayi mbt repeat family protein 0.005 0.0437 0.0489
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0527 0.0515
Plasmodium falciparum phd finger protein, putative 0.0032 0.0205 0.4444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0158 0.0338
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0767 0.0736
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0767 0.24
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0767 1
Giardia lamblia DINP protein human, muc B family 0.0043 0.0349 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.206 0.2358
Loa Loa (eye worm) hypothetical protein 0.0043 0.0349 0.0388
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0622 0.1522
Schistosoma mansoni hypothetical protein 0.0714 0.9117 0.9117
Loa Loa (eye worm) hypothetical protein 0.0088 0.094 0.1067
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0349 0.0388
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Trypanosoma brucei unspecified product 0.0029 0.0176 0.0412
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0176 0.0412
Brugia malayi TAR-binding protein 0.0682 0.8699 1
Schistosoma mansoni tar DNA-binding protein 0.0682 0.8699 0.8699
Echinococcus granulosus snurportin 1 0.0335 0.4164 0.4157
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0349 0.082
Schistosoma mansoni eyes absent homolog 0.0088 0.094 0.094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0438 0.0426
Echinococcus granulosus dnaJ subfamily B 0.0445 0.5602 0.5597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0492 0.0552
Echinococcus granulosus dna polymerase kappa 0.0043 0.0349 0.0337
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0682 0.067
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0437 0.0426
Schistosoma mansoni hypothetical protein 0.0714 0.9117 0.9117
Schistosoma mansoni zinc finger protein 0.0026 0.0132 0.0132
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0437 0.0849
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0058 0.0046
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0437 0.0426
Brugia malayi jmjC domain containing protein 0.0104 0.1147 0.1306
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0767 0.24
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0438 0.0438
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0204 0.0192
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0428 0.5225
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0419 0.0983
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0767 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0682 0.067
Echinococcus multilocularis snurportin 1 0.0335 0.4164 0.4157
Plasmodium falciparum importin beta, putative 0.0031 0.02 0.4265
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.027 0.0296
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0767 0.0736
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.1792 0.1782
Loa Loa (eye worm) hypothetical protein 0.0074 0.0759 0.086
Schistosoma mansoni hypothetical protein 0.0032 0.0205 0.0205
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0092 0.0092
Schistosoma mansoni cpg binding protein 0.0035 0.0248 0.0248
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0123 0.011
Loa Loa (eye worm) hypothetical protein 0.0075 0.0767 0.0869
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0341 0.0341
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0349 0.082
Brugia malayi beta-lactamase family protein 0.0075 0.0767 0.0869
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0249 0.3048 0.304
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0767 0.1801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0249 0.3048 0.3048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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