Detailed information for compound 583876

Basic information

Technical information
  • TDR Targets ID: 583876
  • Name: 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydrox ymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
  • MW: 270.217 | Formula: C10H11FN4O4
  • H donors: 3 H acceptors: 6 LogP: -0.55 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1cnc2c1ncnc2O
  • InChi: 1S/C10H11FN4O4/c11-5-7(17)4(1-16)19-10(5)15-3-14-6-8(15)12-2-13-9(6)18/h2-5,7,10,16-17H,1H2,(H,12,13,18)/t4-,5-,7-,10-/m1/s1
  • InChiKey: NRVOTDBYJXFINS-QYYRPYCUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-purin-6-one
  • 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • 9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one
  • 2'-deoxy-2'-fluoroinosine
  • 80049-87-2
  • 9-(3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one
  • AIDS-223955
  • AIDS223955
  • 2'-Dfin
  • Inosine, 2'-deoxy-2'-fluoro-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0216 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0216 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0134 0.0753
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Echinococcus granulosus glycine receptor subunit alpha 1 0.0135 0.082 0.08
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0212 0.0381
Echinococcus multilocularis carboxylesterase 5A 0.069 0.4798 0.4786
Loa Loa (eye worm) acetylcholinesterase 1 0.069 0.4798 1
Onchocerca volvulus 0.0117 0.0688 0.2009
Brugia malayi hypothetical protein 0.0117 0.0688 0.138
Echinococcus multilocularis glycine receptor subunit beta 0.0135 0.082 0.08
Mycobacterium ulcerans carboxylesterase, LipT 0.0117 0.0688 1
Echinococcus granulosus zinc finger protein 0.0026 0.0035 0.0013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0135 0.082 0.1658
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.012 0.0098
Schistosoma mansoni hypothetical protein 0.1294 0.9123 0.9123
Entamoeba histolytica hypothetical protein 0.0026 0.0037 0.0194
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.1251 0.1232
Brugia malayi CHE-14 protein 0.0044 0.0167 0.0287
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0585 0.0564
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0899 0.0879
Plasmodium falciparum glutathione reductase 0.0071 0.0365 0.6365
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0039 0.0033
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0098 0.0558 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0039 0.0033
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0135 0.082 0.08
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0037 0.0015
Brugia malayi Carboxylesterase family protein 0.0117 0.0688 0.138
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0039 0.0508
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0213 0.2823
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0135 0.082 0.0815
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0039 0.0017
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0257 0.0475
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0154 0.0132
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0107 0.1222
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0135 0.082 0.08
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0025 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0299 0.0277
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0135 0.082 0.0815
Loa Loa (eye worm) hypothetical protein 0.069 0.4798 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.069 0.4798 0.4795
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0202 0.0409
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0091 0.0068
Schistosoma mansoni hypothetical protein 0.0176 0.1113 0.1108
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0117 0.0688 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0299 0.0293
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0037 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0213 0.2823
Echinococcus multilocularis acetylcholinesterase 0.069 0.4798 0.4786
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0062 0.0299 0.0611
Loa Loa (eye worm) carboxylesterase 0.0117 0.0688 0.1423
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0039 0.0508
Brugia malayi jmjC domain containing protein 0.0026 0.0039 0.0019
Loa Loa (eye worm) hypothetical protein 0.004 0.0138 0.0275
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0374 0.0721
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0202 0.018
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Loa Loa (eye worm) LGC-31 protein 0.0135 0.082 0.1699
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0135 0.082 0.1658
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0135 0.082 0.08
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0596 0.0591
Mycobacterium tuberculosis Carboxylesterase LipT 0.0117 0.0688 1
Echinococcus granulosus dnaJ subfamily B 0.1294 0.9123 0.9121
Brugia malayi Cation transporter family protein 0.0135 0.082 0.1658
Echinococcus granulosus muscleblind protein 0.0155 0.0964 0.0944
Echinococcus multilocularis zinc finger protein 0.0026 0.0035 0.0013
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0154 0.0132
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0071 0.0365 0.511
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0039 0.0117
Schistosoma mansoni zinc finger protein 0.0026 0.0035 0.0029
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0344 0.6082
Echinococcus multilocularis GPCR, family 2 0.0049 0.0202 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0025 0.003 0.0065
Brugia malayi Pre-SET motif family protein 0.0033 0.0089 0.0124
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0057 0.0035
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0069 0.0047
Loa Loa (eye worm) hypothetical protein 0.069 0.4798 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Echinococcus multilocularis nAChR subunit 0.0135 0.082 0.08
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.1001 0.098
Echinococcus granulosus nAChR subunit 0.0073 0.0374 0.0352
Brugia malayi Carboxylesterase family protein 0.0117 0.0688 0.138
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1181 0.6658
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0899 0.0879
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1181 0.6658
Loa Loa (eye worm) hypothetical protein 0.0246 0.1614 0.3355
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0039 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0325 0.0303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0039 0.0069
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0117 0.0688 0.0683
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0135 0.082 0.1699
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0062 0.0299 0.0564
Schistosoma mansoni lozenge 0.0058 0.0266 0.026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0073 0.0374 0.0721
Onchocerca volvulus 0.005 0.0212 0.0462
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0213 0.3516
Schistosoma mansoni hypothetical protein 0.003 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0242
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.003 0.0339
Echinococcus granulosus glycine receptor subunit alpha 1 0.0135 0.082 0.08
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0325 0.0303
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0242
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0135 0.082 0.1699
Echinococcus multilocularis para nitrobenzyl esterase 0.0117 0.0688 0.0667
Schistosoma mansoni gliotactin 0.0117 0.0688 0.0683
Echinococcus granulosus peregrin 0.0033 0.0087 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1415 0.2941
Leishmania major telomerase reverse transcriptase, putative 0.0098 0.0558 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0134 0.1918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0957 0.1944
Schistosoma mansoni alpha glucosidase 0.0039 0.0134 0.0128
Loa Loa (eye worm) hypothetical protein 0.046 0.3148 0.6557
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0039 0.024
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0037 0.0031
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0135 0.082 0.0815
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0471 0.045
Onchocerca volvulus 0.0062 0.0299 0.0745
Echinococcus multilocularis glycine receptor subunit beta 0.0135 0.082 0.08
Brugia malayi mbt repeat family protein 0.005 0.0207 0.0372
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0089 0.0067
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1614 0.1595
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0134 0.1918
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0135 0.082 0.0815
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1119 0.11
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0039 0.0017
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Loa Loa (eye worm) hypothetical protein 0.0314 0.2101 0.4372
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.003 1
Echinococcus granulosus phd:f box containing protein 0.0026 0.0039 0.0017
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Echinococcus granulosus acetylcholinesterase 0.069 0.4798 0.4786
Loa Loa (eye worm) hypothetical protein 0.0155 0.0964 0.1999
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0167 0.0941
Mycobacterium ulcerans hypothetical protein 0.005 0.0213 0.2823
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0957 0.1944
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0202 0.018
Brugia malayi jmjC domain containing protein 0.016 0.1001 0.2036
Brugia malayi hypothetical protein 0.0062 0.0299 0.0564
Echinococcus multilocularis expressed conserved protein 0.0096 0.0541 0.0519
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0467 0.7887
Brugia malayi PHD-finger family protein 0.0031 0.0075 0.0094
Echinococcus multilocularis Protein lozenge 0.0058 0.0266 0.0244
Schistosoma mansoni cpg binding protein 0.0098 0.0555 0.0549
Plasmodium vivax glutathione reductase, putative 0.0071 0.0365 0.6365
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Brugia malayi jmjC domain containing protein 0.0105 0.0604 0.1204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) acetylcholine receptor protein 0.0062 0.0299 0.0611
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0107 0.1222
Schistosoma mansoni nAChR subunit 0.0062 0.0299 0.0293
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1119 0.2323
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0134 0.2017
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0135 0.082 0.1658
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0957 0.1984
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0039 0.0017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0334 0.0312
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0483
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0025 0.003 0.0065
Brugia malayi hypothetical protein 0.0062 0.0299 0.0564
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0132
Loa Loa (eye worm) thioredoxin reductase 0.0071 0.0365 0.0748
Schistosoma mansoni survival motor neuron protein 0.005 0.0212 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0089 0.0083
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0037 0.01
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0585 0.1164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0037 0.0015
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0467 0.7887
Echinococcus granulosus GPCR family 2 0.0049 0.0202 0.018
Plasmodium vivax thioredoxin reductase, putative 0.0071 0.0365 0.6365
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0344 0.0658
Echinococcus granulosus geminin 0.0176 0.1113 0.1093
Echinococcus multilocularis thioredoxin glutathione reductase 0.0071 0.0365 0.0343
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0607 0.1211
Schistosoma mansoni neurotransmitter gated ion channel 0.0073 0.0374 0.0368
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.012 0.0098
Onchocerca volvulus 0.0248 0.1629 0.5066
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0213 0.2823
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0207 0.0185
Brugia malayi hypothetical protein 0.0062 0.0299 0.0564
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0065
Schistosoma mansoni hypothetical protein 0.0042 0.0156 0.015
Plasmodium vivax telomerase reverse transcriptase, putative 0.0098 0.0558 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0202 0.0361
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0117 0.0688 0.0683
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0334 0.0312
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0213 0.3344
Schistosoma mansoni hypothetical protein 0.0176 0.1113 0.1108
Schistosoma mansoni acetylcholine receptor-related 0.0062 0.0299 0.0293
Schistosoma mansoni hypothetical protein 0.0105 0.0607 0.0602
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0216 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0167 0.0145
Brugia malayi jmjC domain containing protein 0.0026 0.0039 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1614 0.1595
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1678
Loa Loa (eye worm) hypothetical protein 0.005 0.0213 0.0432
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0553 0.0532
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0213 0.2823
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0213 0.2823
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Plasmodium falciparum telomerase reverse transcriptase 0.0098 0.0558 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0122 0.1444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0107 0.1222
Brugia malayi Cation transporter family protein 0.0135 0.082 0.1658
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0242
Schistosoma mansoni hypothetical protein 0.0042 0.0156 0.015
Loa Loa (eye worm) ACC-1 protein 0.0135 0.082 0.1699
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0213 0.3516
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0325 0.5613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0325 0.4507
Onchocerca volvulus 0.0135 0.082 0.2439
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0066 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0202 0.018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0134 0.0217
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.1774 0.3658
Echinococcus multilocularis muscleblind protein 0.0155 0.0964 0.0944
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.036 0.2434 0.7681
Loa Loa (eye worm) hypothetical protein 0.0068 0.0341 0.0699
Loa Loa (eye worm) hypothetical protein 0.0155 0.0964 0.1999
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.012 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0176 0.1111 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0607 0.1255
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0213 0.3344
Onchocerca volvulus 0.0135 0.082 0.2439
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0039 0.0069
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0073 0.0374 0.0368
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Plasmodium falciparum thioredoxin reductase 0.0025 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0207 0.0185
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0135 0.082 0.1699
Loa Loa (eye worm) hypothetical protein 0.0086 0.0467 0.0962
Schistosoma mansoni alpha-glucosidase 0.0152 0.0943 0.0938
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.1774 0.369
Brugia malayi hypothetical protein 0.0062 0.0299 0.0564
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.0604 0.1248
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0062 0.0299 0.0277
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0025 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0122 0.1799
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0135 0.082 0.08
Brugia malayi mbt repeat family protein 0.005 0.0207 0.0372
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0471 0.0925
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Echinococcus granulosus neuroligin 0.0117 0.0688 0.0667
Echinococcus granulosus BC026374 protein S09 family 0.0117 0.0688 0.0667
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0471 0.0465
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0135 0.082 0.08
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0134 0.2237
Onchocerca volvulus 0.0086 0.0471 0.1305
Onchocerca volvulus 0.0091 0.0503 0.141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.003 0.0065
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0299 0.0293
Schistosoma mansoni hypothetical protein 0.0037 0.012 0.0114
Loa Loa (eye worm) hypothetical protein 0.0073 0.0379 0.0778
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0025 0.003 0.0008
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0039 0.0017
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0135 0.082 0.08
Echinococcus granulosus glycine receptor subunit beta 0.0135 0.082 0.08
Loa Loa (eye worm) GABA receptor subunit 0.0073 0.0374 0.0768
Trypanosoma cruzi trypanothione reductase, putative 0.0025 0.003 0.0339
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0344 0.0322
Brugia malayi hypothetical protein 0.0246 0.1614 0.3321
Onchocerca volvulus 0.0135 0.082 0.2439
Schistosoma mansoni alpha-glucosidase 0.0152 0.0943 0.0938
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0374 0.0721
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1119 0.2285
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0025 0.003 0.0065
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0167 0.0145
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0135 0.082 0.08
Echinococcus granulosus carboxylesterase 5A 0.069 0.4798 0.4786
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0025 0.003 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0325 0.4507
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0069
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0207 0.0202
Onchocerca volvulus 0.0117 0.0688 0.2009
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0167 0.0336
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.03 0.0614
Echinococcus multilocularis protein dispatched 1 0.005 0.0211 0.0189
Toxoplasma gondii RNA-directed DNA polymerase 0.0098 0.0558 0.4896
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0091 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1113 0.3391
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0135 0.082 0.08
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0344 0.0705
Loa Loa (eye worm) hypothetical protein 0.005 0.0213 0.0432
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Onchocerca volvulus 0.005 0.0207 0.0448
Giardia lamblia PHD finger protein 15 0.003 0.0069 0.0748
Echinococcus granulosus glycine receptor subunit beta 0.0135 0.082 0.08
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0135 0.082 0.1658
Brugia malayi Carboxylesterase family protein 0.0117 0.0688 0.138
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0135 0.082 0.08
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0137 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0134 0.0112
Brugia malayi Carboxylesterase family protein 0.0117 0.0688 0.138
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.1001 0.098
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0117 0.0688 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0299 0.0564
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0025 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0344 0.5971
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0213 0.3344
Brugia malayi AMP-binding enzyme family protein 0.005 0.0213 0.0384
Brugia malayi CXXC zinc finger family protein 0.0091 0.0503 0.0993
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0025 0.003 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0134 0.0753
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0135 0.082 0.0815
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0134 0.0753
Brugia malayi jmjC domain containing protein 0.0026 0.0039 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0025 0.003 0.0185
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0202 0.0361
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0325 0.0319
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0585 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0325 0.4507
Loa Loa (eye worm) hypothetical protein 0.0051 0.0216 0.0438
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0344 0.0338
Brugia malayi Bromodomain containing protein 0.0083 0.0448 0.0876
Echinococcus multilocularis neuroligin 0.0117 0.0688 0.0667
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0207 0.0448
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0257 0.0235
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0073 0.0374 0.0368
Giardia lamblia Telomerase catalytic subunit 0.0098 0.0558 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0213 0.2823
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0135 0.082 0.1658
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0122 0.1444
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Echinococcus multilocularis dnaJ subfamily B 0.1294 0.9123 0.9121
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0216 0.0194
Echinococcus granulosus glycine receptor subunit alpha 1 0.0135 0.082 0.08
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0196
Schistosoma mansoni acetylcholine receptor subunit beta 0.0062 0.0299 0.0293
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0471 0.045
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0037 0.0204
Schistosoma mansoni hypothetical protein 0.005 0.0212 0.0206
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0135 0.082 0.08
Leishmania major trypanothione reductase 0.0071 0.0365 0.6365
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0207 0.0185
Onchocerca volvulus 0.0117 0.0688 0.2009
Schistosoma mansoni neuroligin 3 (S09 family) 0.0117 0.0688 0.0683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0242
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0062 0.0117
Brugia malayi hypothetical protein 0.0314 0.2101 0.4344
Toxoplasma gondii NADPH-glutathione reductase 0.0025 0.003 0.0032
Echinococcus multilocularis peregrin 0.0033 0.0087 0.0065
Brugia malayi excitatory GABA receptor EXP-1A 0.0135 0.082 0.1658
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0025 0.003 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0107 0.1222
Brugia malayi hypothetical protein 0.046 0.3148 0.654
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0134 0.0987
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0134 0.0266
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0039 0.0117
Echinococcus granulosus transcription factor Dp 1 0.004 0.0137 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.1416 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0167 0.0336
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0117 0.0688 0.3879
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.0604 0.0583
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0057 0.0051
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0117 0.0688 0.0667
Brugia malayi Cation transporter family protein 0.0135 0.082 0.1658
Plasmodium falciparum glutathione reductase 0.0025 0.003 0.0065
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0196
Onchocerca volvulus 0.0033 0.0089 0.0063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0257 0.0235
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1678
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0207 0.0185
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0135 0.082 0.1699
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1629 0.9184
Loa Loa (eye worm) hypothetical protein 0.005 0.0213 0.0432
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0207 0.0202
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0135 0.082 0.08
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0344 0.6082
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0025 0.003 0.0024
Brugia malayi Telomerase reverse transcriptase 0.0262 0.1729 0.3564
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0257 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0213 0.2823
Loa Loa (eye worm) ACC-1 protein 0.0135 0.082 0.1699
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0025 0.003 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0325 0.0319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1119 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0134 0.2237
Plasmodium vivax hypothetical protein, conserved 0.003 0.0069 0.0808
Trichomonas vaginalis mercuric reductase, putative 0.0025 0.003 0.0169
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0025 0.003 0.0065
Onchocerca volvulus 0.0314 0.2101 0.6599
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0134 0.0112
Schistosoma mansoni patched 1 0.0044 0.0167 0.0161
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0073 0.0374 0.0721
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0207 0.0202
Plasmodium falciparum thioredoxin reductase 0.0071 0.0365 0.6365
Onchocerca volvulus 0.0062 0.0299 0.0745
Schistosoma mansoni cpg binding protein 0.0098 0.0555 0.0549
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0134 0.0753
Loa Loa (eye worm) hypothetical protein 0.0086 0.0471 0.0971
Loa Loa (eye worm) hypothetical protein 0.0056 0.0257 0.0523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0604 0.0598
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Echinococcus granulosus para nitrobenzyl esterase 0.0117 0.0688 0.0667
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0213 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0134 0.2017
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0025 0.003 0.0362
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0039 0.0033
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0135 0.082 0.08
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0025 0.003 0.0065
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0257 0.0251
Loa Loa (eye worm) hypothetical protein 0.0042 0.0156 0.0312
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0062 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.012 0.0098
Brugia malayi hypothetical protein 0.0037 0.012 0.0189
Echinococcus multilocularis BC026374 protein (S09 family) 0.0117 0.0688 0.0667
Brugia malayi AMP-binding enzyme family protein 0.005 0.0213 0.0384
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0135 0.082 0.1658
Plasmodium vivax JmjC domain containing protein 0.0026 0.0039 0.024
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0134 0.0753
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0135 0.082 0.1658
Leishmania major hypothetical protein, conserved 0.0026 0.0039 0.024
Schistosoma mansoni acetylcholinesterase 0.0117 0.0688 0.0683
Schistosoma mansoni hypothetical protein 0.0301 0.201 0.2005
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Brugia malayi Muscleblind-like protein 0.0155 0.0964 0.1959
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0503 0.1038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0242
Schistosoma mansoni cpg binding protein 0.0091 0.0503 0.0498
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0039 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.012 0.0114
Trypanosoma brucei trypanothione reductase 0.0071 0.0365 0.6365
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0093 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0135 0.082 0.08
Loa Loa (eye worm) MBCTL1 0.0056 0.0257 0.0523
Onchocerca volvulus 0.0062 0.0299 0.0745
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0039 0.0017
Echinococcus multilocularis protein patched 0.0044 0.0167 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Loa Loa (eye worm) hypothetical protein 0.0154 0.0957 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0037 0.0211
Onchocerca volvulus 0.0073 0.0374 0.0989
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.1241 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0062 0.0299 0.0564
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0089 0.0083
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Loa Loa (eye worm) glutathione reductase 0.0071 0.0365 0.0748
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0039 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0134 0.0753
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0325 0.2748
Loa Loa (eye worm) hypothetical protein 0.0102 0.0585 0.1208
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0062 0.0299 0.0277
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0062 0.004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.0409
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0135 0.082 0.1699
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1678
Loa Loa (eye worm) carboxylesterase 0.069 0.4798 1
Brugia malayi Thioredoxin reductase 0.0071 0.0365 0.0702
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0365 0.6465
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0025 0.003 0.0052
Onchocerca volvulus 0.0102 0.0585 0.1675
Brugia malayi jmjC domain containing protein 0.0026 0.0039 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0213 0.2823
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0135 0.082 0.1658
Echinococcus multilocularis microtubule associated protein 2 0.1416 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0207 0.0419
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0039 0.024
Brugia malayi hypothetical protein 0.0062 0.0299 0.0564
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0207 0.042
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0299 0.0611
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0604 0.0598
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0025 0.003 0.0052
Brugia malayi Bromodomain containing protein 0.004 0.0138 0.0226
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0135 0.082 0.1699
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0135 0.082 0.08
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0117 0.0688 0.0683
Plasmodium falciparum phd finger protein, putative 0.003 0.0069 0.0808
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0299 0.0277
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0134 0.0753
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0134 0.0753
Schistosoma mansoni nAChR subunit 0.0062 0.0299 0.0293
Onchocerca volvulus 0.046 0.3148 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0057 0.0035
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0135 0.082 0.1658
Echinococcus granulosus thioredoxin glutathione reductase 0.0071 0.0365 0.0343
Schistosoma mansoni BC026374 protein (S09 family) 0.0117 0.0688 0.0683
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0344 0.0322
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Entamoeba histolytica hypothetical protein 0.0037 0.012 0.1678
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0135 0.082 0.08
Schistosoma mansoni bromodomain containing protein 0.0071 0.0361 0.0355
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0344 0.5971
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0135 0.082 0.0815
Trichomonas vaginalis spcc417.12 protein, putative 0.0117 0.0688 0.3879
Onchocerca volvulus 0.0117 0.0688 0.2009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0135 0.082 0.08
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0089 0.0575
Entamoeba histolytica hypothetical protein 0.0073 0.0374 0.6219
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0135 0.082 0.1658
Schistosoma mansoni jumonji domain containing protein 0.014 0.0855 0.0849
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0117 0.0688 0.0667
Onchocerca volvulus 0.0135 0.082 0.2439
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Loa Loa (eye worm) hypothetical protein 0.046 0.3148 0.6557
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0299 0.0564
Brugia malayi Carboxylesterase family protein 0.069 0.4798 1
Loa Loa (eye worm) carboxylesterase 0.0117 0.0688 0.1423
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0145 0.024
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0964 0.0944
Onchocerca volvulus 0.0135 0.082 0.2439
Onchocerca volvulus 0.005 0.0213 0.0467
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0299 0.0564
Schistosoma mansoni hypothetical protein 0.0042 0.0156 0.015
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0062 0.0299 0.0277
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0213 1
Schistosoma mansoni nAChR subunit 0.0135 0.082 0.0815
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0025 0.003 0.0339
Trichomonas vaginalis glutathione reductase, putative 0.0025 0.003 0.0169
Brugia malayi glutathione reductase 0.0071 0.0365 0.0702
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0069 0.0063
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.003 0.0052
Trypanosoma brucei telomerase reverse transcriptase 0.0098 0.0558 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.1251 0.1232
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0167 0.0145
Brugia malayi Bromodomain containing protein 0.0033 0.0087 0.012
Schistosoma mansoni hypothetical protein 0.0042 0.0156 0.015
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0025 0.003 0.0052
Onchocerca volvulus Putative nachr subunit 0.0135 0.082 0.2439
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0069 0.0047
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0065
Echinococcus multilocularis geminin 0.0176 0.1113 0.1093
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0213 0.3516
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Onchocerca volvulus 0.0073 0.0374 0.0989
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0344 0.5679
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0069 0.0396
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0122 0.1799
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1119 0.11
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0257 0.0235
Plasmodium vivax SET domain protein, putative 0.0033 0.0089 0.1174
Schistosoma mansoni hypothetical protein 0.0049 0.0202 0.0196
Echinococcus granulosus nAChR subunit 0.0135 0.082 0.08
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0037 0.0474
Brugia malayi Carboxylesterase family protein 0.069 0.4798 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0062 0.0299 0.0564
Treponema pallidum NADH oxidase 0.0025 0.003 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0202 0.018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0299 0.0611
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0135 0.082 0.1658
Onchocerca volvulus 0.0117 0.0688 0.2009
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0134 0.0753
Echinococcus granulosus acetylcholinesterase 0.069 0.4798 0.4786
Onchocerca volvulus 0.0135 0.082 0.2439
Echinococcus multilocularis nAChR subunit 0.0073 0.0374 0.0352
Echinococcus granulosus expressed conserved protein 0.0096 0.0541 0.0519
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0213 0.2823
Echinococcus multilocularis cpg binding protein 0.0098 0.0555 0.0534
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0039 0.0017
Brugia malayi Pre-SET motif family protein 0.0218 0.1415 0.2906
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.042
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0025 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.0135 0.082 0.1699
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0025 0.003 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0025 0.003 0.0339
Loa Loa (eye worm) runx1 0.0058 0.0266 0.0542
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0039 0.0033
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0325 0.4507
Toxoplasma gondii thioredoxin reductase 0.0071 0.0365 0.3116
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0098 0.0558 1
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0069 0.0132
Loa Loa (eye worm) hypothetical protein 0.0073 0.0374 0.0768
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0135 0.082 0.08
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0585 0.0564
Echinococcus multilocularis acetylcholinesterase 0.069 0.4798 0.4786
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0213 0.0384
Brugia malayi PHD-finger family protein 0.003 0.0069 0.0083
Echinococcus granulosus cpg binding protein 0.0098 0.0555 0.0534
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0069 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1774 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0025 0.003 0.0065
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0135 0.082 0.08
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1113 0.6275

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 8 uM compound was tested in vitro for anti HBV activity in HepG2 2.2.15 cells ChEMBL. 9276020
IC50 (functional) > 100 uM The cytotoxicity of the compound was tested against CEM cells ChEMBL. 9276020
IC50 (functional) > 200 uM The cytotoxicity of the compound was tested against 2.2.15 cells expressed as IC50 ChEMBL. 9276020

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9276020

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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