Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0228 | 0.0566 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0448 | 0.0551 |
Schistosoma mansoni | intermediate filament proteins | 0.0052 | 0.0448 | 0.0469 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0458 | 0.0485 |
Echinococcus granulosus | intermediate filament protein | 0.0052 | 0.0448 | 0.0533 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.0458 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.0458 | 0.0549 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0227 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0052 | 0.0448 | 0.0347 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0118 | 0.1016 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0384 | 0.0434 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0458 | 0.1447 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0415 | 0.0635 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0502 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0204 | 0.0172 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0531 | 0.6541 | 1 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0415 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0228 | 0.0566 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.009 | 0.0927 | 0.2931 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.3663 | 0.5497 |
Onchocerca volvulus | 0.009 | 0.0927 | 0.3044 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0228 | 0.5 |
Echinococcus multilocularis | geminin | 0.0331 | 0.4002 | 0.3939 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0228 | 0.322 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0152 | 0.0006 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.0458 | 0.0549 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.0458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0384 | 0.0282 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0384 | 0.0369 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0228 | 0.0209 |
Echinococcus multilocularis | musashi | 0.0052 | 0.0448 | 0.0347 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.1252 | 0.1798 |
Schistosoma mansoni | lamin | 0.0052 | 0.0448 | 0.0469 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.0458 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0384 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0118 | 0.0039 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0415 | 0.0314 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0118 | 0.018 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0228 | 0.0566 |
Echinococcus granulosus | carboxylesterase 5A | 0.0531 | 0.6541 | 1 |
Brugia malayi | intermediate filament protein | 0.0052 | 0.0448 | 0.0685 |
Onchocerca volvulus | 0.0035 | 0.0228 | 0.0297 | |
Brugia malayi | Carboxylesterase family protein | 0.009 | 0.0927 | 0.1417 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0152 | 0.0006 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0204 | 0.0312 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0148 | 0.0044 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.009 | 0.0927 | 0.1217 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0228 | 0.3909 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0148 | 0.0888 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0228 | 0.3909 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0228 | 0.0348 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0415 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0105 | 0.0019 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0384 | 0.0369 |
Onchocerca volvulus | 0.0229 | 0.2697 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0227 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0384 | 0.0452 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.1252 | 0.1915 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0148 | 0.2759 |
Onchocerca volvulus | 0.009 | 0.0927 | 0.3044 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0384 | 0.0434 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0152 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.4002 | 0.6029 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0152 | 0.0047 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0398 | 0.0608 |
Echinococcus granulosus | lamin dm0 | 0.0052 | 0.0448 | 0.0533 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0227 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0152 | 0.0006 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0415 | 0.0314 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.0458 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0384 | 0.0369 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.009 | 0.0927 | 0.083 |
Brugia malayi | hypothetical protein | 0.009 | 0.0927 | 0.1417 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.009 | 0.0927 | 0.1217 |
Schistosoma mansoni | gliotactin | 0.009 | 0.0927 | 0.1217 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.2612 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.0458 | 0.0357 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0415 | 0.0418 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0148 | 0.0888 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0458 | 0.1447 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.009 | 0.0927 | 0.1217 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.0458 | 0.0357 |
Loa Loa (eye worm) | carboxylesterase | 0.009 | 0.0927 | 0.1293 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0502 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2343 | 0.349 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0502 | 0.0402 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0398 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.0458 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0531 | 0.6541 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0228 | 0.0124 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0138 | 0.0052 |
Schistosoma mansoni | acetylcholinesterase | 0.009 | 0.0927 | 0.1217 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.009 | 0.0927 | 0.083 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0052 | 0.0448 | 0.0551 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0415 | 0.1035 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0458 | 0.1447 |
Brugia malayi | Carboxylesterase family protein | 0.009 | 0.0927 | 0.1417 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0228 | 0.3909 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0152 | 0.0073 |
Echinococcus multilocularis | lamin | 0.0052 | 0.0448 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0228 | 0.0209 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0152 | 0.3096 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0502 | 0.0554 |
Onchocerca volvulus | 0.0052 | 0.0448 | 0.1163 | |
Brugia malayi | hypothetical protein | 0.0035 | 0.0227 | 0.0347 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0148 | 0.0227 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0228 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.009 | 0.0927 | 0.2931 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0152 | 0.0997 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0118 | 0.1016 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.1252 | 0.1798 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0148 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.2697 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0398 | 0.0473 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0228 | 0.0348 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0415 | 0.0418 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0415 | 0.0418 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.009 | 0.0927 | 0.1277 |
Echinococcus granulosus | snurportin 1 | 0.0305 | 0.3663 | 0.5528 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0152 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.3616 | 0.5424 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0384 | 0.0587 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0228 | 0.322 |
Brugia malayi | Carboxylesterase family protein | 0.009 | 0.0927 | 0.1417 |
Schistosoma mansoni | lamin | 0.0052 | 0.0448 | 0.0469 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.0458 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0502 | 0.0402 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.009 | 0.0927 | 0.2931 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0028 | 0.014 | 0.0214 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0531 | 0.6541 | 0.6504 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0228 | 0.0124 |
Echinococcus multilocularis | neuroligin | 0.009 | 0.0927 | 0.083 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0228 | 0.0124 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.0458 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0228 | 0.0348 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0502 | 0.0635 |
Onchocerca volvulus | 0.0035 | 0.0228 | 0.0297 | |
Echinococcus granulosus | acetylcholinesterase | 0.0531 | 0.6541 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0531 | 0.6541 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0531 | 0.6541 | 0.6504 |
Brugia malayi | Carboxylesterase family protein | 0.0531 | 0.6541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0152 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0148 | 0.0086 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.0458 | 0.0567 |
Loa Loa (eye worm) | intermediate filament protein | 0.0052 | 0.0448 | 0.0551 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0818 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0398 | 0.0473 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0227 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0415 | 0.05 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0305 | 0.3663 | 0.5536 |
Onchocerca volvulus | 0.0052 | 0.0448 | 0.1163 | |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0148 | 0.0067 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.014 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0204 | 0.0087 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0228 | 0.0566 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.009 | 0.0927 | 0.1277 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0502 | 0.0618 |
Onchocerca volvulus | 0.005 | 0.0415 | 0.1035 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0227 | 0.0124 |
Echinococcus granulosus | neuroligin | 0.009 | 0.0927 | 0.1277 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0228 | 0.0191 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0227 | 0.019 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.0458 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0118 | 0.1016 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0148 | 0.0888 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0227 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0531 | 0.6541 | 1 |
Onchocerca volvulus | 0.009 | 0.0927 | 0.3044 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0152 | 0.0006 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0228 | 0.0348 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0227 | 0.0124 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.009 | 0.0927 | 0.1217 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2343 | 0.3582 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0195 | 0.2268 | 0.2186 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0502 | 0.0635 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0052 | 0.0448 | 0.0685 |
Echinococcus multilocularis | snurportin 1 | 0.0305 | 0.3663 | 0.3595 |
Brugia malayi | Carboxylesterase family protein | 0.009 | 0.0927 | 0.1417 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0228 | 0.0566 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.009 | 0.0927 | 0.083 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.009 | 0.0927 | 0.3237 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0458 | 1 |
Onchocerca volvulus | 0.0035 | 0.0228 | 0.0297 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.009 | 0.0927 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0531 | 0.6541 | 0.6504 |
Loa Loa (eye worm) | carboxylesterase | 0.0531 | 0.6541 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0228 | 0.0209 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0458 | 0.1447 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0195 | 0.2268 | 0.3361 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.0458 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.009 | 0.0927 | 0.1277 |
Onchocerca volvulus | 0.009 | 0.0927 | 0.3044 | |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0415 | 0.0482 |
Onchocerca volvulus | 0.009 | 0.0927 | 0.3044 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0228 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.4002 | 0.6029 |
Loa Loa (eye worm) | hypothetical protein | 0.0531 | 0.6541 | 1 |
Echinococcus granulosus | geminin | 0.0331 | 0.4002 | 0.6056 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0415 | 0.05 |
Echinococcus granulosus | lamin | 0.0052 | 0.0448 | 0.0533 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0927 | 0.1293 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0228 | 0.0566 |
Loa Loa (eye worm) | carboxylesterase | 0.009 | 0.0927 | 0.1293 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0531 | 0.6541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0436 | 0.0532 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.009 | 0.0927 | 0.3237 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.009 | 0.0927 | 0.1217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.