Detailed information for compound 584688

Basic information

Technical information
  • TDR Targets ID: 584688
  • Name: 2-(2-diethylaminoethyl)-5,11-dimethyl-6H-pyri do[4,3-b]carbazol-2-ium-9-ol; hydron; tetrach loroplatinum(2-)
  • MW: 700.386 | Formula: C23H28Cl4N3OPt
  • H donors: 2 H acceptors: 1 LogP: 7.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cl[Pt-2](Cl)(Cl)Cl.CCN(CC[n+]1ccc2c(c1)c(C)c1c(c2C)[nH]c2c1cc(O)cc2)CC.[H+]
  • InChi: 1S/C23H27N3O.4ClH.Pt/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;;;;;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;4*1H;/q;;;;;+2/p-2
  • InChiKey: DHOHJVBWRYSXEE-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-diethylaminoethyl)-5,11-dimethyl-6H-pyrido[3,4-h]carbazol-2-ium-9-ol; hydron; tetrachloroplatinum
  • 81531-58-0
  • AIDS-156436
  • AIDS156436
  • Platinate(2-), tetrachloro-, (SP-4-1), 2-[2-(diethylamino) ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4, 3-b]carbazolium, hydrogen
  • NSC620257
  • {6H-Pyrido[4,3-b]carbazolium,} {2-[2-(diethylamino)ethyl]-} 9-hydroxy-5,11-dimethyl-, (SP-4-1)-tetrachloroplatinate(2-), hydrogen

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0036 0.1017 0.3078
Mycobacterium ulcerans lipase LipD 0.0036 0.1017 0.0049
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.9986 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.1011 0.0994
Brugia malayi RNA binding protein 0.0123 0.5073 0.508
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0968 0.043
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.9986 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1017 0.0049
Loa Loa (eye worm) inositol-1 0.0036 0.1011 0.1013
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4765 0.4772
Mycobacterium tuberculosis Conserved protein 0.0036 0.1017 0.0196
Brugia malayi hypothetical protein 0.0025 0.0494 0.0494
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1017 0.0196
Loa Loa (eye worm) TAR-binding protein 0.0123 0.5073 0.508
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5073 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Loa Loa (eye worm) beta-lactamase 0.0036 0.1017 0.1019
Brugia malayi hypothetical protein 0.0016 0.0088 0.0088
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1017 0.0196
Mycobacterium tuberculosis Conserved protein 0.0036 0.1017 0.0196
Onchocerca volvulus 0.0036 0.1017 0.4748
Loa Loa (eye worm) hypothetical protein 0.0025 0.0494 0.0494
Loa Loa (eye worm) RNA binding protein 0.0123 0.5073 0.508
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0494 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1017 1
Echinococcus multilocularis tar DNA binding protein 0.0123 0.5073 0.4786
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.2195 0.1732
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.2195 0.1732
Schistosoma mansoni survival motor neuron protein 0.0047 0.152 0.2121
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4765 0.4772
Brugia malayi intermediate filament protein 0.0026 0.0563 0.0564
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1017 0.1019
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.1011 0.0476
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.1011 0.3044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1017 0.0049
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0563 0.0564
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2195 0.3619
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.2195 0.1482
Loa Loa (eye worm) hypothetical protein 0.0026 0.0563 0.0564
Mycobacterium leprae conserved hypothetical protein 0.0036 0.1017 1
Brugia malayi hypothetical protein 0.0035 0.0968 0.097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2195 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2195 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1017 0.1007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0541 0.0542
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Brugia malayi hypothetical protein 0.0228 0.9986 1
Brugia malayi beta-lactamase family protein 0.0036 0.1017 0.1019
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.5073 0.508
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1017 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1017 0.1007
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.1011 0.0476
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.2195 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.1011 0.0994
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1017 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1017 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1011 0.3044
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0494 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.152 0.1522
Brugia malayi beta-lactamase 0.0036 0.1017 0.1019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2195 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1017 0.0196
Loa Loa (eye worm) hypothetical protein 0.0228 0.9986 1
Brugia malayi MH2 domain containing protein 0.0116 0.4765 0.4772
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.1011 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1017 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1011 0.989
Brugia malayi TAR-binding protein 0.0123 0.5073 0.508
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5073 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1017 0.0196
Brugia malayi Inositol-1 0.0036 0.1011 0.1013
Leishmania major hypothetical protein, conserved 0.0036 0.1017 0.3078
Echinococcus granulosus tar DNA binding protein 0.0123 0.5073 0.4786
Onchocerca volvulus 0.0036 0.1017 0.4748
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0968 0.0899
Onchocerca volvulus 0.0047 0.152 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1011 0.989
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5073 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1011 0.989
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1017 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.1017 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1017 1
Brugia malayi beta-lactamase family protein 0.0036 0.1017 0.1019
Onchocerca volvulus 0.0036 0.1017 0.4748
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0563 0.0564
Trichomonas vaginalis esterase, putative 0.0036 0.1017 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.1017 0.0049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.5073 0.508
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2195 0.3619
Schistosoma mansoni hypothetical protein 0.0035 0.0968 0.0899
Mycobacterium ulcerans beta-lactamase 0.0036 0.1017 0.0049
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1017 0.0196
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1017 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1017 0.0196
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1017 0.0482
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5073 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1017 0.0196
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.1011 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1017 0.1019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.2195 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0563 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0123 0.5073 1
Schistosoma mansoni hypothetical protein 0.0047 0.152 0.2121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0968 0.043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1017 0.0482
Loa Loa (eye worm) hypothetical protein 0.0036 0.1017 0.1019
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1017 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.1017 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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