TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 446.492 | Formula: C27H26O6
H donors: 0 H acceptors: 1 LogP: 4.49 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)OC[C@@H]1[C@H]2C(=O)c2c(O1)c1CC3=C(Cc1cc2)O[C@H](C3)C(=C)C
InChi: 1S/C27H26O6/c1-13(2)19-9-15-7-17-14(8-20(15)32-19)5-6-16-26(28)25-18-10-22(29-3)23(30-4)11-21(18)31-12-24(25)33-27(16)17/h5-6,10-11,19,24-25H,1,7-9,12H2,2-4H3/t19-,24-,25+/m1/s1
InChiKey: QNNZJSDZUIJXBG-WVQWTBLQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide Y receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	neuropeptide F-like receptor	0.0886	0.3587	0.3587
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.012	0.0452	0.0452
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.2451	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.02	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus multilocularis	orexin receptor type 2	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.004	0.0125	0.0125
Echinococcus granulosus	neuropeptides capa receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	amine GPCR	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	7tm_1 domain containing protein	0.0886	0.3587	0.3587
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.0296	0.0296
Echinococcus multilocularis	neutral amino acid transporter A	0.2451	1	1
Schistosoma mansoni	amine GPCR	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	neuropeptide receptor	0.0886	0.3587	0.3587
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0886	0.3587	0.3587
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus multilocularis	fmrfamide receptor	0.0886	0.3587	0.3587
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.02	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0105	0.1641
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.012	0.0452	0.0452
Echinococcus granulosus	7TM GPCR rhodopsin	0.0886	0.3587	0.3587
Echinococcus multilocularis	g protein coupled receptor	0.0886	0.3587	0.3587
Brugia malayi	Melatonin receptor type 1A	0.0886	0.3587	0.3587
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.02	0.0174
Brugia malayi	G-protein coupled receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0038	0.0115	0.0115
Echinococcus multilocularis	neuropeptide Y receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	serotonin receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	orexin receptor type 2	0.0886	0.3587	0.3587
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	TYRA-2 protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0886	0.3587	0.3587
Loa Loa (eye worm)	neuropeptide F receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	adenoreceptor	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0082	0.0296	0.0296
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0886	0.3587	0.3587
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0055	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	neuropeptide receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	biogenic amine receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	hypothetical protein	0.0886	0.3587	0.3587
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0055	0.0028
Schistosoma mansoni	hypothetical protein	0.0886	0.3587	0.3587
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0055	0.1442
Echinococcus multilocularis	sex peptide receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0886	0.3587	0.3587
Echinococcus granulosus	expressed conserved protein	0.0092	0.0335	0.0335
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0886	0.3587	0.3587
Brugia malayi	follicle stimulating hormone receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	excitatory amino acid transporter 2	0.2451	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0055	0.1442
Echinococcus multilocularis	neuropeptide receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	Dopamine receptor protein 1	0.0886	0.3587	0.3587
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0886	0.3587	0.3587
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.0115	0.0115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0055	0.1442
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0055	0.0055
Echinococcus multilocularis	neutral amino acid transporter A	0.2451	1	1
Brugia malayi	hypothetical protein	0.0036	0.0105	0.0105
Brugia malayi	CHE-14 protein	0.0042	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	putative neuropeptide receptor	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Schistosoma mansoni	histamine h1 receptor	0.0886	0.3587	0.3587
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.02	1
Echinococcus granulosus	excitatory amino acid transporter 2	0.2451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0886	0.3587	0.3587
Echinococcus granulosus	g protein coupled receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0131	0.0131
Schistosoma mansoni	neuropeptide f receptor 76f	0.0886	0.3587	0.3587
Echinococcus granulosus	g protein coupled receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0886	0.3587	0.3587
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.036	1
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0131	0.0131
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0886	0.3587	0.3587
Echinococcus multilocularis	neuropeptide Y receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0335	0.0335
Echinococcus granulosus	neuropeptide receptor	0.0886	0.3587	0.3587
Brugia malayi	ORL1-like opioid receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0886	0.3587	0.3587
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	opsin-like receptor	0.0886	0.3587	0.3587
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.036	0.036
Onchocerca volvulus		0.0886	0.3587	0.3587
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	fmrfamide receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	AKH receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.0452	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	G protein coupled receptor 139	0.0886	0.3587	0.3587
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	g-protein coupled receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0886	0.3587	0.3587
Schistosoma mansoni	neuropeptide receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	neuropeptide s receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	biogenic amine 5HT receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0031
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Schistosoma mansoni	biogenic amine receptor	0.0886	0.3587	0.3587
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0031	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	biogenic amine receptor	0.0886	0.3587	0.3587
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0055	0.1442
Echinococcus granulosus	fmrfamide receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0886	0.3587	0.3587
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	somatostatin receptor	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0031	0.5
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Entamoeba histolytica	hypothetical protein	0.0036	0.0105	0.1641
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0055	0.1442
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus granulosus	excitatory amino acid transporter 3	0.2451	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0886	0.3587	0.3587
Chlamydia trachomatis	neutral amino acid transporter	0.1086	0.4409	0.4392
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.0532	0.0532
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0038	0.0115	0.0115
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.02	0.02
Loa Loa (eye worm)	neuropeptide F receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0886	0.3587	0.3587
Schistosoma mansoni	neuropeptide receptor	0.0886	0.3587	0.3587
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0055	0.1442
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Loa Loa (eye worm)	G-protein coupled receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0886	0.3587	0.3587
Brugia malayi	putative neuropeptide receptor NPR1	0.0886	0.3587	0.3587
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0038	0.0115	0.0115
Onchocerca volvulus		0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0886	0.3587	0.3587
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0055	0.1442
Echinococcus granulosus	tm gpcr rhodopsin	0.0886	0.3587	0.3587
Schistosoma mansoni	amine GPCR	0.0886	0.3587	0.3587
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	allatostatin A receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	amine GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	neutral amino acid transporter A	0.2451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	neuropeptide s receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.1086	0.4409	0.4409
Brugia malayi	G protein-coupled receptor F59B2.13	0.0886	0.3587	0.3587
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0806	0.326	0.326
Echinococcus granulosus	GPCR family 2	0.0038	0.0115	0.0115
Onchocerca volvulus		0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0038	0.0115	0.0115
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	tm gpcr rhodopsin	0.0886	0.3587	0.3587
Treponema pallidum	glutamate transporter	0.1086	0.4409	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	sodium:dicarboxylate symporter	0.2451	1	1
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	g protein coupled receptor	0.0886	0.3587	0.3587
Brugia malayi	GnHR receptor homolog	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0886	0.3587	0.3587
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0886	0.3587	0.3587
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.02	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.1086	0.4409	0.4409
Chlamydia trachomatis	glutamate symporter	0.2451	1	1
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Schistosoma mansoni	opsin-like receptor	0.0886	0.3587	0.3587
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.2451	1	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0105	0.1641
Schistosoma mansoni	hypothetical protein	0.0036	0.0105	0.0105
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0886	0.3587	0.3587
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0131	0.5
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.0115	0.0115
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.004	0.0125	0.0125
Echinococcus granulosus	neutral amino acid transporter	0.2451	1	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0115	0.0115
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.1086	0.4409	0.4409
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	G-protein coupled receptor	0.0886	0.3587	0.3587
Brugia malayi	neuropeptide F receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	biogenic amine 5HT receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	opsin-like receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0055	0.0055
Loa Loa (eye worm)	excitatory amino acid transporter	0.2451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.1086	0.4409	0.4409
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.02	1
Echinococcus granulosus	allatostatin A receptor	0.0886	0.3587	0.3587
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.2451	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	tm gpcr rhodopsin	0.0886	0.3587	0.3587
Echinococcus granulosus	neuropeptide receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	Excitatory amino acid transporter	0.2451	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	serotonin receptor	0.0886	0.3587	0.3587
Brugia malayi	G-protein coupled receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0886	0.3587	0.3587
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.02	0.02
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0055	0.0055
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	g-protein coupled receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	dro:myosuppressin receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	neuropeptide receptor A26	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Brugia malayi	RE15519p	0.0886	0.3587	0.3587
Echinococcus multilocularis	protein patched	0.0042	0.0131	0.0131
Echinococcus granulosus	neutral amino acid transporter A	0.2451	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0055	0.1442
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0051	0.017	0.017
Echinococcus multilocularis	excitatory amino acid transporter 2	0.2451	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	Excitatory amino acid transporter	0.2451	1	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.02	0.02
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0886	0.3587	0.3587
Echinococcus multilocularis	serotonin receptor	0.0886	0.3587	0.3587
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0886	0.3587	0.3587
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.004	0.0125	0.0125
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0055	0.0055
Echinococcus granulosus	G protein coupled receptor 139	0.0886	0.3587	0.3587
Brugia malayi	Serotonin receptor	0.0886	0.3587	0.3587
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.0115	0.0115
Brugia malayi	Serotonin receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0098	0.036	0.036
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0886	0.3587	0.3587
Echinococcus multilocularis	neutral amino acid transporter A	0.2451	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	Excitatory amino acid transporter	0.2451	1	1
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus granulosus	g protein coupled receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.004	0.0125	0.0125
Treponema pallidum	glutamate/aspartate transporter	0.1086	0.4409	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.036	0.036
Schistosoma mansoni	amine GPCR	0.0886	0.3587	0.3587
Brugia malayi	sulfakinin receptor protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0031
Onchocerca volvulus		0.0024	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Brugia malayi	Dopamine receptor protein 2	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus multilocularis	excitatory amino acid transporter 2	0.2451	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.0532	0.0532
Echinococcus multilocularis	neuropeptides capa receptor	0.0886	0.3587	0.3587
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0886	0.3587	0.3587
Echinococcus multilocularis	g protein coupled receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	neuropeptide receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.0452	0.0452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0055	0.0028
Schistosoma mansoni	patched 1	0.0042	0.0131	0.0131
Echinococcus granulosus	neuropeptide Y receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Brugia malayi	larval opioid receptor	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.2451	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0886	0.3587	0.3587
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.0115	0.0115
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0886	0.3587	0.3587
Onchocerca volvulus		0.0886	0.3587	0.3587
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.2451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.2451	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0031	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0886	0.3587	0.3587
Echinococcus granulosus	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus multilocularis	excitatory amino acid transporter 3	0.2451	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0886	0.3587	0.3587
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0886	0.3587	0.3587
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0886	0.3587	0.3587
Echinococcus granulosus	sex peptide receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	somatostatin receptor	0.0886	0.3587	0.3587
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0055	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0886	0.3587	0.3587
Brugia malayi	G protein-coupled receptor	0.0886	0.3587	0.3587
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0155	0.0155
Brugia malayi	Dopamine receptor	0.0886	0.3587	0.3587
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Entamoeba histolytica	hypothetical protein	0.0036	0.0105	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	GPCR, family 2	0.0038	0.0115	0.0115
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0886	0.3587	0.3587
Brugia malayi	neuropeptide F receptor	0.0886	0.3587	0.3587
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0886	0.3587	0.3587
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0105	0.0105
Brugia malayi	hypothetical protein	0.0886	0.3587	0.3587
Schistosoma mansoni	hypothetical protein	0.0886	0.3587	0.3587
Echinococcus multilocularis	Excitatory amino acid transporter	0.2451	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0886	0.3587	0.3587
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0886	0.3587	0.3587
Schistosoma mansoni	myosin xvIII	0.0886	0.3587	0.3587
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0105	0.0105

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.00000000025 M	Inhibition of NADH dehydrogenase in blowfly flight-muscle submitochondrial preparation experiment I	ChEMBL.	No reference
IC50 (binding)	= 0.0000000015 M	Inhibition of NADH dehydrogenase in blowfly flight-muscle submitochondrial preparation experiment II	ChEMBL.	No reference
Relative activity (binding)	= 100 %	Relative activity against blowfly flight muscle submitochondrial NADH dehydrogenase compared to rotenone	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 58477