Detailed information for compound 584785

Basic information

Technical information
  • TDR Targets ID: 584785
  • Name: (1S)-1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl ]-2-[[(2R)-2-[(2S)-2,3-dihydro-1,4-benzodioxi n-2-yl]-2-hydroxy-ethyl]amino]ethanol; methan esulfonic acid
  • MW: 469.505 | Formula: C21H27NO9S
  • H donors: 4 H acceptors: 5 LogP: -1.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS(=O)(=O)O.O[C@H]([C@H]1COc2c(O1)cccc2)CNC[C@H]([C@@H]1COc2c(O1)cccc2)O
  • InChi: 1S/C20H23NO6.CH4O3S/c22-13(19-11-24-15-5-1-3-7-17(15)26-19)9-21-10-14(23)20-12-25-16-6-2-4-8-18(16)27-20;1-5(2,3)4/h1-8,13-14,19-23H,9-12H2;1H3,(H,2,3,4)/t13-,14+,19+,20-;
  • InChiKey: TWESTNYMJIMXRF-AIMMJYJASA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S)-1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-[[(2R)-2-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-hydroxyethyl]amino]ethanol; methanesulfonic acid
  • (1S)-1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-[[(2R)-2-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-hydroxy-ethyl]amino]ethanol; mesylic acid
  • CGS 10078B
  • (1S)-1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-[[(2R)-2-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-hydroxyethyl]amino]ethanol; methanesulfonic acid
  • (1S)-1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-[[(2R)-2-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2-hydroxy-ethyl]amino]ethanol; methanesulfonic acid
  • Bendacalol mesylate (USAN)
  • D03078

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Excitatory amino acid transporter 0.0635 0.7685 0.9313
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0353 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0148 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1109 0.1424
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0635 0.7685 0.7685
Echinococcus granulosus muscleblind protein 0.0158 0.1838 0.2228
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0623 0.7535 0.9805
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1038 0.1285
Brugia malayi tailless protein 0.0009 0.0018 0.0003
Brugia malayi Importin beta-1 subunit 0.0058 0.0618 0.0784
Onchocerca volvulus 0.0071 0.0769 0.0979
Plasmodium falciparum thioredoxin reductase 0.0037 0.035 0.5391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0148 0.0169
Schistosoma mansoni hypothetical protein 0.0623 0.7535 0.9132
Echinococcus multilocularis excitatory amino acid transporter 2 0.0635 0.7685 0.7685
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0058 0.0273
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.034 0.3974
Brugia malayi glutathione reductase 0.0037 0.035 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0263 0.0319
Brugia malayi ecdysone receptor 0.0009 0.0018 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0148 0.0172
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0282 0.3352 0.4062
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0148 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.034 0.113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0148 0.0169
Brugia malayi kap beta 3 protein 0.0011 0.0038 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0148 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0148 0.018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0148 0.0148
Brugia malayi beta-lactamase 0.0071 0.0769 0.0981
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0018 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0058 0.0273
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0019 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1371 0.1371
Brugia malayi nuclear hormone receptor 0.0009 0.0018 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.034 0.113
Echinococcus multilocularis neutral amino acid transporter A 0.0635 0.7685 0.7685
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.034 0.0412
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.056 0.3915
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0769 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0635 0.7685 0.7685
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0429 0.052
Onchocerca volvulus 0.0071 0.0769 0.0979
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0148 0.0172
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0038 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1015 0.1302
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0482 0.1661
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0769 0.0981
Echinococcus granulosus cpg binding protein 0.0029 0.0262 0.0317
Mycobacterium ulcerans lipase LipD 0.0071 0.0769 0.5414
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0284 0.0284
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0058 0.007
Brugia malayi nuclear hormone receptor 0.002 0.0148 0.0172
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1128 0.145
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1128 0.1368
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0148 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1015 0.1015
Brugia malayi nuclear receptor RXR 0.0011 0.0032 0.0021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1038 0.1285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0148 0.0169
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8252 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0148 0.0169
Schistosoma mansoni nuclear receptor 0.0009 0.0018 0.0022
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0635 0.7685 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0018 0.0003
Schistosoma mansoni hypothetical protein 0.0031 0.0284 0.0344
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.034 0.034
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0148 0.0148
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.034 0.0412
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0058 0.0273
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0058 0.0273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1038 1
Schistosoma mansoni cpg binding protein 0.0028 0.0243 0.0294
Brugia malayi CHE-14 protein 0.0043 0.0429 0.0537
Onchocerca volvulus 0.0229 0.2714 0.3516
Echinococcus granulosus snurportin 1 0.0623 0.7535 0.9132
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0429 0.2933
Leishmania major hypothetical protein, conserved 0.0071 0.0769 0.5483
Schistosoma mansoni hypothetical protein 0.0041 0.041 0.0496
Schistosoma mansoni ap endonuclease 0.0037 0.0353 0.0427
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0284 0.0349
Brugia malayi nuclear receptor NHR-67 0.0009 0.0018 0.0003
Echinococcus granulosus neutral amino acid transporter A 0.0635 0.7685 0.9313
Plasmodium vivax importin-beta 2, putative 0.0058 0.0618 0.7932
Brugia malayi Pre-SET motif family protein 0.0202 0.2374 0.3074
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0353 0.4309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0148 0.0148
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1371 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1147 0.1391
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0429 0.0535
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Echinococcus multilocularis geminin 0.0167 0.1953 0.1953
Entamoeba histolytica hypothetical protein 0.0047 0.0482 0.4076
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0018 0.0003
Loa Loa (eye worm) beta-lactamase 0.0071 0.0769 0.0979
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0356 0.0432
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0058 0.0273
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0635 0.7685 0.7685
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0018 0.0018
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0635 0.7685 0.9313
Chlamydia trachomatis glutamate symporter 0.0635 0.7685 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0148 0.018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0031 0.0284 0.0344
Echinococcus granulosus sodium:dicarboxylate symporter 0.0635 0.7685 0.9313
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0924 0.1136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0319
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1109 0.1424
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0429 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.035 0.0433
Plasmodium falciparum importin beta, putative 0.0058 0.0618 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0148 0.0169
Echinococcus granulosus transportin 1 0.0011 0.0038 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0148 0.018
Schistosoma mansoni hypothetical protein 0.0167 0.1953 0.2366
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0148 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1655 0.2005
Plasmodium falciparum glutathione reductase 0.0037 0.035 0.5391
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0769 0.0932
Schistosoma mansoni cpg binding protein 0.0029 0.0262 0.0317
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1015 0.123
Loa Loa (eye worm) hypothetical protein 0.01 0.1128 0.1448
Echinococcus granulosus neutral amino acid transporter A 0.0635 0.7685 0.9313
Loa Loa (eye worm) hypothetical protein 0.0158 0.1838 0.2374
Echinococcus granulosus excitatory amino acid transporter 3 0.0635 0.7685 0.9313
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0263 0.0319
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0058 0.0075
Echinococcus granulosus excitatory amino acid transporter 2 0.0635 0.7685 0.9313
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0353 0.1177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0769 0.5414
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0058 0.007
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0282 0.3352 0.3352
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1371 0.1661
Echinococcus granulosus excitatory amino acid transporter 2 0.0635 0.7685 0.9313
Onchocerca volvulus 0.0029 0.0263 0.0319
Leishmania major GTP-binding protein, putative 0.0043 0.0429 0.2933
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0769 0.2731
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0319
Echinococcus granulosus expressed conserved protein 0.0094 0.1054 0.1277
Echinococcus granulosus Excitatory amino acid transporter 0.0635 0.7685 0.9313
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Plasmodium vivax glutathione reductase, putative 0.0037 0.035 0.4276
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0058 0.015
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.035 0.4116
Echinococcus multilocularis transportin 1 0.0011 0.0038 0.0038
Onchocerca volvulus 0.002 0.0148 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0353 0.0387
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0353 0.0896
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0148 0.018
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0353 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0148 0.0172
Schistosoma mansoni hypothetical protein 0.0395 0.4744 0.5749
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1838 0.1838
Schistosoma mansoni patched 1 0.0043 0.0429 0.0519
Trichomonas vaginalis ran, putative 0.0043 0.0429 0.1461
Loa Loa (eye worm) hypothetical protein 0.0058 0.0618 0.0781
Echinococcus multilocularis protein dispatched 1 0.0049 0.0503 0.0503
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0429 0.5349
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0353 0.2888
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0148 0.0172
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.035 0.0433
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0148 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1371 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0032 0.0032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1371 0.1722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1015 0.1015
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0032 0.0039
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0635 0.7685 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0284 0.0347
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0148 0.0172
Echinococcus multilocularis Excitatory amino acid transporter 0.0635 0.7685 0.7685
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0148 0.0148
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.035 0.4276
Echinococcus multilocularis neutral amino acid transporter A 0.0635 0.7685 0.7685
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0018 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0148 0.0169
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0353 0.1177
Mycobacterium ulcerans hypothetical protein 0.0071 0.0769 0.5414
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0018 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1371 0.1661
Brugia malayi hypothetical protein 0.0009 0.0018 0.0003
Plasmodium falciparum thioredoxin reductase 0.0013 0.0058 0.0344
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0148 0.0169
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.035 0.0384
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0058 0.0273
Mycobacterium tuberculosis Conserved protein 0.0071 0.0769 0.0932
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.034 0.034
Echinococcus multilocularis Excitatory amino acid transporter 0.0635 0.7685 0.7685
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0148 0.0148
Trypanosoma brucei trypanothione reductase 0.0037 0.035 0.4276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0148 0.0172
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.034 0.4139
Onchocerca volvulus 0.0071 0.0769 0.0979
Brugia malayi steroid hormone receptor 0.002 0.0148 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1015 0.123
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0429 0.0519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0243 0.0294
Leishmania major trypanothione reductase 0.0037 0.035 0.2345
Brugia malayi hypothetical protein 0.0011 0.0032 0.0021
Brugia malayi ecdysteroid receptor 0.002 0.0148 0.0172
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0148 0.018
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0769 0.2731
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0353 0.4149
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0769 0.0932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1015 0.123
Schistosoma mansoni zinc finger protein 0.0009 0.0018 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0769 0.2731
Onchocerca volvulus 0.0028 0.0243 0.0292
Echinococcus multilocularis importin 5 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0769 0.0932
Brugia malayi nuclear receptor RXR 0.0009 0.0018 0.0003
Toxoplasma gondii ABC1 family protein 0.0071 0.0769 0.5483
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0353 0.0387
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0482 0.1661
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0058 0.015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0429 0.5219
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0032 0.0039
Brugia malayi Excitatory amino acid transporter 0.0635 0.7685 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0769 0.0979
Schistosoma mansoni hypothetical protein 0.0041 0.041 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0148 0.0169
Schistosoma mansoni hypothetical protein 0.0041 0.041 0.0496
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0353 0.4309
Schistosoma mansoni ran 0.0043 0.0429 0.052
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0018 0.0022
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0482 0.5972
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0769 0.0932
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0148 0.018
Plasmodium vivax SET domain protein, putative 0.0029 0.0263 0.3086
Schistosoma mansoni hypothetical protein 0.0031 0.0284 0.0344
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4744 0.4744
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0284 0.0347
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0924 0.1136
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0282 0.3352 0.3352
Echinococcus multilocularis GPCR, family 2 0.0031 0.0284 0.0284
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0148 0.018
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.0689
Mycobacterium ulcerans beta-lactamase 0.0071 0.0769 0.5414
Toxoplasma gondii thioredoxin reductase 0.0037 0.035 0.2345
Brugia malayi RNA, U transporter 1 0.0166 0.1936 0.2503
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0058 0.0075
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0618 0.4349
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8252 0.8252
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0635 0.7685 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0148 0.018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0284 0.0284
Plasmodium falciparum glutathione reductase 0.0013 0.0058 0.0344
Echinococcus granulosus FTZ F1 alpha 0.002 0.0148 0.018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0353 0.0436
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0018 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1371 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0769 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0924 0.1136
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0429 0.0519
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0058 0.015
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0429 0.0535
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0067 0.0727 0.0924
Leishmania major importin beta-1 subunit, putative 0.0047 0.0482 0.3335
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0148 0.018
Treponema pallidum glutamate/aspartate transporter 0.0282 0.3352 1
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0018 0.0003
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0282 0.3352 0.4062
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0429 0.0538
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0769 0.0932
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0353 0.4149
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1371 1
Echinococcus granulosus translational activator gcn1 0.0011 0.0038 0.0046
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0284 0.0344
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0018 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0018 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0058 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0098 0.1109 0.1422
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0148 0.0172
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0924 0.5767
Echinococcus granulosus importin subunit beta 1 0.0058 0.0618 0.0748
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.034 0.0412
Brugia malayi Thioredoxin reductase 0.0037 0.035 0.0435
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2374 0.3072
Brugia malayi Pre-SET motif family protein 0.0029 0.0263 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0032 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0018 0.0022
Brugia malayi CXXC zinc finger family protein 0.0028 0.0243 0.0295
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0018 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4744 0.5749
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.034 0.0422
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1371 0.1661
Schistosoma mansoni nuclear hormone receptor 0.002 0.0148 0.018
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8252 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1109 0.1422
Echinococcus multilocularis translational activator gcn1 0.0011 0.0038 0.0038
Echinococcus granulosus GPCR family 2 0.0031 0.0284 0.0344
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0038 0.0025
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0018 0.0022
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.034 0.034
Schistosoma mansoni thyroid hormone receptor 0.002 0.0148 0.018
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.034 0.2269
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0353 0.5432
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0618 0.7932
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0769 0.2731
Schistosoma mansoni hypothetical protein 0.0067 0.0727 0.0881
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0769 0.0932
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0769 0.5414
Schistosoma mansoni importin beta-1 0.0058 0.0618 0.0748
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0148 0.018
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0263 0.0263
Schistosoma mansoni cpg binding protein 0.0029 0.0262 0.0317
Loa Loa (eye worm) excitatory amino acid transporter 0.0635 0.7685 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0429 0.5219
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0429 0.1461
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0924 0.1136
Brugia malayi hypothetical protein 0.0009 0.0018 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0353 0.2246
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0429 0.6744
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0058 0.015
Brugia malayi beta-lactamase family protein 0.0071 0.0769 0.0981
Mycobacterium tuberculosis Conserved protein 0.0071 0.0769 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0148 0.0172
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0058 0.0344
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.034 0.0412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0319
Schistosoma mansoni ran 0.0043 0.0429 0.052
Brugia malayi hypothetical protein 0.0011 0.0032 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0637 0.0772
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1128 0.1128
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0018 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0429 0.5349
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0284 0.0349
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.034 0.2774
Chlamydia trachomatis neutral amino acid transporter 0.0282 0.3352 0.4319
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0148 0.0169
Schistosoma mansoni ap endonuclease 0.0037 0.0353 0.0427
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0058 0.0344
Schistosoma mansoni nuclear receptor 0.0009 0.0018 0.0022
Mycobacterium tuberculosis Conserved protein 0.0071 0.0769 0.0932
Echinococcus granulosus importin 5 0.0011 0.0038 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0148 0.018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0243 0.0292
Entamoeba histolytica Ran family GTPase 0.0043 0.0429 0.3585
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0032 0.0021
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0618 0.0618
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2714 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0148 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0769 0.0932
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1371 1
Trichomonas vaginalis esterase, putative 0.0071 0.0769 0.2731
Echinococcus multilocularis neutral amino acid transporter A 0.0635 0.7685 0.7685
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0769 0.0932
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0148 0.018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0025
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0429 0.0429
Schistosoma mansoni coup transcription factor 0.002 0.0148 0.018
Echinococcus multilocularis excitatory amino acid transporter 3 0.0635 0.7685 0.7685
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0263 0.0319
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1655 0.1655
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0353 0.2363
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0018
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.034 0.0412
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0727 0.0927
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0058 0.015
Echinococcus multilocularis muscleblind protein 0.0158 0.1838 0.1838
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0058 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0769 0.0932
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0018 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1015 0.123
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0148 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0769 0.2731
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1015 0.13
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0032 0.0018
Mycobacterium tuberculosis Probable reductase 0.0083 0.0924 0.1136
Brugia malayi beta-lactamase family protein 0.0071 0.0769 0.0981
Schistosoma mansoni hypothetical protein 0.0041 0.041 0.0496
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0482 0.1661
Echinococcus multilocularis expressed conserved protein 0.0094 0.1054 0.1054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0148 0.0172
Brugia malayi nuclear receptor NHR-88 0.002 0.0148 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.0284 0.0344
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.5436 0.7052
Loa Loa (eye worm) hypothetical protein 0.0036 0.034 0.042
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0148 0.0172
Echinococcus granulosus neutral amino acid transporter 0.0635 0.7685 0.9313
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1128 1
Treponema pallidum glutamate transporter 0.0282 0.3352 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0021 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0353 0.0353
Toxoplasma gondii exonuclease III APE 0.0037 0.0353 0.2363
Schistosoma mansoni hypothetical protein 0.0167 0.1953 0.2366
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0018
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0148 0.0172
Brugia malayi Muscleblind-like protein 0.0158 0.1838 0.2376
Schistosoma mansoni thyroid hormone receptor 0.002 0.0148 0.018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0148 0.0169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0284 0.0344
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0263 0.1692
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0769 0.0932
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0158 0.1838 0.2374
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0353 0.7951
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1038 0.1285
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0618 0.7932
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0148 0.0148
Echinococcus multilocularis snurportin 1 0.0623 0.7535 0.7535
Schistosoma mansoni importin-beta 2 0.0011 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0769 0.0979
Echinococcus granulosus geminin 0.0167 0.1953 0.2366
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0924 0.1136
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0769 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0429 0.0429
Echinococcus multilocularis protein patched 0.0043 0.0429 0.0429
Brugia malayi conserved hypotetical protein 0.0009 0.0018 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0148 0.0172
Echinococcus multilocularis cpg binding protein 0.0029 0.0262 0.0262
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0018 0.0022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.034 0.3974
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0018 0.0018
Brugia malayi nuclear receptor NHR-88 0.0009 0.0018 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0769 0.0769
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0032 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0769 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1015 0.123
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.034 0.7616
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.034 0.113
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0169

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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