Detailed information for compound 584940

Basic information

Technical information
  • TDR Targets ID: 584940
  • Name: ethyl 2-(4-azidophenoxy)-2-methyl-propanoate
  • MW: 250.274 | Formula: C12H16N3O3
  • H donors: 0 H acceptors: 1 LogP: 3.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Oc1ccc(cc1)N=[N+]=[NH-])(C)C
  • InChi: 1S/C12H15N3O3/c1-4-17-11(16)12(2,3)18-10-7-5-9(6-8-10)14-15-13/h5-8H,4H2,1-3H3
  • InChiKey: HBZFZKSPJVDGJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-azidophenoxy)-2-methylpropanoic acid ethyl ester
  • 2-(4-azidophenoxy)-2-methyl-propionic acid ethyl ester
  • ethyl 2-(4-azidophenoxy)-2-methylpropanoate
  • azidofibrate
  • 82054-49-7
  • AIDS-129752
  • AIDS129752
  • Ethyl 2-methyl-2-(4-(2.lambda.~5~-1,2-triazadienyl)phenoxy)propanoate
  • NSC364388
  • NSC 364388
  • Propanoic acid, 2-(4-azidophenoxy)-2-methyl-, ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0827 0.0827
Schistosoma mansoni hypothetical protein 0.0054 0.0827 0.2009
Schistosoma mansoni kinase 0.0049 0.0623 0.1512
Loa Loa (eye worm) TAR-binding protein 0.013 0.4117 0.4117
Loa Loa (eye worm) RNA binding protein 0.013 0.4117 0.4117
Schistosoma mansoni tar DNA-binding protein 0.013 0.4117 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.2699 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0705 0.0705
Brugia malayi hypothetical protein 0.0037 0.0072 0.0072
Brugia malayi TAR-binding protein 0.013 0.4117 0.4117
Schistosoma mansoni hypothetical protein 0.0037 0.0072 0.0174
Giardia lamblia Kinase, PLK 0.0097 0.2699 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4117 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4117 1
Echinococcus multilocularis survival motor neuron protein 1 0.0265 1 1
Echinococcus multilocularis tar DNA binding protein 0.013 0.4117 0.4074
Schistosoma mansoni survival motor neuron protein 0.0054 0.0827 0.2009
Loa Loa (eye worm) hypothetical protein 0.0265 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.2699 0.2699
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Echinococcus granulosus survival motor neuron protein 1 0.0265 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.2699 1
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.2699 0.6557
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.2699 0.2699
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4117 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0705 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2699 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.4117 0.4117
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4117 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0705 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2699 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.2699 0.2647
Brugia malayi RNA binding protein 0.013 0.4117 0.4117
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.2699 0.2647
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0705 0.0705
Brugia malayi RNA recognition motif domain containing protein 0.013 0.4117 0.4117
Trypanosoma brucei polo-like protein kinase 0.0097 0.2699 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2699 0.5
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.2699 1
Echinococcus granulosus tar DNA binding protein 0.013 0.4117 0.4074
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0072 0.0174

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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