Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0255 | 0.5024 | 0.5682 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0606 | 0.0388 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0329 | 0.022 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0329 | 0.022 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.014 | 0.0495 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0329 | 0.076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0151 | 0.2809 | 0.3215 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0329 | 0.076 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0606 | 0.0388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.5024 | 0.6576 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0255 | 0.5024 | 0.5751 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0571 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.014 | 0.016 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0329 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0329 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0571 | 0.0502 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0041 | 0.0456 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0329 | 0.076 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0329 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.031 | 0.6214 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.034 | 0.6854 | 0.9138 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.7469 | 0.855 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0369 | 0.7469 | 1 |
Brugia malayi | GH02984p | 0.0369 | 0.7469 | 0.8526 |
Brugia malayi | Sodium:solute symporter family protein | 0.0041 | 0.0456 | 0.0368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0571 | 0.0339 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0571 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0606 | 0.0388 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0402 | 0.0432 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0606 | 0.0388 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.014 | 0.0323 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0571 | 0.0339 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0329 | 0.1165 |
Brugia malayi | Pre-SET motif family protein | 0.0061 | 0.0899 | 0.0883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.5024 | 0.6576 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0456 | 0.0522 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0606 | 0.0542 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0606 | 0.0694 |
Onchocerca volvulus | 0.0061 | 0.0899 | 0.077 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0606 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.014 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2809 | 0.3215 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.5024 | 0.6576 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.014 | 0.0495 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0151 | 0.2809 | 0.3105 |
Schistosoma mansoni | inositol transporter | 0.0041 | 0.0456 | 0.0178 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0571 | 0.0339 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0329 | 0.0377 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.031 | 0.6214 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0061 | 0.0899 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0369 | 0.7469 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0151 | 0.2809 | 0.3105 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0329 | 0.3661 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0899 | 0.1029 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0061 | 0.0899 | 0.0798 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0152 | 0.2824 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0061 | 0.0899 | 0.0798 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.014 | 0.0495 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0329 | 0.076 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0606 | 0.0694 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.031 | 0.6214 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0329 | 0.076 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0329 | 0.076 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0429 | 0.8736 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.014 | 0.0495 |
Echinococcus multilocularis | solute carrier family 5 | 0.0041 | 0.0456 | 0.0178 |
Loa Loa (eye worm) | RNA binding protein | 0.0255 | 0.5024 | 0.5751 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Loa Loa (eye worm) | TAR-binding protein | 0.0255 | 0.5024 | 0.5751 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0606 | 0.0388 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0041 | 0.0456 | 0.0178 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0606 | 0.0388 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.031 | 0.6214 | 0.6086 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0606 | 0.0388 |
Trichomonas vaginalis | set domain proteins, putative | 0.0488 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0041 | 0.0456 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0571 | 0.0654 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0152 | 0.2824 | 0.6522 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.014 | 0.0323 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0329 | 0.0705 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0061 | 0.0899 | 0.0798 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.014 | 0.0495 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0402 | 0.0432 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0329 | 0.076 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0402 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0402 | 0.0103 |
Echinococcus granulosus | solute carrier family 5 | 0.0041 | 0.0456 | 0.0178 |
Schistosoma mansoni | sodium/solute symporter | 0.0041 | 0.0456 | 0.0178 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0329 | 0.5 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0041 | 0.0456 | 0.0178 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0329 | 0.1165 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.014 | 0.0495 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0152 | 0.2824 | 1 |
Onchocerca volvulus | 0.0035 | 0.0329 | 0.0192 | |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0329 | 0.076 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0369 | 0.7469 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0061 | 0.0899 | 0.0798 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0255 | 0.5024 | 0.5682 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0329 | 0.1165 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0041 | 0.0456 | 0.2226 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0329 | 0.022 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0329 | 0.0377 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0329 | 0.022 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0402 | 0.0103 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0041 | 0.0456 | 0.0178 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0061 | 0.0899 | 0.0798 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0329 | 0.1165 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0061 | 0.0899 | 0.0798 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0061 | 0.0899 | 0.0798 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.4331 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0059 | 0.0851 | 0.073 |
Onchocerca volvulus | 0.0035 | 0.0329 | 0.0192 | |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0041 | 0.0456 | 0.0178 |
Echinococcus granulosus | tar DNA binding protein | 0.0255 | 0.5024 | 0.6576 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.031 | 0.6214 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0606 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Onchocerca volvulus | 0.0035 | 0.0329 | 0.0192 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.014 | 0.0495 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0329 | 0.0705 |
Schistosoma mansoni | inositol transporter | 0.0041 | 0.0456 | 0.0178 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0061 | 0.0899 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0255 | 0.5024 | 0.6576 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.014 | 0.016 |
Brugia malayi | RNA binding protein | 0.0255 | 0.5024 | 0.5682 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0329 | 0.1165 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0329 | 0.076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.5024 | 0.6576 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.014 | 0.0495 |
Onchocerca volvulus | 0.0041 | 0.0456 | 0.0321 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0606 | 0.0388 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0402 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1789 | 0.2045 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0606 | 0.0388 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0329 | 0.076 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0402 | 0.0305 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0041 | 0.0456 | 0.0178 |
Brugia malayi | Pre-SET motif family protein | 0.0429 | 0.8736 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0571 | 0.0339 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.5024 | 0.6576 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0571 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0329 | 0.0377 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0402 | 0.0432 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0402 | 0.0103 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.1789 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1789 | 0.2048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.