Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.7756 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.7756 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.032 | 0.0034 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.032 | 0.0008 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.2535 | 0.2287 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.2535 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0086 | 0.4758 | 0.4758 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.689 | 0.8837 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.4758 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.2535 | 0.4999 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.2535 | 0.4999 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.032 | 0.0017 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.032 | 0.0034 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.032 | 0.0034 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.282 | 0.5642 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.2535 | 0.2535 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.689 | 0.8837 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.003 | 0.1072 | 0.1708 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.689 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.2535 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.032 | 0.0017 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.032 | 1 |
Onchocerca volvulus | 0.0166 | 1 | 0.5 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.282 | 0.3369 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.032 | 0.0017 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.4758 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0119 | 0.689 | 0.8705 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.032 | 0.0017 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.032 | 0.0034 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0086 | 0.4758 | 0.5514 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.7756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4758 | 0.4584 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0313 | 0.0313 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.282 | 0.3369 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.032 | 0.032 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.2535 | 0.2287 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.032 | 0.001 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.032 | 0.0017 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.032 | 0.0017 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.2535 | 0.4999 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.2535 | 0.4999 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.032 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.689 | 0.8837 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0056 | 0.282 | 0.2616 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.2535 | 0.2985 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0086 | 0.4758 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.032 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.032 | 0.5 |
Brugia malayi | glutathione reductase | 0.0052 | 0.2535 | 0.2535 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.689 | 0.8837 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.032 | 0.0008 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.7756 | 1 |
Leishmania major | trypanothione reductase | 0.0052 | 0.2535 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.2535 | 0.4999 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.032 | 0.0017 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.003 | 0.1072 | 0.1708 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.2535 | 0.4999 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.689 | 0.8837 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0086 | 0.4758 | 0.4599 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.003 | 0.1072 | 0.1708 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.2535 | 0.4999 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.032 | 0.0017 |
Toxoplasma gondii | hypothetical protein | 0.003 | 0.1072 | 0.1708 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.282 | 0.5642 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.4758 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.