Detailed information for compound 585263

Basic information

Technical information
  • TDR Targets ID: 585263
  • Name: 1-(3-chlorophenyl)-2-[(2-hydroxy-1,1-dimethyl -ethyl)amino]propan-1-one
  • MW: 255.741 | Formula: C13H18ClNO2
  • H donors: 2 H acceptors: 2 LogP: 2.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(NC(C(=O)c1cccc(c1)Cl)C)(C)C
  • InChi: 1S/C13H18ClNO2/c1-9(15-13(2,3)8-16)12(17)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3
  • InChiKey: AKOAEVOSDHIVFX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone
  • 1-(3-chlorophenyl)-2-[(1-hydroxy-2-methyl-propan-2-yl)amino]propan-1-one
  • 1-(3-chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one
  • BW 306U
  • hydroxybupropion
  • 1-(3-chlorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]propan-1-one
  • 82793-84-8
  • 1-Propanone, 1-(3-chlorophenyl)-2-((2-hydroxy-1,1-dimethylethyl)amino)-, (+-)-
  • B.W.306U
  • BW-306-U
  • CPD-3483

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0367 0.0374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0576 0.9827 1
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0578 0.0578
Loa Loa (eye worm) oxidoreductase 0.0576 0.9827 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Echinococcus multilocularis voltage gated potassium channel subunit 0.0167 0.2773 0.2822
Onchocerca volvulus 0.0167 0.2773 0.2822
Echinococcus multilocularis aldehyde reductase 0.0409 0.6951 0.7073
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0113 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0894 0.091
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0367 0.0374
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0894 0.091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0894 0.091
Entamoeba histolytica aldose reductase, putative 0.0576 0.9827 0.9827
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Schistosoma mansoni zinc finger protein 0.0027 0.0367 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0894 0.091
Entamoeba histolytica aldose reductase, putative 0.0576 0.9827 0.9827
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0013 0.0113 0.0115
Loa Loa (eye worm) oxidoreductase 0.0576 0.9827 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.012 0.1957 0.1992
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0113 0.0113
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0113 0.0115
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0576 0.9827 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0367 0.0374
Brugia malayi nuclear receptor NHR-67 0.0027 0.0367 0.0374
Mycobacterium leprae Conserved hypothetical protein 0.0409 0.6951 0.5922
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0367 0.0374
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0367 0.0374
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0167 0.2773 0.2738
Echinococcus multilocularis muscleblind protein 1 0.0307 0.5196 0.5287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0175
Loa Loa (eye worm) hypothetical protein 0.0031 0.0424 0.0431
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.064 0.0542
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0367 0.0374
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0722 0.0735
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0894 0.091
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0894 0.091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0367 0.0374
Loa Loa (eye worm) oxidoreductase 0.0576 0.9827 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.064 0.064
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0722 0.0735
Schistosoma mansoni potassium channel beta 0.0167 0.2773 0.2822
Trypanosoma cruzi aldo/keto reductase, putative 0.0576 0.9827 1
Onchocerca volvulus 0.0027 0.0367 0.0374
Loa Loa (eye worm) hypothetical protein 0.0031 0.0424 0.0431
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0894 0.091
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0894 0.091
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0894 0.091
Echinococcus granulosus hypothetical protein 0.0576 0.9827 1
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.2773 0.2773
Schistosoma mansoni coup transcription factor 0.0058 0.0894 0.091
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0722 0.0735
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Echinococcus granulosus muscleblind protein 0.0307 0.5196 0.5287
Onchocerca volvulus 0.0576 0.9827 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0367 0.0374
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Mycobacterium ulcerans oxidoreductase 0.0576 0.9827 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0722 0.0735
Schistosoma mansoni hypothetical protein 0.0012 0.011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0894 0.091
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0367 0.0374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0894 0.091
Entamoeba histolytica alcohol dehydrogenase, putative 0.0167 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0175
Brugia malayi nuclear hormone receptor 0.0027 0.0367 0.0374
Schistosoma mansoni nuclear receptor 0.0027 0.0367 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0894 0.091
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0367 0.0374
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0766 0.0779
Toxoplasma gondii aldo-keto reductase 0.0167 0.2773 0.2738
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0586 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.0424 0.0431
Trichomonas vaginalis dullard protein, putative 0.0013 0.0113 0.0113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0367 0.0374
Echinococcus multilocularis 0.0013 0.0113 0.0115
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0894 0.091
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0167 0.2773 0.2822
Loa Loa (eye worm) acetyltransferase 0.0147 0.2423 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0894 0.091
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0576 0.9827 0.9827
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0722 0.0735
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.0424 0.0431
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Schistosoma mansoni nuclear receptor 0.0027 0.0367 0.0374
Echinococcus granulosus voltage gated potassium channel subunit 0.0167 0.2773 0.2822
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0172 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0894 0.091
Onchocerca volvulus 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase 0.0576 0.9827 1
Onchocerca volvulus 0.0576 0.9827 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0367 0.0374
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0578 0.1747
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0172 0.0175
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0894 0.091
Brugia malayi conserved hypotetical protein 0.0027 0.0367 0.0374
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0894 0.091
Plasmodium vivax aldehyde reductase, putative 0.0167 0.2773 1
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0894 0.091
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0894 0.091
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0894 0.091
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0894 0.091
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0367 0.0374
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0894 0.091
Trichomonas vaginalis aldo-keto reductase, putative 0.0167 0.2773 0.2773
Brugia malayi steroid hormone receptor 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0113 0.0113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0894 0.091
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0424 0.0431
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.064 0.064
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0167 0.2773 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.012 0.1957 0.1992
Loa Loa (eye worm) oxidoreductase 0.0576 0.9827 1
Brugia malayi ecdysone receptor 0.0027 0.0367 0.0374
Loa Loa (eye worm) hypothetical protein 0.0012 0.011 0.0112
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0576 0.9827 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Brugia malayi nuclear receptor RXR 0.0027 0.0367 0.0374
Leishmania major aldo-keto reductase-like protein 0.0576 0.9827 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Brugia malayi tailless protein 0.0027 0.0367 0.0374
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.012 0.1957 0.1992
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.2423 0.2465
Brugia malayi Protein-tyrosine phosphatase containing protein 0.012 0.1957 0.1992
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0175
Schistosoma mansoni aldo-keto reductase 0.0576 0.9827 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0113 0.0115
Trichomonas vaginalis aldo-keto reductase, putative 0.0167 0.2773 0.2773
Echinococcus multilocularis muscleblind protein 0.0307 0.5196 0.5287
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0167 0.2773 0.2822
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0367 0.0374
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0894 0.091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0894 0.091
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0491 0.0499
Onchocerca volvulus 0.0576 0.9827 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0576 0.9827 1
Schistosoma mansoni pol-related 0.0576 0.9827 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0115
Brugia malayi nuclear hormone receptor 0.0058 0.0894 0.091
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Leishmania major hypothetical protein, conserved 0.0013 0.0113 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0894 0.091
Onchocerca volvulus 0.0576 0.9827 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0894 0.091
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0894 0.091
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0491 0.0499
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Onchocerca volvulus 0.0576 0.9827 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.012 0.1957 0.1992
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0894 0.091
Trypanosoma brucei prostaglandin f synthase 0.0576 0.9827 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0576 0.9827 1
Trypanosoma brucei aldo/keto reductase, putative 0.0167 0.2773 0.2822
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0722 0.0735
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2352 0.2393
Trichomonas vaginalis aldo-keto reductase, putative 0.0167 0.2773 0.2773
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.064 0.198
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0894 0.091
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0367 0.0374
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0167 0.2773 0.2738
Loa Loa (eye worm) hypothetical protein 0.0307 0.5196 0.5287
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0367 0.0374
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0113 0.0113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0894 0.091
Echinococcus multilocularis thyroid hormone receptor alpha 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase 0.0576 0.9827 1
Brugia malayi NADH-dependent xylose reductase 0.0167 0.2773 0.2822
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0113 0.0115
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0766 0.0779
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0894 0.091
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0175
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Schistosoma mansoni hypothetical protein 0.0034 0.0491 0.0499
Giardia lamblia Aldose reductase 0.0576 0.9827 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0167 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0031 0.0424 0.0431
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0367 0.0374
Brugia malayi hypothetical protein 0.0027 0.0367 0.0374
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0367 0.0374
Trypanosoma cruzi aldo-keto reductase 0.0576 0.9827 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Entamoeba histolytica alcohol dehydrogenase, putative 0.0167 0.2773 0.2773
Loa Loa (eye worm) DR-78 0.0027 0.0367 0.0374
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.2423 0.2465
Schistosoma mansoni aldo-keto reductase 0.0576 0.9827 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase 0.0576 0.9827 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0894 0.091
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0113 0.0115
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0576 0.9827 1
Echinococcus granulosus GPCR family 2 0.0016 0.0172 0.0175
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Toxoplasma gondii aldose reductase, putative 0.0576 0.9827 1
Brugia malayi hypothetical protein 0.0031 0.0424 0.0431
Loa Loa (eye worm) hypothetical protein 0.0031 0.0424 0.0431
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0113 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0894 0.091
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0367 0.0374
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0367 0.0374
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0722 0.0735
Loa Loa (eye worm) hypothetical protein 0.005 0.0766 0.0779
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0894 0.091
Brugia malayi nuclear receptor NHR-88 0.0058 0.0894 0.091
Entamoeba histolytica aldose reductase, putative 0.0576 0.9827 0.9827
Onchocerca volvulus 0.0576 0.9827 1
Echinococcus multilocularis aldo keto reductase 0.0576 0.9827 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.0424 0.0431
Mycobacterium tuberculosis Probable oxidoreductase 0.0576 0.9827 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0172 0.0175
Echinococcus granulosus aldo keto reductase 0.0576 0.9827 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0578 0.0588
Trichomonas vaginalis aldo/keto reductase, putative 0.0576 0.9827 0.9827
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0722 0.0735
Brugia malayi Muscleblind-like protein 0.0307 0.5196 0.5287
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.2423 0.2465
Brugia malayi hypothetical protein 0.0031 0.0424 0.0431
Trypanosoma brucei aldo-keto reductase, putative 0.0576 0.9827 1
Plasmodium falciparum aldo-keto reductase, putative 0.0167 0.2773 1
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0113 0.0115
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0175
Loa Loa (eye worm) protein-tyrosine phosphatase 0.012 0.1957 0.1992
Trichomonas vaginalis aldo/keto reductase, putative 0.0576 0.9827 0.9827
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.0424 0.0431
Trichomonas vaginalis aldo-keto reductase, putative 0.0576 0.9827 0.9827
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Trichomonas vaginalis dullard protein, putative 0.0013 0.0113 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0424 0.0431
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0367 0.0374
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0113 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0424 0.0431
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0113 0.0115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0894 0.091
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0167 0.2773 0.2822
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0894 0.091
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0894 0.091
Onchocerca volvulus 0.0027 0.0367 0.0374
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0894 0.091
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0576 0.9827 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0722 0.0735
Loa Loa (eye worm) hypothetical protein 0.0307 0.5196 0.5287
Echinococcus multilocularis GPCR, family 2 0.0016 0.0172 0.0175
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0367 0.0374
Loa Loa (eye worm) hypothetical protein 0.0031 0.0424 0.0431
Plasmodium falciparum aldehyde reductase, putative 0.0167 0.2773 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0172 0.0175
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0576 0.9827 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0894 0.091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0367 0.0374
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0576 0.9827 1
Brugia malayi hypothetical protein 0.0027 0.0367 0.0374
Echinococcus granulosus aldo keto reductase 0.0576 0.9827 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0167 0.2773 0.2822
Giardia lamblia Aldose reductase 0.0576 0.9827 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0367 0.0374
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0367 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0894 0.091
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0766 0.0779
Loa Loa (eye worm) oxidoreductase 0.0576 0.9827 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0894 0.091
Brugia malayi ecdysteroid receptor 0.0058 0.0894 0.091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0576 0.9827 0.9827
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0576 0.9827 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.064 0.0651
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0175
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0367 0.0374
Echinococcus granulosus aldo keto reductase 0.0576 0.9827 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.012 0.1957 0.1992
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0367 0.0374
Brugia malayi nuclear receptor NHR-88 0.0027 0.0367 0.0374
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0367 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0894 0.091
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0894 0.091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0894 0.091
Trichomonas vaginalis aldo/keto reductase, putative 0.0576 0.9827 0.9827
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0576 0.9827 0.9827
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0894 0.091
Trichomonas vaginalis dullard protein, putative 0.0013 0.0113 0.0113
Brugia malayi nuclear receptor RXR 0.0031 0.0424 0.0431
Trypanosoma cruzi aldo/keto reductase, putative 0.0167 0.2773 0.2822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0172 0.0175
Loa Loa (eye worm) hypothetical protein 0.0058 0.0894 0.091
Leishmania major prostaglandin f synthase, putative 0.0576 0.9827 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.064 0.0542
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0367 0.0374
Echinococcus granulosus aldehyde reductase 0.0409 0.6951 0.7073

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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