Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1636 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.1078 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.021 | 0.0817 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.2573 | 1 |
Onchocerca volvulus | 0.0043 | 0.3106 | 0.2022 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.1435 | 0.5576 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.4849 | 0.4673 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1501 | 0.5834 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.2573 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.3241 | 0.2178 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0891 | 0.3461 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.114 | 0.4398 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3272 | 0.3042 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1359 | 0.1359 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4849 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1501 | 0.5834 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.4849 | 0.4673 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.1636 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.1636 | 0.6357 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.2573 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4849 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.4849 | 0.4849 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.1501 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.1501 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.1078 | 0.4155 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.114 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.1501 | 0.5834 |
Loa Loa (eye worm) | fatty acid synthase | 0.0025 | 0.1472 | 0.1181 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3272 | 0.3272 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.4849 | 0.4849 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.114 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.1435 | 0.5576 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1636 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.1106 | 0.4299 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.1636 | 0.6357 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4849 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.1501 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.1501 | 0.5834 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4849 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.1636 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.0767 | 0.2981 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.2573 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.4849 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.1359 | 0.528 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.1501 | 0.5834 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1359 | 0.1063 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.0876 | 0.3708 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.1636 | 0.6337 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.1636 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0566 | 0.2199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4849 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.074 | 0.2574 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.1501 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.114 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.0767 | 0.2941 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.4849 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.1501 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0548 | 0.0225 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.0767 | 0.2981 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.4849 | 0.4673 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.1078 | 0.4188 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.3442 | 0.3442 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0014 | 0.0056 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.4849 | 0.4849 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.1636 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0079 | 0.0306 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0014 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.1636 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2975 | 0.2735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.