Detailed information for compound 585314

Basic information

Technical information
  • TDR Targets ID: 585314
  • Name: 1-(4-fluorophenyl)-4-(3-indan-5-yloxypropyl)p iperazine
  • MW: 354.461 | Formula: C22H27FN2O
  • H donors: 0 H acceptors: 0 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)N1CCN(CC1)CCCOc1ccc2c(c1)CCC2
  • InChi: 1S/C22H27FN2O/c23-20-6-8-21(9-7-20)25-14-12-24(13-15-25)11-2-16-26-22-10-5-18-3-1-4-19(18)17-22/h5-10,17H,1-4,11-16H2
  • InChiKey: DQAHJZNZWUQWQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-fluorophenyl)-4-[3-(5-indanyloxy)propyl]piperazine
  • 1-[3-(2,3-dihydro-1H-inden-5-yloxy)propyl]-4-(4-fluorophenyl)piperazine
  • 5-(3-(4-(4-fluorophenyl)-1-piperazinyl)propoxy)indan
  • 82859-89-0
  • BP 528
  • BP-528
  • Piperazine, 1-(3-((2,3-dihydro-1H-inden-5-yl)oxy)propyl)-4-(4-fluorophenyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Schistosoma mansoni cpg binding protein 0.0032 0.0343 0.0343
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0387 0.1834
Toxoplasma gondii ABC1 family protein 0.0035 0.0387 0.4159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1154 0.1154
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0036 0.0134
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Echinococcus multilocularis GPCR, family 2 0.0032 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0156 0.2072 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1154 0.1154
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0036 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.131 0.6305
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0134
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0166 0.5
Schistosoma mansoni hypothetical protein 0.0431 0.5928 0.5928
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0387 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0387 0.3719
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0387 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0134
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0084
Brugia malayi hypothetical protein 0.0038 0.0426 0.2021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0134
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1983 0.1983
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0036 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0036 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0036 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0149 0.1983 0.9566
Schistosoma mansoni thyroid hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.076 0.3643
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0387 0.0387
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0722 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0236 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Loa Loa (eye worm) beta-lactamase 0.0035 0.0387 0.1834
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0387 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0387 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0024 0.0076
Brugia malayi hypothetical protein 0.0024 0.0236 0.1103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1154 0.1154
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.076 1
Echinococcus multilocularis muscleblind protein 0.0149 0.1983 0.1983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0036 0.0134
Brugia malayi MH2 domain containing protein 0.0119 0.1563 0.7534
Echinococcus granulosus dnaJ subfamily B 0.0431 0.5928 0.5928
Schistosoma mansoni hypothetical protein 0.0069 0.0862 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0134
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0342 0.1618
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1154 0.1154
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0236 0.3185
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0048 0.0048
Onchocerca volvulus 0.003 0.0318 0.1387
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0236 0.3185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0236 0.1103
Mycobacterium ulcerans beta-lactamase 0.0035 0.0387 1
Onchocerca volvulus 0.0035 0.0387 0.1723
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0387 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0387 0.1834
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0134
Brugia malayi nuclear receptor NHR-88 0.001 0.0036 0.0134
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0342 0.1618
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.0032 0.0343 0.0343
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0387 0.077
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0036 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0387 0.3719
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0387 0.077
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0236 0.3185
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0166 0.0166
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0166 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0036 0.0134
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0387 0.077
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0036 0.0036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1154 0.5549
Brugia malayi beta-lactamase family protein 0.0035 0.0387 0.1834
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0387 0.3719
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0069 0.0862 0.4136
Schistosoma mansoni hypothetical protein 0.0032 0.0342 0.0342
Schistosoma mansoni ap endonuclease 0.0019 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0032 0.0342 0.0342
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0036 0.0036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0342 0.0342
Entamoeba histolytica hypothetical protein 0.0038 0.0426 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0342 0.1618
Leishmania major hypothetical protein, conserved 0.0024 0.0236 0.3185
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1563 0.7534
Echinococcus multilocularis smad 0.0008 0.0008 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0793 0.0793
Echinococcus multilocularis geminin 0.0722 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0342 0.0342
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0318 0.1502
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0134
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1563 0.7534
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.0032 0.0342 0.0342
Echinococcus granulosus Smad4 0.0008 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0342 0.1618
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.076 0.076
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0236 0.3185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Brugia malayi Muscleblind-like protein 0.0149 0.1983 0.9566
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0387 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0011 0.0048 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0387 0.3719
Entamoeba histolytica hypothetical protein 0.0038 0.0426 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0166 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0387 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Brugia malayi steroid hormone receptor 0.001 0.0036 0.0134
Echinococcus granulosus muscleblind protein 0.0149 0.1983 0.1983
Echinococcus granulosus FTZ F1 alpha 0.0394 0.5411 0.5411
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.131 0.6305
Mycobacterium ulcerans lipase LipD 0.0035 0.0387 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Brugia malayi beta-lactamase family protein 0.0035 0.0387 0.1834
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0426 0.0426
Brugia malayi ecdysteroid receptor 0.001 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.0722 1 1
Onchocerca volvulus 0.0035 0.0387 0.1723
Schistosoma mansoni smad 0.0008 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0166 0.0762
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0149 0.1983 0.9566
Brugia malayi nuclear hormone receptor 0.001 0.0036 0.0134
Brugia malayi CXXC zinc finger family protein 0.003 0.0318 0.1502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0101 0.131 0.6305
Echinococcus granulosus cpg binding protein 0.0032 0.0343 0.0343
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0036 0.0036
Brugia malayi hypothetical protein 0.0156 0.2072 1
Trichomonas vaginalis esterase, putative 0.0035 0.0387 0.3719
Mycobacterium ulcerans hypothetical protein 0.0035 0.0387 1
Schistosoma mansoni hypothetical protein 0.0062 0.076 0.076
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0036 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0387 0.3719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1154 0.5549
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.131 0.6305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.0038 0.0426 0.0426
Echinococcus multilocularis cpg binding protein 0.0032 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0008 0.0008
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0008 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0134
Entamoeba histolytica hypothetical protein 0.0038 0.0426 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.3039 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0387 0.077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1154 0.1154
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0036 0.0134
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0236 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0134
Schistosoma mansoni coup transcription factor 0.001 0.0036 0.0036
Brugia malayi hypothetical protein 0.0016 0.0115 0.0517
Schistosoma mansoni thyroid hormone receptor 0.001 0.0036 0.0036
Brugia malayi beta-lactamase 0.0035 0.0387 0.1834
Onchocerca volvulus 0.0035 0.0387 0.1723
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.076 0.076
Echinococcus granulosus smad 0.0008 0.0008 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0387 0.077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0387 0.077
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0387 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0697 1
Schistosoma mansoni Smad4 0.0008 0.0008 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0426 0.0426
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.5928 0.5928
Onchocerca volvulus 0.0156 0.2072 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0035 0.0387 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0387 1
Echinococcus multilocularis Smad4 0.0008 0.0008 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0862 0.4136
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0236 1
Brugia malayi DnaJ domain containing protein 0.0062 0.076 0.3643
Schistosoma mansoni ap endonuclease 0.0019 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Entamoeba histolytica hypothetical protein 0.0038 0.0426 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0134
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0036 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0387 0.0387
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0134
Mycobacterium tuberculosis Conserved protein 0.0035 0.0387 0.077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0342 0.0342
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0048 0.0048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0166 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0387 0.077
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.1834
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.003 0.0318 0.0318
Echinococcus granulosus GPCR family 2 0.0032 0.0342 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0134
Mycobacterium tuberculosis Conserved protein 0.0035 0.0387 0.077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0387 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.0032 0.0342 0.0342

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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