Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0231 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0062 | 0.0039 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0231 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.402 | 0.402 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.7322 | 0.5522 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 0.7147 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Brugia malayi | thymidylate synthase | 0.013 | 0.402 | 0.402 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0062 | 0.0039 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0231 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0186 | 0.7322 | 0.5522 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0231 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0062 | 0.0039 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.7322 | 0.5522 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0231 | 1 | 1 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0186 | 0.7322 | 0.5522 |
Onchocerca volvulus | 0.013 | 0.402 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.7147 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0231 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 35605 | ||
Annotator: | millerja@u.washington.edu | Comment: | References: | 16048931 | ||
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | amastigote (BTO:0000062) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 35605 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 16048931 |
2 literature references were collected for this gene.