Detailed information for compound 585465

Basic information

Technical information
  • TDR Targets ID: 585465
  • Name: 1-isobutyl-5-methyl-4-oxo-thieno[2,3-d]pyrimi dine-2-carboxylic acid
  • MW: 266.316 | Formula: C12H14N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c(nc(=O)c2c1scc2C)C(=O)O)C
  • InChi: 1S/C12H14N2O3S/c1-6(2)4-14-9(12(16)17)13-10(15)8-7(3)5-18-11(8)14/h5-6H,4H2,1-3H3,(H,16,17)
  • InChiKey: ILANNHKYENEETR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-isobutyl-5-methyl-4-oxo-2-thieno[2,3-d]pyrimidinecarboxylic acid
  • 5-methyl-1-(2-methylpropyl)-4-oxo-thieno[2,3-d]pyrimidine-2-carboxylic acid
  • 1-isobutyl-4-keto-5-methyl-thieno[2,3-d]pyrimidine-2-carboxylic acid
  • 5-methyl-1-(2-methylpropyl)-4-oxothieno[2,3-d]pyrimidine-2-carboxylic acid
  • tiprinast
  • 5-methyl-1-(2-methylpropyl)-4-oxothieno[3,2-e]pyrimidine-2-carboxylic acid
  • 1-isobutyl-5-methyl-4-oxo-thieno[3,2-e]pyrimidine-2-carboxylic acid
  • 1-isobutyl-5-methyl-4-oxo-2-thieno[3,2-e]pyrimidinecarboxylic acid
  • 1-isobutyl-4-keto-5-methyl-thieno[3,2-e]pyrimidine-2-carboxylic acid
  • 5-methyl-1-(2-methylpropyl)-4-oxo-thieno[3,2-e]pyrimidine-2-carboxylic acid
  • 83153-39-3
  • 1,4-Dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno(2,3-d)pyrimidine-2-carboxylic acid
  • MJ 12175
  • Thieno(2,3-d)pyrimidine-2-carboxylic acid, 1,4-dihydro-5-methyl-(2-methylpropyl)-4-oxo-
  • Thieno(2,3-d)pyrimidine-2-carboxylic acid, 1,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxo-
  • Tiprinastum [Latin]
  • Triprinast

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0672 0.1004
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0478 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.006 0.009
Leishmania major trypanothione reductase 0.0048 0.1168 0.7491
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.151 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0672 0.0672
Brugia malayi hypothetical protein 0.0017 0.0253 0.0378
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0252 0.3185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.2542 0.3794
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.2542 0.3794
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0521 0.2968
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0521 0.0777
Plasmodium vivax glutathione reductase, putative 0.0048 0.1168 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0392 0.2991
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0252 0.1033
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0478 0.0714
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0672 0.0672
Schistosoma mansoni hypothetical protein 0.0012 0.0105 0.0105
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0252 0.0252
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0147 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.263 0.3926
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0252 0.1033
Schistosoma mansoni DNA helicase recq5 0.001 0.006 0.006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.006 0.009
Loa Loa (eye worm) hypothetical protein 0.0232 0.6558 0.979
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0521 0.4158
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.151 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0521 0.3663
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.6699 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0122 0.3349 0.4999
Brugia malayi Thioredoxin reductase 0.0048 0.1168 0.1744
Schistosoma mansoni hypothetical protein 0.0067 0.1724 0.1724
Echinococcus granulosus GPCR family 2 0.0031 0.0672 0.0672
Schistosoma mansoni hypothetical protein 0.0031 0.0672 0.0672
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0478 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.1168 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1724 0.2574
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0521 0.3663
Schistosoma mansoni hypothetical protein 0.0047 0.1152 0.1152
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.1168 0.2985
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2542 0.2542
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.6558 0.6558
Echinococcus multilocularis GPCR, family 2 0.0031 0.0672 0.0672
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0252 0.1033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.0774
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0672 0.0672
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.3195 0.477
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.006 0.00000000092258
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0252 0.3185
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3321 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.151 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.006 0.006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0252 0.1733
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.151 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2964 0.8837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2964 0.8837
Loa Loa (eye worm) hypothetical protein 0.012 0.3285 0.4904
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0672 0.0672
Brugia malayi hypothetical protein 0.0026 0.0521 0.0777
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0242 0.1253
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.1168 0.1744
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0123 0.0184
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.151 0.41
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0252 0.1033
Loa Loa (eye worm) RecQ helicase 0.0024 0.0478 0.0714
Brugia malayi hypothetical protein 0.012 0.3285 0.4904
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.1168 1
Schistosoma mansoni hypothetical protein 0.0349 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0123 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0521 0.3663
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.151 0.151
Toxoplasma gondii thioredoxin reductase 0.0048 0.1168 0.764
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.6558 0.6558
Brugia malayi MH2 domain containing protein 0.0117 0.3195 0.477
Schistosoma mansoni hypothetical protein 0.0349 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.0774
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2542 0.2542
Onchocerca volvulus Huntingtin homolog 0.012 0.3285 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0252 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.151 0.151
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0252 0.1033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0252 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2542 0.2542
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.263 0.3926
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.006 0.006
Treponema pallidum NADH oxidase 0.0017 0.0252 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.3195 0.477
Plasmodium falciparum thioredoxin reductase 0.0017 0.0252 0.1733
Plasmodium falciparum glutathione reductase 0.0017 0.0252 0.1733
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0252 0.005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1152 0.1719
Plasmodium falciparum thioredoxin reductase 0.0048 0.1168 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.1168 0.1168
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0252 0.1033
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0105 0.0105
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0252 0.0774
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0252 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2542 0.2542
Leishmania major hypothetical protein, conserved 0.0026 0.0521 0.2744
Schistosoma mansoni survival motor neuron protein 0.0047 0.1152 0.1152
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2964 0.8837
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0478 0.0478
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.1168 0.1168
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0328 0.0328
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0521 0.4158
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0252 0.0252
Echinococcus multilocularis geminin 0.0349 1 1
Brugia malayi glutathione reductase 0.0048 0.1168 0.1744
Schistosoma mansoni DNA helicase recq1 0.001 0.006 0.006
Loa Loa (eye worm) glutathione reductase 0.0048 0.1168 0.1744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2542 0.2542
Loa Loa (eye worm) hypothetical protein 0.012 0.3285 0.4904
Schistosoma mansoni hypothetical protein 0.0031 0.0672 0.0672
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0672 0.1004
Plasmodium falciparum glutathione reductase 0.0048 0.1168 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0252 0.1324
Trypanosoma brucei trypanothione reductase 0.0048 0.1168 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0105 0.0105
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0252 0.0774
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0252 0.1324
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0252 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.263 0.3926
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0252 0.0252
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2542 0.2542
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3321 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1724 0.2574
Onchocerca volvulus Huntingtin homolog 0.012 0.3285 1
Brugia malayi follicle stimulating hormone receptor 0.0237 0.6699 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2542 0.2542
Schistosoma mansoni hypothetical protein 0.0031 0.0672 0.0672
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0098 0.263 0.3926
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0521 0.3177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0252 0.1033
Echinococcus granulosus bloom syndrome protein 0.0024 0.0478 0.0478
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3321 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.006 0.009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.151 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.151 0.151
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0252 0.5
Brugia malayi hypothetical protein 0.0232 0.6558 0.979
Loa Loa (eye worm) hypothetical protein 0.0031 0.0672 0.1004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0672 0.1004
Mycobacterium tuberculosis Probable reductase 0.0109 0.2964 0.8837
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.006 0.006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2964 0.8837
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3321 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2964 0.8837
Schistosoma mansoni hypothetical protein 0.0031 0.0672 0.0672
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0252 0.1733

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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