Detailed information for compound 58551

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.244 | Formula: C7H11N3O5S
  • H donors: 5 H acceptors: 4 LogP: -1.78 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1c(=O)[nH][nH]c1=S
  • InChi: 1S/C7H11N3O5S/c11-1-2-3(12)4(13)5(15-2)10-6(14)8-9-7(10)16/h2-5,11-13H,1H2,(H,8,14)(H,9,16)
  • InChiKey: ZARHFEAWTPQLDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0036 0.0152 0.0149
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0644 0.1248
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0644 0.1008
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.011 0.0458
Loa Loa (eye worm) hypothetical protein 0.0065 0.0376 0.111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0246 0.0382
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0019 0.0031
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0367 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0116 0.0335
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0116 0.0177
Loa Loa (eye worm) glutathione reductase 0.005 0.0261 0.0767
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0116 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0356 0.0687
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0066 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0171 0.2613
Toxoplasma gondii hypothetical protein 0.0051 0.0272 0.0621
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.001 0.0007
Brugia malayi beta-lactamase family protein 0.0036 0.0152 0.045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0246 0.0473
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0167 0.032
Plasmodium falciparum importin beta, putative 0.003 0.011 0.4131
Echinococcus multilocularis musashi 0.0027 0.0083 0.0125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0152 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0068 0.2503
Onchocerca volvulus 0.0036 0.0152 0.2318
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0048 0.0104
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0171 0.0326
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0171 0.2613
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0048 0.0071
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.058 0.4341 0.434
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0356 0.0687
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0753 0.075
Brugia malayi follicle stimulating hormone receptor 0.0454 0.3367 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0116 0.0344
Schistosoma mansoni coup transcription factor 0.0031 0.0116 0.0219
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0116 0.0344
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0116 0.1758
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0019 0.0016
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0031
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0753 0.1728
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0116 0.0335
Brugia malayi Ets-domain containing protein 0.0076 0.0461 0.137
Brugia malayi RNA binding protein 0.0062 0.0356 0.1057
Echinococcus granulosus lamin dm0 0.0027 0.0083 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0083 0.0237
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0066 0.0976
Onchocerca volvulus 0.0099 0.0642 0.9971
Schistosoma mansoni alpha-glucosidase 0.0148 0.1016 0.1971
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0171 0.2613
Echinococcus multilocularis snurportin 1 0.0323 0.236 0.3707
Trichomonas vaginalis esterase, putative 0.0036 0.0152 0.2318
Toxoplasma gondii thioredoxin reductase 0.005 0.0261 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0257 0.3957
Echinococcus granulosus importin subunit beta 1 0.003 0.011 0.0207
Loa Loa (eye worm) fli-1 protein 0.0231 0.1651 0.4898
Brugia malayi intermediate filament protein 0.0027 0.0083 0.0246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.001 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0116 0.0344
Leishmania major GTP-binding protein, putative 0.0022 0.0048 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0116 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0116 0.0335
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0171 0.2613
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.001 0.0007
Echinococcus granulosus geminin 0.0179 0.1253 0.2433
Brugia malayi nuclear hormone receptor 0.0031 0.0116 0.0344
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0019 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.003
Trichomonas vaginalis ran, putative 0.0022 0.0048 0.0704
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0367 0.0364
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0019 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0083 0.0246
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0627
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.2329 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0116 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0171 0.072
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0152 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0152 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0644 0.1248
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.001 0.0109
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0753 0.075
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0009
Echinococcus granulosus tar DNA binding protein 0.0062 0.0356 0.0687
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0843 0.6362 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0644 0.1906
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0019 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1038 0.4447
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0019 0.0252
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0019 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0116 0.0344
Onchocerca volvulus 0.0027 0.0083 0.1243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0246 0.0473
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.001 0.003
Plasmodium falciparum glutathione reductase 0.005 0.0261 1
Schistosoma mansoni ran 0.0022 0.0048 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0261 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0116 0.0344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0753 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0116 0.0335
Leishmania major importin beta-1 subunit, putative 0.0025 0.0066 0.0269
Schistosoma mansoni alpha-glucosidase 0.0148 0.1016 0.1971
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0152 0.0639
Brugia malayi hypothetical protein 0.0038 0.0167 0.0497
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0068 0.0149
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0116 0.0335
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0152 0.0149
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.001 0.0272
Brugia malayi ecdysteroid receptor 0.0031 0.0116 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0222 0.094
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2561
Schistosoma mansoni alpha glucosidase 0.0038 0.0171 0.0326
Brugia malayi Thioredoxin reductase 0.005 0.0261 0.0775
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0152 0.045
Brugia malayi nuclear receptor NHR-88 0.0031 0.0116 0.0344
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.001 0.0272
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0192
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0019 0.0025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0602
Echinococcus granulosus intermediate filament protein 0.0027 0.0083 0.0155
Brugia malayi Importin beta-1 subunit 0.003 0.011 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0116 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0356 0.0687
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0367 0.0708
Brugia malayi RNA, U transporter 1 0.0086 0.0538 0.1599
Echinococcus multilocularis lamin dm0 0.0027 0.0083 0.0125
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0134
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0644 0.2755
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0116 0.1758
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0237
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2561
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0644 0.1913
Toxoplasma gondii exonuclease III APE 0.0018 0.0019 0.0037
Schistosoma mansoni kinase 0.0051 0.0267 0.0513
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0152 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0116 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.2329 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0851 0.0848
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0246 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0171 0.072
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0644 1
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0116 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Plasmodium falciparum thioredoxin reductase 0.0017 0.001 0.0272
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0019 0.0627
Schistosoma mansoni intermediate filament proteins 0.0027 0.0083 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0152 0.2318
Brugia malayi beta-lactamase family protein 0.0036 0.0152 0.045
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0171 0.2613
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0851 0.1954
Echinococcus granulosus snurportin 1 0.0323 0.236 0.4588
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.2329 1
Echinococcus granulosus microtubule associated protein 2 0.0684 0.5141 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.12 0.3558
Mycobacterium leprae Probable lipase LipE 0.0036 0.0152 0.0343
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0152 0.0343
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.007
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0116 0.0219
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0116 0.0219
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0116 0.0177
Entamoeba histolytica Ran family GTPase 0.0022 0.0048 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0116 0.0219
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0252
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0116 0.0177
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0367 0.1564
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0083 0.0237
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0019 0.0145
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2561
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0019 0.007
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0066 0.0976
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0261 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0116 0.0344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0152 0.0442
Schistosoma mansoni hypothetical protein 0.0179 0.1253 0.2433
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0116 0.0177
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0152 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0297 0.1265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0367 0.0364
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0048 0.0088
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0171 0.2613
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0116 0.0335
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1038 0.4447
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0356 0.0687
Schistosoma mansoni lamin 0.0027 0.0083 0.0155
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.001 0.0016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0171 0.0386
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0851 0.0848
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0116 0.0177
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0152 0.0149
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0644 0.2755
Brugia malayi hypothetical protein 0.0025 0.0068 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0171 0.2613
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0116 0.0219
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.001 0.0016
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0461 0.1362
Trypanosoma brucei glucosidase, putative 0.0038 0.0171 0.072
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.001 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0152 0.0149
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0116 0.0219
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.0278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0753 0.075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0116 0.0219
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.12 0.1882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0246 0.0473
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.001 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0019 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.2503
Loa Loa (eye worm) RNA binding protein 0.0062 0.0356 0.1049
Echinococcus multilocularis lamin 0.0027 0.0083 0.0125
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.001 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0116 0.0344
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.5141 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0116 0.0219
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0003 0.0009
Trypanosoma brucei polo-like protein kinase 0.01 0.0644 0.2755
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0851 0.0848
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.001 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0116 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0356 0.0687
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0367 0.0364
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0116 0.0219
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.058 0.4341 1
Schistosoma mansoni gabp alpha 0.0076 0.0461 0.0892
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0152 0.0289
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0003 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0152 0.0639
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0171 0.2613
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.001 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0116 0.0177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0194
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0367 0.0708
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0152 0.5761
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0261 0.0767
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0753 0.075
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0116 0.0219
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.175
Schistosoma mansoni ap endonuclease 0.0018 0.0019 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0019 0.0252
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0116 0.0219
Echinococcus multilocularis geminin 0.0179 0.1253 0.1966
Mycobacterium tuberculosis Conserved protein 0.0036 0.0152 0.0149
Schistosoma mansoni ran 0.0022 0.0048 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0116 0.0344
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0356 0.1057
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0152 0.2318
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0152 0.0149
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.001 0.0011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0171 0.2613
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0356 0.1049
Schistosoma mansoni hypothetical protein 0.0323 0.236 0.4588
Onchocerca volvulus 0.0036 0.0152 0.2318
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0116 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0171 0.0498
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0317
Schistosoma mansoni hypothetical protein 0.0038 0.0167 0.032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0167 0.0258
Mycobacterium tuberculosis Probable reductase 0.0114 0.0753 0.075
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0152 0.2318
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0194
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.001 0.0014
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.058 0.4341 0.434
Brugia malayi Fli-1 protein 0.0231 0.1651 0.4902
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0116 0.0219
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0116 0.1758
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.0278
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.2329 1
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.001 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0152 0.2318
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1316 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0116 0.0177
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0261 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0116 0.0344
Entamoeba histolytica hypothetical protein 0.0025 0.0066 0.0976
Onchocerca volvulus 0.0031 0.0116 0.1758
Plasmodium vivax importin-beta 2, putative 0.003 0.011 0.4131
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0171 0.0263
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0222 0.094
Schistosoma mansoni importin beta-1 0.003 0.011 0.0207
Onchocerca volvulus 0.0036 0.0152 0.2318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0226
Trypanosoma brucei trypanothione reductase 0.005 0.0261 0.1109
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0048 0.175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0116 0.0219
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0116 0.0219
Brugia malayi steroid hormone receptor 0.0031 0.0116 0.0344
Schistosoma mansoni ets-related 0.0231 0.1651 0.3207
Mycobacterium ulcerans lipase LipD 0.0036 0.0152 0.0149
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.011 0.0458
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.12 0.1882
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0222 0.094
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0261 1
Plasmodium falciparum thioredoxin reductase 0.005 0.0261 1
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0461 0.072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.001 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0644 0.2755
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.011 0.0246
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0222 0.094
Echinococcus granulosus lamin 0.0027 0.0083 0.0155
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0152 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0116 0.0177
Plasmodium vivax glutathione reductase, putative 0.005 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1169 0.1166
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0261 0.0258
Plasmodium falciparum glutathione reductase 0.0017 0.001 0.0272
Schistosoma mansoni hypothetical protein 0.0179 0.1253 0.2433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0116 0.0344
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0152 0.2318
Mycobacterium tuberculosis Conserved protein 0.0036 0.0152 0.0149
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0116 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0116 0.0219
Onchocerca volvulus 0.0027 0.0083 0.1243
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.5141 0.808
Mycobacterium ulcerans hypothetical protein 0.0036 0.0152 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0246 0.0473
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0066 0.0976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.003
Leishmania major hypothetical protein, conserved 0.0036 0.0152 0.0639
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0644 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0152 0.0149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0356 0.1049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0442
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.001 0.0272
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0152 0.0149
Echinococcus multilocularis importin subunit beta 1 0.003 0.011 0.0168
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0171 0.2613
Loa Loa (eye worm) beta-lactamase 0.0036 0.0152 0.0442
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0257 0.3957
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0246 0.0382
Schistosoma mansoni lamin 0.0027 0.0083 0.0155
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.12 0.233
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0194
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0367 0.0364
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0367 0.0839
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0116 0.0219
Giardia lamblia Kinase, PLK 0.01 0.0644 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0246 0.0722
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0116 0.0344
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0367 0.0708
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0116 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0116 0.0335
Brugia malayi glutathione reductase 0.005 0.0261 0.0775
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0246 0.073
Mycobacterium ulcerans hypothetical protein 0.0168 0.1169 0.1166
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1038 0.4447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0116 0.0335
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0171 0.0506
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0171 0.2613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0116 0.0219
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.0278
Leishmania major trypanothione reductase 0.005 0.0261 0.1109
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0356 0.0555
Brugia malayi TAR-binding protein 0.0062 0.0356 0.1057
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0152 0.0639
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0644 1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0171 0.072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0152 0.0149
Toxoplasma gondii pantoate-beta-alanine ligase 0.058 0.4341 1
Brugia malayi Ets-domain containing protein 0.0076 0.0461 0.137
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0116 0.0219
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.001 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.2503
Toxoplasma gondii ABC1 family protein 0.0036 0.0152 0.0343
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0068 0.0278
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.236 0.7007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0454 0.3367 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.12 0.3564
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0461 0.0892
Brugia malayi beta-lactamase 0.0036 0.0152 0.045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0167 0.032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.001 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1632 0.1629
Entamoeba histolytica hypothetical protein 0.0038 0.0167 0.2561
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0116 0.0219

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 M l-1 Compound was evaluated in vitro against NCI CNS cancer cell line SNB19 at concentration up to 10e -4 mol/L; Not active ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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