Detailed information for compound 586034

Basic information

Technical information
  • TDR Targets ID: 586034
  • Name: ethyl N-[4-[[(2R,4R)-2-(2,4-dichlorophenyl)-2 -(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]meth ylsulfanyl]phenyl]carbamate
  • MW: 508.417 | Formula: C23H23Cl2N3O4S
  • H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)Nc1ccc(cc1)SC[C@H]1CO[C@](O1)(Cn1cncc1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C23H23Cl2N3O4S/c1-2-30-22(29)27-17-4-6-19(7-5-17)33-13-18-12-31-23(32-18,14-28-10-9-26-15-28)20-8-3-16(24)11-21(20)25/h3-11,15,18H,2,12-14H2,1H3,(H,27,29)/t18-,23+/m1/s1
  • InChiKey: OGPIBXIQNMQSPY-JPYJTQIMSA-N  

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Synonyms

  • N-[4-[[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • N-[4-[[(2R,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester
  • tubulazole
  • 84697-22-3
  • Carbamic acid, (4-((((2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)phenyl)-, ethyl ester, rel-
  • Carbamic acid, (4-(((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)phenyl)-, ethyl ester, cis-(+-)-
  • Ethyl ( -)-cis-p-(((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-p-ylmethylthio)thio)carbanilate
  • NSC 376450
  • R 46846
  • Tubulozol [Spanish]
  • Tubulozole (free base)
  • Tubulozole C
  • Tubulozolum [Latin]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major zeta tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Plasmodium falciparum alpha tubulin 1 Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major epsilon tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major delta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major gamma-tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Neospora caninum Beta-tubulin, related Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Theileria parva tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Trypanosoma congolense tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania donovani zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit epsilon Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium falciparum tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma cruzi tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium falciparum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Entamoeba histolytica tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Giardia lamblia Epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K10389 tubulin gamma, putative Get druggable targets OG5_127652 All targets in OG5_127652
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_143817 All targets in OG5_143817
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania braziliensis epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma mansoni tubulin subunit gamma Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin delta chain, putative Get druggable targets OG5_143817 All targets in OG5_143817
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania braziliensis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium berghei tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin epsilon chain, putative alpha tubulin 1 453 aa 465 aa 26.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin epsilon chain, putative gamma-tubulin 447 aa 479 aa 28.2 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Trypanosoma brucei epsilon tubulin epsilon tubulin, putative 470 aa 488 aa 68.0 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii alpha tubulin TUBA1 0.0492 0.6055 0.767
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0132 0.0017
Echinococcus multilocularis hypothetical protein 0.0492 0.6055 0.6054
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Leishmania major beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0295
Plasmodium vivax tubulin beta chain, putative 0.0636 0.7854 1
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Trypanosoma brucei beta tubulin 0.0363 0.4437 0.5575
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Trichomonas vaginalis tubulin, putative 0.0199 0.2383 0.3034
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus granulosus cpg binding protein 0.006 0.0654 0.0832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Giardia lamblia Delta tubulin 0.0166 0.1975 0.2387
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0119
Schistosoma mansoni tubulin subunit beta 0.0166 0.1975 0.2515
Leishmania major beta tubulin 0.0636 0.7854 1
Brugia malayi tubulin alpha chain - mouse 0.0492 0.6055 0.7675
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0414 0.0366
Schistosoma mansoni tubulin subunit epsilon 0.0395 0.4839 0.6161
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin gamma chain, putative 0.0636 0.7854 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.3593 0.4491
Echinococcus granulosus peroxisome assembly protein 26 0.0492 0.6055 0.7709
Echinococcus multilocularis peroxisome assembly protein 26 0.0492 0.6055 0.6054
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1156 0.1341
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0132 0.0131
Echinococcus multilocularis tubulin subunit beta 0.0636 0.7854 0.7854
Trichomonas vaginalis helicase, putative 0.0013 0.006 0.0076
Trichomonas vaginalis tubulin alpha chain, putative 0.0363 0.4437 0.5649
Plasmodium vivax tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Echinococcus multilocularis tubulin gamma 1 chain 0.0396 0.4845 0.4845
Leishmania major zeta tubulin, putative 0.0503 0.6188 0.7843
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Trypanosoma brucei epsilon tubulin 0.0363 0.4437 0.5575
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0707 0.0761
Echinococcus multilocularis tubulin epsilon chain 0.0395 0.4839 0.4839
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Plasmodium vivax delta tubulin, putative 0.0166 0.1975 0.2387
Giardia lamblia Epsilon tubulin 0.0198 0.2377 0.2908
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit alpha 0.0166 0.1975 0.2515
Plasmodium falciparum alpha tubulin 2 0.0492 0.6055 0.767
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Leishmania major beta tubulin 0.0636 0.7854 1
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Loa Loa (eye worm) tubulin beta chain 0.0166 0.1975 0.24
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0371 0.031
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Treponema pallidum cell division protein FtsZ 0.0166 0.1975 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0414 0.0527
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Giardia lamblia Beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0326 0.3977 0.4988
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0707 0.0761
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Brugia malayi CXXC zinc finger family protein 0.0057 0.0613 0.0642
Loa Loa (eye worm) hypothetical protein 0.0069 0.0758 0.0826
Echinococcus multilocularis tubulin alpha 3 chain 0.0492 0.6055 0.6054
Trypanosoma brucei tubulin gamma chain 0.0396 0.4845 0.6104
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Echinococcus multilocularis tubulin subunit TubB 0.0492 0.6055 0.6054
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0758 0.0829
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0376
Schistosoma mansoni alpha tubulin 0.0492 0.6055 0.7709
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1656 0.2108
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1606 0.2045
Trichomonas vaginalis tubulin, putative 0.0197 0.2359 0.3004
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0296 0.0232
Loa Loa (eye worm) acetyltransferase 0.0141 0.1656 0.1987
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Trypanosoma brucei zeta tubulin, putative 0.0503 0.6188 0.7843
Plasmodium falciparum tubulin beta chain 0.0636 0.7854 1
Brugia malayi Tubulin beta-1 chain 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Brugia malayi beta-tubulin, identical 0.0636 0.7854 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0414 0.0366
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Toxoplasma gondii beta-1 tubulin, putative 0.0636 0.7854 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0166 0.1975 1
Giardia lamblia Alpha-tubulin 0.0492 0.6055 0.767
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Trichomonas vaginalis tubulin beta chain, putative 0.0197 0.2359 0.3004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0132 0.0666
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus granulosus tubulin beta 1 chain 0.0636 0.7854 1
Echinococcus granulosus tubulin subunit TubB 0.0492 0.6055 0.7709
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0132 0.002
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0414 0.0527
Trypanosoma brucei tubulin delta chain 0.0368 0.4495 0.5651
Loa Loa (eye worm) hypothetical protein 0.0326 0.3977 0.4988
Mycobacterium leprae cell division protein FtsZ 0.0166 0.1975 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Entamoeba histolytica tubulin gamma chain 0.0396 0.4845 0.6104
Leishmania major beta tubulin 0.0636 0.7854 1
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Entamoeba histolytica tubulin alpha chain, putative 0.0492 0.6055 0.767
Toxoplasma gondii beta-tubulin, putative 0.0636 0.7854 1
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0636 0.7854 0.7854
Brugia malayi Tubulin beta chain 0.0197 0.2359 0.2899
Trypanosoma cruzi alpha tubulin, putative 0.0492 0.6055 0.767
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1156 0.1344
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0326 0.3977 0.5063
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0166 0.1975 0.2515
Loa Loa (eye worm) beta-tubulin 0.0636 0.7854 1
Onchocerca volvulus 0.0197 0.2359 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Brugia malayi Tubulin beta chain 0.0166 0.1975 0.2403
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Brugia malayi RNA binding protein 0.0065 0.0707 0.0764
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.4437 0.5575
Echinococcus multilocularis cpg binding protein 0.006 0.0654 0.0654
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0613 0.0639
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Leishmania major beta tubulin 0.0636 0.7854 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Trypanosoma brucei zeta tubulin 0.0503 0.6188 0.7843
Entamoeba histolytica tubulin family protein 0.0636 0.7854 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0396 0.4845 0.6169
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0371 0.031
Loa Loa (eye worm) tubulin beta chain 0.0636 0.7854 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0395 0.4839 0.6096
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Plasmodium falciparum tubulin gamma chain 0.0396 0.4845 0.6104
Trichomonas vaginalis tubulin gamma chain, putative 0.0166 0.1975 0.2515
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0368 0.4495 0.5651
Echinococcus granulosus tar DNA binding protein 0.0065 0.0707 0.09
Echinococcus multilocularis tubulin alpha 0.0363 0.4437 0.4437
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0296 0.0376
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Echinococcus granulosus tubulin delta chain 0.0166 0.1975 0.2515
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Schistosoma mansoni ap endonuclease 0.0019 0.0132 0.0168
Trypanosoma brucei alpha tubulin, putative 0.0197 0.2359 0.2884
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Brugia malayi Cell division protein ftsZ 0.0166 0.1975 0.2403
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0075
Echinococcus granulosus GPCR family 2 0.0032 0.0296 0.0376
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0296 0.0229
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0371 0.031
Echinococcus granulosus beta tubulin 0.0636 0.7854 1
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0707 0.0707
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0075 0.0096
Leishmania major beta tubulin 0.0636 0.7854 1
Leishmania major gamma-tubulin 0.0396 0.4845 0.6104
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1156 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Loa Loa (eye worm) hypothetical protein 0.0492 0.6055 0.7674
Loa Loa (eye worm) hypothetical protein 0.0101 0.1156 0.1341
Echinococcus granulosus alpha tubulin 0.0492 0.6055 0.7709
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0132 0.0167
Loa Loa (eye worm) tubulin beta-1 chain 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha chain 0.0492 0.6055 0.7709
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Echinococcus granulosus tubulin epsilon chain 0.0395 0.4839 0.6161
Echinococcus multilocularis tubulin delta chain 0.0166 0.1975 0.1975
Schistosoma mansoni hypothetical protein 0.0397 0.4859 0.6187
Trichomonas vaginalis tubulin, putative 0.0636 0.7854 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0166 0.1975 0.2515
Loa Loa (eye worm) tubulin alpha chain 0.0492 0.6055 0.7674
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0198 0.2377 0.2908
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Trypanosoma brucei epsilon tubulin 0.0395 0.4839 0.6096
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Plasmodium falciparum tubulin delta chain, putative 0.0166 0.1975 0.2387
Brugia malayi TAR-binding protein 0.0065 0.0707 0.0764
Plasmodium falciparum alpha tubulin 1 0.0492 0.6055 0.767
Echinococcus multilocularis Tubulin alpha 1 chain 0.0492 0.6055 0.6054
Leishmania major delta tubulin, putative 0.0368 0.4495 0.5651
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Echinococcus granulosus tubulin gamma 1 chain 0.0396 0.4845 0.6169
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0636 0.7854 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0119 0.0151
Brugia malayi Tubulin gamma chain 0.0396 0.4845 0.6112
Echinococcus granulosus Tubulin alpha 1 chain 0.0492 0.6055 0.7709
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0414 0.0527
Leishmania major alpha tubulin 0.0492 0.6055 0.767
Leishmania major beta tubulin 0.0636 0.7854 1
Trypanosoma cruzi tubulin delta chain 0.0368 0.4495 0.5651
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0075 0.0095
Toxoplasma gondii alpha-tubulin I, putative 0.0492 0.6055 0.767
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Leishmania major beta tubulin 0.0636 0.7854 1
Brugia malayi Tubulin alpha chain 0.0492 0.6055 0.7675
Toxoplasma gondii tubulin, putative 0.0032 0.0299 0.0217
Brugia malayi Tubulin alpha-2 chain 0.0492 0.6055 0.7675
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0296 0.0295
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.4839 0.6161
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Echinococcus multilocularis GPCR, family 2 0.0032 0.0296 0.0295
Schistosoma mansoni hypothetical protein 0.0032 0.0296 0.0376
Trypanosoma brucei alpha tubulin 0.0492 0.6055 0.767
Entamoeba histolytica tubulin alpha-1 chain 0.0492 0.6055 0.767
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0132 0.0167
Trichomonas vaginalis tubulin alpha chain, putative 0.0636 0.7854 1
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Schistosoma mansoni tubulin subunit delta 0.0166 0.1975 0.2515
Schistosoma mansoni hypothetical protein 0.0069 0.0758 0.0965
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0132 0.0666
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Schistosoma mansoni tubulin subunit alpha 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin beta-4 chain 0.0636 0.7854 1
Plasmodium vivax tubulin alpha chain, putative 0.0492 0.6055 0.767
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Trypanosoma cruzi zeta tubulin, putative 0.0503 0.6188 0.7843
Toxoplasma gondii beta tubulin 0.0636 0.7854 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus tubulin subunit beta 0.0636 0.7854 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0076
Trypanosoma brucei beta tubulin 0.0636 0.7854 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0492 0.6055 0.7674
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0296 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0707 0.0901
Loa Loa (eye worm) tubulin alpha 2 0.0326 0.3977 0.4988
Trichomonas vaginalis tubulin epsilon chain, putative 0.0636 0.7854 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1656 0.1655
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0707 0.0764
Loa Loa (eye worm) tubulin alpha 2 0.0129 0.1515 0.1805
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709
Trypanosoma cruzi tubulin gamma chain 0.0396 0.4845 0.6104
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0296 0.3593 0.4575
Echinococcus granulosus Tubulin beta 2C chain 0.0636 0.7854 1
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.4839 0.6096
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0076
Giardia lamblia Gamma tubulin 0.0396 0.4845 0.6104
Brugia malayi alpha-tubulin 0.0492 0.6055 0.7675
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0166 0.1975 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.0636 0.7854 1
Echinococcus granulosus tubulin alpha 0.0363 0.4437 0.5649
Schistosoma mansoni cpg binding protein 0.006 0.0654 0.0832
Echinococcus multilocularis tubulin alpha 1C chain 0.0492 0.6055 0.6054
Echinococcus granulosus tubulin alpha 3 chain 0.0492 0.6055 0.7709
Echinococcus multilocularis tubulin beta 1 chain 0.0636 0.7854 0.7854
Leishmania major beta tubulin 0.0636 0.7854 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1296 0.1508
Echinococcus multilocularis Tubulin beta 2C chain 0.0636 0.7854 0.7854
Schistosoma mansoni tubulin subunit beta 0.0636 0.7854 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.0707 0.0761
Brugia malayi tubulin alpha-2 chain 0.0492 0.6055 0.7675
Schistosoma mansoni tubulin subunit gamma 0.0396 0.4845 0.6169
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1415 0.1802
Loa Loa (eye worm) tubulin alpha-3 chain 0.0296 0.3593 0.4491
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0197 0.2359 0.3004
Brugia malayi Tubulin alpha chain 0.0166 0.1975 0.2403
Loa Loa (eye worm) BEN-1 protein 0.0636 0.7854 1
Echinococcus multilocularis tubulin alpha chain 0.0492 0.6055 0.6054
Leishmania major beta tubulin 0.0636 0.7854 1
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4859 0.6187
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0076
Loa Loa (eye worm) tubulin gamma chain 0.0396 0.4845 0.611
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0492 0.6055 0.7709
Leishmania major epsilon tubulin, putative 0.0395 0.4839 0.6096
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0075 0.0095
Leishmania major beta tubulin 0.0636 0.7854 1
Plasmodium vivax tubulin gamma chain, putative 0.0396 0.4845 0.6104
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0132 0.0666
Echinococcus granulosus tubulin alpha 1C chain 0.0492 0.6055 0.7709
Leishmania major beta tubulin 0.0636 0.7854 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0414 0.0366
Trichomonas vaginalis tubulin beta chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) alpha-tubulin 0.0492 0.6055 0.7674
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1656 0.199
Mycobacterium ulcerans cell division protein FtsZ 0.0166 0.1975 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4859 0.4859
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1975 0.2515
Loa Loa (eye worm) hypothetical protein 0.0032 0.0296 0.0229
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 0.6055 0.7709
Loa Loa (eye worm) tubulin beta-2A chain 0.0636 0.7854 1
Schistosoma mansoni cpg binding protein 0.0057 0.0613 0.0781
Trypanosoma cruzi beta tubulin, putative 0.0636 0.7854 1
Echinococcus multilocularis beta tubulin 0.0636 0.7854 0.7854
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.2359 0.3004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 95480-32-3. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase II gene/enzyme was studied References: 8468004
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium berghei 4714  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 12503686 12654761 16406111 8475033
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 4714  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 12503686 12654761 16406111 8475033

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

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