Detailed information for compound 586076

Basic information

Technical information
  • TDR Targets ID: 586076
  • Name: potassium 4-chloro-2-(2-furylmethylamino)-5-s ulfamoyl-benzoic acid chloride
  • MW: 406.303 | Formula: C12H12Cl2KN2O5S
  • H donors: 3 H acceptors: 4 LogP: 2.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N.[Cl-].[KH+]
  • InChi: 1S/C12H11ClN2O5S.ClH.K/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19;;/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);1H;/q;;+1/p-1
  • InChiKey: OBQXJHXAVCXBHK-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • potassium 4-chloro-2-(2-furylmethylamino)-5-sulfamoylbenzoic acid chloride
  • potassium 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoyl-benzoic acid chloride
  • potassium 4-chloro-2-(2-furfurylamino)-5-sulfamoyl-benzoic acid chloride
  • potassium 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid chloride
  • Diumide-K continus
  • 84788-22-7
  • Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-, compd. with potassium chloride (kcl) (1:1)
  • Diumide-K

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Schistosoma mansoni lamin 0.0028 0.1211 0.143
Echinococcus granulosus muscleblind protein 0.0155 1 1
Loa Loa (eye worm) RNA binding protein 0.0133 0.8466 0.8466
Brugia malayi hypothetical protein 0.0015 0.0313 0.0313
Echinococcus multilocularis lamin dm0 0.0028 0.1211 0.1211
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0625 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0431 0.0431
Echinococcus granulosus twitchin 0.0015 0.0313 0.0313
Echinococcus multilocularis roundabout 2 0.0015 0.0313 0.0313
Brugia malayi intermediate filament protein 0.0028 0.1211 0.1211
Echinococcus granulosus plexin a4 0.002 0.0643 0.0643
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0625 0.0625
Schistosoma mansoni vesicular amine transporter 0.0015 0.0313 0.037
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0313 0.0313
Loa Loa (eye worm) plexin A 0.002 0.0643 0.0643
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.1911 0.1911
Schistosoma mansoni intermediate filament proteins 0.0028 0.1211 0.143
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0953 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0625 0.0625
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0953 1
Brugia malayi RNA binding protein 0.0133 0.8466 0.8466
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.0313 0.037
Echinococcus multilocularis Immunoglobulin 0.0015 0.0313 0.0313
Entamoeba histolytica hypothetical protein 0.0038 0.1911 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0013 0.0209 0.0209
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0313 0.0313
Echinococcus granulosus lamin dm0 0.0028 0.1211 0.1211
Entamoeba histolytica hypothetical protein 0.0038 0.1911 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.0313 0.037
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.5244 0.6194
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0625 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0173 0.0173
Echinococcus multilocularis muscleblind protein 0.0155 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0464 0.0464
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.0313 0.037
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.5244 0.5244
Entamoeba histolytica hypothetical protein 0.0024 0.0953 0.2554
Onchocerca volvulus 0.0028 0.1211 0.2309
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0953 1
Schistosoma mansoni nephrin 0.0015 0.0313 0.037
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.1211 0.1211
Echinococcus multilocularis musashi 0.0028 0.1211 0.1211
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0625 0.0625
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0209 0.0209
Echinococcus multilocularis Immunoglobulin 0.0015 0.0313 0.0313
Onchocerca volvulus 0.0028 0.1211 0.2309
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0953 1
Echinococcus multilocularis tar DNA binding protein 0.0133 0.8466 0.8466
Brugia malayi TAR-binding protein 0.0133 0.8466 0.8466
Schistosoma mansoni ap endonuclease 0.0019 0.0625 0.0738
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0312 0.0312
Schistosoma mansoni lamin 0.0028 0.1211 0.143
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0313 0.0313
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0953 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0953 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.5244 0.5244
Entamoeba histolytica hypothetical protein 0.0038 0.1911 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0953 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.8466 0.8466
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0625 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.5244 0.5244
Echinococcus granulosus roundabout 2 0.0015 0.0313 0.0313
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.8466 0.8466
Entamoeba histolytica hypothetical protein 0.0038 0.1911 1
Echinococcus granulosus tar DNA binding protein 0.0133 0.8466 0.8466
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.1911 0.1911
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0625 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Echinococcus multilocularis neuroglian 0.0015 0.0313 0.0313
Echinococcus multilocularis plexin a4 0.002 0.0643 0.0643
Echinococcus granulosus Immunoglobulin 0.0015 0.0313 0.0313
Echinococcus multilocularis lamin 0.0028 0.1211 0.1211
Schistosoma mansoni tar DNA-binding protein 0.0133 0.8466 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0953 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0953 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0464 0.0464
Schistosoma mansoni plexin 0.0017 0.0431 0.0509
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0953 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0209 0.0209
Loa Loa (eye worm) intermediate filament protein 0.0028 0.1211 0.1211
Brugia malayi hypothetical protein 0.0038 0.1911 0.1911
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.1211 0.1211
Schistosoma mansoni tar DNA-binding protein 0.0133 0.8466 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.1911 0.2258
Schistosoma mansoni tar DNA-binding protein 0.0133 0.8466 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus lamin 0.0028 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0313 0.0313
Brugia malayi Plexin repeat family protein 0.0017 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0038 0.1911 0.2258
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.5244 0.5244
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0953 1
Echinococcus granulosus intermediate filament protein 0.0028 0.1211 0.1211
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0953 0.5
Echinococcus granulosus defective proboscis extension response 0.0015 0.0313 0.0313
Schistosoma mansoni ap endonuclease 0.0019 0.0625 0.0738
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0313 0.0313
Brugia malayi plexin A 0.002 0.0643 0.0643
Echinococcus multilocularis muscleblind protein 1 0.0155 1 1
Loa Loa (eye worm) TAR-binding protein 0.0133 0.8466 0.8466
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0625 0.0625
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0625 0.5
Onchocerca volvulus 0.0017 0.0431 0.0822
Loa Loa (eye worm) hypothetical protein 0.0013 0.0173 0.0173
Onchocerca volvulus 0.0086 0.5244 1
Echinococcus granulosus neuroglian 0.0015 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0028 0.1211 0.1211
Schistosoma mansoni tar DNA-binding protein 0.0133 0.8466 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.8466 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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