Detailed information for compound 586261

Basic information

Technical information
  • TDR Targets ID: 586261
  • Name: 8-benzyloxy-2-methyl-imidazo[1,2-a]pyrazin-3- amine hydrochloride
  • MW: 290.748 | Formula: C14H15ClN4O
  • H donors: 1 H acceptors: 2 LogP: 3.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2n(c1N)ccnc2OCc1ccccc1.Cl
  • InChi: 1S/C14H14N4O.ClH/c1-10-12(15)18-8-7-16-14(13(18)17-10)19-9-11-5-3-2-4-6-11;/h2-8H,9,15H2,1H3;1H
  • InChiKey: PMZOKIXJLLVLEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-benzyloxy-2-methyl-3-imidazo[1,2-a]pyrazinamine hydrochloride
  • 2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyrazin-3-amine hydrochloride
  • (8-benzoxy-2-methyl-imidazo[1,2-a]pyrazin-3-yl)amine hydrochloride
  • 2-methyl-8-phenylmethoxyimidazo[1,2-a]pyrazin-3-amine hydrochloride
  • 3-amino-2-methyl-8-phenylmethoxyimidazo(1,2-a)pyrazine
  • 2-methyl-8-phenylmethoxyimidazo[3,2-a]pyrazin-3-amine hydrochloride
  • 8-benzyloxy-2-methyl-imidazo[3,2-a]pyrazin-3-amine hydrochloride
  • 8-benzyloxy-2-methyl-3-imidazo[3,2-a]pyrazinamine hydrochloride
  • (8-benzoxy-2-methyl-imidazo[3,2-a]pyrazin-3-yl)amine hydrochloride
  • 2-methyl-8-phenylmethoxy-imidazo[3,2-a]pyrazin-3-amine hydrochloride
  • 85333-47-7
  • Sch 32651
  • Imidazo(1,2-a)pyrazin-3-amine, 2-methyl-8-(phenylmethoxy)-, monohydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 alpha 0.002 0.0173 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1755 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0173 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0173 0.0289
Schistosoma mansoni hypothetical protein 0.0167 0.5999 0.5999
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0173 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0173 0.0231
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Loa Loa (eye worm) hypothetical protein 0.0034 0.0715 0.0952
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0173 0.0289
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0536 0.0893
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0173 0.0231
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0173 0.0289
Plasmodium vivax SET domain protein, putative 0.0029 0.055 0.2027
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.7809 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0173 0.0289
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.031 0.0017
Echinococcus granulosus geminin 0.0167 0.5999 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.263 0.263
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.7809 1
Leishmania major trypanothione reductase 0.0084 0.2707 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.6963 0.8917
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0297 0.1094
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0173 0.0173
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1755 0.6481
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0173 0.0231
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0297 0.1094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0173 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.055 0.055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0536 0.2739
Brugia malayi AMP-binding enzyme family protein 0.0023 0.031 0.0413
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0536 0.1976
Plasmodium falciparum thioredoxin reductase 0.0029 0.0536 0.1976
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0536 0.1976
Trypanosoma brucei trypanothione reductase 0.0084 0.2707 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.031 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.031 0.0395
Onchocerca volvulus 0.0023 0.031 0.0161
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.023 0.0306
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0536 0.0713
Loa Loa (eye worm) hypothetical protein 0.0023 0.031 0.0413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0173 0.0231
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0173 0.0231
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0173 0.0231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0173 0.0289
Plasmodium falciparum glutathione reductase 0.0084 0.2707 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0173 0.0231
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.2707 0.3605
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0173 0.0231
Brugia malayi Thioredoxin reductase 0.0084 0.2707 0.3605
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0536 0.1976
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0536 0.0893
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0173 0.0231
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.2707 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.6963 0.8874
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0173 0.0173
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.6963 0.8917
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0536 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0076 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.7809 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0173 0.0289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.031 0.1394
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.133 0.1772
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0047
Schistosoma mansoni coup transcription factor 0.002 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0049 0.133 0.1772
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1755 0.1755
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0536 0.1976
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.031 0.0413
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0297 0.1318
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0297 0.1094
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.031 0.1141
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0297 0.0379
Onchocerca volvulus 0.0233 0.8631 1
Brugia malayi ecdysteroid receptor 0.002 0.0173 0.0231
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.031 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0002
Echinococcus multilocularis geminin 0.0167 0.5999 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.263 0.4384
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.031 0.1394
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0507 0.0845
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.2707 0.3465
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0297 0.1094
Brugia malayi nuclear hormone receptor 0.002 0.0173 0.0231
Onchocerca volvulus 0.0082 0.263 0.2904
Schistosoma mansoni nuclear hormone receptor 0.002 0.0173 0.0173
Brugia malayi glutathione reductase 0.0084 0.2707 0.3605
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0173 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0101
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0297 0.1318
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0173 0.0289
Brugia malayi steroid hormone receptor 0.002 0.0173 0.0231
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.031 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.031 0.1394
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.031 0.1394
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.031 0.1394
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0173 0.0231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.055 0.2027
Onchocerca volvulus 0.0029 0.055 0.0445
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0536 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0536 0.1976
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0536 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0173 0.0289
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0173 0.0231
Plasmodium vivax glutathione reductase, putative 0.0084 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.031 0.0413
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.2727 0.4545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0173 0.0289
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.2707 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.031 0.0413
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0536 0.0685
Brugia malayi Pre-SET motif family protein 0.0029 0.055 0.0732
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.6963 0.8917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0173 0.0231
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.031 0.1394
Brugia malayi nuclear receptor NHR-88 0.002 0.0173 0.0231
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.263 0.4384
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0536 0.2739
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.055 0.0916
Schistosoma mansoni thyroid hormone receptor 0.002 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0173 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.055 0.055
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.6963 0.8917
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0173 0.0231
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.2727 0.4545
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0002
Loa Loa (eye worm) glutathione reductase 0.0084 0.2707 0.3605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0173 0.0231
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0076 0.0276
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.133 0.1772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0173 0.0231
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1755 0.2246
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0297 0.4813
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0173 0.0289
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1755 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0173 0.0289
Loa Loa (eye worm) hypothetical protein 0.0029 0.055 0.0732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0173 0.0289
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.031 0.1141
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0173 0.0173
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.6963 0.8917
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0536 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.031 0.1394
Schistosoma mansoni hypothetical protein 0.0167 0.5999 0.5999
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0173 0.0231
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.055 0.0916
Plasmodium falciparum glutathione reductase 0.0029 0.0536 0.1976
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0715 0.0952
Toxoplasma gondii thioredoxin reductase 0.0084 0.2707 1
Brugia malayi Pre-SET motif family protein 0.0205 0.7509 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0101
Trichomonas vaginalis set domain proteins, putative 0.0233 0.8631 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.055 0.0916
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0173 0.0289
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1755 0.1755
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0536 0.1976
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0173 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0173 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0173 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.031 0.1141
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0297 0.1094
Loa Loa (eye worm) hypothetical protein 0.0082 0.263 0.3502
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.055 0.055
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0536 0.1976
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.263 0.3502
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0076 0.0276
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0173 0.0173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.133 0.1772
Schistosoma mansoni hypothetical protein 0.0034 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.002 0.0173 0.0231
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.031 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0173 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0173 0.0231
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0536 0.1976
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.023 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.031 0.1394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.055 0.055
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.031 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0173 0.0173
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0536 0.1976
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0536 0.1976
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0173 0.0289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0536 0.1976
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.7509 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0173 0.0231
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0297 0.1094
Schistosoma mansoni thyroid hormone receptor 0.002 0.0173 0.0173
Plasmodium falciparum thioredoxin reductase 0.0084 0.2707 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0173 0.0231
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1755 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.031 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0173 0.0231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0536 0.1976
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0536 0.1976
Treponema pallidum NADH oxidase 0.0029 0.0536 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0536 0.2739
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1755 0.2925
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0101
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0536 0.1976
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1755 0.6481
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0536 0.1976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0047
Mycobacterium tuberculosis Probable reductase 0.0191 0.6963 0.8917
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.7809 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1755 0.2925
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0536 0.1976

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.