Detailed information for compound 586324

Basic information

Technical information
  • TDR Targets ID: 586324
  • Name: N-[4-[(2-phenylpyrazol-3-yl)sulfamoyl]phenyl] acetamide
  • MW: 356.399 | Formula: C17H16N4O3S
  • H donors: 2 H acceptors: 4 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccnn1c1ccccc1
  • InChi: 1S/C17H16N4O3S/c1-13(22)19-14-7-9-16(10-8-14)25(23,24)20-17-11-12-18-21(17)15-5-3-2-4-6-15/h2-12,20H,1H3,(H,19,22)
  • InChiKey: PSFOMYYDCTXBHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(2-phenyl-3-pyrazolyl)sulfamoyl]phenyl]acetamide
  • N-[4-[(2-phenylpyrazol-3-yl)sulfamoyl]phenyl]ethanamide
  • N4-acetylsulfaphenazole
  • 855-91-4
  • ZINC04722458
  • Acetamide, N-(4-(((1-phenyl-1H-pyrazol-5-yl)amino)sulfonyl)phenyl)-
  • N(4)-Acetylsulfaphenzazole
  • A3834/0162788

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0067 0.0179
Loa Loa (eye worm) hypothetical protein 0.0118 0.1391 0.427
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0.0145 0.042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.032 0.1415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0157 0.6071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0145 0.042
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0035 0.0546
Schistosoma mansoni hypothetical protein 0.0076 0.0875 0.4269
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Echinococcus multilocularis expressed protein 0.0017 0.0155 0.012
Onchocerca volvulus 0.0029 0.0305 0.9466
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0201 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.032 0.0286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.032 0.0887
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0492
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0124 0.0089
Schistosoma mansoni DNA helicase recq1 0.001 0.0067 0.0328
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0646
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0058 0.007
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0009 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0147 0.0717
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0035 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0734 0.0701
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.032 0.0286
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0235 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0145 0.0708
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.0087
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0124 0.0089
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0124 0.0277
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0235 0.0624
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0067 0.1934
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0155 0.5781
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0124 0.0355
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0037 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0705
Schistosoma mansoni Smad4 0.0007 0.0037 0.0183
Echinococcus granulosus GPCR family 2 0.0016 0.0144 0.0542
Schistosoma mansoni DNA helicase recq5 0.001 0.0067 0.0328
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.0542
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.032 0.1562
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0567 0.1656
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0124 0.0277
Brugia malayi MH2 domain containing protein 0.0237 0.2854 0.8778
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0155 0.5781
Onchocerca volvulus Bile acid receptor homolog 0.003 0.032 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0169 0.6617
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0144 0.034
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0124 0.0277
Loa Loa (eye worm) steroid hormone receptor 0.003 0.032 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.032 0.096
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0035 0.2801
Entamoeba histolytica hypothetical protein 0.0076 0.0875 1
Schistosoma mansoni hypothetical protein 0.0172 0.2049 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.032 0.0887
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0007 0.0037 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.032 0.096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0243 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0009 0.0045
Schistosoma mansoni cpg binding protein 0.0029 0.0305 0.1488
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0147 0.0112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.032 0.0286
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2854 0.8788
Brugia malayi steroid hormone receptor 0.003 0.032 0.0887
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.032 0.0286
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0035 0.008
Trichomonas vaginalis ferritin, putative 0.0017 0.0155 0.6102
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0243 0.2718
Brugia malayi hypothetical protein 0.0016 0.0145 0.0342
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0144 0.0418
Brugia malayi nuclear receptor RXR 0.0016 0.0145 0.0342
Onchocerca volvulus 0.0024 0.0243 0.7286
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.032 0.0887
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.000000002369
Loa Loa (eye worm) hypothetical protein 0.0269 0.3246 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.032 0.0286
Brugia malayi nuclear receptor NHR-88 0.003 0.032 0.0887
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0734 0.2239
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0124 0.0441
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0155 0.6011
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0037 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0145 0.042
Entamoeba histolytica hypothetical protein 0.0076 0.0875 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.0734 0.347
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0035 0.2801
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0243 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0145 0.0342
Brugia malayi MH2 domain containing protein 0.0016 0.0147 0.0348
Brugia malayi Smad1 0.0016 0.0147 0.0348
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0035 0.0423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.1119
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0143 0.8401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.032 0.1415
Schistosoma mansoni zinc finger protein 0.0014 0.0124 0.0605
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0169 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0243 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0559 0.1631
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 1
Schistosoma mansoni ferritin 0.0017 0.0155 0.0757
Entamoeba histolytica hypothetical protein 0.0076 0.0875 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0646
Brugia malayi MH1 domain containing protein 0.0009 0.0058 0.0072
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0067 0.5
Schistosoma mansoni thyroid hormone receptor 0.003 0.032 0.1562
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0102 0.1096
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0567 0.1723
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0124 0.0605
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0305 0.0913
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0037 0.0087
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2854 0.8788
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.032 0.1562
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0235 1
Schistosoma mansoni ferritin 0.0017 0.0155 0.0757
Echinococcus granulosus bloom syndrome protein 0.0023 0.0235 0.0994
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0147 0.0554
Schistosoma mansoni apoferritin-2 0.0017 0.0155 0.0757
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0124 0.0089
Loa Loa (eye worm) oxidoreductase 0.0007 0.0035 0.008
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0546
Echinococcus granulosus Smad4 0.0016 0.0147 0.0554
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0124 0.0277
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0124 0.3117
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0035 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.000000002369
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0646
Echinococcus multilocularis smad 0.0016 0.0147 0.0112
Brugia malayi RNA binding protein 0.0064 0.0734 0.2177
Schistosoma mansoni cpg binding protein 0.0031 0.0325 0.1587
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0179
Schistosoma mansoni hypothetical protein 0.0035 0.0371 0.1812
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0559 0.2728
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.032 0.1562
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0067 0.0159
Brugia malayi nuclear hormone receptor 0.003 0.032 0.0887
Brugia malayi CXXC zinc finger family protein 0.0029 0.0305 0.084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0157 0.6071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0492
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0145 0.0545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0559 0.2601
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.032 0.0887
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0145 0.0342
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0145 0.042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.032 0.0286
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0243 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0058 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.032 0.096
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.032 0.0887
Loa Loa (eye worm) hypothetical protein 0.0016 0.0145 0.042
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0035 0.0546
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0147 0.0112
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0124 0.0355
Loa Loa (eye worm) RNA binding protein 0.0064 0.0734 0.2239
Schistosoma mansoni nuclear receptor 0.0014 0.0124 0.0605
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0169 0.8056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.032 0.0887
Schistosoma mansoni coup transcription factor 0.003 0.032 0.1562
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0734 0.3582
Schistosoma mansoni cpg binding protein 0.0031 0.0325 0.1587
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0243 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0559 0.2728
Schistosoma mansoni ferritin 0.0017 0.0155 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.032 0.0887
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0492
Schistosoma mansoni Smad4 0.0007 0.0037 0.0183
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0124 0.0605
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0243 0.2718
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.032 0.0887
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0875 0.0842
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.032 0.1415
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0067 0.0159
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0124 0.0277
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0124 0.0277
Brugia malayi hypothetical protein 0.0014 0.0124 0.0277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0704 0.3435
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0037 0.0182
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.032 0.1415
Echinococcus granulosus FTZ F1 alpha 0.003 0.032 0.1415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0559 0.2601
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.032 0.096
Brugia malayi nuclear receptor RXR 0.0014 0.0124 0.0277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.032 0.1562
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.032 0.1415
Entamoeba histolytica hypothetical protein 0.0076 0.0875 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0155 0.6011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0035 0.1751
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0124 0.0441
Brugia malayi MH1 domain containing protein 0.0016 0.0147 0.0348
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0037 0.0011
Echinococcus multilocularis ferritin 0.0017 0.0155 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.01
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0145 0.0708
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0035 0.0423
Onchocerca volvulus 0.0014 0.0124 0.3117
Brugia malayi tailless protein 0.0014 0.0124 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0559 0.2728
Brugia malayi Steroid receptor seven-up type 2 0.003 0.032 0.0887
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0037 0.0002
Schistosoma mansoni nuclear hormone receptor 0.003 0.032 0.1562
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0169 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0035 0.0546
Brugia malayi hypothetical protein 0.0076 0.0875 0.2615
Echinococcus multilocularis cpg binding protein 0.0031 0.0325 0.0291
Onchocerca volvulus 0.003 0.032 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0147 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.032 0.0887
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0037 0.0007
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0035 0.0273
Echinococcus multilocularis Smad4 0.0016 0.0147 0.0112
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0037 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Echinococcus granulosus smad 0.0016 0.0147 0.0554
Brugia malayi MH2 domain containing protein 0.0007 0.0037 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Brugia malayi hypothetical protein 0.0014 0.0124 0.0277
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0243 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0147 0.0717
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0067 0.0032
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0147 0.0425
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0145 0.042
Brugia malayi MH1 domain containing protein 0.0009 0.0058 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0734 0.3582
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0035 0.0546
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0124 0.0089
Schistosoma mansoni nuclear receptor 0.0014 0.0124 0.0605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0559 0.1699
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0492
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.032 0.1562
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0011
Schistosoma mansoni Smad4 0.0016 0.0147 0.0717
Schistosoma mansoni ferritin light chain 0.0017 0.0155 0.0757
Mycobacterium ulcerans hypothetical protein 0.0024 0.0243 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0058 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Schistosoma mansoni smad 0.0016 0.0147 0.0717
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0102 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0035 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.032 0.096
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.032 1
Brugia malayi hypothetical protein 0.0016 0.0145 0.0342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0124 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Brugia malayi photoreceptor-specific nuclear receptor 0.0269 0.3246 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.01
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.032 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0734 0.3582
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0492
Echinococcus granulosus ferritin 0.0017 0.0155 0.0596
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0705
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0157 0.6071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0243 0.2718
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.032 0.1415
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0124 0.0605
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.014 0.2136
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0102 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.032 0.0887
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0243 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0559 0.0526
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0157 0.6071
Onchocerca volvulus 0.0014 0.0124 0.3117
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0546
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0734 0.2239
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0175 0.0855
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Brugia malayi MH2 domain containing protein 0.0016 0.0147 0.0348
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0705
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0035 0.2801
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.0944
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0124 0.0605
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0035 0.2801
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0124 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0559 0.0526
Brugia malayi MH1 domain containing protein 0.0016 0.0147 0.0348
Brugia malayi ecdysteroid receptor 0.003 0.032 0.0887
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0169 0.6421
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0124 0.0441
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0144 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.032 0.096
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0067 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.000000002369
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.032 0.1562
Schistosoma mansoni ferritin 0.0017 0.0155 0.0757
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.032 0.1562
Schistosoma mansoni apoferritin-2 0.0017 0.0155 0.0757
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0734 0.3582
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0035 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0734 0.2177
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.032 0.1562
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0155 0.5781
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.008
Echinococcus granulosus geminin 0.0172 0.2049 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0722
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0035 0.0326
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0875 0.4269
Brugia malayi ecdysone receptor 0.0014 0.0124 0.0277
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.032 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0035 0.0423
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0371 0.1047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0243 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0102 0.3518
Brugia malayi conserved hypotetical protein 0.0014 0.0124 0.0277
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.011
Brugia malayi nuclear receptor NHR-67 0.0014 0.0124 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.032 0.0887
Schistosoma mansoni ferritin light chain 0.0017 0.0155 0.0757
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0124 0.3117
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0155 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.032 0.0887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.032 0.096
Schistosoma mansoni smad 0.0007 0.0037 0.0183
Loa Loa (eye worm) Smad1 0.0016 0.0147 0.0425
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0037 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.032 0.0887
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0124 0.0089
Brugia malayi TAR-binding protein 0.0064 0.0734 0.2177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.032 0.1415
Loa Loa (eye worm) RecQ helicase 0.0023 0.0235 0.0699
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.032 0.1415
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0124 0.0605
Loa Loa (eye worm) hypothetical protein 0.005 0.0567 0.1723
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0102 0.3218
Echinococcus multilocularis FTZ F1 alpha 0.003 0.032 0.0286
Echinococcus multilocularis GPCR, family 2 0.0016 0.0144 0.011
Schistosoma mansoni thyroid hormone receptor 0.003 0.032 0.1562
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0722
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0567 0.1656
Brugia malayi nuclear receptor NHR-88 0.0014 0.0124 0.0277
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0124 0.0089
Schistosoma mansoni smad1 5 8 and 0.0016 0.0147 0.0717
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0235 0.0201
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0035 0.0546
Schistosoma mansoni hypothetical protein 0.0172 0.2049 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0546
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0124 0.0441
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0145 0.011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0722
Loa Loa (eye worm) DR-78 0.0014 0.0124 0.0355
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.096
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.032 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0734 0.3582
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.0944
Loa Loa (eye worm) hypothetical protein 0.0016 0.0144 0.0418
Echinococcus multilocularis geminin 0.0172 0.2049 0.2021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.032 0.0887
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0705
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0875 0.4168
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0623 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0147 0.0717
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0355
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.032 0.1562
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0118
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0155 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0037 0.0087
Brugia malayi nuclear hormone receptor 0.0014 0.0124 0.0277
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0035 0.0273
Echinococcus granulosus cpg binding protein 0.0031 0.0325 0.144
Echinococcus granulosus expressed protein 0.0017 0.0155 0.0596
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0124 0.0441
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0147 0.0554

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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