TDR Targets

Basic information

Technical information

TDR Targets ID: 586389
Name: 2-chloro-5-[(N-methylanilino)carbamoyl]benzen esulfonamide
MW: 339.797 | Formula: C14H14ClN3O3S
H donors: 2 H acceptors: 3 LogP: 2.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(c(c1)S(=O)(=O)N)Cl)NN(c1ccccc1)C
InChi: 1S/C14H14ClN3O3S/c1-18(11-5-3-2-4-6-11)17-14(19)10-7-8-12(15)13(9-10)22(16,20)21/h2-9H,1H3,(H,17,19)(H2,16,20,21)
InChiKey: QWNNFYQUBPILCG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-chloro-5-[(N'-methyl-N'-phenylhydrazino)-oxomethyl]benzenesulfonamide
2-chloro-5-[[methyl(phenyl)amino]carbamoyl]benzenesulfonamide
metipamide
2-chloro-5-[(methyl-phenylamino)carbamoyl]benzenesulfonamide
2-chloro-5-[(methyl-phenyl-amino)carbamoyl]benzenesulfonamide
85683-41-6
Benzoic acid, 3-(aminosulfonyl)-4-chloro-, 2-methyl-2-phenylhydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	aminopeptidase N PepN	0.0048	0.0151	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Brugia malayi	hypothetical protein	0.0048	0.0151	0.0345
Trypanosoma cruzi	aminopeptidase, putative	0.0048	0.0151	1
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0048	0.0151	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0048	0.0151	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0109	0.0248
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0048	0.0151	1
Entamoeba histolytica	aminopeptidase, putative	0.0048	0.0151	0.5
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0048	0.0151	0.0151
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0901	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Onchocerca volvulus		0.0048	0.0151	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0048	0.0151	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0151	0.0151
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Trypanosoma brucei	Aminopeptidase M1, putative	0.0048	0.0151	1
Onchocerca volvulus		0.0048	0.0151	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0048	0.0151	1
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0901	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0109	0.0109
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0109	0.0109
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0109	0.0109
Brugia malayi	Peptidase family M1 containing protein	0.0048	0.0151	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0109	0.0109
Toxoplasma gondii	aminopeptidase N protein	0.0048	0.0151	1
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0048	0.0151	0.5
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0048	0.0151	1
Onchocerca volvulus		0.0048	0.0151	1
Trypanosoma cruzi	aminopeptidase, putative	0.0048	0.0151	1
Echinococcus multilocularis	aminopeptidase N	0.0048	0.0151	0.0151
Toxoplasma gondii	aminopeptidase n, putative	0.0048	0.0151	1
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0048	0.0151	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0048	0.0151	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0048	0.0151	1
Echinococcus granulosus	aminopeptidase N	0.0048	0.0151	0.0151
Mycobacterium ulcerans	aminopeptidase N PepN	0.0048	0.0151	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.2164	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0048	0.0151	0.0151
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0048	0.0151	0.0151
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0109	0.0109
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0048	0.0151	1
Brugia malayi	Peptidase family M1 containing protein	0.0048	0.0151	0.0345
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0048	0.0151	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0048	0.0151	0.0151
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0048	0.0151	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0151	0.0151
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0048	0.0151	1
Brugia malayi	hypothetical protein	0.0414	0.4381	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0048	0.0151	0.0151
Brugia malayi	Peptidase family M1 containing protein	0.0048	0.0151	0.0345
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0048	0.0151	1
Brugia malayi	hypothetical protein	0.0048	0.0151	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0109	0.0109
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0048	0.0151	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0109	0.0109
Brugia malayi	TATA binding protein associated factor	0.0048	0.0151	0.0345
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0048	0.0151	0.0151
Trypanosoma brucei	aminopeptidase, putative	0.0048	0.0151	1
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0048	0.0151	0.0151
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0901	1	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0151	0.0151
Mycobacterium leprae	conserved hypothetical protein	0.0035	0	0.5
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0048	0.0151	1
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0048	0.0151	1
Toxoplasma gondii	aminopeptidase N, putative	0.0048	0.0151	1
Loa Loa (eye worm)	aminopeptidase N	0.0048	0.0151	0.0151
Mycobacterium leprae	Probable lipase LipE	0.0035	0	0.5
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0048	0.0151	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0048	0.0151	0.0151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 135086

Bibliographic References

No literature references available for this target.

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Detailed information for compound 586389