Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.3014 | 0.2671 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.7807 | 0.6861 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.7807 | 0.7699 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.7807 | 0.7747 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0054 | 0.7807 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0038 | 0.3609 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.3609 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.3417 | 0.3237 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.754 | 0.754 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3014 | 0.3014 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0038 | 0.3609 | 0.3434 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0038 | 0.3609 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0038 | 0.3609 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.3417 | 0.3237 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0038 | 0.3609 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.3609 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.3417 | 0.0578 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0038 | 0.3609 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0038 | 0.3609 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.754 | 0.742 |
Echinococcus multilocularis | lamin | 0.0054 | 0.7807 | 0.7747 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0038 | 0.3609 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0038 | 0.3609 | 1 |
Onchocerca volvulus | 0.0054 | 0.7807 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.754 | 0.742 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3417 | 0.939 |
Schistosoma mansoni | lamin | 0.0054 | 0.7807 | 0.6861 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0038 | 0.3609 | 0.3434 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3417 | 0.939 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.3609 | 0.0852 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0038 | 0.3609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.7807 | 0.7807 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.104 | 0.0601 |
Echinococcus granulosus | lamin | 0.0054 | 0.7807 | 0.7747 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.3417 | 0.3417 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3417 | 0.939 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.7807 | 0.7807 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.3609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.754 | 0.754 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0038 | 0.3609 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0038 | 0.3609 | 0.0852 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.3417 | 0.0578 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.7807 | 0.7699 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0038 | 0.3609 | 0.3609 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3417 | 0.939 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.235 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.754 | 0.754 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.7807 | 0.7807 |
Brugia malayi | Inositol-1 | 0.0037 | 0.3417 | 0.3094 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.7807 | 0.7747 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.7807 | 0.7747 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.104 | 0.104 |
Schistosoma mansoni | lamin | 0.0054 | 0.7807 | 0.6861 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.3417 | 0.939 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0054 | 0.7807 | 0.7747 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0038 | 0.3609 | 0.3295 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0038 | 0.3609 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0038 | 0.3609 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.