TDR Targets

Basic information

Technical information

TDR Targets ID: 586832
Name: [(2R,3S,5S)-5-(5-fluoro-2,4-dioxo-pyrimidin-1 -yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl te tradecyl hydrogen phosphate
MW: 522.544 | Formula: C23H40FN2O8P
H donors: 3 H acceptors: 5 LogP: 4.54 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCCCCOP(=O)(OC[C@H]1O[C@@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O)O
InChi: 1S/C23H40FN2O8P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-32-35(30,31)33-17-20-19(27)15-21(34-20)26-16-18(24)22(28)25-23(26)29/h16,19-21,27H,2-15,17H2,1H3,(H,30,31)(H,25,28,29)/t19-,20+,21-/m0/s1
InChiKey: IGXUBNSHRZHJRV-HBMCJLEFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(2R,3S,5S)-5-(5-fluoro-2,4-dioxo-1-pyrimidinyl)-3-hydroxy-2-tetrahydrofuranyl]methyl tetradecyl hydrogen phosphate
[(2R,3S,5S)-5-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methyl tetradecyl hydrogen phosphate
[(2R,3S,5S)-5-(5-fluoro-2,4-diketo-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl myristyl hydrogen phosphate
[(2R,3S,5S)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl tetradecyl hydrogen phosphate
tetradecyl 2'-deoxy-5-fluoro-5'-uridylate
86976-77-4
5'-Uridylic acid, 2'-deoxy-5-fluoro-, monotetradecyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aldo keto reductase	0.0092	0.5507	0.5507
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0027	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0092	0.5507	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0027	0	0.5
Echinococcus multilocularis	aldo keto reductase	0.0092	0.5507	0.5507
Leishmania major	prostaglandin f synthase, putative	0.0092	0.5507	1
Echinococcus granulosus	aldo keto reductase	0.0092	0.5507	0.5507
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1504	0.2732
Onchocerca volvulus		0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase	0.0092	0.5507	0.5507
Mycobacterium ulcerans	oxidoreductase	0.0092	0.5507	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Toxoplasma gondii	aldose reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Schistosoma mansoni	aldo-keto reductase	0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Loa Loa (eye worm)	hypothetical protein	0.0146	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Plasmodium falciparum	aldehyde reductase, putative	0.0027	0	0.5
Plasmodium vivax	aldehyde reductase, putative	0.0027	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1504	0.2732
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Trypanosoma cruzi	aldo/keto reductase, putative	0.0092	0.5507	1
Loa Loa (eye worm)	oxidoreductase	0.0092	0.5507	0.5507
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1504	0.1504
Entamoeba histolytica	aldose reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0092	0.5507	0.5507
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Mycobacterium leprae	Conserved hypothetical protein	0.0066	0.3261	0.5922
Loa Loa (eye worm)	hypothetical protein	0.0092	0.5507	0.5507
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Echinococcus granulosus	muscleblind protein	0.0146	1	1
Onchocerca volvulus		0.0092	0.5507	1
Echinococcus multilocularis	aldehyde reductase	0.0066	0.3261	0.3261
Trypanosoma brucei	prostaglandin f synthase	0.0092	0.5507	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1504	0.1504
Loa Loa (eye worm)	oxidoreductase	0.0092	0.5507	0.5507
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Trypanosoma cruzi	aldo-keto reductase	0.0092	0.5507	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0092	0.5507	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Loa Loa (eye worm)	oxidoreductase	0.0092	0.5507	0.5507
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Onchocerca volvulus		0.0092	0.5507	1
Echinococcus multilocularis	muscleblind protein	0.0146	1	1
Onchocerca volvulus		0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Giardia lamblia	Aldose reductase	0.0092	0.5507	0.5
Leishmania major	aldo-keto reductase-like protein	0.0092	0.5507	1
Giardia lamblia	Aldose reductase	0.0092	0.5507	0.5
Trichomonas vaginalis	aldo/keto reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase	0.0092	0.5507	0.5507
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0092	0.5507	0.5507
Entamoeba histolytica	aldose reductase, putative	0.0092	0.5507	1
Echinococcus granulosus	hypothetical protein	0.0092	0.5507	0.5507
Loa Loa (eye worm)	hypothetical protein	0.0146	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0092	0.5507	0.5507
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1504	0.1504
Echinococcus granulosus	aldo keto reductase	0.0092	0.5507	0.5507
Schistosoma mansoni	pol-related	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Entamoeba histolytica	aldose reductase, putative	0.0092	0.5507	1
Loa Loa (eye worm)	oxidoreductase	0.0092	0.5507	0.5507
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0092	0.5507	0.5507
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0092	0.5507	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0092	0.5507	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0092	0.5507	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Loa Loa (eye worm)	oxidoreductase	0.0092	0.5507	0.5507
Onchocerca volvulus		0.0092	0.5507	1
Echinococcus granulosus	aldehyde reductase	0.0066	0.3261	0.3261
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0092	0.5507	0.5507
Schistosoma mansoni	aldo-keto reductase	0.0092	0.5507	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Echinococcus multilocularis	muscleblind protein 1	0.0146	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Trichomonas vaginalis	aldo-keto reductase, putative	0.0092	0.5507	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1504	0.2732
Echinococcus multilocularis	aldo keto reductase	0.0092	0.5507	0.5507
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1504	0.1504
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1504	0.1504
Trypanosoma brucei	aldo-keto reductase, putative	0.0092	0.5507	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1504	0.1504
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0092	0.5507	0.5507
Onchocerca volvulus		0.0092	0.5507	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0092	0.5507	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 163532

Bibliographic References

No literature references available for this target.

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Detailed information for compound 586832