Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.2382 | 0.5901 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.2382 | 0.2696 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.8835 | 0.8835 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4036 | 0.4568 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4036 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.4036 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2975 | 0.2975 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2975 | 0.737 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2975 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.2382 | 0.2696 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.6474 | 0.6474 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.2382 | 0.2382 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4036 | 0.4568 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.2382 | 0.5901 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2975 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2975 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2975 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.4036 | 0.4036 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.2382 | 0.5901 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4036 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0088 | 0.8835 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2975 | 0.3367 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.2382 | 0.5901 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.6474 | 0.6474 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2975 | 0.737 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.2382 | 0.5901 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.2382 | 0.2382 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.8835 | 0.8835 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.6474 | 0.7327 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.2382 | 0.5901 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.4036 | 0.4036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.4036 | 0.4568 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.2382 | 0.2696 |
Brugia malayi | hypothetical protein | 0.0088 | 0.8835 | 0.8835 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2975 | 0.3367 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.4036 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.2382 | 0.2382 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.2382 | 0.2696 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2382 | 0.2382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.