Detailed information for compound 587242

Basic information

Technical information
  • TDR Targets ID: 587242
  • Name: 2-chloro-1,3,5-trinitro-benzene
  • MW: 247.55 | Formula: C6H2ClN3O6
  • H donors: 0 H acceptors: 6 LogP: 2.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc([N+](=O)[O-])c(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C6H2ClN3O6/c7-6-4(9(13)14)1-3(8(11)12)2-5(6)10(15)16/h1-2H
  • InChiKey: HJRJRUMKQCMYDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-1,3,5-trinitrobenzene
  • Picryl Chloride
  • 88-88-0
  • Picrylchloride
  • HSDB 5262
  • 79874_FLUKA
  • NSC106297
  • NSC 106297
  • 4-05-00-00757 (Beilstein Handbook Reference)
  • AI3-08846
  • BRN 1588666
  • Benzene, 1-chloro-2,4,6-trinitro-
  • CCRIS 3098
  • EINECS 201-864-3
  • 1-Chloro-2,4,6-trinitrobenzene
  • 2,4,6-Trinitro-1-chlorobenzene
  • 2,4,6-Trinitrochlorobenzene
  • Benzene, 2-chloro-1,3,5-trinitro-
  • NSC1872

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0028 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0382 0.1844
Onchocerca volvulus 0.008 0.0185 0.1993
Echinococcus granulosus thioredoxin glutathione reductase 0.018 0.049 0.243
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.1814
Plasmodium falciparum thioredoxin reductase 0.0179 0.0488 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0131 0.2685
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0028 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0074 0.0074
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0241 0.0679 0.0679
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2015 0.2748
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0013 0.0062
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0062 0.0131 0.1529
Loa Loa (eye worm) hypothetical protein 0.0048 0.0088 0.0427
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0074 0.0102
Giardia lamblia Cysteinyl-tRNA synthetase 0.0048 0.0088 0.64
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.005 0.05
Schistosoma mansoni aldehyde dehydrogenase 0.03 0.0856 0.4251
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0241 0.0679 0.0679
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0074 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0351 0.0479
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0028 0.014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0028 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Schistosoma mansoni aldehyde dehydrogenase 0.03 0.0856 0.4251
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0028 0.0136
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0028 0.0136
Schistosoma mansoni hypothetical protein 0.0082 0.0193 0.0959
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0179 0.0488 1
Brugia malayi Thioredoxin reductase 0.0179 0.0488 0.2356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0028 0.0136
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0028 0.0136
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0351 0.1742
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.1008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.005 0.0243
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0131 0.2685
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0288
Echinococcus granulosus jun protein 0.0101 0.0251 0.1247
Toxoplasma gondii aldehyde dehydrogenase 0.03 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1346 0.6504
Mycobacterium ulcerans aldehyde dehydrogenase 0.03 0.0856 0.0845
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0035 0.0405
Schistosoma mansoni patched 1 0.0043 0.0073 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0028 0.0136
Brugia malayi hypothetical protein 0.0302 0.0865 0.4177
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0062 0.0131 0.0118
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.2613
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0013 0.0151
Loa Loa (eye worm) hypothetical protein 0.0099 0.0243 0.1173
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.005 0.05
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0074 0.1527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0028 0.0136
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0028 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Brugia malayi nuclear receptor NHR-88 0.0028 0.0028 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0028 0.0136
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.005 0.0243
Echinococcus multilocularis dna polymerase eta 0.0023 0.0013 0.0018
Loa Loa (eye worm) glutaminase 0.0269 0.0763 0.3685
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0354
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0074 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0028 0.014
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0288
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0287 0.0818 0.0803
Brugia malayi ecdysteroid receptor 0.0028 0.0028 0.0136
Leishmania major hypothetical protein, conserved 0.0043 0.0074 0.0869
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0062 0.0131 0.2685
Loa Loa (eye worm) hypothetical protein 0.0698 0.207 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0351 0.1742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Plasmodium vivax glutathione reductase, putative 0.0179 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0035 0.0167
Echinococcus multilocularis tumor protein p63 0.0345 0.0993 0.1355
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.03 0.0856 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.0363 0.1802
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.03 0.0856 0.4251
Mycobacterium ulcerans hypothetical protein 0.0043 0.0074 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0351 0.1742
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0016 0.0075
Brugia malayi steroid hormone receptor 0.0028 0.0028 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0309 0.1493
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.3296 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.038 0.1884
Brugia malayi MH2 domain containing protein 0.0144 0.0382 0.1844
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.034
Brugia malayi hypothetical protein 0.003 0.0035 0.0167
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0028 0.0038
Echinococcus multilocularis GPCR, family 2 0.0038 0.0058 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0062 0.0131 0.0633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Schistosoma mansoni survival motor neuron protein 0.0094 0.0228 0.1133
Schistosoma mansoni jun-related protein 0.0082 0.0193 0.0959
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0028 0.0038
Echinococcus granulosus tumor protein p63 0.0345 0.0993 0.493
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0175 0.0846
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0016 0.0182
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0048 0.0088 0.0427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0309 0.1493
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0074 0.0369
Echinococcus granulosus expressed conserved protein 0.0094 0.023 0.1139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0131 0.2685
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0431 0.0588
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2015 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0013 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Trichomonas vaginalis glutathione reductase, putative 0.0062 0.0131 0.1574
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0028 0.014
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0028 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0074 0.0821
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0062 0.0131 0.2685
Brugia malayi hypothetical protein 0.0043 0.0074 0.0359
Treponema pallidum NADH oxidase 0.0062 0.0131 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0035 0.0711
Onchocerca volvulus 0.0302 0.0865 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0074 0.1527
Loa Loa (eye worm) beta-lactamase 0.0043 0.0074 0.036
Brugia malayi nuclear hormone receptor 0.0028 0.0028 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0016 0.0182
Plasmodium falciparum glutathione reductase 0.0179 0.0488 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Echinococcus multilocularis expressed conserved protein 0.0094 0.023 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0821
Schistosoma mansoni hypothetical protein 0.0331 0.0951 0.472
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0074 0.0821
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.005 0.1594
Trypanosoma brucei unspecified product 0.0023 0.0013 0.0264
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0028 0.0136
Schistosoma mansoni alpha glucosidase 0.0036 0.005 0.025
Mycobacterium ulcerans aldehyde dehydrogenase 0.03 0.0856 0.0845
Echinococcus multilocularis jun protein 0.0101 0.0251 0.0343
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0016 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0147 0.0391 0.1943
Mycobacterium ulcerans hypothetical protein 0.0024 0.0016 0.0003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.03 0.0856 0.1168
Loa Loa (eye worm) hypothetical protein 0.0082 0.0193 0.0932
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0075
Echinococcus granulosus survival motor neuron protein 1 0.046 0.1346 0.6682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0074 0.0101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0028 0.0148
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0062 0.0131 0.2685
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Plasmodium falciparum cysteine--tRNA ligase 0.0048 0.0088 0.1814
Schistosoma mansoni coup transcription factor 0.0028 0.0028 0.014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0228 0.1103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.005 0.05
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0013 0.0018
Onchocerca volvulus 0.0094 0.0228 0.2505
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0016 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0062 0.0131 0.2685
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0175 0.087
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0253 0.1255
Onchocerca volvulus 0.0093 0.0225 0.2465
Onchocerca volvulus 0.0043 0.0074 0.0694
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0013 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0028 0.0136
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0035 0.0711
Brugia malayi bZIP transcription factor family protein 0.0101 0.0251 0.1214
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0821
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0016 0.0016
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0048 0.0088 0.1033
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.005 0.0588
Loa Loa (eye worm) hypothetical protein 0.0302 0.0865 0.4177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.028
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0048 0.0088 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0175 0.087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0016 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0431 0.2083
Mycobacterium ulcerans glutaminase 0.0269 0.0763 0.0751
Brugia malayi hypothetical protein 0.008 0.0185 0.0893
Brugia malayi TAR-binding protein 0.0076 0.0175 0.0846
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0028 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0028 0.014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0058 0.0079
Onchocerca volvulus 0.0043 0.0074 0.0694
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2015 1
Schistosoma mansoni hypothetical protein 0.0331 0.0951 0.472
Brugia malayi glutathione reductase 0.0179 0.0488 0.2356
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0382 0.1844
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0132 0.0346 0.0472
Plasmodium falciparum thioredoxin reductase 0.0062 0.0131 0.2685
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0058 0.028
Brugia malayi hypothetical protein 0.046 0.1346 0.6504
Brugia malayi beta-lactamase family protein 0.0043 0.0074 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0073 0.0805
Echinococcus multilocularis protein dispatched 1 0.0049 0.0092 0.0125
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0028 0.0136
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0431 0.0588
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0074 0.0074
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0028 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0028 0.0136
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0062 0.0131 0.2685
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0048 0.0088 0.0121
Leishmania major trypanothione reductase 0.0179 0.0488 0.5694
Plasmodium vivax cysteine--tRNA ligase, putative 0.0048 0.0088 0.1814
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0062 0.0131 0.1529
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0028 0.0136
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0074 0.0074
Schistosoma mansoni glutaminase 0.0269 0.0763 0.3787
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0028 0.014
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.2613
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0074 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0028 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0074 0.037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0028 0.014
Trichomonas vaginalis esterase, putative 0.0043 0.0074 0.0821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0028 0.0136
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0058 0.028
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.03 0.0856 0.0856
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0351 0.1695
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.3296 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0035 0.0711
Schistosoma mansoni retinoic acid receptor RXR 0.0147 0.0391 0.1943
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0013 0.0264
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0351 0.1695
Schistosoma mansoni DNA polymerase eta 0.0023 0.0013 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.005 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Leishmania major cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.1033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0074 0.036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0287 0.0818 0.0818
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0241 0.0679 0.0679
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.0074
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0016 0.0113
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0288
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0248 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0062 0.0131 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0028 0.0136
Mycobacterium leprae Probable lipase LipE 0.0043 0.0074 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0351 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0016 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0028 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.005 0.05
Leishmania major DNA polymerase kappa, putative 0.0023 0.0013 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0074 0.1527
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.1814
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0193 0.0932
Echinococcus multilocularis survival motor neuron protein 1 0.046 0.1346 0.1837
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0058 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0028 0.0038
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.1529
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0175 0.0239
Leishmania major hypothetical protein, conserved 0.003 0.0035 0.0405
Trichomonas vaginalis mercuric reductase, putative 0.0062 0.0131 0.1574
Loa Loa (eye worm) RNA binding protein 0.0076 0.0175 0.0846
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0131 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0074 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.005 0.1033
Brugia malayi CHE-14 protein 0.0043 0.0073 0.0354
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0073 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0035 0.0711
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0013 0.0264
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0016 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0028 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0062
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0248 0.1232
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0241 0.0679 0.0679
Brugia malayi beta-lactamase family protein 0.0043 0.0074 0.036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0789 0.0789
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0073 0.0364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0074 0.0369
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.005 0.05
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.005 0.0069
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0062 0.0131 0.065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0062 0.0131 0.0118
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0462
Onchocerca volvulus 0.0043 0.0074 0.0694
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0013 0.0064
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0081 0.039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0028 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0016 0.0016
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0431 0.214
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.2613
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0062 0.0131 1
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0048 0.0088 0.0076
Trichomonas vaginalis glutaminase, putative 0.0269 0.0763 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0241 0.0679 0.0664
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0016 0.0113
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.3212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.005 0.05
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0062 0.0131 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0248 0.0338
Onchocerca volvulus 0.0048 0.0088 0.0859
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0136
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0028 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.2685
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0431 0.2083
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0074 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0028 0.0148
Brugia malayi small heat shock protein 0.0698 0.207 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0028 0.0038
Echinococcus multilocularis protein patched 0.0043 0.0073 0.01
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0028 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0074 0.0821
Loa Loa (eye worm) thioredoxin reductase 0.0179 0.0488 0.2356
Schistosoma mansoni hypothetical protein 0.0094 0.0228 0.1133
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2422 0.7331 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0062 0.0131 0.2685
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0028 0.014
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0369
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0058 0.0079
Brugia malayi RNA binding protein 0.0076 0.0175 0.0846
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.005 0.0588
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0179 0.0488 0.0488
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0016 0.0113
Mycobacterium tuberculosis Probable reductase 0.0241 0.0679 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0028 0.0136
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0028 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Loa Loa (eye worm) glutaminase 2 0.0269 0.0763 0.3685
Schistosoma mansoni alpha-glucosidase 0.0138 0.0363 0.1802
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0074 0.0074
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0073 0.0354
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0028 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0035 0.0711
Echinococcus granulosus geminin 0.0331 0.0951 0.472
Mycobacterium tuberculosis Probable oxidoreductase 0.0287 0.0818 0.0818
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0074 0.037
Toxoplasma gondii ABC1 family protein 0.0043 0.0074 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.005 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0351 0.1742
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0081 0.039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0103 0.0497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0309 0.1493
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0016 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0175 0.087
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0062 0.0131 0.065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.0251 0.0343
Loa Loa (eye worm) hypothetical protein 0.012 0.0309 0.1493
Echinococcus granulosus dna polymerase eta 0.0023 0.0013 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0028 0.0136
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.0251 0.1247
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.005 0.1594
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0074 0.036
Mycobacterium ulcerans beta-lactamase 0.0043 0.0074 0.0062
Plasmodium falciparum glutathione reductase 0.0062 0.0131 0.2685
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0013 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0062 0.0131 0.2685
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0016 0.0003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0013 0.0064
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0013 0.0013
Trypanosoma brucei glucosidase, putative 0.0036 0.005 0.1033
Echinococcus granulosus GPCR family 2 0.0038 0.0058 0.0288
Mycobacterium ulcerans lipase LipD 0.0043 0.0074 0.0062
Echinococcus multilocularis thioredoxin glutathione reductase 0.018 0.049 0.0668
Echinococcus granulosus dna polymerase kappa 0.0023 0.0013 0.0064
Plasmodium falciparum cysteine--tRNA ligase 0.0048 0.0088 0.1814
Toxoplasma gondii NADPH-glutathione reductase 0.0062 0.0131 0.1529
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0248 0.1199
Echinococcus granulosus leucyl tRNA synthetase 0.0048 0.0088 0.0439
Echinococcus granulosus tar DNA binding protein 0.0076 0.0175 0.087
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0028 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0351 0.1742
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0062 0.0131 0.0179
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0287 0.0818 0.0818
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.005 0.025
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0074 0.0059
Trypanosoma brucei trypanothione reductase 0.0179 0.0488 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0074 0.037
Brugia malayi beta-lactamase 0.0043 0.0074 0.036
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0048 0.0088 0.1814
Brugia malayi glutaminase DH11.1 0.0269 0.0763 0.3685
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.038 0.0518
Leishmania major DNA polymerase eta, putative 0.0023 0.0013 0.0151
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0096 0.0475
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0062 0.0131 0.2685
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0016 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0058 0.0288
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0028 0.014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0028 0.0136
Giardia lamblia NADH oxidase lateral transfer candidate 0.0062 0.0131 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0058 0.028
Mycobacterium tuberculosis Conserved protein 0.0043 0.0074 0.0074
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0062 0.0131 0.1529
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0048 0.0088 0.0439
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0073 0.0364
Brugia malayi hypothetical protein 0.002 0.0002 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0028 0.014
Echinococcus granulosus cysteinyl tRNA synthetase 0.0048 0.0088 0.0439
Loa Loa (eye worm) hypothetical protein 0.01 0.0248 0.1199
Schistosoma mansoni hypothetical protein 0.0082 0.0193 0.0958
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0028 0.014
Loa Loa (eye worm) glutathione reductase 0.0179 0.0488 0.2356
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0074 0.1527
Plasmodium vivax thioredoxin reductase, putative 0.0179 0.0488 1
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0028 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0075
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0062 0.0131 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0074 0.036
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.005 0.05
Mycobacterium ulcerans aldehyde dehydrogenase 0.03 0.0856 0.0845
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0028 0.0136
Echinococcus multilocularis geminin 0.0331 0.0951 0.1297
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0175 0.087
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0175 0.0846
Toxoplasma gondii thioredoxin reductase 0.0179 0.0488 0.5694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0028 0.0136
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0048 0.0088 0.0439
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0013 0.0264
Onchocerca volvulus 0.005 0.0096 0.0943
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0035 0.0711
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0175 0.087
Mycobacterium tuberculosis Probable dehydrogenase 0.0241 0.0679 0.0679
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0062 0.0131 0.1529
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0028 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0016 0.0182
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0175 0.0846
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.005 0.05
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0028 0.014
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0013 0.0018
Entamoeba histolytica hypothetical protein 0.0043 0.0074 0.2613
Onchocerca volvulus 0.0028 0.0028 0.0148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

7 literature references were collected for this gene.

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