Detailed information for compound 587311

Basic information

Technical information
  • TDR Targets ID: 587311
  • Name: methyl N-[(E,5R)-5-[5-[(2E,4E)-2,5-dimethyloc ta-2,4-dienoyl]-6-hydroxy-4-oxo-pyran-2-yl]he x-1-enyl]carbamate
  • MW: 417.495 | Formula: C23H31NO6
  • H donors: 2 H acceptors: 4 LogP: 5.16 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=CC=C(C(=O)c1c(O)oc(cc1=O)[C@@H](CC/C=C/NC(=O)OC)C)C)C
  • InChi: 1S/C23H31NO6/c1-6-9-15(2)11-12-17(4)21(26)20-18(25)14-19(30-22(20)27)16(3)10-7-8-13-24-23(28)29-5/h8,11-14,16,27H,6-7,9-10H2,1-5H3,(H,24,28)/b13-8+,15-11+,17-12+/t16-/m1/s1
  • InChiKey: MHYAUZGPOFPRQM-JNZIYJEQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(E,5R)-5-[5-[(2E,4E)-2,5-dimethyl-1-oxoocta-2,4-dienyl]-6-hydroxy-4-oxo-2-pyranyl]hex-1-enyl]carbamic acid methyl ester
  • N-[(E,5R)-5-[5-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-6-hydroxy-4-keto-pyran-2-yl]hex-1-enyl]carbamic acid methyl ester
  • methyl N-[(E,5R)-5-[5-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-6-hydroxy-4-oxopyran-2-yl]hex-1-enyl]carbamate
  • myxopyronin A
  • 88192-98-7
  • Carbamic acid, (5-(3-(2,5-dimethyl-1-oxo-2,4-octadienyl)-4-hydroxy-2-oxo-2H-pyran-6-yl)-1-hexenyl)-, methyl ester, (R-(E,E,E))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cyclin B 0.0384 0.2336 0.2709
Echinococcus granulosus excitatory amino acid transporter 3 0.0761 0.4728 0.5483
Trypanosoma cruzi cyclin 6, putative 0.0384 0.2336 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0033 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0033 0.0033
Loa Loa (eye worm) histone methyltransferase 0.002 0.0028 0.0058
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0033 0.0069
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0033 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0033 0.0069
Echinococcus granulosus cyclin y 0.0067 0.0329 0.0381
Trichomonas vaginalis cyclin B, putative 0.0384 0.2336 0.7998
Echinococcus multilocularis G1:S specific cyclin D1 0.053 0.3263 0.3263
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0033 0.0069
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0367 0.1573
Echinococcus granulosus sodium:dicarboxylate symporter 0.0761 0.4728 0.5483
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0028 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0794 0.34
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0367 0.0367
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0337 0.2041 0.2367
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.06 0.3128
Schistosoma mansoni ran 0.0044 0.0184 0.0213
Trypanosoma cruzi cyclin 9, putative 0.0067 0.0329 0.1408
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.06 0.1001
Echinococcus multilocularis cyclin G2 0.0067 0.0329 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0167 0.0715
Mycobacterium ulcerans hypothetical protein 0.011 0.06 0.3128
Mycobacterium tuberculosis Conserved protein 0.011 0.06 0.1001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0201 0.0201
Entamoeba histolytica cyclin, domain containing protein 0.0067 0.0329 0.0855
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0773 0.0773
Brugia malayi Cyclin, N-terminal domain containing protein 0.0384 0.2336 0.494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0184 0.0786
Echinococcus multilocularis cyclin t1 0.0067 0.0329 0.0329
Leishmania major cyclin 0.0384 0.2336 1
Echinococcus multilocularis neutral amino acid transporter A 0.0761 0.4728 0.4728
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0367 0.1031
Brugia malayi Excitatory amino acid transporter 0.0761 0.4728 1
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0329 0.0776
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.06 0.1752
Echinococcus multilocularis excitatory amino acid transporter 3 0.0761 0.4728 0.4728
Mycobacterium leprae Probable lipase LipE 0.011 0.06 0.4374
Brugia malayi jmjC domain containing protein 0.0058 0.027 0.0571
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0201 0.0426
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0184 0.0388
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0167 0.0715
Trichomonas vaginalis cyclin B, putative 0.0384 0.2336 0.7998
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.06 0.0696
Echinococcus granulosus GPCR family 2 0.0047 0.0201 0.0233
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0509 0.0802
Echinococcus multilocularis cyclin k 0.0067 0.0329 0.0329
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.06 0.1001
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1382 0.1603
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Trichomonas vaginalis cyclin D, putative 0.0067 0.0329 0.0776
Loa Loa (eye worm) hypothetical protein 0.0041 0.0163 0.0346
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0033 0.0069
Schistosoma mansoni cyclin G 0.0067 0.0329 0.0381
Entamoeba histolytica hypothetical protein 0.0067 0.0329 0.0855
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.027 0.0313
Entamoeba histolytica cyclin, putative 0.0279 0.1672 0.6973
Echinococcus multilocularis GPCR, family 2 0.0047 0.0201 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0141 0.2354
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0033 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Trichomonas vaginalis cyclin B3, putative 0.0067 0.0329 0.0776
Toxoplasma gondii hypothetical protein 0.0048 0.0206 0.1655
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0028 0.0032
Onchocerca volvulus 0.011 0.06 0.1209
Trypanosoma brucei cyclin 3 0.0067 0.0329 0.1408
Plasmodium falciparum cyclin 1 0.0067 0.0329 0.1968
Echinococcus granulosus neutral amino acid transporter 0.0761 0.4728 0.5483
Brugia malayi hypothetical protein 0.0025 0.006 0.0126
Brugia malayi beta-lactamase family protein 0.011 0.06 0.1269
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0761 0.4728 0.4728
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0033 0.0038
Echinococcus multilocularis Excitatory amino acid transporter 0.0761 0.4728 0.4728
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1788 0.7652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1066 0.1236
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0067 0.0329 0.548
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0761 0.4728 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0197 0.0255
Echinococcus multilocularis dnaJ subfamily B 0.0812 0.5052 0.5052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0367 0.0367
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0201 0.0233
Echinococcus multilocularis protein dispatched 1 0.0047 0.02 0.02
Brugia malayi Cyclin, N-terminal domain containing protein 0.053 0.3263 0.69
Echinococcus multilocularis Cyclin L1 0.0067 0.0329 0.0329
Plasmodium falciparum glutathione reductase 0.0038 0.0141 0.0845
Plasmodium falciparum thioredoxin reductase 0.0038 0.0141 0.0845
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0184 0.0786
Schistosoma mansoni cyclin G2 0.0067 0.0329 0.0381
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0201 0.0201
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0067 0.0329 0.0329
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1382 0.1382
Schistosoma mansoni cpg binding protein 0.0057 0.0263 0.0305
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.0993
Brugia malayi hypothetical protein 0.0067 0.0329 0.0696
Leishmania major trypanothione reductase 0.0038 0.0141 0.0605
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0201 0.0426
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0511 0.0511
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.026 0.0301
Echinococcus multilocularis excitatory amino acid transporter 2 0.0761 0.4728 0.4728
Echinococcus multilocularis muscleblind protein 0.0164 0.094 0.094
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0279 0.1672 0.1938
Echinococcus multilocularis cyclin b3 0.0279 0.1672 0.1672
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0684 0.0793
Echinococcus multilocularis neutral amino acid transporter A 0.0761 0.4728 0.4728
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0033 0.0038
Onchocerca volvulus 0.0061 0.0286 0.0539
Schistosoma mansoni tsg101-related 0.0047 0.0197 0.0229
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0848 0.1794
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.006 0.0255
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0367 0.0915
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0033 0.0038
Echinococcus multilocularis cyclin y 0.0067 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.004 0.0154 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0141 0.0844
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Echinococcus granulosus cyclin B 0.0384 0.2336 0.2709
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0033 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0286 0.0331
Plasmodium vivax cyclin 4, putative 0.0067 0.0329 0.548
Schistosoma mansoni g1/s-specific cyclin C 0.0067 0.0329 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0329 0.548
Loa Loa (eye worm) glutathione reductase 0.0038 0.0141 0.0299
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0201 0.0426
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0549 0.116
Brugia malayi hypothetical protein 0.0067 0.0329 0.0696
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1788 0.7652
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0167 0.0715
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0329 0.1968
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.2797 0.3243
Echinococcus granulosus neutral amino acid transporter A 0.0761 0.4728 0.5483
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.06 0.2569
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.06 0.1269
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0448 0.0669
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.026 0.081
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0761 0.4728 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0033 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0033 0.0069
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.06 0.1001
Echinococcus granulosus geminin 0.0171 0.0985 0.1143
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0479
Schistosoma mansoni cyclins 0.0279 0.1672 0.1938
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0848 0.1794
Loa Loa (eye worm) cyclin domain-containing protein 0.0279 0.1672 0.3535
Schistosoma mansoni ran 0.0044 0.0184 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0033 0.0069
Echinococcus multilocularis Excitatory amino acid transporter 0.0761 0.4728 0.4728
Echinococcus granulosus cyclin G2 0.0067 0.0329 0.0381
Schistosoma mansoni coup transcription factor 0.0021 0.0033 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0141 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0033 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0184 0.0786
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0761 0.4728 0.4728
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0005 0.0006
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0163 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0367 0.0915
Loa Loa (eye worm) excitatory amino acid transporter 0.0761 0.4728 1
Treponema pallidum glutamate/aspartate transporter 0.0337 0.2041 1
Echinococcus multilocularis geminin 0.0171 0.0985 0.0985
Schistosoma mansoni hypothetical protein 0.0067 0.0329 0.0381
Plasmodium vivax cyclin homologue, putative 0.0067 0.0329 0.548
Trypanosoma cruzi CYC2-like cyclin, putative 0.0384 0.2336 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0184 0.0194
Trypanosoma brucei mitotic cyclin 0.0067 0.0329 0.1408
Trichomonas vaginalis cyclins, putative 0.0384 0.2336 0.7998
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0684 0.0684
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0141 0.0604
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0033 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0033 0.0069
Plasmodium vivax hypothetical protein, conserved 0.011 0.06 1
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0684 0.5494
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1066 0.1236
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0067 0.0329 0.0381
Giardia lamblia Hypothetical protein 0.0067 0.0329 0.0855
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0794 0.34
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0286 0.0331
Trypanosoma cruzi cyclin, putative 0.0384 0.2336 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0033 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0684 0.3697
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.06 0.1752
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0067 0.0329 0.2643
Brugia malayi ecdysteroid receptor 0.0021 0.0033 0.0069
Onchocerca volvulus 0.011 0.06 0.1209
Leishmania major mitotic cyclin, putative 0.0067 0.0329 0.1408
Echinococcus granulosus cyclin t1 0.0067 0.0329 0.0381
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0163 0.0346
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0796 0.446
Schistosoma mansoni hypothetical protein 0.0171 0.0985 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0033 0.0069
Echinococcus granulosus cyclins 0.0279 0.1672 0.1938
Trichomonas vaginalis cyclins, putative 0.0067 0.0329 0.0776
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Echinococcus granulosus cyclins 0.0279 0.1672 0.1938
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0067 0.0329 0.0381
Toxoplasma gondii cyclin dependent kinase binding protein 0.0067 0.0329 0.2643
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0033 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0033 0.0038
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0761 0.4728 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0336 0.0711
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1066 0.1066
Brugia malayi Pre-SET motif family protein 0.0061 0.0286 0.0604
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0521 0.0604
Echinococcus granulosus cyclin 0.0067 0.0329 0.0381
Echinococcus granulosus cyclin G2 0.0067 0.0329 0.0381
Trichomonas vaginalis cyclins, putative 0.0384 0.2336 0.7998
Trichomonas vaginalis cyclin B, putative 0.0279 0.1672 0.5607
Schistosoma mansoni tsg101-related 0.0057 0.0263 0.0305
Trichomonas vaginalis cyclin B3, putative 0.0067 0.0329 0.0776
Loa Loa (eye worm) hypothetical protein 0.0233 0.1382 0.2923
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0005 0.0005
Onchocerca volvulus Cyclin L homolog 0.0067 0.0329 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0067 0.0329 0.0696
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0511 0.0593
Echinococcus multilocularis snurportin 1 0.0645 0.3991 0.3991
Echinococcus multilocularis neutral amino acid transporter A 0.0761 0.4728 0.4728
Giardia lamblia Hypothetical protein 0.0067 0.0329 0.0855
Schistosoma mansoni cyclin d 0.053 0.3263 0.3783
Trichomonas vaginalis cyclin B, putative 0.0384 0.2336 0.7998
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.06 0.0696
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0291 0.0615
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.2797 0.2797
Onchocerca volvulus Cyclin L homolog 0.0067 0.0329 0.0631
Trichomonas vaginalis cyclin B, putative 0.0384 0.2336 0.7998
Toxoplasma gondii hypothetical protein 0.0067 0.0329 0.2643
Toxoplasma gondii exonuclease III APE 0.0038 0.0141 0.1134
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0367 0.0777
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0163 0.019
Echinococcus granulosus cyclin b3 0.0279 0.1672 0.1938
Trypanosoma cruzi cyclin, putative 0.0384 0.2336 1
Mycobacterium ulcerans lipase LipD 0.011 0.06 0.3128
Trichomonas vaginalis cyclins, putative 0.0172 0.0993 0.3166
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1788 0.7652
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0141 0.01
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0704 0.4363 0.9204
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.253 0.5351
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0357
Entamoeba histolytica cyclin family protein 0.0279 0.1672 0.6973
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0684 0.3697
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.026 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.06 0.2569
Schistosoma mansoni importin beta-1 0.006 0.0285 0.033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0509 0.0802
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.026 0.081
Leishmania major hypothetical protein, conserved 0.0022 0.0041 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0033 0.0069
Schistosoma mansoni hypothetical protein 0.0067 0.0329 0.0381
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0225 0.0963
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0201 0.0233
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0796 0.1427
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.06 0.1752
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0041 0.0174
Schistosoma mansoni survival motor neuron protein 0.0048 0.0204 0.0236
Brugia malayi hypothetical protein 0.0068 0.0336 0.0711
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0645 0.3991 0.844
Schistosoma mansoni patched 1 0.0041 0.0163 0.019
Echinococcus multilocularis protein patched 0.0041 0.0163 0.0163
Leishmania major cyclin 9, putative 0.0067 0.0329 0.1408
Plasmodium vivax glutathione reductase, putative 0.0038 0.0141 0.2354
Brugia malayi Cyclin C 0.0067 0.0329 0.0696
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Schistosoma mansoni Cyclin fold protein 0.0067 0.0329 0.0381
Echinococcus multilocularis expressed conserved protein 0.009 0.0474 0.0474
Schistosoma mansoni hypothetical protein 0.0047 0.0201 0.0233
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0067 0.0329 0.1968
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0033 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0033 0.0069
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0255
Plasmodium falciparum importin beta, putative 0.006 0.0285 0.1704
Onchocerca volvulus 0.0048 0.0204 0.0365
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0384 0.2336 1
Echinococcus granulosus cyclins 0.0279 0.1672 0.1938
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0773 0.0896
Leishmania major GTP-binding protein, putative 0.0044 0.0184 0.0786
Brugia malayi MH2 domain containing protein 0.0117 0.0641 0.1356
Mycobacterium ulcerans hypothetical protein 0.0157 0.0895 0.5138
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Onchocerca volvulus 0.0057 0.0263 0.0492
Echinococcus granulosus G1:S specific cyclin D1 0.053 0.3263 0.3783
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0684 0.2927
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0041 0.0174
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0448 0.0669
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0204 0.0431
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0285 0.1219
Trypanosoma brucei trypanothione reductase 0.0038 0.0141 0.0605
Trichomonas vaginalis cyclin A, putative 0.0067 0.0329 0.0776
Brugia malayi RNA, U transporter 1 0.0172 0.0991 0.2096
Brugia malayi nuclear receptor NHR-88 0.0021 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0105 0.0566 0.1197
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0033 0.0033
Brugia malayi beta-lactamase family protein 0.011 0.06 0.1269
Echinococcus granulosus neuropeptide s receptor 0.0457 0.2797 0.3243
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0367 0.0426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0286 0.0331
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0684 0.0793
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.027 0.027
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0212 0.0357
Schistosoma mansoni microtubule-associated protein tau 0.1376 0.8624 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0033 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0201 0.0233
Schistosoma mansoni cpg binding protein 0.006 0.0284 0.0329
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0367 0.1573
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0026 0.0055
Brugia malayi steroid hormone receptor 0.0021 0.0033 0.0069
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0033 0.0038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0184 0.1099
Schistosoma mansoni hypothetical protein 0.004 0.0154 0.0179
Loa Loa (eye worm) hypothetical protein 0.0102 0.0549 0.116
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.06 0.1001
Entamoeba histolytica cyclin family protein 0.0279 0.1672 0.6973
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0141 0.0604
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0021 0.0024
Echinococcus granulosus cyclin A3 4 0.0067 0.0329 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0329 0.0776
Giardia lamblia Hypothetical protein 0.0279 0.1672 0.6973
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0073 0.0367 0.0777
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0033 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.011 0.06 0.1001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0367 0.1573
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Trichomonas vaginalis glutaminase, putative 0.0269 0.1609 0.5381
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0255
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0167 0.0715
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0184 0.0184
Echinococcus granulosus excitatory amino acid transporter 2 0.0761 0.4728 0.5483
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0367 0.0367
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.06 0.0696
Echinococcus granulosus dnaJ subfamily B 0.0812 0.5052 0.5858
Echinococcus granulosus cyclin k 0.0067 0.0329 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.1672 0.5607
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0286 0.0286
Giardia lamblia Cyclin A 0.0279 0.1672 0.6973
Echinococcus granulosus excitatory amino acid transporter 2 0.0761 0.4728 0.5483
Toxoplasma gondii thioredoxin reductase 0.0038 0.0141 0.1135
Trypanosoma brucei cyclin 9 0.0067 0.0329 0.1408
Echinococcus granulosus importin subunit beta 1 0.006 0.0285 0.033
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0067 0.0329 0.1408
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0033 0.0069
Echinococcus granulosus snurportin 1 0.0645 0.3991 0.4627
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0641 0.1356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0033 0.0069
Loa Loa (eye worm) hypothetical protein 0.0164 0.094 0.1989
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0895 0.1644
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0796 1
Schistosoma mansoni cyclin l 0.0067 0.0329 0.0381
Mycobacterium tuberculosis Conserved protein 0.011 0.06 0.1001
Schistosoma mansoni cyclin k 0.0067 0.0329 0.0381
Onchocerca volvulus 0.0384 0.2336 0.4905
Mycobacterium ulcerans beta-lactamase 0.011 0.06 0.3128
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0291 0.0337
Plasmodium vivax SET domain protein, putative 0.0061 0.0286 0.4759
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Onchocerca volvulus Protein CNPPD1 homolog 0.0067 0.0329 0.0631
Onchocerca volvulus 0.0067 0.0329 0.0631
Brugia malayi Cyclin, N-terminal domain containing protein 0.0279 0.1672 0.3535
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0263 0.0557
Brugia malayi CXXC zinc finger family protein 0.0057 0.0263 0.0557
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Echinococcus granulosus cyclins 0.0067 0.0329 0.0381
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0021 0.0021
Trypanosoma cruzi mitotic cyclin, putative 0.0067 0.0329 0.1408
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0033 0.0033
Loa Loa (eye worm) glutaminase 0.0269 0.1609 0.3402
Echinococcus granulosus neutral amino acid transporter A 0.0761 0.4728 0.5483
Trichomonas vaginalis cyclin B, putative 0.0067 0.0329 0.0776
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.06 0.1269
Brugia malayi hypothetical protein 0.0016 0.0004 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0141 0.0604
Loa Loa (eye worm) CYL-1 protein 0.0067 0.0329 0.0696
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0684 0.3697
Brugia malayi cyclin fold protein 1 variant b 0.0067 0.0329 0.0696
Onchocerca volvulus 0.011 0.06 0.1209
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0033 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.011 0.06 0.2569
Trichomonas vaginalis cyclin B3, putative 0.0279 0.1672 0.5607
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0212 0.0357
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1066 0.1236
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0286 0.0331
Echinococcus granulosus cyclins 0.0279 0.1672 0.1938
Loa Loa (eye worm) hypothetical protein 0.0149 0.0848 0.1794
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0684 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0033 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0286 0.2295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0033 0.0069
Schistosoma mansoni cyclin B3 0.0279 0.1672 0.1938
Schistosoma mansoni hypothetical protein 0.004 0.0154 0.0179
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0184 0.1476
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0337 0.2041 0.2041
Loa Loa (eye worm) hypothetical protein 0.0384 0.2336 0.494
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0067 0.0329 0.0329
Echinococcus granulosus Excitatory amino acid transporter 0.0761 0.4728 0.5483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0264 0.0306
Echinococcus multilocularis muscleblind protein 1 0.0164 0.094 0.094
Mycobacterium leprae conserved hypothetical protein 0.011 0.06 0.4374
Schistosoma mansoni ap endonuclease 0.0038 0.0141 0.0164
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.06 0.1752
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0509 0.0802
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.026 0.055
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0067 0.0329 0.0696
Entamoeba histolytica cyclin, domain containing protein 0.0067 0.0329 0.0855
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0033 0.0038
Toxoplasma gondii ABC1 family protein 0.011 0.06 0.4822
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0184 0.0213
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0067 0.0329 0.2643
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0141 0.0141
Echinococcus multilocularis importin subunit beta 1 0.006 0.0285 0.0285
Loa Loa (eye worm) cyclin C 0.0067 0.0329 0.0696
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0357
Echinococcus granulosus cpg binding protein 0.006 0.0284 0.0329
Trichomonas vaginalis cyclin A, putative 0.0384 0.2336 0.7998
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0509 0.1754
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Giardia lamblia Cyclin fold protein 1, putative 0.0067 0.0329 0.0855
Plasmodium falciparum cyclin 0.0279 0.1672 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1066 0.1236
Echinococcus granulosus cyclins 0.0279 0.1672 0.1938
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0367 0.0426
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Trypanosoma brucei mitotic cyclin 6 0.0384 0.2336 1
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.1732 0.8371
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0033 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1788 0.7652
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.027 0.027
Echinococcus multilocularis microtubule associated protein 2 0.1376 0.8624 0.8624
Trichomonas vaginalis cyclins, putative 0.0279 0.1672 0.5607
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0201 0.0426
Schistosoma mansoni jumonji domain containing protein 0.0058 0.027 0.0313
Echinococcus granulosus Excitatory amino acid transporter 0.0761 0.4728 0.5483
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.026 0.0259
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0367 0.0426
Loa Loa (eye worm) hypothetical protein 0.0096 0.0511 0.1082
Echinococcus multilocularis cyclin y 0.0067 0.0329 0.0329
Entamoeba histolytica Ran family GTPase 0.0044 0.0184 0.0194
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0336 0.039
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.06 0.1752
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0141 0.0298
Mycobacterium ulcerans glutaminase 0.0269 0.1609 1
Brugia malayi CHE-14 protein 0.0041 0.0163 0.0346
Mycobacterium tuberculosis Conserved protein 0.011 0.06 0.1001
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.2797 0.2797
Trichomonas vaginalis cyclin B, putative 0.0067 0.0329 0.0776
Brugia malayi Cyclin, N-terminal domain containing protein 0.0384 0.2336 0.494
Entamoeba histolytica cyclin, putative 0.0384 0.2336 1
Toxoplasma gondii cyclin 4, putative 0.0067 0.0329 0.2643
Brugia malayi Pre-SET motif family protein 0.0415 0.253 0.5351
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0236 0.0499
Leishmania major hypothetical protein, conserved 0.011 0.06 0.2569
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0212 0.0909
Chlamydia trachomatis glutamate symporter 0.0761 0.4728 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.06 0.06
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0141 0.0605
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0336 0.0336
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0683 0.0792
Loa Loa (eye worm) beta-lactamase 0.011 0.06 0.1269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0286 0.0286
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0141 0.0299
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0255
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0033 0.0038
Echinococcus granulosus cyclin B3 1 0.0279 0.1672 0.1938
Leishmania major importin beta-1 subunit, putative 0.0049 0.0212 0.0909
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0279 0.1672 0.1672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0005 0.0006
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0511 0.1082
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0367 0.1031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0367 0.0915
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0184 0.0388
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0141 0.0298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1066 0.1066
Loa Loa (eye worm) hypothetical protein 0.0051 0.0222 0.047
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0448 0.0669
Loa Loa (eye worm) hypothetical protein 0.053 0.3263 0.69
Brugia malayi Thioredoxin reductase 0.0038 0.0141 0.0299
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0144 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0033 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0033 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0141 0.0604
Brugia malayi Importin beta-1 subunit 0.006 0.0285 0.0602
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0329 0.0696
Trichomonas vaginalis cyclin D, putative 0.0279 0.1672 0.5607
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0033 0.0033
Echinococcus multilocularis cyclin 0.0067 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.006 0.0285 0.0602
Loa Loa (eye worm) hypothetical protein 0.0463 0.2835 0.5997
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0761 0.4728 0.5483
Trichomonas vaginalis cyclins, putative 0.0384 0.2336 0.7998
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0285 0.1219
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0641 0.1356
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Trichomonas vaginalis cyclins, putative 0.0384 0.2336 0.7998
Plasmodium vivax importin-beta 2, putative 0.006 0.0285 0.4746
Schistosoma mansoni hypothetical protein 0.004 0.0154 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1732 0.7247
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Brugia malayi jmjC domain containing protein 0.0061 0.0291 0.0615
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1732 0.7247
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.1732 0.7247
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0601 0.4827
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0794 0.34
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0337 0.2041 0.2367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0033 0.0069
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0448 0.0669
Echinococcus multilocularis cpg binding protein 0.006 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.011 0.06 0.1269
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0141 0.0164
Entamoeba histolytica cyclin C, putative 0.0067 0.0329 0.0855
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0033 0.0038
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0184 0.3061
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0163 0.0163
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0367 0.1573
Echinococcus multilocularis cyclin A3 4 0.0067 0.0329 0.0329
Brugia malayi nuclear hormone receptor 0.0021 0.0033 0.0069
Giardia lamblia Cyclin B-like protein 0.0067 0.0329 0.0855
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0285 0.2289
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Brugia malayi glutaminase DH11.1 0.0269 0.1609 0.3402
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0329 0.0776
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0033 0.0069
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0367 0.0426
Brugia malayi glutathione reductase 0.0038 0.0141 0.0299
Schistosoma mansoni tsg101-related 0.0057 0.0263 0.0305
Schistosoma mansoni hypothetical protein 0.0047 0.0201 0.0233
Toxoplasma gondii hypothetical protein 0.0212 0.1245 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0291 0.0337
Schistosoma mansoni glutaminase 0.0269 0.1609 0.1865
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.06 0.1001
Schistosoma mansoni hypothetical protein 0.0102 0.0549 0.0636
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0067 0.0329 0.0381
Brugia malayi beta-lactamase 0.011 0.06 0.1269
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0005 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0848 0.1794
Brugia malayi hypothetical protein 0.0233 0.1382 0.2923
Echinococcus multilocularis cyclin G2 0.0067 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0069
Mycobacterium tuberculosis Probable reductase 0.0086 0.0448 0.0669
Schistosoma mansoni hypothetical protein 0.0047 0.0201 0.0233
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0448 0.0669
Echinococcus multilocularis cyclin B3 1 0.0279 0.1672 0.1672
Onchocerca volvulus 0.0472 0.2892 0.609
Echinococcus granulosus expressed conserved protein 0.009 0.0474 0.055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0033 0.0033
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.026 0.026
Brugia malayi Muscleblind-like protein 0.0164 0.094 0.1989
Trichomonas vaginalis ran, putative 0.0044 0.0184 0.0253
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.06 0.3128
Loa Loa (eye worm) hypothetical protein 0.0384 0.2336 0.494
Loa Loa (eye worm) hypothetical protein 0.0164 0.094 0.1989
Echinococcus granulosus microtubule associated protein 2 0.1376 0.8624 1
Schistosoma mansoni hypothetical protein 0.0812 0.5052 0.5858
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0329 0.1408
Schistosoma mansoni hypothetical protein 0.0048 0.0204 0.0236
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.06 0.1001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1066 0.1236
Trypanosoma cruzi mitotic cyclin, putative 0.0067 0.0329 0.1408
Leishmania major mitotic cyclin, putative 0.0067 0.0329 0.1408
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0604
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.1066 0.2254
Trichomonas vaginalis set domain proteins, putative 0.0472 0.2892 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0033 0.0069
Loa Loa (eye worm) glutaminase 2 0.0269 0.1609 0.3402
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0163 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0033 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0033 0.0069
Giardia lamblia G2/mitotic-specific cyclin B 0.0384 0.2336 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0033 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0291 0.0337
Echinococcus granulosus Cyclin L1 0.0067 0.0329 0.0381
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0141 0.2352
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Entamoeba histolytica hypothetical protein 0.0049 0.0212 0.0325
Echinococcus granulosus cyclin y 0.0067 0.0329 0.0381
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0337 0.2041 0.2041
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.026 0.1113
Schistosoma mansoni ap endonuclease 0.0038 0.0141 0.0164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1732 0.5823
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0212 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0329 0.0776
Schistosoma mansoni hypothetical protein 0.0645 0.3991 0.4627
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0511 0.1687
Echinococcus multilocularis cyclin B 0.0384 0.2336 0.2336
Loa Loa (eye worm) cyclin domain-containing protein 0.0067 0.0329 0.0696
Treponema pallidum glutamate transporter 0.0337 0.2041 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0286 0.0331
Schistosoma mansoni cpg binding protein 0.006 0.0284 0.0329
Trichomonas vaginalis esterase, putative 0.011 0.06 0.1752
Trichomonas vaginalis cyclins, putative 0.0067 0.0329 0.0776
Echinococcus granulosus muscleblind protein 0.0164 0.094 0.109
Trichomonas vaginalis cyclin D, putative 0.0279 0.1672 0.5607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.1066 0.2254
Echinococcus multilocularis cyclins 0.0279 0.1672 0.1672
Schistosoma mansoni hypothetical protein 0.0171 0.0985 0.1143
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0367 0.0426
Echinococcus multilocularis excitatory amino acid transporter 2 0.0761 0.4728 0.4728
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0684 0.1183
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0144 0.0168

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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