Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2744 | 0.3519 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.7834 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0578 | 0.0742 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2636 | 0.9606 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.699 | 0.8837 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2636 | 0.338 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.2108 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2744 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2744 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2744 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0274 | 0.0351 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2636 | 0.338 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0578 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.0578 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0578 | 0.5 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2744 | 0.3519 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.699 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2636 | 0.2636 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2744 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0578 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7798 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2744 | 0.3519 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0274 | 0.0351 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.7834 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.699 | 0.8837 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2744 | 0.3519 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2744 | 0.2985 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2744 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.7834 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0578 | 0.5 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2744 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.699 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2744 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2744 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7798 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.699 | 0.8837 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.2108 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.7834 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0578 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7798 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0578 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2636 | 0.9606 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.699 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2636 | 0.9606 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2744 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0578 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2744 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2636 | 0.9606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.