Detailed information for compound 587480

Basic information

Technical information
  • TDR Targets ID: 587480
  • Name: 1-(1H-pyrrol-2-yl)-9H-pyrido[3,4-b]indol-6-ol
  • MW: 249.267 | Formula: C15H11N3O
  • H donors: 3 H acceptors: 2 LogP: 2.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c1ccnc(c1[nH]2)c1ccc[nH]1
  • InChi: 1S/C15H11N3O/c19-9-3-4-12-11(8-9)10-5-7-17-15(14(10)18-12)13-2-1-6-16-13/h1-8,16,18-19H
  • InChiKey: WDLOHMDDICIDKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1H-pyrrol-2-yl)-9H-$b-carbolin-6-ol
  • eudistomin M
  • 88704-39-6
  • 9H-Pyrido(3,4-b)indol-6-ol, 1-(1H-pyrrol-2-yl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.402 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.3324 0.8268
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0258 0.0258
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0508 0.5629
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0958 0.2384
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1544 0.384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0214 0.0767
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Schistosoma mansoni survival motor neuron protein 0.005 0.0576 0.2062
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0039 0.0392 0.034
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.058 1 1
Schistosoma mansoni endoplasmin 0.0046 0.0508 0.1817
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0611 0.7098
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.058 1 1
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Plasmodium vivax heat shock protein, putative 0.0174 0.2779 0.2779
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0258 0.0642
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0039 0.0392 0.0974
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0039 0.0392 0.0392
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0508 0.5898
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.039 0.4532
Echinococcus multilocularis heat shock protein 90 0.0039 0.039 0.097
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0508 0.5898
Onchocerca volvulus 0.005 0.0576 0.1506
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0392 0.0974
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0039 0.0392 0.034
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0039 0.0392 0.0392
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.402 1
Schistosoma mansoni neuropeptide receptor 0.0157 0.2489 0.8907
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0039 0.0392 0.0974
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0508 0.5898
Treponema pallidum heat shock protein 90 0.0043 0.0458 1
Schistosoma mansoni hypothetical protein 0.0033 0.0279 0.0999
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0039 0.0392 0.1402
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Brugia malayi hypothetical protein 0.0243 0.402 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0174 0.2794 1
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.088 0.219
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0039 0.0392 0.034
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.039 0.7414
Brugia malayi hypothetical protein 0.0027 0.0175 0.0436
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0508 0.5629
Plasmodium vivax heat shock protein 90, putative 0.003 0.0234 0.0234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1544 0.384
Echinococcus multilocularis endoplasmin 0.0043 0.0458 0.1139
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0039 0.0392 0.034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0053 0.0053
Echinococcus granulosus heat shock protein 0.0046 0.0508 0.1263
Schistosoma mansoni heat shock protein 0.0046 0.0508 0.1817
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0039 0.0392 0.4549
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0258 0.0642
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0458 0.0407
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0175 0.1514
Loa Loa (eye worm) hypothetical protein 0.0033 0.0279 0.0694
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0458 0.0407
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0576 0.1433
Schistosoma mansoni thyroid hormone receptor 0.0146 0.2292 0.8205
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0284 0.0284
Mycobacterium tuberculosis Probable oxidoreductase 0.0039 0.0392 0.034
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0234 0.2246
Trichomonas vaginalis hypothetical protein 0.058 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0039 0.0392 0.034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0392 0.0974
Schistosoma mansoni heat shock protein 0.0046 0.0508 0.1817
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.039 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0039 0.0392 0.4192
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0175 0.2036
Schistosoma mansoni ap endonuclease 0.002 0.0053 0.019
Schistosoma mansoni dihydropteridine reductase 0.0039 0.0392 0.1402
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0053 0.0616
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0258 0.0642
Brugia malayi RNA binding protein 0.0129 0.1978 0.492
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0508 0.5629
Toxoplasma gondii exonuclease III APE 0.002 0.0053 0.0053
Plasmodium vivax endoplasmin, putative 0.0046 0.0508 0.0508
Brugia malayi Endoplasmin precursor 0.0046 0.0508 0.1263
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0279 0.0694
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1978 0.708
Trichomonas vaginalis heat shock protein, putative 0.0039 0.039 0.039
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0039 0.0392 0.034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.076 0.8824
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.088 0.219
Leishmania major oxidoreductase-like protein 0.0039 0.0392 0.4549
Echinococcus multilocularis neuropeptide receptor 0.0157 0.2489 0.619
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1975 0.4913
Brugia malayi heat shock protein 90 0.0046 0.0508 0.1263
Echinococcus multilocularis tar DNA binding protein 0.0129 0.1978 0.492
Schistosoma mansoni hypothetical protein 0.0033 0.0279 0.0999
Echinococcus granulosus neuropeptide receptor 0.0157 0.2489 0.619
Echinococcus granulosus GPCR family 2 0.0033 0.0279 0.0694
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Plasmodium falciparum heat shock protein 90, putative 0.0174 0.2779 0.2779
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Onchocerca volvulus 0.0039 0.0392 0.1024
Echinococcus granulosus heat shock protein 90 0.0039 0.039 0.097
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0258 0.3
Loa Loa (eye worm) endoplasmin 0.0046 0.0508 0.1263
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.2099 0.5222
Loa Loa (eye worm) hypothetical protein 0.0243 0.402 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0508 0.5898
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0167 0.0167
Schistosoma mansoni P2X receptor subunit 0.0067 0.088 0.3151
Plasmodium falciparum heat shock protein 90 0.0046 0.0508 0.0508
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0034 0.0401
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.1978 0.492
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Giardia lamblia Grp94/Hsp90 0.0043 0.0458 0.89
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0258 0.0258
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.088 0.219
Schistosoma mansoni P2X receptor subunit 0.0067 0.088 0.3151
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0458 0.0458
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.058 1 1
Echinococcus granulosus endoplasmin 0.0043 0.0458 0.1139
Trypanosoma brucei pteridine reductase 1 0.0039 0.0392 0.4192
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0039 0.0392 0.034
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0039 0.0392 0.4549
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0167 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1978 0.708
Brugia malayi Pre-SET motif family protein 0.0029 0.0214 0.0533
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0508 0.0508
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0214 0.0533
Mycobacterium tuberculosis Possible oxidoreductase 0.0039 0.0392 0.034
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0234 0.0583
Brugia malayi isocitrate dehydrogenase 0.0032 0.0258 0.0642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0279 0.0694
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0258 0.0258
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0053 0.0616
Leishmania major cathepsin L-like protease 0.0066 0.0861 1
Echinococcus multilocularis heat shock protein 0.0046 0.0508 0.1263
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1978 0.708
Loa Loa (eye worm) RNA binding protein 0.0129 0.1978 0.492
Echinococcus granulosus heat shock protein 90 0.0046 0.0508 0.1263
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0508 1
Echinococcus multilocularis G protein coupled receptor 139 0.0157 0.2489 0.619
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0053 0.0132
Onchocerca volvulus Huntingtin homolog 0.0126 0.1935 0.5059
Loa Loa (eye worm) TAR-binding protein 0.0129 0.1978 0.492
Loa Loa (eye worm) heat shock protein 75 0.003 0.0234 0.0583
Brugia malayi Hsp90 protein 0.003 0.0234 0.0583
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Mycobacterium tuberculosis Possible oxidoreductase 0.0039 0.0392 0.034
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0458 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0175 0.0175
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Onchocerca volvulus 0.0039 0.0392 0.1024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0533
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0279 0.0694
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Schistosoma mansoni ap endonuclease 0.002 0.0053 0.019
Echinococcus multilocularis geminin 0.0174 0.2794 0.695
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0436
Schistosoma mansoni hypothetical protein 0.0033 0.0279 0.0999
Schistosoma mansoni endoplasmin 0.0046 0.0508 0.1817
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.039 0.4532
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0258 0.0642
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.058 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Brugia malayi hypothetical protein 0.0017 0.0005 0.0011
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0126 0.1935 0.4814
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0104 0.1544 0.384
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0039 0.0392 0.0974
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0279 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0174 0.2794 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0053 0.0132
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Loa Loa (eye worm) hypothetical protein 0.0039 0.0392 0.0974
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0039 0.0392 0.4549
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0458 0.5317
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Onchocerca volvulus Huntingtin homolog 0.0126 0.1935 0.5059
Mycobacterium ulcerans oxidoreductase 0.0039 0.0392 0.034
Leishmania major pteridine reductase 1 0.0039 0.0392 0.4549
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0053 0.0132
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Echinococcus granulosus tar DNA binding protein 0.0129 0.1978 0.492
Trypanosoma brucei oxidoreductase-like protein 0.0039 0.0392 0.4192
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0039 0.0392 0.0392
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0175 0.2036
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0508 0.0508
Onchocerca volvulus 0.0156 0.2458 0.6427
Plasmodium vivax SET domain protein, putative 0.0029 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.005 0.0576 0.2062
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.088 0.219
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.2292 0.5702
Schistosoma mansoni P2X receptor subunit 0.0067 0.088 0.3151
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1978 0.708
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0279 0.0694
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0053 0.0132
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0258 0.2541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0214 0.0767
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0861 1
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0039 0.0392 0.7714
Echinococcus granulosus geminin 0.0174 0.2794 0.695
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0234 0.4618
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0258 0.0642
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0861 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0214 0.0533
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0039 0.0392 0.034
Leishmania major cathepsin L-like protease 0.0066 0.0861 1
Onchocerca volvulus 0.0029 0.0214 0.056
Schistosoma mansoni hypothetical protein 0.0135 0.2099 0.7514
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1544 0.384
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0039 0.0392 0.4549
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0214 0.0533
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0053 0.0616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0214 0.0767
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0039 0.0392 0.034
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0284 0.0284
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Trichomonas vaginalis set domain proteins, putative 0.0232 0.3825 0.3825
Brugia malayi MH2 domain containing protein 0.0128 0.1975 0.4913
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0508 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0039 0.0392 0.4549
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0508 0.1263
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1978 0.708
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0234 0.0583
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0861 1
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Brugia malayi TAR-binding protein 0.0129 0.1978 0.492
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0508 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0175 0.0175
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0039 0.0392 0.0392
Plasmodium falciparum enoyl-acyl carrier reductase 0.058 1 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0039 0.0392 0.034
Schistosoma mansoni hypothetical protein 0.0033 0.0279 0.0999
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0508 0.5898
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0258 0.0642
Echinococcus multilocularis GPCR, family 2 0.0033 0.0279 0.0694
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0279 0.0694
Leishmania major heat shock protein, putative 0.003 0.0234 0.2724
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0258 0.0206
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0458 0.0458
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0039 0.0392 0.0392
Brugia malayi hypothetical protein 0.0156 0.2458 0.6115
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0053 0.0053
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0039 0.0392 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.058 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0958 0.2384
Echinococcus multilocularis heat shock protein 90 0.0046 0.0508 0.1263
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Brugia malayi hypothetical protein 0.0126 0.1935 0.4814
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0258 0.3
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0214 0.0767
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0279 0.0694
Schistosoma mansoni heat shock protein 0.003 0.0234 0.0839
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0053 0.1044
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Leishmania major cathepsin L-like protease 0.0066 0.0861 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.2099 0.5222
Brugia malayi Pre-SET motif family protein 0.0204 0.3324 0.8268
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0234 0.0234
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Loa Loa (eye worm) hypothetical protein 0.0126 0.1935 0.4814
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0039 0.0392 0.4549
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.1978 0.492
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0234 0.0613
Plasmodium falciparum endoplasmin, putative 0.0033 0.0284 0.0284
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0195 0.0485
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0861 1
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0039 0.0392 0.034
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0053 0.0053
Plasmodium vivax enoyl-acyl carrier protein reductase 0.058 1 1
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.088 0.219
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0053 0.0053
Toxoplasma gondii Hsp90 domain-containing protein 0.0174 0.2779 0.2779
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.088 0.219
Loa Loa (eye worm) retinol dehydrogenase 12 0.0039 0.0392 0.0974
Schistosoma mansoni thyroid hormone receptor 0.0146 0.2292 0.8205
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0258 0.3
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0508 0.0508
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1975 0.4913
Mycobacterium ulcerans short chain dehydrogenase 0.0039 0.0392 0.034
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0258 0.2541
Leishmania major hypothetical protein, conserved 0.0027 0.0175 0.2036
Onchocerca volvulus 0.0232 0.3825 1
Leishmania major heat shock protein 83-1 0.0046 0.0508 0.5898
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0392 0.034
Loa Loa (eye worm) hypothetical protein 0.0156 0.2458 0.6115
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0258 0.0924
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0458 0.0069
Schistosoma mansoni P2X receptor subunit 0.0067 0.088 0.3151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Trypanosoma cruzi heat shock protein, putative 0.003 0.0234 0.2724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0861 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0039 0.0392 0.034
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0258 0.0642
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0258 0.0642
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0071 0.0958 0.343
Loa Loa (eye worm) oxidoreductase 0.0039 0.0392 0.0974
Trypanosoma brucei heat shock protein, putative 0.0046 0.0508 0.5629

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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