Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.1739 | 0.2096 |
Echinococcus multilocularis | expressed protein | 0.0034 | 0.1312 | 0.1581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4692 | 0.4692 |
Brugia malayi | glutathione reductase | 0.0038 | 0.1689 | 0.2809 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.6012 | 0.7244 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.1689 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.4783 | 0.5764 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1531 | 0.1531 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.4783 | 0.4783 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0033 | 0.1232 | 0.9331 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0034 | 0.132 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.3204 | 0.3861 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1431 | 0.1724 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.6523 | 0.8716 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0038 | 0.1689 | 0.2257 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.1689 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4692 | 0.4692 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.4783 | 0.5764 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0034 | 0.132 | 0.7536 |
Schistosoma mansoni | transcription factor btf3 | 0.0034 | 0.132 | 0.132 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.1739 | 0.2096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.4692 | 0.5654 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.132 | 0.7817 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.6523 | 0.8716 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.4692 | 0.5654 |
Brugia malayi | RNA binding protein | 0.0067 | 0.4692 | 0.7804 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0038 | 0.1777 | 0.2141 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.6012 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.1689 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0103 | 0.8299 | 0.8299 |
Brugia malayi | beta-NAC-like protein | 0.0034 | 0.132 | 0.2196 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.4692 | 0.7804 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0193 | 0.0257 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.1689 | 0.2035 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.1689 | 0.2035 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.4692 | 0.5654 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0193 | 0.5 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0038 | 0.1777 | 0.2141 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.1689 | 0.2809 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.3204 | 0.5329 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0103 | 0.8299 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0033 | 0.1232 | 0.7294 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.6523 | 0.8716 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.1689 | 1 |
Leishmania major | basic transcription factor 3a, putative | 0.0034 | 0.132 | 0.7817 |
Loa Loa (eye worm) | ICD-1 protein | 0.0034 | 0.132 | 0.1591 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.4783 | 0.4783 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0086 | 0.6523 | 0.8683 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.6523 | 0.8716 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.132 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.4783 | 0.5764 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0103 | 0.8299 | 0.8299 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.7484 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.1232 | 0.7294 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.4437 | 0.5347 |
Leishmania major | trypanothione reductase | 0.0038 | 0.1689 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4692 | 0.4692 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.1232 | 0.9331 |
Toxoplasma gondii | NAC domain-containing protein | 0.0034 | 0.132 | 0.7536 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.4692 | 0.7804 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.6012 | 0.6012 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.6523 | 0.8716 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.1689 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.6523 | 0.8716 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.0038 | 0.1777 | 0.2956 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1531 | 0.1844 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.8299 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.1312 | 0.1581 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0034 | 0.132 | 0.7536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4692 | 0.4692 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.6012 | 0.7244 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.4692 | 0.5654 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.3204 | 0.5329 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1531 | 0.2546 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0193 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.6012 | 0.7244 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.4783 | 0.5764 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0034 | 0.132 | 0.7817 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0193 | 0.5 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0033 | 0.1232 | 0.6946 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0193 | 0.114 |
Trichomonas vaginalis | rotamase, putative | 0.0034 | 0.1312 | 0.9937 |
Echinococcus granulosus | transcription factor btf3 | 0.0034 | 0.132 | 0.1591 |
Schistosoma mansoni | rotamase | 0.0034 | 0.1312 | 0.1312 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0193 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.132 | 0.7817 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0193 | 0.1459 |
Echinococcus granulosus | expressed protein | 0.0034 | 0.1312 | 0.1581 |
Onchocerca volvulus | 0.0081 | 0.6012 | 0.5 | |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0193 | 0.114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4692 | 0.4692 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.7484 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.01 | 0.7953 | 0.9583 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.01 | 0.7953 | 0.9583 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.7484 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0103 | 0.8299 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.1689 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.132 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.4692 | 0.5654 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.132 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0193 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0034 | 0.1312 | 0.2182 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1312 | 0.9937 |
Echinococcus multilocularis | transcription factor btf3 | 0.0034 | 0.132 | 0.1591 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.132 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0033 | 0.1232 | 0.7294 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.1232 | 0.7294 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.1689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1777 | 0.2141 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3204 | 0.3861 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.7484 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.